Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST004432)

(Analysis AN007413)

Metabolite	Structure	F1	F2	F3	F4	F5
13-Docosenamide	ME1235075	0.29	0.67	2.99	0.74	0.32
"1,2-Dioleoyl-sn-Glycero-3-Phosphocholine"	ME1235244	1.10	1.06	1.24	0.86	0.70
2-Acetamido-2-Deoxy-D-Mannopyranose	ME1235216	0.98	0.91	0.99	1.04	1.11
1-Hydroxylamino-2-phenylethane	ME1235035	1.02	0.97	1.03	0.87	1.09
1-Naphthyl glucuronide	ME1235415	0.90	0.73	0.86	1.13	1.45
"1-pentadecanoyl-2-(11Z,14Z-eicosadienoyl)-glycero-3-phosphocholine"	ME1235971	0.44	0.94	0.37	3.18	0.52
"2-cis,4-trans-xanthoxin"	ME1235958	1.27	0.87	0.85	1.00	1.04
"1-(11Z,14Z-eicosadienoyl)-2-tetradecanoyl-glycero-3-phosphocholine"	ME1235961	0.85	1.17	1.33	1.12	0.52
"2-Azaniumylethyl 2,3-di(tetradecanoyloxy)propyl phosphate"	ME1235806	1.18	0.95	0.96	0.95	0.96
1-Stearoyl-2-vaccenoyl-sn-glycero-3-phosphocholine	ME1235950	0.55	1.44	1.45	0.73	0.68
1-O-Hexadecyl-sn-glycero-3-phosphocholine	ME1235125	1.12	0.95	0.78	1.06	1.11
2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine	ME1235853	1.09	1.04	0.93	0.96	0.97
"1-tetradecanoyl-2-(11Z,14Z-eicosadienoyl)-glycero-3-phosphocholine"	ME1235965	2.22	0.59	0.49	0.41	1.25
1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocholine	ME1235327	1.13	1.00	0.96	0.96	0.94
"2C-Methyl-D-erythritol 2,4-cyclodiphosphate"	ME1235422	0.87	0.95	1.62	0.77	0.75
"1,2-Dimyristoleoyl-sn-glycero-3-phosphocholine"	ME1235892	1.06	1.23	0.82	1.00	0.84
"1-[(3aS,8bR)-8b-hydroxy-7-methoxy-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-3-yl]ethanone"	ME1236078	0.98	0.97	1.05	1.01	0.99
1-Deoxyvaleric-acid	ME1235714	0.88	1.17	1.25	0.95	0.71
"1,2-di-[(11Z)-octadecenoyl]-sn-glycero-3-phosphocholine"	ME1236006	1.17	0.95	0.97	0.97	0.93
"(1R,2R,5R,8R,9S,10R,12S)-12-Hydroxy-11-methyl-6-methylidene-16-oxo-15-oxapentacyclo[9.3.2.15,8.01,10.02,8]heptadecane-9-carboxylic acid"	ME1235695	1.17	0.95	1.04	1.00	0.85
1-{4-[(3-Aminopropyl)amino]butyl}guanidine	ME1235588	1.01	0.99	1.01	0.99	1.00
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	ME1235580	0.98	1.01	1.01	1.01	0.98
1-Hydroxy-2-naphthaldehyde	ME1235566	0.87	0.98	1.24	1.04	0.88
2-azaniumylethyl (2R)-2-[(9Z)-octadec-9-enoyloxy]-3-(stearoyloxy)propyl phosphate	ME1235334	1.15	0.97	1.00	0.97	0.92
"1,28-Dicaffeoyloctacosanediol"	ME1236061	0.80	0.95	1.51	1.05	0.72
"11-Hydroxy-9-(hydroxymethyl)-2,6a,6b,9,12a-pentamethyl-10-(3,4,5-trihydroxyoxan-2-yl)oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-2,4a-dicarboxylic acid"	ME1235640	1.32	0.96	0.89	0.95	0.87
"1,2-Dipalmitoleoyl-sn-glycero-3-phosphocholine"	ME1235843	1.28	0.93	0.94	0.93	0.92
11-Oxo-beta-amyrin	ME1235594	1.13	0.97	0.99	0.94	0.96
1-(2-Cyclohexylethyl)-3-(2-methoxyphenylacetyl)indole	ME1235879	1.22	0.97	0.95	0.96	0.90
"(1R,2S,3S,4S,4aR,11bR)-1,2,3,4-tetrahydroxy-2,3,4,4a,5,11b-hexahydro-1H-[1,3]dioxolo[4,5-j]phenanthridin-6-one"	ME1236270	1.02	0.97	1.01	0.85	1.12
