Clustering data with hclust algorithm for NIH WCMC Pilot & Feasibility Project: ?Metabolite changes associated with weight loss? (Study ST000257)
ESI negative ion mode ( Oxylipins analysis) (Analysis AN000406)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 15(16)-EpODE | ME701848 | 0.29 | NA | 0.24 | 0.41 | 0.39 | 0.40 | NA | 0.16 | 0.17 | 0.34 | 0.53 | NA | 0.11 | 0.31 | 8.64 |
| 15-HEPE | ME701835 | 2.25 | 2.02 | 0.36 | 1.73 | 0.40 | 0.93 | 1.34 | 0.21 | 1.48 | 0.05 | 1.87 | 1.24 | 0.26 | 1.31 | 0.14 |
| 6-keto PGF1a | ME701806 | 0.80 | 2.84 | 0.09 | NA | NA | 0.33 | 1.64 | 0.24 | NA | NA | 1.11 | 1.84 | 0.12 | NA | NA |
| 12-HEPE | ME701836 | 1.69 | 2.49 | 0.56 | 0.17 | 0.92 | 0.76 | 1.94 | 0.71 | 0.26 | 0.57 | 1.41 | 1.96 | 0.72 | 0.31 | 0.52 |
| 5-HETE | ME701834 | 1.41 | 1.82 | 0.92 | 0.11 | 1.63 | 0.41 | 1.69 | 0.80 | 0.14 | 0.39 | 1.91 | 1.92 | 0.76 | 0.26 | 0.85 |
| 8(9)-EpETrE | ME701852 | NA | 2.89 | 0.11 | NA | 0.13 | NA | 1.63 | 0.15 | NA | 0.09 | NA | 3.78 | 0.16 | NA | 0.07 |
| 11(12)-EpETrE | ME701851 | 0.18 | 3.58 | 0.50 | 0.04 | 0.15 | 0.14 | 2.24 | 0.45 | 0.08 | 0.11 | 0.34 | 6.52 | 0.42 | 0.15 | 0.09 |
| 14(15)-EpETrE | ME701850 | 0.05 | 3.30 | 0.17 | NA | 0.09 | 0.04 | 2.15 | 0.14 | NA | 0.06 | 0.15 | 5.66 | 0.13 | NA | 0.05 |
| TXB2 | ME701805 | 0.04 | 4.18 | 0.03 | 0.03 | 0.04 | 0.02 | 5.12 | 0.06 | 0.05 | 0.09 | 0.04 | 4.46 | 0.07 | 0.04 | 0.08 |
| 5-KETE | ME701845 | 0.33 | 4.13 | 0.54 | 0.06 | 0.55 | 0.15 | 3.36 | 0.49 | 0.06 | 0.11 | 0.49 | 4.28 | 0.46 | 0.12 | 0.27 |
| 11-HETE | ME701831 | 0.60 | 3.98 | 0.22 | 0.04 | 0.47 | 0.13 | 4.16 | 0.18 | 0.04 | 0.06 | 0.79 | 3.72 | 0.19 | 0.05 | 0.37 |
| PGD2 | ME701808 | 0.58 | 4.45 | 0.03 | 0.03 | 0.02 | 0.08 | 4.23 | 0.04 | 0.01 | 0.00 | 0.88 | 4.57 | 0.05 | 0.03 | 0.01 |
| PGE2 | ME701807 | 0.82 | 4.58 | 0.02 | 0.10 | 0.06 | 0.58 | 3.22 | 0.05 | 0.08 | 0.03 | 2.20 | 3.03 | 0.04 | 0.14 | 0.03 |
| 12-HETE | ME701830 | 0.86 | 4.26 | 0.13 | 0.11 | 0.56 | 0.41 | 2.81 | 0.17 | 0.15 | 0.71 | 1.00 | 2.78 | 0.20 | 0.17 | 0.68 |
| 15-HETE | ME701829 | 1.39 | 3.20 | 0.48 | 0.08 | 0.68 | 0.39 | 3.19 | 0.34 | 0.08 | 0.10 | 1.53 | 2.79 | 0.36 | 0.10 | 0.30 |
| 12(13)-EpOME | ME701846 | 0.90 | 1.08 | 0.59 | 0.36 | 0.98 | 0.81 | 0.73 | 0.39 | 0.33 | 0.43 | 2.61 | 0.80 | 0.45 | 0.46 | 4.01 |
| 4-HDoHE | ME701841 | NA | NA | 0.07 | 0.02 | 3.47 | NA | NA | 0.08 | 0.03 | 2.49 | NA | NA | 0.09 | 0.03 | 2.72 |
| 9(10)-EpODE | ME701849 | 0.37 | NA | 0.64 | NA | 2.42 | 0.67 | NA | 0.36 | NA | 0.31 | 1.18 | NA | 0.37 | NA | 2.67 |
| 13-KODE | ME701842 | 0.71 | 1.58 | 0.35 | NA | 3.49 | 0.34 | 0.44 | 0.21 | NA | 0.11 | 1.16 | 0.24 | 0.17 | NA | 2.65 |
| 9-KODE | ME701843 | 0.40 | 1.24 | 0.32 | NA | 3.95 | 0.29 | 0.84 | 0.17 | NA | 0.19 | 0.80 | 0.69 | 0.14 | NA | 2.98 |
| 5-HEPE | ME701838 | 1.65 | NA | 1.35 | NA | 1.12 | 0.42 | NA | 1.25 | NA | 0.28 | 1.29 | NA | 1.23 | NA | 0.43 |
| 15-HETrE | ME701828 | 1.93 | NA | 1.25 | 0.10 | NA | 0.94 | NA | 1.02 | 0.10 | NA | 2.19 | NA | 1.21 | 0.11 | NA |
