Clustering data with hclust algorithm for Inhibition of autophagy/proteasome degradation or inhibition of protein synthesis in models of muscle insulin resistance affect TCA cycle (Study ST000513)
GC POSITIVE ION MODE (Analysis AN000786)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Isocitrate | ME157258 | 1.25 | 0.97 | 0.58 | 0.77 | 0.22 | 4.35 | 0.09 | 0.44 | 2.95 | 1.48 | 0.11 | 0.83 |
| cis-Aconitic Acid | ME157256 | 0.47 | 0.47 | 0.63 | 4.95 | 0.41 | 0.47 | 0.94 | 0.71 | 0.47 | 0.75 | 0.51 | 0.86 |
| Glutamate | ME157255 | 0.34 | 0.62 | 0.68 | 0.68 | 0.45 | 0.56 | 0.25 | 0.41 | 0.90 | 0.94 | 1.96 | 2.12 |
| Citrate | ME157257 | 1.00 | 0.95 | 0.71 | 0.80 | 0.80 | 0.88 | 0.71 | 0.80 | 0.86 | 0.82 | 1.53 | 1.44 |
| Fumarate | ME157251 | 1.03 | 0.82 | 0.62 | 0.73 | 0.82 | 0.64 | 0.66 | 0.54 | 0.97 | 0.89 | 1.60 | 1.51 |
| Malate | ME157254 | 1.01 | 0.81 | 0.60 | 0.68 | 0.74 | 0.56 | 0.64 | 0.52 | 0.99 | 0.94 | 1.57 | 1.63 |
| Ketoglutarate | ME157253 | 0.75 | 1.01 | 1.82 | 1.50 | 0.78 | 0.68 | 0.89 | 0.96 | 0.79 | 1.15 | 0.66 | 1.00 |
| Lactate | ME157249 | 1.22 | 1.20 | 1.11 | 1.12 | 1.17 | 0.52 | 1.12 | 0.97 | 1.06 | 0.96 | 0.77 | 0.72 |
| Succinate | ME157250 | 0.96 | 0.97 | 0.89 | 1.41 | 1.22 | 1.16 | 1.68 | 1.30 | 0.69 | 0.82 | 0.65 | 0.91 |
Factors:
| F1 | group:Control/Colch | genotype:Irlox |
| F2 | group:Control/Colch | genotype:Irlox IGFRlox |
| F3 | group:Control/Saline | genotype:Irlox |
| F4 | group:Control/Saline | genotype:Irlox IGFRlox |
| F5 | group:HFD+Colch | genotype:Irlox |
| F6 | group:HFD+Colch | genotype:Irlox IGFRlox |
| F7 | group:HFD/Saline | genotype:Irlox |
| F8 | group:HFD/Saline | genotype:Irlox IGFRlox |
| F9 | group:IRKO/Colch | genotype:IR -/- |
| F10 | group:IRKO/Saline | genotype:IR -/- |
| F11 | group:MIGIRKO/Colch | genotype:IR -/- IGFR -/- |
| F12 | group:MIGIRKO/Saline | genotype:IR -/- IGFR -/- |
