Clustering data with hclust algorithm for A study of changes in lipid metabolism of ovarian cancer cells co-cultured with adipocytes: UHPLC-QTOF MS analysis (Study ST000089)
UHPLC-QTOFMS positive ion mode (Analysis AN000141)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
|---|---|---|---|---|---|---|---|---|
| SM (d42:1) | ME656966 | 0.03 | 0.02 | 0.01 | 0.01 | NA | 3.32 | 3.15 |
| PC (34:3) | ME656850 | 0.13 | 0.14 | 0.04 | 0.04 | NA | 2.52 | 2.70 |
| SM (d41:1) | ME656965 | 0.14 | 0.12 | 0.04 | 0.04 | NA | 2.78 | 2.66 |
| PC (38:3) | ME656866 | NA | NA | 0.03 | 0.03 | 0.03 | 2.65 | 2.86 |
| PC (18:1/16:0) | ME656835 | NA | NA | 0.01 | 0.01 | 0.00 | 2.83 | 2.94 |
| SM (d18:1/16:1) | ME656957 | 0.04 | 0.04 | 0.02 | 0.02 | NA | 2.99 | 2.89 |
| Niacinamide | ME656831 | 0.10 | 0.09 | NA | NA | NA | 1.71 | 2.67 |
| PC (38:6) B | ME656873 | 0.05 | 0.06 | NA | NA | NA | 1.54 | 2.93 |
| PC (33:0) | ME656844 | 0.04 | 0.04 | NA | NA | NA | 2.36 | 2.27 |
| PC (34:0) | ME656847 | 0.04 | 0.04 | NA | NA | NA | 2.32 | 2.30 |
| 1-hexadecyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine | ME656787 | 0.03 | 0.03 | NA | NA | NA | 2.35 | 2.30 |
| plasmenyl-PE (34:1) | ME656928 | 0.03 | 0.03 | NA | NA | NA | 2.34 | 2.31 |
| SM (34:1) | ME656943 | 0.01 | 0.01 | NA | NA | NA | 2.37 | 2.34 |
| PC (33:1) | ME656845 | 0.02 | 0.02 | NA | NA | NA | 2.32 | 2.36 |
| SM (34:0) | ME656942 | 0.02 | 0.02 | NA | NA | NA | 2.33 | 2.34 |
| PC (35:2) | ME656853 | 0.04 | 0.04 | NA | NA | NA | 2.28 | 2.33 |
| SM (d40:2) A | ME656964 | 0.07 | 0.07 | NA | NA | NA | 2.25 | 2.29 |
| PC (38:6) A | ME656872 | 0.02 | 0.03 | NA | NA | NA | 2.32 | 2.18 |
| PE (38:4) | ME656920 | 0.02 | 0.02 | NA | NA | NA | 2.40 | 2.13 |
| PC (30:1) | ME656838 | 0.03 | 0.03 | NA | NA | NA | 2.51 | 2.18 |
| PC (31:0) | ME656839 | 0.02 | 0.02 | NA | NA | NA | 2.53 | 2.18 |
| PC (38:2) | ME656865 | 0.01 | 0.01 | NA | NA | NA | 2.46 | 2.26 |
| PC (32:1) | ME656841 | 0.02 | 0.02 | NA | NA | NA | 2.41 | 2.28 |
| PC (30:0) | ME656837 | 0.03 | 0.03 | NA | NA | NA | 2.44 | 2.23 |
| PC (32:3) | ME656843 | 0.03 | 0.04 | NA | NA | NA | 2.44 | 2.21 |
| PC (32:2) | ME656842 | 0.03 | 0.04 | NA | NA | NA | 2.40 | 2.25 |
| SM (d18:2/23:0) | ME656960 | 0.03 | 0.03 | NA | NA | NA | 2.42 | 2.24 |
| PC (38:5) A | ME656870 | 0.04 | 0.04 | NA | NA | NA | 2.12 | 2.47 |
| PC (35:1) | ME656852 | 0.04 | 0.04 | NA | NA | NA | 2.18 | 2.42 |
| PC (38:4) B | ME656869 | 0.04 | 0.05 | NA | NA | NA | 2.18 | 2.40 |
