Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for C13 Pyruvate Flux in 3t3 L1 (Study ST000271)

ESI/QTOF negative ion mode (Analysis AN000434)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10
Nicotinamide Adenine Dinucleotide reduced_13C_4	ME702758	3.91	0.01	0.21	NA	NA	0.89	0.58	1.59	0.23	0.58
Adenosine monophosphate_13C_1	ME702684	1.32	1.14	1.92	NA	NA	0.12	NA	0.51	NA	NA
Ribose-5-phosphate or xylulose 5-phosphate_13C_1	ME702764	NA	NA	1.36	0.27	0.60	0.42	NA	1.21	0.42	2.71
Adenosine diphosphate_13C_1	ME702679	NA	0.69	NA	0.21	0.53	NA	0.64	NA	1.88	2.06
Adenosine monophosphate_13C_3	ME702686	NA	0.27	1.07	0.16	0.80	0.64	0.41	NA	1.76	2.89
Nicotinamide Adenine Dinucleotide reduced_13C_1	ME702755	1.60	NA	0.57	2.01	NA	0.51	1.50	0.60	0.41	0.81
Adenosine triphosphate_13C_1	ME702694	NA	0.06	NA	NA	2.07	0.39	1.85	0.33	1.37	0.92
Adenosine triphosphate_13C_4	ME702697	1.55	NA	0.37	NA	0.59	1.69	NA	NA	NA	0.81
3-phosphoglyceraldehyde_13C_2	ME702719	NA	0.74	NA	NA	0.93	1.87	1.21	0.25	NA	NA
Adenosine monophosphate_13C_2	ME702685	NA	NA	1.20	0.10	1.98	1.64	NA	NA	0.57	0.51
Glutamate_13C_3	ME702735	NA	0.45	NA	0.54	NA	0.30	NA	2.55	NA	1.16
Sucrose_13C_1	ME702777	NA	1.06	NA	0.63	NA	1.04	NA	1.52	NA	0.75
Aspartate_13C_2	ME702691	0.90	1.75	0.04	1.35	0.70	1.78	0.43	1.60	0.10	1.35
Glutamate_13C_1	ME702733	0.28	1.49	0.14	0.99	0.43	1.91	0.42	2.24	0.33	1.76
Glutamate_13C_2	ME702734	0.05	1.72	0.00	1.16	0.06	1.74	NA	2.34	0.09	1.84
Citrate or Isocitrate_13C_1	ME702700	0.39	1.00	0.37	0.97	0.61	1.33	0.42	1.16	1.26	2.49
Citrate or Isocitrate_13C_2	ME702701	0.21	1.28	0.07	1.49	0.36	1.40	0.16	1.66	0.33	3.05
6-Phosphogluconate_13C_1	ME702670	0.82	2.51	NA	0.47	1.07	1.17	NA	1.31	0.29	0.35
Fructose 1,6-bisphosphate_13C_1	ME702711	0.71	2.14	0.12	0.20	1.02	2.19	0.64	1.73	0.91	0.33
Sedoheptulose 7-phosphate_13C_1	ME702770	0.76	1.73	0.15	0.43	0.79	2.36	0.82	2.64	0.25	0.08
Adenosine diphosphate_13C_2	ME702680	0.65	0.74	0.99	0.66	0.89	0.15	1.45	2.48	0.98	NA
Adenosine diphosphate_13C_3	ME702681	0.47	0.07	NA	0.38	1.32	0.93	0.98	1.63	1.59	1.63
AMP	ME702781	0.47	0.41	0.75	0.88	1.21	0.74	1.01	0.78	1.99	1.76
3-Glycerophosphate	ME702728	0.86	0.81	1.00	0.92	1.12	0.70	0.73	0.58	1.78	1.49
Citrate or Isocitrate	ME702699	0.69	0.76	0.92	0.65	1.01	0.92	0.66	0.72	2.20	1.48
Erythrose 4-phosphate	ME702706	0.56	0.98	NA	0.31	1.39	1.31	1.32	1.44	NA	0.69
Nicotinamide Adenine Dinucleotide oxidized_13C_1	ME702750	0.77	1.55	0.12	0.06	2.29	1.87	1.21	0.73	0.31	1.08
Fructose 1,6-bisphosphate_13C_2	ME702712	0.47	1.12	0.50	1.45	2.01	0.65	1.10	1.30	0.77	0.63
Malate_13C_1	ME702742	0.80	1.53	0.61	1.59	0.86	1.28	0.57	1.06	0.58	1.11
Malate	ME702660	0.90	1.12	1.11	1.28	1.15	0.99	0.59	0.71	1.02	1.13
Malate_13C_2	ME702743	1.00	1.27	0.96	1.42	0.88	1.07	0.77	0.89	0.74	1.00