| 9,10-DiHOME | ME701814 | 0.97 | NA | 1.67 | 0.20 | NA | 0.76 | NA | 1.12 | 0.18 | NA | 2.73 | NA | 1.14 | 0.24 | NA |
| 12,13-DiHOME | ME701813 | 0.38 | NA | 3.30 | 0.13 | NA | 0.32 | NA | 1.70 | 0.08 | NA | 1.47 | NA | 1.48 | 0.13 | NA |
| 15,16-DiHODE | ME701815 | 0.52 | NA | 2.66 | 0.29 | NA | 0.54 | NA | 1.92 | 0.22 | NA | 1.11 | NA | 1.06 | 0.43 | NA |
| 14,15-DiHETrE | ME701817 | 0.07 | NA | 3.05 | 0.01 | NA | 0.06 | NA | 2.52 | 0.01 | NA | 0.11 | NA | 2.98 | 0.02 | NA |
| 19,20-DiHDoPA | ME701823 | 0.08 | NA | 3.86 | 0.01 | NA | 0.08 | NA | 2.69 | 0.02 | NA | 0.11 | NA | 2.11 | 0.03 | NA |
| PGE1 | ME701857 | 1.26 | NA | NA | 0.15 | 0.38 | 1.13 | NA | NA | 0.14 | 0.02 | 4.20 | NA | NA | 0.24 | 0.11 |
| 9,12,13-TriHOME | ME701811 | 1.06 | NA | 1.06 | 0.19 | NA | 0.48 | NA | 0.31 | 0.14 | NA | 5.13 | NA | 0.44 | 0.17 | NA |
| SUM-TriHOME | ME701812 | 1.06 | NA | 0.79 | 0.20 | NA | 0.52 | NA | 0.21 | 0.16 | NA | 5.54 | NA | 0.33 | 0.19 | NA |
| 9-HODE | ME701825 | 2.20 | 0.58 | 0.60 | 0.20 | 3.26 | 0.53 | 0.43 | 0.22 | 0.16 | 0.16 | 3.97 | 0.46 | 0.23 | 0.24 | 1.76 |
| 12(13)-Ep-9-KODE | ME701855 | 0.84 | 1.34 | 0.64 | NA | 1.80 | 0.46 | 0.71 | 0.47 | NA | 0.06 | 4.04 | 0.50 | 0.38 | NA | 0.89 |
| 9(10)-EpOME | ME701847 | 1.07 | 1.04 | 0.60 | NA | 1.27 | 0.81 | 0.75 | 0.42 | NA | 0.36 | 2.83 | 1.24 | 0.40 | NA | 1.25 |
| 9-HOTE | ME701827 | 1.59 | 1.42 | 0.66 | 0.40 | 2.28 | 0.47 | 1.19 | 0.31 | 0.29 | 0.25 | 2.80 | 1.54 | 0.23 | 0.41 | 1.27 |
| 9-HETE | ME701832 | 2.23 | NA | 0.75 | 0.08 | 2.71 | 0.35 | NA | 0.59 | 0.10 | 0.22 | 2.47 | NA | 0.54 | 0.16 | 1.81 |
| 8-HETE | ME701833 | 2.06 | NA | 0.59 | NA | 1.46 | 0.43 | NA | 0.43 | NA | 0.24 | 2.43 | NA | 0.50 | NA | 0.86 |
| 9-HEPE | ME701837 | 2.75 | NA | 1.24 | NA | 1.76 | 0.12 | NA | 0.35 | NA | 0.19 | 1.69 | NA | 0.36 | NA | 0.53 |
| 14-HDoHE | ME701840 | 2.68 | NA | 0.40 | 0.17 | 0.69 | 1.57 | NA | 0.46 | 0.23 | 0.61 | 3.59 | NA | 0.70 | 0.28 | 0.61 |
| 17-HDoHE | ME701839 | 2.62 | NA | 0.63 | 0.13 | 1.49 | 1.36 | NA | 0.44 | 0.14 | 0.20 | 3.27 | NA | 0.76 | 0.16 | 0.80 |
| 13-HODE | ME701824 | 3.17 | 0.23 | 0.89 | 0.22 | 1.92 | 1.24 | 0.20 | 0.41 | 0.19 | 0.09 | 4.70 | 0.18 | 0.38 | 0.27 | 0.90 |
| 13-HOTE | ME701826 | 2.41 | NA | 0.28 | 0.12 | 1.62 | 1.44 | NA | 0.15 | 0.09 | 0.12 | 4.81 | NA | 0.13 | 0.14 | 0.69 |
Factors:
| F1 | Treatment:HFD | Tissue Type:Adipose |
| F2 | Treatment:HFD | Tissue Type:Hypothalmus |
| F3 | Treatment:HFD | Tissue Type:Liver |
| F4 | Treatment:HFD | Tissue Type:Muscle |
| F5 | Treatment:HFD | Tissue Type:Plasma |
| F6 | Treatment:LFD | Tissue Type:Adipose |
| F7 | Treatment:LFD | Tissue Type:Hypothalmus |
| F8 | Treatment:LFD | Tissue Type:Liver |
| F9 | Treatment:LFD | Tissue Type:Muscle |
| F10 | Treatment:LFD | Tissue Type:Plasma |
| F11 | Treatment:SW | Tissue Type:Adipose |
| F12 | Treatment:SW | Tissue Type:Hypothalmus |
| F13 | Treatment:SW | Tissue Type:Liver |
| F14 | Treatment:SW | Tissue Type:Muscle |
| F15 | Treatment:SW | Tissue Type:Plasma |
