Clustering data with hclust algorithm for Replication study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate (Study ST000548)
GC POSITIVE ION MODE (Analysis AN000836)| Metabolite | Structure | F1 | F2 | F3 | F4 |
|---|---|---|---|---|---|
| Glu EIC Results | ME161156 | 1.71 | 0.19 | 2.16 | 0.19 |
| Glu TIC Results | ME161155 | 1.70 | 0.25 | 2.00 | 0.24 |
| Asp EIC Results | ME161152 | 0.35 | 0.11 | 3.54 | 2.88 |
| Asp TIC Results | ME161151 | 0.39 | 0.14 | 3.25 | 3.01 |
| 2HG EIC Results | ME161154 | 0.62 | 0.26 | 1.62 | 3.94 |
| 2HG TIC Results | ME161153 | 0.63 | 0.29 | 1.48 | 3.97 |
| Ratio of 2HG/Glu EIC | ME161158 | 0.21 | 0.66 | 0.17 | 5.12 |
| Ratio of 2HG/Glu TIC | ME161157 | 0.23 | 0.64 | 0.20 | 4.81 |
Factors:
| F1 | Time Point:CS-24h | Sample Source:293T HEK cell line |
| F2 | Time Point:CS-48h | Sample Source:293T HEK cell line |
| F3 | Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells |
| F4 | Time Point:QC | Sample Source:- |
