Clustering data with hclust algorithm for Metabolite changes associated with methionine stress sensitivity of cancer (CSH QTOF MS analysis) (Study ST000077)
ESI/QTOF negative ion mode (Analysis AN000124)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
|---|---|---|---|---|---|---|---|---|---|
| PC (36:4) A | ME655873 | 0.53 | 0.48 | 0.39 | 0.48 | 0.70 | 0.54 | 0.64 | 5.22 |
| LPC (16:0) | ME655856 | 0.31 | 0.20 | 0.21 | 0.31 | 0.29 | 0.23 | 0.24 | 7.68 |
| PC (38:4) | ME655878 | 0.37 | 0.33 | 0.22 | 0.37 | 0.40 | 0.48 | 0.52 | 6.58 |
| PG (34:1) | ME655896 | 2.07 | 0.62 | 0.55 | 1.26 | 1.25 | 1.02 | 0.96 | 0.01 |
| PI (32:1) | ME655903 | 1.97 | 0.90 | 0.75 | 1.09 | 1.05 | 1.00 | 0.97 | 0.01 |
| PG (34:2) | ME655897 | 2.32 | 0.64 | 0.31 | 1.66 | 0.47 | 1.28 | 1.01 | 0.07 |
| PI (34:2) | ME655905 | 1.94 | 0.98 | 0.49 | 1.43 | 0.50 | 1.27 | 1.15 | 0.04 |
| Cer (d39:1) | ME655841 | 0.88 | 1.53 | 1.15 | 0.53 | 1.22 | 0.89 | 1.68 | 0.07 |
| Cer (d36:1) | ME655839 | 0.55 | 1.64 | 1.43 | 0.52 | 1.03 | 0.98 | 1.78 | 0.01 |
| Cer (d38:1) | ME655840 | 0.68 | 1.59 | 1.49 | 0.52 | 1.24 | 0.88 | 1.45 | 0.03 |
| PI (32:0) (16:0/16:0) | ME655902 | 1.72 | 1.17 | 1.17 | 0.48 | 1.86 | 0.54 | 0.75 | 0.01 |
| PI (40:6) | ME655914 | 1.61 | 1.40 | 0.94 | 0.66 | 1.27 | 0.71 | 0.95 | 0.27 |
| plasmenyl-PC (38:0) | ME655922 | 1.36 | 0.89 | 0.99 | 1.11 | 1.51 | 0.86 | 0.89 | 0.14 |
| PC (33:1) | ME655863 | 1.38 | 0.98 | 0.96 | 0.97 | 1.36 | 1.00 | 1.11 | 0.02 |
| PE (38:4) B | ME655893 | 1.27 | 0.96 | 0.95 | 1.05 | 1.37 | 1.02 | 1.14 | 0.05 |
| GlcCer (d42:1) | ME655854 | 1.26 | 0.96 | 1.03 | 0.97 | 1.52 | 0.90 | 1.05 | 0.09 |
| plasmenyl-PE (34:2) | ME655926 | 1.21 | 0.89 | 1.03 | 0.92 | 1.67 | 0.94 | 1.04 | 0.09 |
| PC (36:1) | ME655870 | 1.10 | 0.99 | 1.06 | 0.93 | 1.57 | 0.94 | 1.07 | 0.12 |
| PE (38:1) A | ME655891 | 1.18 | 1.00 | 1.03 | 0.86 | 1.63 | 0.92 | 1.08 | 0.09 |
| plasmenyl-PE (36:5) | ME655930 | 1.12 | 0.91 | 1.25 | 0.86 | 1.54 | 0.92 | 1.16 | 0.03 |
| plasmenyl-PE (36:4) | ME655929 | 1.25 | 1.00 | 1.19 | 0.84 | 1.47 | 0.88 | 1.11 | 0.05 |