| SM (d18:1/14:0) | ME656955 | 0.05 | 0.04 | NA | NA | NA | 2.21 | 2.21 |
| plasmenyl-PE (36:1) | ME656930 | 0.09 | 0.10 | NA | NA | NA | 2.18 | 2.28 |
| PC (33:2) | ME656846 | 0.10 | 0.11 | NA | NA | NA | 2.14 | 2.28 |
| SM (d38:1) | ME656962 | 0.11 | 0.11 | NA | NA | NA | 2.15 | 2.27 |
| PC (35:3) | ME656854 | 0.11 | 0.13 | NA | NA | NA | 1.94 | 2.41 |
| plasmenyl-PC (34:2) | ME656927 | 0.15 | 0.18 | NA | NA | NA | 1.87 | 2.37 |
| PC (40:5) A | ME656877 | NA | NA | 0.10 | 0.09 | 0.09 | 2.12 | 2.03 |
| PS (36:2) | ME656939 | 0.07 | 0.09 | NA | NA | NA | 1.97 | 2.18 |
| SM (33:1) | ME656941 | 0.05 | 0.06 | NA | NA | NA | 2.04 | 2.02 |
| LPC (16:0) | ME656821 | NA | NA | 0.10 | 0.12 | NA | 1.91 | 1.72 |
| Ceramide (d40:1) | ME656801 | 0.47 | 0.53 | NA | NA | NA | 1.53 | 1.82 |
| DG (38:4) | ME656813 | 0.42 | 0.49 | NA | NA | NA | 1.50 | 1.95 |
| 1-Stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine | ME656789 | 0.32 | 0.39 | NA | NA | NA | 1.87 | 1.89 |
| Ceramide (d42:1) | ME656802 | 0.24 | 0.28 | NA | NA | NA | 1.99 | 2.03 |
| PC (36:3) A | ME656857 | 0.20 | 0.23 | 0.03 | 0.04 | 0.01 | 2.51 | 4.77 |
| PC (34:2) | ME656849 | 0.46 | 0.56 | 0.06 | 0.07 | 0.01 | 2.97 | 3.93 |
| PC (36:2) | ME656856 | 0.11 | 0.13 | 0.02 | 0.02 | 0.01 | 4.05 | 4.12 |
| SM (d18:1/16:0) | ME656956 | 0.06 | 0.06 | 0.01 | 0.01 | 0.01 | 4.20 | 4.14 |
| SM (d16:1/20:0) | ME656952 | 0.07 | 0.08 | 0.02 | 0.02 | 0.01 | 3.37 | 3.63 |
| N-Tetracosenoyl-4-sphingenyl-1-O-phosphorylcholine | ME656833 | 0.02 | 0.03 | 0.01 | 0.01 | 0.01 | 3.70 | 3.83 |
| PC (16:0/16:0) | ME656834 | 0.04 | 0.05 | 0.01 | 0.01 | 0.00 | 3.68 | 3.64 |
| SM (d40:1) | ME656963 | 0.10 | 0.10 | 0.02 | 0.02 | 0.01 | 3.58 | 3.55 |
| PC (36:4) | ME656858 | 0.06 | 0.07 | 0.03 | 0.04 | 0.03 | 3.28 | 4.17 |
| PC (36:1) | ME656855 | 0.16 | 0.18 | 0.05 | 0.05 | 0.03 | 3.69 | 4.20 |
| PC (38:4) A | ME656868 | 0.16 | 0.17 | 0.05 | 0.05 | 0.04 | 3.61 | 4.08 |
| DG (34:1) | ME656808 | 1.07 | 1.28 | NA | NA | NA | 0.79 | 0.76 |
| DG (36:2) | ME656810 | 1.11 | 1.33 | NA | NA | NA | 0.68 | 0.74 |
| plasmenyl-PE (34:2) | ME656929 | 0.67 | 0.81 | NA | NA | NA | 1.26 | 1.44 |
| Ceramide (d18:1/23:0) | ME656800 | 0.88 | 0.96 | NA | NA | NA | 1.03 | 1.19 |
| Cholesterol | ME656804 | 1.10 | 1.21 | 0.04 | 0.04 | NA | 1.19 | 1.27 |
| DG (36:3) | ME656811 | 1.52 | 1.84 | NA | NA | NA | 0.05 | 0.11 |
| TG (14:0/14:0/14:0) | ME656968 | 1.89 | 1.95 | 0.02 | 0.02 | NA | NA | NA |
| TG (49:3) | ME656985 | 1.82 | 1.90 | 0.01 | 0.01 | NA | NA | NA |
