Clustering data with hclust algorithm for Investigating large scale metabolomics in mice tissue lacking insulin receptors and IGF-1 receptors (Study ST000551)
Reversed phase POSITIVE ION MODE (Analysis AN000842)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
|---|---|---|---|---|---|---|---|---|---|
| N-Valerylglycine methyl ester | ME165633 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.89 | 2.26 |
| 9S-hydroxy-12R,13S-epoxy-10E,15Z-octadecadienoic acid | ME165580 | 0.51 | 0.00 | 0.98 | 0.00 | 0.91 | 0.00 | 0.15 | 4.26 |
| Guanidylic acid (guanosine monophosphate) | ME165631 | 0.00 | 0.80 | 0.00 | 0.00 | 0.31 | 1.00 | 0.61 | 4.07 |
| Uridine monophosphate (UMP) | ME165634 | 0.00 | 0.97 | 0.00 | 0.00 | 0.34 | 0.99 | 0.36 | 4.21 |
| NU 7026 | ME165510 | 0.00 | 0.58 | 2.84 | 0.00 | 2.15 | 1.22 | 0.26 | 0.92 |
| Tetrahydropteridine | ME165474 | 1.02 | 1.38 | 3.76 | 0.00 | 1.27 | 0.31 | 0.97 | 0.00 |
| N(alpha)-t-Butoxycarbonyl-L-leucine | ME165395 | 0.61 | 1.08 | 2.59 | 1.20 | 1.11 | 0.33 | 0.92 | 0.57 |
| Sulfadoxine glucuronide | ME165628 | 0.62 | 0.64 | 3.01 | 0.25 | 1.19 | 0.40 | 1.27 | 0.66 |
| Anandamide (20:2, n-6) | ME165389 | 0.34 | 0.91 | 0.69 | 0.17 | 2.70 | 0.55 | 0.85 | 1.36 |
| 3R-aminononanoic acid | ME165432 | 1.44 | 1.03 | 1.71 | 1.04 | 1.80 | 0.57 | 0.88 | 0.00 |
| Pro Gly Gln | ME165592 | 1.38 | 1.12 | 1.19 | 0.82 | 2.03 | 0.69 | 1.07 | 0.00 |
| Pro Leu Cys | ME165505 | 1.40 | 1.45 | 0.93 | 0.79 | 1.29 | 1.46 | 0.95 | 0.11 |
| 4-Acetamido-2-amino-6-nitrotoluene | ME165375 | 1.25 | 1.41 | 1.41 | 0.94 | 1.21 | 0.79 | 1.17 | 0.23 |
| Carnosine | ME165374 | 1.25 | 1.41 | 1.39 | 0.89 | 1.25 | 0.89 | 1.12 | 0.22 |
| Val Ile Pro | ME165480 | 1.54 | 1.30 | 1.41 | 0.60 | 1.54 | 0.94 | 0.89 | 0.20 |
| Leu Leu Pro | ME165586 | 1.52 | 1.42 | 1.56 | 0.54 | 1.54 | 1.15 | 0.80 | 0.00 |
| 2-Amino-4-oxo-6-(1,2-dioxoprolyl)-7,8-dihydroxypteridine | ME165421 | 1.51 | 1.56 | 1.31 | 0.46 | 1.63 | 1.07 | 0.93 | 0.02 |
| aminohippuric acid | ME165570 | 1.41 | 1.46 | 1.33 | 0.58 | 1.44 | 1.15 | 1.04 | 0.02 |
| L-Anserine | ME165363 | 1.37 | 1.47 | 1.39 | 0.53 | 1.42 | 1.15 | 1.02 | 0.07 |
| Glu Arg Pro | ME165606 | 0.85 | 1.68 | 1.79 | 0.00 | 1.45 | 1.56 | 1.05 | 0.00 |
| Cellobiose | ME165409 | 0.68 | 1.75 | 1.98 | 0.67 | 1.52 | 0.99 | 0.71 | 0.26 |
| Levan | ME165498 | 0.61 | 1.63 | 2.22 | 0.78 | 1.71 | 0.81 | 0.72 | 0.13 |
