Clustering data with hclust algorithm for (Study ST004223)
None (Direct infusion) NEGATIVE ION MODE (Analysis AN007028)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
|---|---|---|---|---|---|---|---|---|---|
| CL 18:2/18:2/18:2/20:4 | ME1140837 | 1.94 | 2.10 | 1.82 | 1.83 | 0.73 | 0.70 | 0.84 | 0.67 |
| BMP 18:1_20:4 | ME1140873 | 1.04 | 0.93 | 1.16 | 0.90 | NA | NA | NA | NA |
| BMP 18:1_22:6 | ME1140875 | 0.78 | 0.83 | 0.80 | 0.74 | 1.19 | 0.99 | 1.22 | 0.80 |
| BMP 18:2_20:4, 16:0_22:6 | ME1140872 | 0.64 | 0.60 | 0.73 | 0.62 | 1.15 | 0.98 | 1.31 | 0.92 |
| PI 16:0/20:4 | ME1140883 | 1.02 | 0.92 | 1.12 | 0.97 | NA | NA | NA | NA |
| PS 20:0/20:2, 18:0/22:2 | ME1140906 | 0.24 | 0.36 | 0.21 | 0.35 | 1.06 | 1.37 | 1.08 | 1.31 |
| SHexCer 18:1;O2/25:1 | ME1140821 | 0.37 | 0.87 | 0.33 | 0.86 | 0.97 | 1.28 | 0.95 | 1.26 |
| PI 16:0/16:0 | ME1140879 | 0.50 | 0.50 | 0.53 | 0.62 | 1.17 | 1.11 | 1.16 | 1.07 |
| CL 20:4/18:2/18:1/16:1 | ME1140831 | 0.96 | 1.02 | 0.98 | 0.91 | 0.82 | 0.87 | 1.42 | 0.89 |
| CL 18:1/18:1/16:1/16:1 | ME1140825 | NA | NA | NA | NA | 1.11 | 0.75 | 1.32 | 0.76 |
| CL 20:4/18:2/18:1/16:0, 20:4/18:1/18:1/16:1 | ME1140832 | 1.31 | 1.39 | 1.19 | 1.24 | 0.91 | 0.87 | 1.04 | 0.84 |
| CL 18:1/18:1/18:1/16:0, 18:0/18:1/18:1/16:1 | ME1140830 | NA | NA | NA | NA | 1.07 | 0.98 | 0.99 | 0.96 |
| PA 18:0/20:2 | ME1140864 | 0.08 | 0.25 | 0.07 | 0.18 | 0.89 | 1.64 | 0.92 | 1.59 |
| SHexCer 18:1;O2/22:0 | ME1140812 | 0.19 | 0.41 | 0.15 | 0.40 | 1.09 | 1.33 | 1.03 | 1.38 |
| PI 18:0/18:1 | ME1140885 | 0.72 | 1.05 | 0.85 | 1.22 | 0.92 | 1.10 | 0.99 | 1.06 |
| CL 18:2/18:2/20:3/22:6 | ME1140848 | 0.92 | 1.10 | 0.94 | 1.05 | NA | NA | NA | NA |
| SHexCer 18:1;O2/25:0, 18:1;O2/24:1;O | ME1140822 | 0.59 | 1.48 | 0.58 | 1.45 | 0.81 | 1.14 | 0.83 | 1.23 |
| CL 18:2/18:2/20:4/22:6 | ME1140847 | 0.91 | 1.06 | 1.00 | 1.06 | NA | NA | NA | NA |
| PI 16:0/18:1 | ME1140881 | 2.12 | 1.68 | 2.01 | 1.81 | 0.74 | 0.74 | 0.78 | 0.72 |
| BMP 22:6_22:6 | ME1140877 | 0.94 | 1.02 | 1.04 | 0.98 | 1.03 | 1.01 | 1.06 | 0.90 |
| PI 16:0/16:1 | ME1140878 | 1.20 | 0.88 | 1.01 | 0.87 | NA | NA | NA | NA |
| PS 18:0/20:2 | ME1140901 | 0.12 | 0.21 | 0.11 | 0.21 | 1.03 | 1.43 | 1.09 | 1.42 |
| CL 18:2/18:2/18:2/22:5, 18:1/18:2/18:2/22:6 | ME1140843 | 0.99 | 1.12 | 0.85 | 0.99 | NA | NA | NA | NA |
| CL 20:4/18:1/16:1/16:0, 18:2/18:2/18:1/16:1 | ME1140827 | 1.25 | 1.28 | 1.26 | 1.19 | 0.88 | 0.84 | 1.18 | 0.79 |
| BMP 18:0_20:4 | ME1140874 | 1.20 | 1.48 | 1.09 | 1.30 | 0.89 | 0.93 | 0.94 | 0.93 |