| TG (50:5) | ME656991 | 1.84 | 1.88 | 0.01 | 0.01 | NA | NA | NA |
| TG (46:3) | ME656976 | 1.84 | 1.89 | 0.01 | 0.01 | NA | NA | NA |
| TG (52:6) | ME657003 | 1.84 | 1.89 | 0.01 | 0.01 | NA | NA | NA |
| TG (44:2) | ME656972 | 1.84 | 1.87 | 0.02 | 0.02 | NA | NA | NA |
| TG (51:4) | ME656996 | 1.85 | 1.87 | 0.01 | 0.01 | NA | NA | NA |
| TG (58:4) A | ME657033 | 1.90 | 1.50 | NA | NA | NA | 0.01 | 0.04 |
| TG (62:3) | ME657043 | 1.88 | 1.43 | NA | NA | NA | 0.07 | 0.09 |
| TG (53:1) | ME657004 | 1.99 | 1.71 | 0.01 | 0.01 | NA | NA | NA |
| TG (49:0) | ME656982 | 1.77 | 1.68 | NA | NA | NA | 0.01 | 0.01 |
| TG (56:5) | ME657025 | 1.80 | 1.65 | NA | NA | NA | 0.00 | 0.01 |
| TG (58:5) | ME657034 | 1.81 | 1.62 | NA | NA | NA | 0.01 | 0.02 |
| TG (58:8) | ME657037 | 1.80 | 1.63 | NA | NA | NA | 0.01 | 0.03 |
| TG (52:0) | ME656997 | 3.32 | 2.87 | 0.01 | 0.01 | 0.00 | 0.01 | 0.02 |
| TG (54:2) | ME657010 | 3.39 | 2.79 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 |
| TG (52:1) | ME656998 | 2.90 | 2.79 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 |
| TG (50:3) | ME656989 | 2.92 | 2.92 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 |
| TG (46:1) | ME656974 | 3.00 | 2.96 | 0.01 | 0.01 | 0.00 | 0.01 | 0.01 |
| TG (48:2) | ME656979 | 3.05 | 3.03 | 0.02 | 0.02 | 0.00 | 0.00 | 0.01 |
| TG (48:0) | ME656977 | 3.02 | 3.19 | 0.02 | 0.02 | 0.00 | 0.02 | 0.03 |
| TG (54:3) | ME657011 | 3.25 | 2.94 | 0.02 | 0.02 | 0.00 | 0.00 | 0.02 |
| TG (54:5) | ME657013 | 3.26 | 2.95 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 |
| TG (50:0) | ME656986 | 3.24 | 2.97 | 0.02 | 0.01 | 0.00 | 0.01 | 0.02 |
| TG (54:4) | ME657012 | 3.23 | 2.98 | 0.02 | 0.02 | 0.00 | 0.00 | 0.01 |
| TG (50:1) | ME656987 | 3.17 | 3.02 | 0.03 | 0.02 | 0.00 | 0.01 | 0.03 |
| TG (52:2) | ME656999 | 3.16 | 3.03 | 0.03 | 0.02 | 0.00 | 0.01 | 0.02 |
| TG (48:1) | ME656978 | 3.16 | 3.05 | 0.02 | 0.01 | 0.00 | 0.01 | 0.02 |
| TG (52:4) | ME657001 | 3.17 | 3.05 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 |
| TG (52:3) | ME657000 | 3.14 | 3.07 | 0.03 | 0.02 | 0.00 | 0.00 | 0.01 |
| TG (46:0) | ME656973 | 3.12 | 3.10 | 0.02 | 0.01 | 0.00 | 0.01 | 0.01 |
| TG (50:2) | ME656988 | 3.11 | 3.10 | 0.02 | 0.02 | 0.00 | 0.01 | 0.01 |
| TG (58:6) | ME657035 | 2.57 | 2.47 | 0.01 | 0.01 | NA | 0.00 | 0.01 |
| TG (56:3) | ME657023 | 2.85 | 2.40 | 0.01 | 0.01 | NA | 0.01 | 0.02 |
| TG (58:7) | ME657036 | 2.70 | 2.44 | 0.02 | 0.01 | NA | 0.01 | 0.02 |
| TG (56:4) | ME657024 | 2.80 | 2.49 | 0.01 | 0.00 | NA | 0.01 | 0.02 |
