Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Investigating large scale metabolomics in mice serum lacking insulin receptors and IGF-1 receptors (Study ST000549)

Reversed phase POSITIVE ION MODE (Analysis AN000839)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8
7(Z),11(Z)-Heptacosadiene	ME164750	7.53	0.00	0.00	0.90	0.00	0.00	0.00	0.54
MS-275	ME164751	6.24	0.00	0.00	1.15	0.14	0.00	0.00	1.10
Tubastatin A	ME164732	3.11	0.22	0.23	1.05	0.10	1.04	0.20	2.00
Trp Tyr Tyr	ME164745	3.37	0.00	0.00	2.39	0.28	0.00	0.00	2.04
Tyr Thr Gln	ME164676	3.11	0.04	0.03	2.11	0.46	0.13	0.12	1.98
Oxindole	ME164671	0.48	3.28	1.47	1.26	0.00	1.94	0.93	0.00
L-Tryptophan	ME164741	0.57	2.85	0.41	2.06	0.12	2.55	0.57	0.00
N(alpha)-t-Butoxycarbonyl-L-leucine	ME164667	0.76	2.30	0.70	1.12	0.39	2.44	0.54	0.43
Oxyquinoline	ME164681	0.63	2.58	0.85	1.05	0.34	2.18	0.88	0.31
Ile Pro	ME164747	0.89	2.21	0.44	0.35	0.70	2.18	1.57	0.13
Methdilazine	ME164666	0.12	2.19	1.52	0.60	0.00	2.44	1.85	0.00
C12	ME164749	0.19	1.00	0.44	0.61	1.48	0.66	0.52	2.37
(S)-ATPA	ME164634	1.16	1.28	0.00	3.05	0.08	1.35	0.34	1.23
Niacin (Nicotinic acid)	ME164632	1.59	0.44	0.58	2.82	0.46	0.86	0.79	0.78
Prometon	ME164656	1.36	0.58	0.58	2.39	0.70	0.70	0.46	1.33
2,3-bis (4-Hydroxyphenyl) Propionitrile	ME164665	2.10	0.40	0.49	2.29	0.14	0.28	0.68	1.78
L-Glutamic acid dibutyl ester	ME164736	1.76	0.05	0.65	2.15	0.88	0.26	0.37	1.70
Prometon + 1.7550333	ME164658	1.10	0.20	0.74	2.02	0.77	0.27	0.63	1.97
(+)-Tephrorin A	ME164684	2.79	0.41	0.74	0.25	0.00	1.42	1.79	0.77
CB3717	ME164685	2.44	1.04	0.94	0.20	0.22	1.32	1.43	0.74
Sarcoaldesterol A	ME164748	2.84	1.39	0.72	0.00	0.31	0.95	1.53	0.72
2-Amino-3-methyl-1-butanol + 10.466517	ME164701	2.40	0.80	1.42	1.29	0.10	1.19	1.09	0.35
Isowillardiine	ME164618	2.28	1.13	1.21	1.69	0.08	0.69	1.25	0.44
LysoPE(0:0/18:2(9Z,12Z))	ME164715	2.36	0.70	0.77	0.96	0.82	0.96	1.08	0.57
Naphthalic anhydride	ME164606	2.68	0.73	1.00	1.35	0.81	0.93	0.87	0.13
Uric acid	ME164641	2.85	0.37	0.29	1.40	0.84	1.31	0.45	0.64
endo-1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-N-oxide	ME164682	3.01	0.33	0.77	1.34	0.99	0.64	0.61	0.56
Fexofenadine	ME164714	2.67	0.45	0.53	1.59	0.68	0.61	0.86	0.84
N-n-Hexanoylglycine methyl ester	ME164627	1.68	0.67	0.46	1.12	2.18	0.33	0.66	0.65
Lys Lys Lys	ME164700	0.61	0.20	1.45	1.08	1.71	0.60	1.01	0.92
Lys Lys Lys + 10.543157	ME164708	0.68	0.20	1.40	0.67	1.58	0.64	1.07	1.23
N-Methyl-2-pyrrolidinone	ME164733	0.23	1.51	0.96	0.95	0.92	1.47	0.99	1.01
Phe His Phe	ME164673	0.18	1.37	1.04	1.10	0.63	1.71	1.38	0.74
Val Gly	ME164730	1.11	2.27	0.90	1.04	0.17	1.37	1.16	0.72
Corticosterone	ME164686	0.60	1.92	0.57	1.25	0.49	1.39	1.06	1.06
Indoleacrylic acid	ME164668	0.82	1.81	0.68	1.16	0.69	1.51	0.64	1.01