| Duartin, Dimethyl Ether | ME165630 | 1.47 | 0.76 | 1.02 | 0.63 | 0.03 | 1.03 | 1.33 | 1.50 |
| L-Glutamic acid dibutyl ester | ME165394 | 0.83 | 0.59 | 1.11 | 1.31 | 1.91 | 0.41 | 1.04 | 0.73 |
| 2,3-bis (4-Hydroxyphenyl) Propionitrile | ME165629 | 1.22 | 1.05 | 1.22 | 1.69 | 0.00 | 1.08 | 0.95 | 1.05 |
| 2S-aminoheptanoic acid | ME165379 | 0.82 | 1.13 | 1.12 | 1.34 | 0.55 | 1.53 | 1.01 | 0.66 |
| DL-2-Aminooctanoic acid | ME165368 | 1.50 | 1.37 | 1.44 | 1.14 | 0.34 | 1.20 | 1.02 | 0.45 |
| PA(20:0/18:0) | ME165619 | 0.70 | 1.89 | 0.84 | 0.46 | 1.17 | 0.93 | 1.11 | 1.02 |
| 12,13S-epoxy-9Z,11-octadecadienoic acid | ME165486 | 0.91 | 0.40 | 1.06 | 0.54 | 1.30 | 0.89 | 0.72 | 1.75 |
| 3-Buten-1-amine | ME165453 | 1.01 | 0.90 | 0.71 | 0.82 | 0.69 | 0.82 | 1.18 | 1.58 |
| ADMA | ME165423 | 0.93 | 0.79 | 0.79 | 1.00 | 0.74 | 1.05 | 1.00 | 1.48 |
| L-Glutamate | ME165398 | 0.69 | 0.67 | 0.91 | 1.11 | 0.89 | 0.92 | 0.89 | 1.63 |
| L-Threonine | ME165496 | 0.67 | 0.86 | 1.14 | 1.03 | 0.92 | 1.02 | 0.90 | 1.33 |
| N-Acryloylglycine | ME165578 | 0.49 | 0.87 | 0.94 | 0.99 | 0.91 | 1.00 | 1.15 | 1.37 |
| 12-amino-dodecanoic acid | ME165566 | 0.83 | 0.83 | 0.91 | 0.77 | 1.13 | 0.83 | 0.93 | 1.51 |
| Tris(butoxyethyl)phosphate | ME165437 | 0.86 | 1.01 | 0.77 | 0.63 | 1.13 | 0.91 | 0.91 | 1.53 |
| Glutathione, oxidized | ME165466 | 0.70 | 0.85 | 1.34 | 0.62 | 0.79 | 0.86 | 1.00 | 1.60 |
| Oxypurinol | ME165553 | 0.71 | 0.93 | 1.07 | 0.67 | 0.80 | 0.98 | 1.03 | 1.55 |
| Cytosine | ME165495 | 0.62 | 0.76 | 0.89 | 0.64 | 0.82 | 1.10 | 0.99 | 1.77 |
| 5-Aminoimidazole ribonucleotide | ME165548 | 0.44 | 0.80 | 0.82 | 0.94 | 0.86 | 0.95 | 0.96 | 1.84 |
| Benserazide | ME165377 | 0.55 | 0.71 | 0.70 | 0.89 | 0.78 | 0.96 | 1.01 | 1.92 |
| ?-Glutamyl-?-cyanoalanine | ME165499 | 0.47 | 0.63 | 0.70 | 0.51 | 0.67 | 1.04 | 0.95 | 2.36 |
| Threonate | ME165390 | 0.50 | 0.83 | 0.96 | 0.59 | 0.54 | 1.04 | 0.93 | 2.14 |
| Mycosporine | ME165422 | 0.87 | 1.03 | 1.79 | 0.98 | 1.08 | 1.02 | 0.99 | 0.49 |
| Streptidine | ME165483 | 0.66 | 1.32 | 1.51 | 0.89 | 1.20 | 1.26 | 1.29 | 0.13 |
| Istamycin C1 | ME165454 | 0.65 | 0.88 | 0.89 | 0.83 | 1.13 | 1.37 | 0.87 | 1.19 |
| Pantetheine | ME165531 | 0.38 | 1.10 | 0.78 | 1.08 | 1.41 | 1.49 | 0.89 | 0.82 |
| N1-(5-Phospho-D-ribosyl)-AMP | ME165478 | 1.27 | 0.90 | 1.12 | 1.13 | 1.16 | 0.98 | 1.04 | 0.54 |
| 13H-Dibenzo[a,g]fluorene | ME165525 | 1.29 | 0.77 | 1.20 | 1.37 | 1.09 | 0.95 | 1.00 | 0.51 |