"2,3-Dihydroxy-3-methylbutanoic acid"	ME1235531	0.82	0.90	1.23	0.82	1.21
2-Chloroadenosine	ME1235180	1.04	1.27	1.01	1.11	0.54
1-[(9Z)-hexadecenoyl]-2-[(11Z)-octadecenoyl]-sn-glycero-3-phosphocholine	ME1235946	1.43	1.01	0.66	0.59	1.22
"(1R,2S,4S,6R,7S,8R,9S,12S,13S,18S)-6-methoxy-7,9,13-trimethyl-6-[(3S)-3-methyl-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutyl]-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosan-16-one"	ME1236278	1.26	0.94	0.87	0.93	1.00
2-Arachidonoylglycerol	ME1235365	1.15	0.82	0.65	1.07	1.36
"2,5-Dimethylbenzaldehyde"	ME1235295	1.17	0.92	0.98	1.00	0.95
"1b,3a,7b-Trihydroxy-5b-cholanate"	ME1236026	1.44	0.80	1.11	1.01	0.68
"2,2^,3-Trihydroxy-3^-methoxy-5,5^-dicarboxybiphenyl"	ME1235994	1.22	0.97	0.93	0.93	0.94
2-[2-(1-Azabicyclo[2.2.2]octan-3-ylidene)-2-fluoroethoxy]-9H-carbazole;hydrochloride	ME1235278	1.22	0.89	1.03	1.09	0.82
"11,14-Eicosadienoic acid"	ME1235421	1.15	1.04	0.97	0.96	0.86
15(S)-HPETE	ME1235688	1.08	0.91	0.93	0.86	1.21
11a-Hydroxytetracycline	ME1236048	0.99	0.87	0.84	1.14	1.21
1-Stearoyl-2-docosahexanoyl-sn-glycero-3-phosphocholine	ME1235905	0.50	1.34	1.30	1.15	0.68
1-(11Z-eicosenoyl)-2-(9Z-tetradecenoyl)-glycero-3-phosphocholine	ME1235951	2.89	0.23	0.27	0.67	1.03
1-Palmitoyl-2-thiopalmitoyl phosphatidylcholine	ME1235451	0.58	1.71	1.22	0.79	0.51
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine	ME1235307	1.22	1.33	1.08	0.85	0.41
2^-Deoxycytidine-5^-monophosphate	ME1235148	0.90	1.07	1.18	1.01	0.84
"2-[(2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1,4-dihydronaphthalene-1,4-dione"	ME1236261	0.98	1.03	1.12	1.02	0.85
2-Chloro-2^-Deoxyadenosine	ME1235207	1.49	0.77	0.90	0.88	0.98
"2,3-Dihydrobenzofuran"	ME1235073	1.02	0.97	1.04	0.88	1.08
1-O-Octadecyl-SN-glycero-3-phosphocholine	ME1235319	0.97	0.43	0.79	0.48	2.34
1-Palmitoyl-2-pyrenedecanoylphosphatidylcholine	ME1235462	1.50	0.74	1.03	0.82	0.92
20-Dihydrodydrogesterone	ME1235964	1.04	1.04	1.04	1.04	0.84
1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine	ME1235375	0.77	0.74	0.95	0.63	1.88
2-Chloro-3-Deazaadenosine	ME1235478	1.24	1.08	0.93	0.97	0.75
"1,2-Distearoyl-sn-glycero-3-phosphocholine"	ME1235938	0.37	0.74	3.21	0.29	0.30
13-Demethyl tacrolimus	ME1236008	1.18	1.00	0.96	0.88	0.97
1-Aminocyclobutanecarboxylic acid	ME1235051	1.01	0.94	1.07	0.92	1.05
"2,3^,5-Trichlorobiphenyl"	ME1235601	0.87	0.99	1.11	0.86	1.15
"1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide"	ME1235127	1.34	1.60	0.43	0.79	0.68
19-(4-Hydroxyphenyl)nonadecanoic acid	ME1236019	1.00	1.13	0.82	1.05	0.99
"2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6,8-bis[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one"	ME1235282	0.98	0.97	1.09	1.13	0.87
"2,3,6-Trihydroxypyridine"	ME1235536	0.87	1.36	0.98	0.99	0.73
1-(4-Hydroxy-2-methylpyrimidin-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium bromide	ME1235989	1.03	1.13	1.04	1.08	0.71