LysoPE(0:0/22:0)	ME164722	1.80	0.33	1.68	0.93	0.42	1.28	1.39	0.42
Estra-1,3,5(10)-triene-3,6alpha,17beta-triol triacetate + 10.542064	ME164704	1.24	0.45	1.61	1.15	0.43	1.37	1.23	0.68
PE(18:0/0:0)	ME164713	1.32	0.82	1.25	1.20	0.34	1.26	1.44	0.65
PE(19:1(9Z)/0:0)	ME164703	1.13	0.67	1.34	1.20	0.37	1.41	1.54	0.56
PE(19:1(9Z)/0:0) + 10.729481	ME164709	1.77	0.43	1.33	1.30	0.33	0.94	1.65	0.53
PE(19:1(9Z)/0:0) + 10.803823	ME164710	1.68	0.39	1.02	1.38	0.38	0.96	1.67	0.68
Buprenorphine	ME164697	1.48	0.74	1.34	1.50	0.42	1.00	1.22	0.65
Gymnodimine	ME164718	1.57	0.66	1.08	1.40	0.44	1.20	1.35	0.57
1,2-Dioctanoyl-sn-glycerol	ME164724	0.93	0.68	1.38	1.61	0.49	1.67	1.10	0.42
L-Leucine	ME164657	1.02	0.34	0.88	1.64	0.96	1.52	0.77	0.77
Rebaudioside C	ME164687	1.53	0.97	1.03	0.68	0.62	1.47	1.03	0.80
6-Methoxyquinoline	ME164661	1.69	0.92	0.63	1.03	0.53	1.14	0.83	1.30
alpha-Hydroxytamoxifen	ME164688	1.83	1.13	0.46	0.84	0.73	1.38	0.88	0.91
3-ketosphingosine	ME164723	2.15	0.31	0.58	1.12	0.97	0.67	0.85	1.20
4-heptynoic acid	ME164643	1.58	0.78	0.84	1.62	0.87	0.69	0.77	1.00
2(5H)-Furanone	ME164647	1.47	0.83	0.92	1.37	0.75	0.77	1.04	0.98
L-Glutamic acid n-butyl ester	ME164648	1.55	0.77	0.97	1.49	0.71	0.77	0.85	1.05
2-Methyleneglutarate	ME164646	1.75	0.68	0.76	1.52	0.66	0.94	0.92	0.92
Taurine	ME164607	1.68	0.90	0.65	1.38	0.66	0.98	0.79	1.10
Phenacylamine	ME164652	0.66	1.63	0.70	1.68	0.89	1.35	0.83	0.60
Phenylpyruvic acid	ME164653	0.69	1.84	0.49	2.09	0.83	1.13	0.77	0.66
Caproic acid	ME164650	0.83	1.51	1.15	1.31	0.34	1.09	1.16	1.00
(-)-11-hydroxy-9,10-dihydrojasmonic acid	ME164672	1.16	1.31	0.91	1.28	0.66	1.74	0.84	0.47
Benzaldehyde	ME164663	1.04	1.57	0.91	1.40	0.72	1.42	1.00	0.42
Creatinine	ME164623	1.14	1.39	1.06	1.46	0.75	1.31	1.07	0.30
Estra-1,3,5(10)-triene-3,6alpha,17beta-triol triacetate	ME164692	1.39	1.35	1.16	1.44	0.63	1.03	0.93	0.57
L-Valine + 1.2355758	ME164638	0.89	1.49	1.02	1.28	0.78	1.09	0.97	0.80
N4-Acetylaminobutanal	ME164639	1.05	1.35	1.07	1.11	0.72	1.15	1.02	0.81
Piperideine + 1.3051474	ME164640	1.10	1.45	1.04	1.11	0.77	1.24	1.03	0.61
3,6-dioxo-decanoic acid	ME164660	1.12	1.00	0.94	1.67	0.48	1.37	0.78	0.91
N(alpha)-t-Butoxycarbonyl-L-leucine + 3.9469597	ME164669	1.41	0.89	0.79	1.61	0.59	1.42	0.62	0.88
Traumatic Acid	ME164675	1.08	1.33	0.96	1.90	0.53	1.21	0.71	0.75
Barbital	ME164654	1.04	1.08	0.88	1.79	0.63	1.42	0.93	0.56
Heptanoic acid, 2-amino-, (R)-; (R)-2-Aminoheptanoic acid	ME164628	1.08	1.28	0.83	1.50	0.68	1.49	0.79	0.67
Amitrole	ME164601	1.26	1.17	0.66	1.52	1.10	1.09	0.57	0.81
L-Isoleucine	ME164731	0.89	1.26	0.67	1.71	0.92	1.12	0.73	0.89
Piperideine	ME164599	0.94	1.21	0.76	1.26	0.93	1.30	0.84	0.87
ADMA	ME164631	0.99	1.27	0.70	1.45	0.76	1.15	0.80	1.06
DL-pipecolic acid	ME164600	1.00	1.47	0.81	1.37	0.79	1.04	0.86	0.93