Acetyl-CoA	ME702676	0.99	0.74	0.68	0.32	1.22	1.13	1.26	1.10	1.52	1.03
Glutamate	ME702732	1.07	0.84	0.91	0.77	1.32	1.10	1.00	0.91	1.04	1.04
ADP	ME702782	0.85	0.77	0.79	0.73	1.08	1.20	1.04	1.06	1.23	1.25
Ribose-5-phosphate or xylulose 5-phosphate	ME702763	0.83	0.71	0.71	0.81	1.40	1.09	0.98	0.84	1.34	1.29
3-phosphoglyceraldehyde	ME702717	0.93	1.22	0.84	0.87	0.97	1.31	0.76	1.20	1.09	0.80
Glucose 6-phosphate or fructose-6-phosphate	ME702721	1.02	1.14	0.76	0.73	1.29	1.12	0.90	1.16	0.96	0.94
Ribose-5-phosphate or xylulose 5-phosphate_13C_2	ME702765	1.08	1.00	0.81	0.75	1.11	1.15	0.90	1.13	1.02	1.06
ATP	ME702783	1.11	1.13	0.79	0.70	1.04	1.11	1.01	1.19	0.98	0.94
Fructose 1,6-bisphosphate	ME702659	1.04	1.13	0.83	0.83	0.94	1.06	0.94	1.17	1.04	1.02
Nicotinamide Adenine Dinucleotide oxidized	ME702661	0.84	0.79	0.66	0.65	1.23	1.31	1.22	1.19	1.02	1.11
Sucrose	ME702664	0.83	0.84	0.52	0.62	1.36	1.34	1.08	1.24	1.12	1.04
Aspartate	ME702689	0.98	1.03	0.61	0.63	1.30	1.52	1.06	1.23	0.77	0.88
Glucose 6-phosphate or fructose-6-phosphate_13C_2	ME702723	0.83	1.00	0.70	0.47	1.31	1.53	1.05	1.19	0.90	1.02
2 or 3-phosphoglycerate_2PG/3PG	ME702665	1.11	0.83	0.30	0.38	1.68	1.45	1.31	1.32	0.74	0.88
Phosphoenolpyruvate	ME702663	1.13	0.78	0.16	0.34	1.93	1.44	1.43	1.34	0.58	0.87
Adenosine triphosphate_13C_2	ME702695	1.07	1.20	0.53	0.53	1.18	1.14	1.55	1.22	0.78	0.80
Adenosine triphosphate_13C_3	ME702696	1.31	0.95	0.71	0.52	1.56	0.96	1.55	1.18	0.77	0.49
Nicotinamide Adenine Dinucleotide oxidized_13C_2	ME702751	0.99	1.02	0.78	0.68	1.50	0.98	1.51	1.16	0.63	0.75
Aspartate_13C_1	ME702690	0.76	1.40	0.30	0.67	1.06	1.95	0.83	1.73	0.42	0.89
6-Phosphogluconate	ME702669	1.40	1.53	0.57	0.53	1.01	1.32	1.24	1.17	0.64	0.58
Sedoheptulose 7-phosphate	ME702769	1.06	1.49	0.41	0.50	0.88	1.36	1.16	1.84	0.69	0.62
6-Phosphogluconate_13C_2	ME702671	1.77	NA	0.39	1.21	0.71	1.68	0.57	0.72	1.62	0.35
Nicotinamide Adenine Dinucleotide reduced	ME702662	1.27	0.32	1.19	0.47	0.20	0.99	1.69	1.09	1.81	0.97

Factors:

F1	Drug combination:Isoproterenol \| 13C-label position in pyruvate:C1
F2	Drug combination:Isoproterenol \| 13C-label position in pyruvate:C2
F3	Drug combination:Isoproterenol + Leelamine \| 13C-label position in pyruvate:C1
F4	Drug combination:Isoproterenol + Leelamine \| 13C-label position in pyruvate:C2
F5	Drug combination:None \| 13C-label position in pyruvate:C1
F6	Drug combination:None \| 13C-label position in pyruvate:C2
F7	Drug combination:Rosiglitazone \| 13C-label position in pyruvate:C1
F8	Drug combination:Rosiglitazone \| 13C-label position in pyruvate:C2
F9	Drug combination:Rosiglitazone + Leelamine \| 13C-label position in pyruvate:C1
F10	Drug combination:Rosiglitazone + Leelamine \| 13C-label position in pyruvate:C2

Data matrix