1-Myristoyl-3-osbondoyl-sn-glycerol	ME1236279	0.94	0.93	0.97	1.19	1.01
"2-Acetoxy-3-geranylgeranyl-1,4-dihydroxybenzene"	ME1235608	1.19	0.96	0.95	0.96	0.94
"1,2-Dibenzoylbenzene"	ME1235401	1.18	0.92	0.96	0.99	0.95
1-Methylxanthine	ME1235154	0.78	0.98	1.14	1.17	0.96
1-Oleoyl-2-acetyl-sn-glycerol	ME1235262	0.98	0.91	0.75	1.19	1.22
15(S)-HETE-d8	ME1235698	1.24	1.30	0.72	0.97	0.70
16alpha-Hydroxyestrone	ME1235306	1.04	1.00	1.00	0.93	1.02
1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine	ME1235793	1.71	0.65	0.39	0.51	1.71
"(1Z,13S,14R,15E)-1-Anthracen-9-yl-14-hydroxy-13-(hydroxymethyl)nonacosa-1,15-dien-12-one"	ME1235472	0.75	1.27	1.38	0.97	0.56
1-Heptanol	ME1235460	1.28	1.57	0.47	0.81	0.71
1-Tetradecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine	ME1236071	0.48	1.12	2.03	1.16	0.21
"(1S,3S,4S,6S,7S,8R,11S,12S,14S,15R,16R)-15-[(2S)-2,5-dihydroxy-5-(hydroxymethyl)-6-methylheptan-2-yl]-4,6,14-trihydroxy-7,12,16-trimethylpentacyclo[9.7.0.01,3.03,8.012,16]octadecane-7-carboxylic acid"	ME1236266	1.15	0.94	0.96	0.97	0.98
"(1S,9S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene"	ME1236226	1.20	0.98	0.97	0.93	0.90
"1-[(2-Chloro-1,3-thiazol-5-yl)methyl]-2-methyl-3-nitroguanidine"	ME1235906	0.77	1.15	1.01	0.72	1.28
1-deoxy-D-xylulose 5-phosphate	ME1235399	0.81	1.03	1.47	0.91	0.75
1-(2-Amino-4-methylpentanoyl)pyrrolidine-2-carboxylic acid	ME1236004	1.08	0.98	0.92	0.96	1.06
"15-cis-4,4^-Diapophytoene"	ME1235980	0.56	0.83	1.58	0.36	1.58
"15-Deoxy-delta-12,14-prostaglandin J2"	ME1235230	1.39	1.14	0.78	0.75	0.86
"17alpha,21-Dihydroxypregnenolone"	ME1235541	1.06	1.07	1.15	0.91	0.78
25-Hydroxy-24-epi-brassinolide	ME1236013	1.18	0.70	0.69	1.11	1.41
25-Azacholesterol	ME1235620	0.30	0.97	2.70	0.59	0.37
"13,14-dihydro-15-keto PGD2"	ME1235223	0.94	1.33	0.46	1.39	0.88
2-Aminoanthraquinone	ME1235492	0.80	1.13	1.15	1.21	0.72
"1-(6-((3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"	ME1235260	0.92	0.85	0.97	0.93	1.34
"2,8-Quinolinediol"	ME1235199	1.03	1.17	1.05	0.95	0.75
"1,2-Dipentadecanoyl-sn-glycero-3-phosphocholine"	ME1235886	1.32	0.91	0.91	0.90	0.96
"15,15-Difluoro-9alpha,11alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester"	ME1236092	1.09	1.16	1.03	1.03	0.67
"12-Butan-2-yl-19-hexyl-6-(1-hydroxyethyl)-9-(hydroxymethyl)-16,18-dimethyl-15-(2-methylpropyl)-1-oxa-4,7,10,13,16-pentazacyclononadecane-2,5,8,11,14,17-hexone"	ME1235649	0.60	1.49	1.23	1.31	0.32
"16alpha,17-Dihydroxypregn-4-ene-3,20-dione cyclic acetal with 2-furyl methyl ketone"	ME1235710	1.03	1.10	1.03	0.91	0.90
"(13R,17R)-17-[(1R,2S)-1,2-dihydroxyheptyl]-1,5,10-triazabicyclo[11.4.0]heptadec-15-en-11-one"	ME1235579	1.04	0.92	0.82	0.97	1.25
"1-(2-Hydroxyphenyl)-3-phenylpropane-1,3-dione"	ME1235448	1.09	0.94	0.85	1.25	0.93
1-Oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine	ME1235811	0.43	1.71	1.18	1.27	0.32