| plasmenyl-PE (34:1) | ME655925 | 1.18 | 1.00 | 1.22 | 0.91 | 1.47 | 0.93 | 1.05 | 0.00 |
| plasmenyl-PE (36:2) | ME655928 | 1.23 | 1.00 | 1.24 | 0.92 | 1.38 | 0.93 | 1.05 | 0.02 |
| PI (36:1) | ME655906 | 1.41 | 1.05 | 1.21 | 0.83 | 1.48 | 0.82 | 0.91 | 0.03 |
| PI (38:3) | ME655910 | 1.25 | 1.13 | 1.20 | 0.78 | 1.37 | 0.84 | 1.05 | 0.19 |
| PI (38:4) | ME655911 | 1.28 | 1.14 | 1.14 | 0.72 | 1.34 | 0.81 | 1.16 | 0.26 |
| Cer (d42:1) | ME655845 | 1.19 | 1.05 | 1.18 | 0.71 | 1.53 | 0.86 | 1.11 | 0.20 |
| GlcCer (d41:1) | ME655853 | 1.23 | 1.11 | 1.28 | 0.72 | 1.45 | 0.72 | 1.15 | 0.15 |
| SM (d42:1) | ME655946 | 1.00 | 0.94 | 1.05 | 0.88 | 1.76 | 0.86 | 0.96 | 0.39 |
| Cer (d44:1) | ME655848 | 1.26 | 0.82 | 1.10 | 0.73 | 1.98 | 0.79 | 0.90 | 0.20 |
| plasmenyl-PE (36:1) | ME655927 | 1.12 | 0.95 | 1.20 | 0.87 | 1.78 | 0.86 | 0.95 | 0.01 |
| plasmenyl-PE (40:5) | ME655932 | 1.15 | 0.95 | 1.16 | 0.80 | 1.79 | 0.83 | 1.05 | 0.05 |
| GlcCer (d40:1) | ME655852 | 1.12 | 1.08 | 1.30 | 0.70 | 1.78 | 0.70 | 1.02 | 0.09 |
| plasmenyl-PC (36:0) | ME655918 | 1.16 | 1.00 | 1.31 | 0.77 | 1.77 | 0.72 | 0.92 | 0.10 |
| plasmenyl-PE (40:6) | ME655933 | 1.16 | 0.93 | 1.32 | 0.73 | 1.78 | 0.77 | 1.03 | 0.06 |
| PC (34:4) | ME655868 | 1.25 | 0.90 | 0.75 | 1.06 | 1.37 | 1.06 | 1.10 | 0.39 |
| LPE (20:4) | ME655858 | 1.11 | 1.05 | 0.76 | 1.02 | 1.54 | 0.99 | 1.15 | 0.22 |
| LPE (22:6) | ME655859 | 1.16 | 1.14 | 0.80 | 0.99 | 1.40 | 0.92 | 1.21 | 0.23 |
| PI (38:6) | ME655913 | 1.56 | 0.96 | 0.80 | 0.82 | 1.42 | 0.92 | 1.14 | 0.22 |
| 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1^-sn-glycerol) | ME655834 | 1.48 | 0.88 | 0.73 | 1.14 | 1.36 | 1.04 | 1.12 | 0.02 |
| PE (36:4) B | ME655890 | 1.59 | 0.93 | 0.74 | 1.02 | 1.18 | 1.01 | 1.25 | 0.12 |
| Cer (d40:1) | ME655842 | 0.91 | 1.29 | 1.43 | 0.52 | 1.59 | 0.77 | 1.20 | 0.11 |
| GlcCer (d34:1) | ME655850 | 0.87 | 1.16 | 1.53 | 0.72 | 1.40 | 0.75 | 1.18 | 0.25 |
| GlcCer (d38:1) | ME655851 | 0.99 | 1.30 | 1.46 | 0.71 | 1.41 | 0.76 | 1.12 | 0.05 |
| SM (d40:1) | ME655944 | 1.05 | 0.89 | 1.03 | 0.85 | 1.56 | 0.82 | 0.94 | 0.79 |