| TG (51:1) | ME656993 | 2.76 | 2.53 | 0.01 | 0.01 | NA | 0.00 | 0.01 |
| TG (54:6) | ME657014 | 2.78 | 2.51 | 0.01 | 0.01 | NA | 0.00 | 0.01 |
| TG (44:1) | ME656971 | 2.55 | 2.63 | 0.01 | 0.01 | NA | 0.00 | 0.00 |
| TG (51:2) | ME656994 | 2.67 | 2.62 | 0.01 | 0.01 | NA | 0.00 | 0.01 |
| TG (48:3) | ME656980 | 2.65 | 2.67 | 0.01 | 0.01 | NA | 0.00 | 0.01 |
| TG (51:3) | ME656995 | 2.65 | 2.66 | 0.01 | 0.01 | NA | 0.00 | 0.01 |
| TG (49:2) | ME656984 | 2.65 | 2.65 | 0.01 | 0.01 | NA | 0.01 | 0.01 |
| TG (46:2) | ME656975 | 2.66 | 2.65 | 0.01 | 0.01 | NA | 0.00 | 0.01 |
| TG (50:4) | ME656990 | 2.66 | 2.65 | 0.01 | 0.01 | NA | 0.00 | 0.01 |
| TG (56:7) | ME657027 | 2.69 | 2.59 | 0.02 | 0.01 | NA | 0.01 | 0.01 |
| TG (56:6) | ME657026 | 2.71 | 2.59 | 0.01 | 0.01 | NA | 0.01 | 0.02 |
| TG (52:5) | ME657002 | 2.71 | 2.60 | 0.01 | 0.01 | NA | 0.00 | 0.01 |
| TG (53:4) | ME657007 | 2.71 | 2.59 | 0.01 | 0.01 | NA | 0.00 | 0.01 |
| TG (53:3) | ME657006 | 2.70 | 2.54 | 0.03 | 0.02 | NA | 0.01 | 0.03 |
| TG (49:1) | ME656983 | 2.73 | 2.56 | 0.01 | 0.01 | NA | 0.01 | 0.02 |
| TG (53:2) | ME657005 | 2.73 | 2.55 | 0.02 | 0.01 | NA | 0.00 | 0.01 |
| TG (60:3) | ME657040 | 2.95 | 1.95 | 0.02 | 0.02 | NA | 0.04 | 0.06 |
| TG (54:1) | ME657009 | 3.05 | 2.20 | 0.01 | 0.01 | NA | 0.00 | 0.01 |
| TG (56:2) | ME657022 | 3.05 | 2.19 | 0.01 | 0.01 | NA | 0.01 | 0.02 |
| TG (56:1) | ME657021 | 3.07 | 2.16 | 0.01 | 0.01 | NA | 0.01 | 0.02 |
| TG (58:1) | ME657029 | 3.06 | 2.14 | 0.02 | 0.01 | NA | 0.03 | 0.03 |
| TG (58:2) | ME657031 | 3.04 | 2.04 | 0.01 | 0.01 | NA | 0.02 | 0.03 |
| TG (58:3) | ME657032 | 2.99 | 2.08 | 0.01 | 0.01 | NA | 0.02 | 0.04 |
| TG (60:2) | ME657039 | 3.00 | 2.07 | 0.02 | 0.01 | NA | 0.02 | 0.03 |
Factors:
| F1 | Treatment:Human Adipocytes grown in the ABSENCE of SKOV3ip1 OvCa Cells (Control) | Time Point:4 hours |
| F2 | Treatment:Human Adipocytes grown in the PRESENCE of SKOV3ip1 OvCa cells (Co-Culture) | Time Point:4 hours |
| F3 | Treatment:Media from Human Adipocytes and SKOV3ip1 OvCa Cells Co-Cultured | Time Point:4 hours |
| F4 | Treatment:Media from Human Adipocytes Culturing Only | Time Point:4 hours |
| F5 | Treatment:Media from SKOV3ip1 OvCa Cells Culturing Only | Time Point:4 hours |
| F6 | Treatment:SKOV3ip1 OvCa cells grown in the ABSENCE of human adipocytes (Control) | Time Point:4 hours |
| F7 | Treatment:SKOV3ip1 OvCa cells grown in the PRESENCE of Human Adipocytes (Co-Culture) | Time Point:4 hours |