| Creatinine | ME165369 | 1.16 | 0.82 | 1.16 | 1.37 | 1.16 | 0.93 | 1.03 | 0.52 |
| 5S-HETE di-endoperoxide | ME165533 | 1.10 | 0.77 | 0.66 | 1.06 | 1.13 | 1.04 | 1.10 | 0.99 |
| 12-hydroxy-10-octadecynoic acid | ME165487 | 1.25 | 0.96 | 0.67 | 0.97 | 1.03 | 1.13 | 0.90 | 1.06 |
| 18-hydroxy-9S,10R-epoxy-stearic acid | ME165371 | 1.26 | 0.98 | 0.70 | 0.99 | 1.02 | 1.12 | 0.88 | 1.04 |
| cis-Caryophyllene | ME165424 | 1.25 | 1.00 | 0.69 | 1.00 | 1.03 | 1.10 | 0.89 | 1.05 |
| D-Proline | ME165408 | 0.87 | 1.05 | 1.12 | 1.19 | 1.17 | 1.07 | 0.83 | 0.82 |
| Isopropylamine | ME165522 | 1.21 | 1.08 | 1.14 | 1.13 | 0.79 | 1.04 | 1.00 | 0.79 |
| L-Glutamic acid n-butyl ester | ME165364 | 1.19 | 1.02 | 1.11 | 1.11 | 1.01 | 0.96 | 0.92 | 0.83 |
| Lys Val | ME165410 | 1.11 | 0.93 | 0.93 | 0.74 | 1.06 | 1.13 | 1.16 | 0.86 |
| Heliamine | ME165534 | 0.91 | 0.98 | 0.90 | 0.97 | 1.03 | 1.00 | 1.00 | 1.13 |
| Trovafloxacin | ME165591 | 1.12 | 0.91 | 0.93 | 1.02 | 1.07 | 0.99 | 0.94 | 1.01 |
| Irbesartan | ME165564 | 1.03 | 1.12 | 0.91 | 0.93 | 0.99 | 1.07 | 0.96 | 1.00 |
| Zopiclone | ME165615 | 0.99 | 1.02 | 0.93 | 0.94 | 1.06 | 1.08 | 1.00 | 0.97 |
| Tiludronic acid | ME165567 | 0.98 | 1.06 | 0.98 | 0.97 | 1.03 | 1.00 | 0.99 | 1.00 |
| Flusulfamide | ME165540 | 1.02 | 1.05 | 0.97 | 0.97 | 1.00 | 1.02 | 1.00 | 0.99 |
| Urapidil | ME165476 | 1.02 | 1.04 | 0.97 | 0.96 | 1.02 | 1.01 | 0.99 | 1.00 |
| Deoxytubulosine | ME165441 | 1.01 | 1.04 | 0.98 | 0.95 | 1.03 | 1.03 | 0.97 | 1.00 |
| Amphotericin B | ME165491 | 1.02 | 1.04 | 0.97 | 0.97 | 1.04 | 1.00 | 0.98 | 0.99 |
| PD 0325901 | ME165596 | 1.02 | 1.04 | 0.98 | 0.96 | 1.04 | 1.02 | 0.98 | 0.98 |
| Chikusetsusaponin IV | ME165587 | 1.01 | 1.01 | 1.00 | 0.96 | 1.02 | 0.99 | 1.00 | 1.00 |
| Dinophysistoxin 1 | ME165526 | 1.00 | 1.02 | 1.01 | 0.96 | 1.00 | 1.02 | 1.00 | 1.00 |
| Lys Trp His | ME165497 | 1.02 | 1.01 | 0.98 | 0.95 | 1.01 | 1.03 | 0.99 | 1.00 |
| 20-carboxy-LTB4 | ME165438 | 1.02 | 1.01 | 0.96 | 0.99 | 1.01 | 1.02 | 1.00 | 0.99 |
| 3beta-(Acetyloxy)-5beta-methyl-6beta-chloroestr-9-en-17-one | ME165436 | 1.01 | 1.00 | 1.00 | 0.99 | 1.01 | 1.01 | 0.99 | 0.99 |
| His Glu Asn | ME165463 | 1.02 | 1.03 | 0.98 | 0.98 | 1.01 | 1.00 | 0.98 | 1.01 |
| Hexaflumuron | ME165527 | 1.02 | 1.03 | 0.99 | 0.98 | 1.02 | 1.00 | 0.98 | 1.00 |
| Sulfamethazine | ME165583 | 1.02 | 1.03 | 0.99 | 0.97 | 1.02 | 1.01 | 0.98 | 1.00 |