| PC (37:4) | ME655875 | 0.97 | 1.12 | 1.23 | 0.70 | 1.28 | 0.78 | 1.10 | 0.79 |
| plasmenyl-PC (40:4) | ME655924 | 1.04 | 1.12 | 1.37 | 0.77 | 1.28 | 0.79 | 1.12 | 0.40 |
| PS (39:3) | ME655937 | 0.92 | 0.99 | 1.06 | 1.05 | 0.97 | 1.05 | 1.01 | 0.92 |
| PG (44:1) | ME655901 | 1.20 | 1.06 | 1.09 | 1.01 | 0.91 | 1.01 | 1.12 | 0.50 |
| SM (d32:1) | ME655938 | 1.48 | 1.05 | 0.93 | 1.06 | 0.80 | 1.03 | 1.15 | 0.39 |
| PC (36:2) | ME655871 | 1.32 | 1.03 | 0.92 | 1.11 | 0.79 | 1.09 | 1.14 | 0.53 |
| PE (38:2) A | ME655892 | 1.33 | 1.02 | 0.92 | 1.10 | 0.81 | 1.07 | 1.12 | 0.55 |
| SM (d36:1) | ME655941 | 1.19 | 1.03 | 1.08 | 0.95 | 1.16 | 0.94 | 1.09 | 0.44 |
| SM (d38:1) | ME655942 | 1.15 | 1.02 | 1.06 | 0.93 | 1.20 | 0.90 | 1.05 | 0.59 |
| SM (d33:1) | ME655939 | 1.33 | 0.98 | 0.99 | 0.89 | 1.06 | 0.91 | 1.09 | 0.70 |
| SM (d34:1) | ME655940 | 1.29 | 0.97 | 0.94 | 0.95 | 0.97 | 0.93 | 1.08 | 0.85 |
| PC (36:3) | ME655872 | 1.36 | 1.04 | 0.86 | 0.93 | 0.65 | 1.01 | 1.19 | 1.01 |
| PC (38:5) | ME655879 | 1.22 | 0.93 | 0.55 | 1.16 | 0.74 | 1.30 | 1.38 | 0.75 |
| PC (32:0) | ME655861 | 1.41 | 1.00 | 0.75 | 1.16 | 0.76 | 1.31 | 1.37 | 0.09 |
| PS (36:2) | ME655936 | 1.21 | 1.06 | 0.81 | 1.22 | 0.77 | 1.29 | 1.26 | 0.26 |
| PC (30:0) | ME655860 | 1.54 | 0.87 | 0.81 | 1.22 | 0.95 | 1.19 | 1.21 | 0.02 |
| PI (34:1) | ME655904 | 1.46 | 1.00 | 0.89 | 1.05 | 1.15 | 1.07 | 1.17 | 0.00 |
| PC (32:1) | ME655862 | 1.41 | 1.01 | 0.89 | 1.14 | 1.09 | 1.12 | 1.11 | 0.02 |
| PE (34:1) B | ME655883 | 1.42 | 0.95 | 0.89 | 1.19 | 1.05 | 1.13 | 1.16 | 0.00 |
| plasmenyl-PC (34:1) | ME655917 | 1.43 | 1.11 | 1.02 | 1.15 | 0.70 | 1.07 | 1.12 | 0.23 |
| PC (35:2) | ME655869 | 1.49 | 1.06 | 0.86 | 1.11 | 0.87 | 1.11 | 1.15 | 0.19 |
| PE (40:2) A | ME655894 | 1.42 | 1.06 | 0.91 | 1.13 | 0.95 | 1.08 | 1.19 | 0.07 |
| PE (35:2) | ME655885 | 1.41 | 1.08 | 0.89 | 1.19 | 0.80 | 1.20 | 1.23 | 0.02 |
| PE (36:2) B | ME655887 | 1.37 | 1.10 | 1.01 | 1.16 | 0.82 | 1.12 | 1.21 | 0.01 |
| plasmenyl-PC (34:0) | ME655916 | 1.28 | 1.14 | 1.06 | 1.14 | 0.84 | 1.11 | 1.23 | 0.01 |