1-Stearidonoyl-3-eicosapentaenoyl-sn-glycerol	ME1236281	1.17	0.95	0.97	0.96	0.96
1-(2-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole hydrochloride	ME1235314	1.01	1.12	1.05	0.91	0.87
"(1R,2R,4S)-p-Menthane-1,2,8-triol 8-glucoside"	ME1235711	1.08	1.04	0.94	1.04	0.90
1-Heptadecanoyl-sn-glycero-3-phosphocholine	ME1235239	1.07	1.10	0.99	0.87	0.92
11-Aminoundecanoic acid	ME1235423	1.28	0.85	1.04	0.94	0.91
11beta-PGE2	ME1235057	1.34	1.09	0.87	0.71	0.91
26-Hydroxyecdysone	ME1235561	1.11	0.94	0.93	0.94	1.08
15-Deoxoeucosterol	ME1236020	1.11	0.96	0.99	0.97	0.97
"(13E)-labda-7,13-dien-15-ol"	ME1236254	1.07	0.70	1.35	0.93	0.99
"(1R,2R,5Z,12R,13S,16Z)-25-(9H-pyrido[3,4-b]indol-1-yl)-11,22-diazapentacyclo[11.11.2.12,22.02,12.04,11]heptacosa-5,16,25-trien-13-ol"	ME1235709	1.05	1.08	0.95	0.95	0.95
"1,8-Diazacyclotetradecane-2,9-dione"	ME1235532	0.97	0.96	1.01	1.05	1.03
"(1S)-((2R,4S,5R)-5-Ethylquinuclidin-2-yl)(quinolin-4-yl)methanol"	ME1235697	1.11	1.06	0.92	0.94	0.95
10-deoxyformamycin	ME1235141	1.16	1.02	1.14	0.93	0.73
"1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol"	ME1236272	1.06	1.05	0.98	0.98	0.92
1-Octadecyl-2-acetyl-sn-glycero-3-phosphocholine	ME1235255	1.36	0.59	0.53	0.99	1.61
"1,26-Dicaffeoylhexacosanediol"	ME1236054	1.13	0.99	0.89	0.93	1.05
"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"	ME1235245	2.13	0.38	0.61	0.39	1.49
"2^,3^-Cyclic GMP"	ME1236028	0.80	1.03	1.10	1.07	1.01
27-Hydroxycholesterol	ME1235467	1.10	0.98	0.96	0.97	0.99
1-beta-D-Galactosylsphingosine	ME1235919	1.23	0.93	0.95	0.93	0.96
1-Methylguanosine	ME1235568	1.07	0.81	0.90	0.79	1.42
2-[(4-{2-[(4-Cyclohexylbutyl)(cyclohexylcarbamoyl)amino]ethyl}phenyl)sulfanyl]-2-methylpropanoic acid	ME1235925	1.22	0.95	1.11	0.93	0.78
"2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide"	ME1235921	0.54	2.08	0.77	1.18	0.25
1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate	ME1236049	0.70	1.43	1.28	1.03	0.48
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate	ME1235913	0.68	0.35	0.41	0.14	3.36
2-Aminoadenosine	ME1235858	0.99	1.04	1.04	1.06	0.87
1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-YL)heptyl]oxy]phenyl]ethanone	ME1235342	0.89	1.05	1.10	1.02	0.92
"1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine"	ME1235967	1.24	0.68	0.86	1.07	1.23
"(1R,6R,11S,13S,14R,21R)-7,19,23-triazahexacyclo[9.9.1.11,13.12,6.07,21.014,19]tricosane"	ME1235706	1.28	0.95	0.95	0.91	0.90

Factors:

F1	Sample source:Brain cortex \| Treatment:cKO \| Genotype:Nexcre/+ NMNAT2f/f
F2	Sample source:Brain cortex \| Treatment:cKO S/+ \| Genotype:Nexcre/+ NMNAT2f/f Sarm1null/+
F3	Sample source:Brain cortex \| Treatment:cKO S/S \| Genotype:Nexcre/+ NMNAT2f/f Sarm1null/null
F4	Sample source:Brain cortex \| Treatment:Ctrl-2 \| Genotype:Nexcre/+ NMNAT2f/+ Sarm1null/+
F5	Sample source:Brain cortex \| Treatment:Ctrl \| Genotype:Nexcre/+ NMNAT2f/+

Data matrix