| His Thr Leu | ME165435 | 1.00 | 1.01 | 0.99 | 0.98 | 1.01 | 1.01 | 0.99 | 1.00 |
| Tyr Arg Thr | ME165511 | 1.01 | 1.01 | 0.99 | 0.97 | 1.01 | 1.02 | 0.99 | 1.00 |
| Ovaliflavanone A | ME165450 | 1.01 | 1.03 | 0.98 | 0.97 | 1.02 | 1.01 | 0.99 | 1.00 |
| (S)-AL 8810 | ME165425 | 1.01 | 1.02 | 0.98 | 0.98 | 1.02 | 1.01 | 0.99 | 1.00 |
| Rimocidine | ME165427 | 1.01 | 1.02 | 0.98 | 0.98 | 1.02 | 1.02 | 0.98 | 0.99 |
| Farnesyl Thiosalicylic Acid | ME165446 | 1.01 | 1.01 | 0.98 | 0.98 | 1.02 | 1.02 | 0.99 | 1.00 |
| PI(20:5(5Z,8Z,11Z,14Z,17Z)/14:1(9Z)) | ME165430 | 1.01 | 1.01 | 0.98 | 0.98 | 1.02 | 1.02 | 0.98 | 1.00 |
| CAY10470 | ME165484 | 1.01 | 1.01 | 0.99 | 0.98 | 1.03 | 1.02 | 0.97 | 0.99 |
| Arg Met His | ME165492 | 1.02 | 1.02 | 0.99 | 0.99 | 1.02 | 1.01 | 0.97 | 1.00 |
| Dioncopeltine A | ME165452 | 1.00 | 1.02 | 0.99 | 0.99 | 1.02 | 1.01 | 0.98 | 1.00 |
| Lycoflexine | ME165448 | 1.01 | 1.02 | 0.99 | 0.99 | 1.02 | 1.01 | 0.98 | 0.99 |
| Horhammericine | ME165481 | 1.03 | 1.00 | 0.98 | 0.98 | 1.02 | 1.01 | 0.98 | 0.99 |
| 7?-(Thiomethyl)spironolactone sulfone | ME165500 | 1.02 | 1.01 | 0.99 | 0.97 | 1.01 | 1.01 | 0.98 | 1.01 |
| 5-phosphoribosyl-1-diphosphate | ME165508 | 1.01 | 0.99 | 0.98 | 0.98 | 1.02 | 1.01 | 0.99 | 1.01 |
| W146 | ME165461 | 1.02 | 1.00 | 0.98 | 0.98 | 1.01 | 1.00 | 0.99 | 1.01 |
| Emmotin A | ME165443 | 0.95 | 1.00 | 0.97 | 0.98 | 1.01 | 1.03 | 0.97 | 1.07 |
| Tetradecylamine | ME165524 | 0.94 | 0.97 | 0.95 | 0.98 | 1.07 | 1.03 | 0.99 | 1.03 |
| 3-methyl pyruvic acid | ME165477 | 0.82 | 1.15 | 1.29 | 1.09 | 0.74 | 1.23 | 1.03 | 0.79 |
| ?-D-Glucose | ME165387 | 0.76 | 1.19 | 1.22 | 0.81 | 0.95 | 1.30 | 1.06 | 0.78 |
| Phenylpyruvic acid | ME165428 | 0.87 | 1.46 | 0.94 | 0.87 | 1.19 | 1.25 | 1.01 | 0.61 |
| Pro Ile Gln | ME165406 | 1.29 | 1.19 | 1.18 | 0.64 | 1.23 | 1.05 | 0.99 | 0.59 |
| Isoprene | ME165412 | 0.99 | 1.07 | 1.45 | 0.90 | 1.29 | 0.94 | 0.78 | 0.77 |
| L-Valine | ME165405 | 0.92 | 1.20 | 1.29 | 0.88 | 1.17 | 1.03 | 0.88 | 0.80 |
| Arborinine | ME165415 | 1.17 | 1.28 | 1.14 | 1.03 | 1.26 | 1.18 | 0.81 | 0.45 |
| Ala Asp Cys | ME165376 | 1.16 | 1.24 | 1.05 | 1.04 | 1.22 | 1.16 | 0.82 | 0.59 |
| Gly Met Cys | ME165519 | 1.15 | 1.27 | 1.05 | 1.02 | 1.20 | 1.17 | 0.82 | 0.59 |
| Hypoxanthine | ME165380 | 1.03 | 1.17 | 1.31 | 1.01 | 1.13 | 1.10 | 1.02 | 0.47 |
| Inosine 5^-monophosphate (IMP) | ME165360 | 1.04 | 1.20 | 1.36 | 0.99 | 1.14 | 1.12 | 1.01 | 0.42 |