| PC (33:2) | ME655864 | 1.75 | 0.93 | 0.66 | 1.23 | 0.69 | 1.15 | 1.13 | 0.31 |
| PE (36:4) | ME655889 | 1.67 | 1.01 | 0.70 | 1.10 | 0.70 | 1.08 | 1.31 | 0.35 |
| PG (40:7) | ME655900 | 1.63 | 0.98 | 0.66 | 1.08 | 0.88 | 1.15 | 1.46 | 0.01 |
| PE (36:3) B | ME655888 | 1.65 | 1.11 | 0.88 | 1.03 | 0.80 | 1.04 | 1.29 | 0.03 |
| PG (36:3) | ME655899 | 1.62 | 1.08 | 0.80 | 1.06 | 0.77 | 1.09 | 1.35 | 0.10 |
| PI (38:5) | ME655912 | 1.60 | 1.25 | 0.74 | 1.09 | 0.53 | 1.21 | 1.44 | 0.01 |
| PC (38:2) | ME655876 | 1.50 | 1.14 | 0.85 | 1.25 | 0.61 | 1.20 | 1.22 | 0.04 |
| PE (34:2) B | ME655884 | 1.69 | 1.08 | 0.74 | 1.26 | 0.56 | 1.20 | 1.27 | 0.02 |
| PI (36:2) | ME655907 | 1.71 | 1.04 | 0.67 | 1.28 | 0.63 | 1.23 | 1.24 | 0.03 |
| Cer (d43:1) | ME655847 | 1.49 | 1.05 | 0.86 | 0.87 | 1.06 | 1.00 | 1.23 | 0.32 |
| PG (36:2) | ME655898 | 1.50 | 1.19 | 0.95 | 0.91 | 1.00 | 0.98 | 1.28 | 0.03 |
| PC (34:0) | ME655865 | 1.22 | 1.10 | 0.96 | 1.01 | 1.09 | 1.08 | 1.29 | 0.10 |
| plasmenyl-PC (32:0) | ME655915 | 1.23 | 1.11 | 1.06 | 1.07 | 0.97 | 1.08 | 1.23 | 0.05 |
| PC (34:1) | ME655866 | 1.17 | 1.06 | 1.04 | 1.06 | 1.16 | 1.06 | 1.09 | 0.19 |
| SM (d42:2) | ME655947 | 1.27 | 1.04 | 1.00 | 1.06 | 1.00 | 1.04 | 1.15 | 0.29 |
| plasmenyl-PE (40:7) | ME655934 | 1.47 | 1.02 | 1.25 | 0.82 | 1.16 | 0.89 | 1.17 | 0.02 |
| PI (36:4) | ME655909 | 1.42 | 1.09 | 1.05 | 0.81 | 1.31 | 0.89 | 1.14 | 0.10 |
| plasmenyl-PE (38:6) | ME655931 | 1.43 | 1.04 | 1.10 | 0.81 | 1.27 | 0.90 | 1.25 | 0.02 |
| plasmenyl-PC (36:1) | ME655919 | 1.27 | 1.10 | 1.27 | 1.00 | 1.09 | 0.95 | 1.09 | 0.02 |
| Cer (d34:0) | ME655836 | 1.29 | 1.18 | 1.04 | 0.95 | 1.12 | 0.94 | 1.17 | 0.14 |
| PI (36:3) | ME655908 | 1.38 | 1.05 | 1.06 | 0.96 | 1.16 | 0.95 | 1.13 | 0.11 |
| GlcCer (d42:2) | ME655855 | 1.39 | 1.13 | 1.09 | 0.92 | 1.05 | 0.94 | 1.27 | 0.03 |
| PE (44:3) A | ME655895 | 1.26 | 1.13 | 1.18 | 0.90 | 1.14 | 0.93 | 1.24 | 0.05 |
| plasmenyl-PE 34:0; | ME655935 | 1.32 | 1.23 | 1.17 | 0.84 | 1.11 | 0.89 | 1.21 | 0.05 |
| Cer (d41:1) | ME655844 | 1.06 | 1.23 | 1.15 | 0.62 | 1.27 | 0.92 | 1.43 | 0.24 |