| CL 18:2/18:2/22:6/22:6 | ME1140851 | 0.85 | 1.09 | 1.01 | 1.09 | NA | NA | NA | NA |
| CL 18:2/18:3/20:4/22:6 | ME1140846 | 0.94 | 1.13 | 1.01 | 0.92 | NA | NA | NA | NA |
| PS 20:0/22:2 | ME1140910 | 0.24 | 0.30 | 0.21 | 0.29 | 1.16 | 1.31 | 1.16 | 1.20 |
| PG 18:0/18:1 | ME1140871 | 2.30 | 1.50 | 2.34 | 1.85 | 0.77 | 0.75 | 0.72 | 0.65 |
| PG 18:2/18:2 | ME1140869 | 1.80 | 1.71 | 1.87 | 1.65 | 0.80 | 0.71 | 0.92 | 0.72 |
| CL 20:4/20:4/22:6/22:5, 18:2/22:6/22:6/22:5 | ME1140852 | 0.79 | 1.03 | 0.97 | 1.29 | NA | NA | NA | NA |
| CL 22:6/18:1/18:1/18:1, 20:4/20:3/18:1/18:1 | ME1140845 | 0.92 | 1.07 | 0.92 | 0.96 | 1.04 | 1.01 | 1.01 | 0.96 |
| CL 20:4/20:4/18:1/18:1 | ME1140844 | 0.99 | 1.11 | 0.97 | 1.00 | 1.02 | 0.99 | 1.03 | 0.93 |
| SHexCer 18:1;O2/24:2;O | ME1140820 | 0.10 | 0.28 | 0.11 | 0.28 | 1.07 | 1.42 | 1.05 | 1.40 |
| SHexCer 18:1;O2/24:2 | ME1140816 | 0.29 | 0.70 | 0.28 | 0.68 | 1.08 | 1.31 | 1.03 | 1.17 |
| PS 18:1/22:6 | ME1140903 | 1.46 | 1.44 | 1.35 | 1.27 | 0.85 | 0.91 | 0.92 | 0.89 |
| PG 16:0/16:0 | ME1140867 | 0.56 | 0.58 | 0.63 | 0.60 | 1.14 | 1.08 | 1.14 | 1.09 |
| PS 18:1/20:4 | ME1140899 | 0.36 | 0.44 | 0.34 | 0.41 | 1.10 | 1.23 | 1.17 | 1.19 |
| PA 18:0/22:4 | ME1140866 | 0.28 | 0.67 | 0.21 | 0.43 | 0.97 | 1.47 | 0.93 | 1.35 |
| PA P18:0/20:4 | ME1140862 | NA | NA | NA | NA | 0.90 | 1.17 | 0.88 | 1.08 |
| PS 18:2/20:4 | ME1140898 | 1.16 | 1.01 | 0.97 | 0.80 | NA | NA | NA | NA |
| CL 20:4/18:1/18:1/16:0, 20:3/18:1/18:1/16:1, 20:3/18:1/18:1/16:1 | ME1140833 | 1.28 | 1.30 | 1.20 | 1.21 | 0.96 | 0.90 | 1.01 | 0.84 |
| CL 20:4/18:1/18:1/18:0, 20:3/18:1/18:1/18:1 | ME1140841 | NA | NA | NA | NA | 1.10 | 0.93 | 1.11 | 0.83 |
| PA 18:0/20:1 | ME1140865 | 0.13 | 0.27 | 0.09 | 0.22 | 1.00 | 1.56 | 0.98 | 1.44 |
| CL 18:2/18:2/20:1/22:6, 18:1/18:2/20:2/22:6 | ME1140850 | 1.36 | 1.55 | 1.25 | 1.47 | 0.92 | 0.87 | 0.92 | 0.82 |
| CL 18:2/18:2/20:2/22:6, 18:1/18:2/20:3/22:6 | ME1140849 | 1.55 | 1.84 | 1.45 | 1.73 | 0.83 | 0.83 | 0.83 | 0.78 |
| LysoCL18:1/18:1/22:6 | ME1140855 | 0.46 | 0.53 | 0.62 | 0.64 | 1.06 | 1.27 | 1.05 | 1.14 |
| SHexCer 18:1;O2/24:1 | ME1140817 | 0.26 | 0.62 | 0.24 | 0.61 | 1.00 | 1.34 | 1.00 | 1.34 |
| PI 18:2/20:4, 16:0-22:6 | ME1140887 | NA | NA | NA | NA | 1.01 | 1.00 | 1.01 | 0.98 |
| CL 18:2/18:1/18:1/18:1 | ME1140834 | 1.15 | 1.17 | 1.18 | 1.07 | 1.04 | 0.91 | 1.02 | 0.85 |
| PI P18:0/20:4 | ME1140886 | 1.81 | 1.72 | 2.38 | 2.25 | 0.74 | 0.73 | 0.78 | 0.63 |