Avizafone	ME164737	1.19	1.18	1.56	0.85	0.46	0.77	1.38	0.92
Tetrahydrofuran	ME164670	1.20	0.98	1.47	0.76	0.88	0.66	1.47	0.75
Acetoacetic acid	ME164617	1.48	1.12	1.04	1.17	0.62	0.93	1.02	0.90
2-Amino-3-methyl-1-butanol	ME164612	1.40	0.92	0.92	1.31	0.88	0.93	0.89	0.88
18-hydroxy-9S,10R-epoxy-stearic acid	ME164699	1.14	0.92	1.04	1.20	0.83	1.02	0.96	0.96
L-Glutamic acid n-butyl ester + 1.51668	ME164651	1.30	0.85	1.08	1.29	0.78	1.03	0.83	0.97
4-Hydroxy-2-butynal	ME164610	0.96	1.24	0.99	0.77	1.04	1.11	1.05	0.89
2,2-Dimethyl-3,4-bis(4-methoxyphenyl)-2H-1-benzopyran-7-ol acetate	ME164693	1.01	1.01	0.95	1.11	0.85	1.01	1.23	0.89
Alanine	ME164620	1.05	0.96	0.81	0.90	0.91	1.03	1.12	1.14
1-Ethyl-1,3-dimethyl-cyclohexane skeleton	ME164683	1.06	1.01	0.99	1.05	0.96	1.03	0.91	1.02
Hydroxyibuprofen	ME164690	1.00	1.02	0.91	1.15	0.98	1.05	0.84	1.06
9,13-dihydroxy-10-ethoxy-11-octadecenoic acid + 10.442588	ME164742	0.59	0.94	1.29	0.76	1.53	0.76	0.86	1.06
1,5-Anhydrosorbitol	ME164625	1.20	0.69	1.02	1.12	1.19	0.74	1.08	0.88
L-alpha-glutamyl-L-hydroxyproline	ME164689	0.99	1.10	1.26	0.84	1.04	0.75	1.10	0.97
Pantoic acid	ME164735	0.87	1.03	1.25	0.94	1.01	0.88	1.05	1.00
9,13-dihydroxy-10-ethoxy-11-octadecenoic acid + 10.527603	ME164707	0.77	0.74	1.27	0.90	1.24	0.79	1.09	1.03
13,14-dihydro Prostaglandin F1?	ME164706	0.85	0.69	1.25	0.92	1.10	0.90	1.16	1.00
9,13-dihydroxy-10-ethoxy-11-octadecenoic acid	ME164698	0.85	0.74	1.07	0.94	1.16	0.89	1.14	1.04
L-Valine	ME164614	0.72	0.73	0.87	1.32	1.09	1.07	0.92	1.11
Prostaglandin D1 Alcohol	ME164705	0.71	0.53	1.01	1.01	1.42	0.84	1.02	1.12
Nitrapyrin	ME164677	1.18	1.79	1.38	0.54	0.48	1.21	1.52	0.45
Thr Ser Ser	ME164624	0.91	1.59	1.37	0.92	0.76	1.24	1.35	0.32
Urea	ME164615	1.04	1.47	1.36	0.88	0.95	1.20	1.03	0.44
1,4-Naphthoquinone	ME164659	1.49	1.25	1.48	1.20	0.40	1.11	0.70	0.86
L-Pipecolic acid	ME164629	1.75	1.59	1.31	1.43	0.80	1.15	0.75	0.00
p-Aminobenzoic acid	ME164739	1.40	1.49	1.41	1.73	0.55	1.22	0.78	0.17
4-Oxoproline	ME164644	1.50	1.59	0.90	2.45	0.38	1.13	0.82	0.13
2-(6^-Methylthio)hexylmalic acid	ME164635	1.68	1.83	0.60	0.89	0.39	1.75	0.59	0.80
Acetone cyanohydrin	ME164740	2.08	1.67	0.18	1.28	0.55	1.32	0.77	0.67
2-Aminopropanol	ME164619	2.00	2.39	0.63	1.03	0.10	2.02	0.62	0.23
1-Aminocyclohexanecarboxylic acid	ME164630	1.38	2.20	0.41	1.82	0.08	1.72	0.50	0.72
Tranexamic acid	ME164642	1.38	1.98	0.51	1.69	0.03	1.98	0.76	0.47

Factors:

F1	Group:CD \| Genotype:Irlox
F2	Group:Control \| Genotype:IGFR lox
F3	Group:Control \| Genotype:Irlox
F4	Group:Control \| Genotype:IRlox IGFR lox
F5	Group:HFD \| Genotype:Irlox
F6	Group:IGFRKO \| Genotype:IGFR -/-
F7	Group:IRKO \| Genotype:IR -/-
F8	Group:MIGIRKO \| Genotype:IR -/- IGFR -/-

Data matrix