| 2-Aminomethylpyrimidine | ME165504 | 0.96 | 1.14 | 1.12 | 1.10 | 1.19 | 0.97 | 1.11 | 0.57 |
| L-Histidine | ME165444 | 0.96 | 1.10 | 1.14 | 1.12 | 1.19 | 0.97 | 1.08 | 0.59 |
| 7-Hydroxydoxazosin | ME165473 | 1.05 | 1.15 | 1.12 | 0.93 | 1.12 | 1.11 | 1.14 | 0.53 |
| Taurine | ME165373 | 1.03 | 1.09 | 1.14 | 1.08 | 1.07 | 1.11 | 1.02 | 0.62 |
| Creatine | ME165358 | 1.05 | 1.07 | 1.18 | 0.97 | 1.08 | 1.06 | 1.06 | 0.66 |
| Niacinamide | ME165359 | 1.03 | 1.09 | 1.27 | 0.95 | 1.12 | 1.08 | 1.03 | 0.59 |
| Pyridine | ME165402 | 1.01 | 1.07 | 1.26 | 0.98 | 1.10 | 1.06 | 1.06 | 0.60 |
| Ile Pro | ME165365 | 0.95 | 1.20 | 1.16 | 0.98 | 0.94 | 1.31 | 1.20 | 0.43 |
| N-Hydroxymethylnicotinamide | ME165455 | 1.15 | 1.22 | 1.10 | 0.85 | 0.96 | 1.17 | 1.10 | 0.61 |
| Fampridine | ME165386 | 1.26 | 0.87 | 0.94 | 0.44 | 1.00 | 0.85 | 1.13 | 1.29 |
| Estra-1,3,5(10)-triene-3,6alpha,17beta-triol triacetate | ME165411 | 1.41 | 1.29 | 1.00 | 0.58 | 1.29 | 0.94 | 0.69 | 0.98 |
| PA(15:0/0:0) | ME165575 | 1.67 | 1.38 | 0.39 | 0.73 | 0.99 | 1.09 | 1.01 | 0.87 |
| 11-deoxy-PGF1? | ME165555 | 1.64 | 1.05 | 0.66 | 0.69 | 1.15 | 1.05 | 0.86 | 0.96 |
| Prostaglandin D1 Alcohol | ME165520 | 1.44 | 1.14 | 0.66 | 0.75 | 0.96 | 1.14 | 0.94 | 1.01 |
| 13,14-dihydro Prostaglandin F1? | ME165362 | 1.49 | 1.15 | 0.64 | 0.74 | 0.95 | 1.15 | 0.93 | 1.01 |
| 9,13-dihydroxy-10-ethoxy-11-octadecenoic acid | ME165366 | 1.49 | 1.15 | 0.64 | 0.74 | 0.95 | 1.15 | 0.93 | 1.01 |
| Leu Ser Trp | ME165593 | 1.05 | 3.52 | 0.00 | 0.00 | 3.84 | 0.60 | 0.00 | 0.00 |
| 4-Hydroxy-2,2^,4^,6^-tetrachlorobiphenyl | ME165576 | 0.00 | 6.40 | 0.00 | 0.00 | 2.62 | 0.93 | 0.00 | 0.00 |
| Pro Val Tyr | ME165601 | 0.00 | 7.08 | 0.00 | 0.00 | 2.26 | 0.88 | 0.00 | 0.00 |
| Nafoxidine | ME165521 | 0.00 | 7.28 | 0.00 | 0.00 | 3.02 | 0.00 | 0.00 | 0.00 |
| Gln Met Lys | ME165579 | 0.00 | 8.21 | 0.00 | 0.00 | 2.46 | 0.00 | 0.00 | 0.00 |
| Phthalide | ME165460 | 0.00 | 7.91 | 0.00 | 0.22 | 2.08 | 0.40 | 0.00 | 0.00 |
Factors:
| F1 | Group:CD | Genotype:Irlox | Diet:Chow |
| F2 | Group:Control | Genotype:IGFR lox | Diet:Chow |
| F3 | Group:Control | Genotype:Irlox | Diet:Chow |
| F4 | Group:Control | Genotype:IRlox IGFR lox | Diet:Chow |
| F5 | Group:HFD | Genotype:Irlox | Diet:High Fat Diet |
| F6 | Group:IGFRKO | Genotype:IGFR -/- | Diet:Chow |
| F7 | Group:IRKO | Genotype:IR -/- | Diet:Chow |
| F8 | Group:MIGIRKO | Genotype:IR -/- IGFR -/- | Diet:Chow |