| CL 18:2/18:2/16:1/22:6 | ME1140836 | 0.99 | 1.11 | 1.01 | 0.87 | NA | NA | NA | NA |
| PG 18:1/18:1 | ME1140870 | 0.83 | 0.75 | 0.87 | 0.84 | 1.12 | 0.94 | 1.20 | 0.92 |
| PA 18:0/20:4 | ME1140863 | 0.24 | 0.43 | 0.19 | 0.33 | 1.08 | 1.38 | 1.06 | 1.29 |
| CL 18:1/18:1/18:1/16:1, 18:2/18:1/18:1/16:0 | ME1140829 | 1.08 | 1.12 | 1.02 | 1.03 | 1.07 | 0.92 | 1.04 | 0.88 |
| CL 18:2/18:2/18:2/20:2 | ME1140839 | 0.90 | 0.99 | 0.88 | 0.89 | 1.06 | 1.01 | 1.05 | 0.96 |
| PS 18:0/20:1 | ME1140902 | 0.13 | 0.21 | 0.11 | 0.20 | 1.09 | 1.40 | 1.11 | 1.37 |
| PS 18:0/20:4 | ME1140900 | 0.61 | 0.81 | 0.56 | 0.80 | 1.04 | 1.11 | 1.11 | 1.08 |
| PA16:0/16:0 | ME1140857 | 0.51 | 0.79 | 0.53 | 0.68 | 1.08 | 1.17 | 1.06 | 1.11 |
| PA 16:0/16:1 | ME1140856 | 0.26 | 0.43 | 0.26 | 0.38 | 1.14 | 1.19 | 1.22 | 1.18 |
| PI 18:0/22:4 | ME1140892 | 0.50 | 0.69 | 0.54 | 0.77 | 1.02 | 1.25 | 1.05 | 1.12 |
| PS 20:0/22:4 | ME1140909 | 0.37 | 0.57 | 0.31 | 0.53 | 1.07 | 1.21 | 1.16 | 1.19 |
| PS 22:6/22:6 | ME1140912 | 0.31 | 0.34 | 0.32 | 0.34 | 1.23 | 1.16 | 1.20 | 1.16 |
| PI 18:0/18:2 | ME1140884 | 0.31 | 0.40 | 0.37 | 0.48 | 1.07 | 1.29 | 1.13 | 1.20 |
| CL 18:1/18:1/18:1/18:1 | ME1140835 | 0.75 | 0.91 | 0.77 | 0.90 | 1.08 | 1.03 | 1.08 | 0.99 |
| PG 16:0/18:1 | ME1140868 | 0.81 | 0.76 | 0.84 | 0.79 | 1.08 | 1.02 | 1.12 | 0.99 |
| LysoCL 18:1/18:1/18:1 | ME1140853 | 0.34 | 0.40 | 0.48 | 0.48 | 1.11 | 1.17 | 1.28 | 1.07 |
| PI 18:1/22:6 | ME1140890 | 0.34 | 0.29 | 0.43 | 0.40 | 1.13 | 1.20 | 1.21 | 1.18 |
| PA 18:0/18:2, 18:1/18:1 | ME1140860 | 0.19 | 0.38 | 0.18 | 0.31 | 0.97 | 1.48 | 1.00 | 1.42 |
| PS 18:0/18:2 | ME1140896 | 0.28 | 0.35 | 0.29 | 0.33 | 1.11 | 1.28 | 1.15 | 1.23 |
| PS 22:4/22:0 | ME1140913 | NA | NA | NA | NA | 0.73 | 1.20 | 0.73 | 1.41 |
| PS P18:0/18:2 | ME1140894 | NA | NA | NA | NA | 0.99 | 0.98 | 1.06 | 0.96 |
| SHexCer 18:1;O2/24:0;O | ME1140823 | 0.55 | 1.29 | 0.58 | 1.35 | 0.87 | 1.15 | 0.85 | 1.23 |
| PI 18:1/20:4 | ME1140888 | 1.06 | 0.91 | 1.06 | 0.95 | 0.94 | 1.08 | 0.96 | 1.04 |
| PI 18:0/22:6 | ME1140891 | 0.28 | 0.29 | 0.36 | 0.39 | 1.18 | 1.21 | 1.20 | 1.16 |
| LysoCL18:2/18:2/20:3, 18:2/18:1/20:4 | ME1140854 | 0.56 | 0.56 | 0.56 | 0.56 | 1.02 | 1.24 | 1.12 | 1.00 |
| PS P18:0/18:1 | ME1140895 | NA | NA | NA | NA | 1.01 | 0.92 | 1.12 | 0.93 |
| PA 16:0/18:2 | ME1140858 | 0.30 | 0.49 | 0.30 | 0.43 | 1.13 | 1.29 | 1.10 | 1.18 |
| PS 16:0/18:1 | ME1140893 | 0.82 | 0.80 | 0.73 | 0.70 | 1.07 | 1.05 | 1.10 | 1.02 |