| plasmenyl-PC (36:3) | ME655920 | 1.07 | 1.27 | 1.17 | 0.79 | 1.06 | 0.93 | 1.28 | 0.35 |
| plasmenyl-PC (38:4) | ME655923 | 1.14 | 1.28 | 1.28 | 0.79 | 0.95 | 0.89 | 1.25 | 0.29 |
| Cer (d32:1) | ME655835 | 0.87 | 1.22 | 1.13 | 1.01 | 0.97 | 1.17 | 1.47 | 0.04 |
| Cer (d34:1) | ME655837 | 0.84 | 1.26 | 1.26 | 0.89 | 1.04 | 1.08 | 1.43 | 0.06 |
| Cer (d34:2) | ME655838 | 1.20 | 1.23 | 0.98 | 0.96 | 0.88 | 1.09 | 1.45 | 0.09 |
| Cer (d40:2) | ME655843 | 1.05 | 1.35 | 1.03 | 0.80 | 0.99 | 1.10 | 1.52 | 0.05 |
| Cer (d42:2) | ME655846 | 1.12 | 1.29 | 0.99 | 0.80 | 0.98 | 1.14 | 1.56 | 0.02 |
| FA (18:1) | ME655849 | 0.99 | 0.91 | 0.95 | 0.83 | 1.29 | 0.69 | 1.11 | 1.35 |
| plasmenyl-PC (36:4) | ME655921 | 0.89 | 1.10 | 0.90 | 0.68 | 1.24 | 0.90 | 1.24 | 1.14 |
| SM (d38:2) | ME655943 | 1.03 | 0.89 | 0.98 | 0.82 | 0.87 | 0.78 | 0.84 | 1.99 |
| SM (d42:3) | ME655948 | 1.15 | 0.88 | 0.82 | 0.93 | 0.65 | 0.85 | 0.93 | 2.04 |
| PC (36:5) | ME655874 | 1.11 | 0.64 | 0.47 | 1.19 | 0.81 | 1.09 | 0.95 | 1.98 |
| PC (40:5) | ME655881 | 1.13 | 0.82 | 0.58 | 0.92 | 0.95 | 1.08 | 1.14 | 1.57 |
| SM (d40:2) | ME655945 | 1.17 | 0.93 | 0.82 | 0.99 | 0.76 | 0.93 | 1.04 | 1.49 |
| PC (34:2) | ME655867 | 1.28 | 0.82 | 0.65 | 1.09 | 0.59 | 1.02 | 0.99 | 1.75 |
| PE (36:2) A | ME655886 | 1.28 | 0.86 | 0.67 | 1.09 | 0.63 | 1.03 | 0.99 | 1.60 |
| PC (38:6) | ME655880 | 0.87 | 0.62 | 0.57 | 0.56 | 1.06 | 0.65 | 0.84 | 3.38 |
| PC (40:6) | ME655882 | 0.78 | 0.54 | 0.43 | 0.65 | 0.83 | 0.81 | 0.87 | 3.74 |
| LPC (18:1) | ME655857 | 0.84 | 0.87 | 0.56 | 0.88 | 0.93 | 0.73 | 0.80 | 2.79 |
| PC (38:3) | ME655877 | 1.11 | 0.83 | 0.68 | 0.79 | 0.70 | 0.81 | 0.97 | 2.48 |
Factors:
| F1 | Treatment:100uM Met | Timepoint:0 hours |
| F2 | Treatment:370uM Hcy | Timepoint:12 hours |
| F3 | Treatment:370uM Hcy | Timepoint:24 hours |
| F4 | Treatment:370uM Hcy | Timepoint:2 hours |
| F5 | Treatment:370uM Hcy | Timepoint:48 hours |
| F6 | Treatment:370uM Hcy | Timepoint:4 hours |
| F7 | Treatment:370uM Hcy | Timepoint:8 hours |
| F8 | Treatment:quality check | Timepoint:quality check |