| PS 20:1/22:6 | ME1140908 | 0.40 | 0.50 | 0.35 | 0.49 | 0.99 | 1.30 | 1.11 | 1.25 |
| SHexCer 18:1;O2/24:0 | ME1140818 | 0.20 | 0.44 | 0.18 | 0.45 | 1.10 | 1.31 | 1.02 | 1.36 |
| PS 18:0/18:1 | ME1140897 | 0.33 | 0.50 | 0.30 | 0.49 | 1.12 | 1.25 | 1.12 | 1.18 |
| SHexCer 18:1;O2/22:0;O | ME1140815 | 0.59 | 1.35 | 0.56 | 1.28 | 0.86 | 1.15 | 0.83 | 1.26 |
| SHexCer 18:1;O2/23:0 | ME1140814 | 0.28 | 0.52 | 0.23 | 0.51 | 1.06 | 1.30 | 1.01 | 1.35 |
| SHexCer 18:0;O2/24:0 | ME1140819 | NA | NA | NA | NA | 0.88 | 1.10 | 0.85 | 1.20 |
| PI 16:1/20:4 | ME1140882 | 0.03 | 0.03 | 0.04 | 0.03 | 1.31 | 1.25 | 1.28 | 1.23 |
| PI 18:0/20:4 | ME1140889 | 1.24 | 1.13 | 1.21 | 1.14 | 0.95 | 0.98 | 0.94 | 0.93 |
| CL 18:2/18:2/18:2/20:3 | ME1140838 | NA | NA | NA | NA | 1.02 | 0.95 | 1.08 | 0.94 |
| PS 18:0/22:6 | ME1140904 | 2.13 | 2.16 | 2.04 | 1.86 | 0.71 | 0.71 | 0.71 | 0.70 |
| CL 18:2/18:1/18:1/16:1, 18:1/18:1/18:1/16:2, 18:2/18:1/18:0/16:2, 18:2/18:2/18:0/16:1 | ME1140828 | 1.07 | 1.07 | 1.13 | 0.97 | 1.04 | 0.88 | 1.14 | 0.85 |
| SHexCer 18:1;O2/22:1;O | ME1140813 | 0.15 | 0.38 | 0.14 | 0.35 | 1.09 | 1.34 | 1.04 | 1.39 |
| CL 18:2/18:2/18:2/16:1 | ME1140826 | 1.07 | 1.02 | 1.02 | 0.86 | NA | NA | NA | NA |
| PS 20:0/20:1, 18:0/22:1 | ME1140907 | 0.23 | 0.24 | 0.17 | 0.23 | 1.19 | 1.28 | 1.19 | 1.21 |
| BMP 20:4_22:6 | ME1140876 | 1.06 | 1.00 | 1.03 | 0.89 | NA | NA | NA | NA |
| SHexCer 18:1;O2/25:1;O | ME1140824 | 0.55 | 1.51 | 0.48 | 1.43 | NA | NA | NA | NA |
| PI 16:0/18:2 | ME1140880 | 1.18 | 0.95 | 1.10 | 1.06 | 1.09 | 0.95 | 0.98 | 0.89 |
| PS 20:0/20:4, 18:0/22:4 | ME1140905 | 1.12 | 1.36 | 0.93 | 1.17 | 0.89 | 1.06 | 0.88 | 1.01 |
| PS 20:0/22:1 | ME1140911 | 1.12 | 0.99 | 0.88 | 0.95 | NA | NA | NA | NA |
| PA 18:0/18:1 | ME1140861 | 0.31 | 0.59 | 0.26 | 0.49 | 1.01 | 1.42 | 0.95 | 1.31 |
| PA 16:0/18:1 | ME1140859 | 0.22 | 0.40 | 0.20 | 0.34 | 1.08 | 1.38 | 1.06 | 1.30 |
| CL 18:1/18:2/18:2/20:2 | ME1140840 | 1.32 | 1.48 | 1.29 | 1.36 | 0.93 | 0.89 | 0.92 | 0.84 |
Factors:
| F1 | Sample source:mouse cerebrum | genotype:Cre+ |
| F2 | Sample source:mouse cerebrum | genotype:Cre- |
| F3 | Sample source:mouse cerebrum | genotype:Trem2 KO/Cre+ |
| F4 | Sample source:mouse cerebrum | genotype:Trem2 KO/Cre- |
| F5 | Sample source:mouse spinal cord | genotype:Cre+ |
| F6 | Sample source:mouse spinal cord | genotype:Cre- |
| F7 | Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+ |
| F8 | Sample source:mouse spinal cord | genotype:Trem2 KO/Cre- |
