Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Large Scale C18 Profiling of the Effects of Curcumin Supplementation of Older Adults: Relation to Vascular Function (Study ST000566)

Reversed phase POSITIVE ION MODE (Analysis AN000870)

Metabolite	Structure	F1	F2	F3	F4	F5	F6
Phe Gly Trp	ME167950	0.99	0.33	0.58	0.92	NA	2.25
Mycalamide A	ME167904	0.82	1.41	1.81	0.81	NA	0.16
Celiprolol	ME167940	1.40	1.40	0.61	0.84	NA	0.60
Ursodeoxycholic acid 3-sulfate	ME167896	1.52	1.86	0.40	0.87	NA	0.10
2S-amino-3-oxo-butanoic acid	ME167873	1.26	1.54	0.79	0.97	NA	0.31
Diethyl Oxalpropionate	ME167890	1.30	1.78	0.80	0.84	NA	0.10
6-methyltetrahydropterin	ME167868	0.88	0.79	0.92	0.72	NA	1.72
cis-Caryophyllene	ME167909	0.69	0.71	1.30	0.89	NA	1.51
Benzenamine sulfate	ME167813	0.83	0.51	1.14	1.32	NA	1.32
N2-Succinylglutamic acid	ME167937	1.13	0.60	1.37	1.04	NA	0.92
N6-Acetyl-N6-hydroxy-L-lysine	ME167864	1.35	1.03	0.99	1.16	NA	0.42
3-Pyridylacetic acid	ME167863	1.23	1.33	1.00	0.93	NA	0.43
L-Glutamic acid dibutyl ester	ME167897	1.21	1.28	1.04	1.01	NA	0.39
N-Oleoyl-L-Serine	ME167913	1.14	1.33	0.87	1.12	NA	0.48
N-palmitoyl serine	ME167908	1.15	1.23	0.84	1.17	NA	0.56
Levobunolol glucuronide	ME167853	1.24	1.08	0.84	1.13	NA	0.66
Corey PG-Lactone Diol	ME167898	1.26	1.15	0.79	0.99	NA	0.73
Metipranolol	ME167900	1.29	1.12	0.79	0.93	NA	0.78
(Z)-N-(2-hydroxyethyl)hexadec-7-enamide	ME167927	0.92	1.27	0.87	1.05	NA	0.86
Tetrahydrocorticosterone	ME167907	1.19	1.38	0.67	0.88	NA	0.77
3-ketosphingosine	ME167931	1.09	1.42	0.81	0.94	NA	0.65
methyl-10-hydroperoxy-8E,12Z,15Z-octadecatrienoate	ME167905	1.13	1.29	0.81	1.02	NA	0.68
Allodeoxycholic Acid	ME167925	1.04	1.34	0.81	1.03	NA	0.71
Tetrahydropalmatine	ME167856	1.06	1.28	0.84	0.98	NA	0.77
10-Deoxymethynolide	ME167901	1.17	1.23	0.86	0.91	NA	0.76
DL-pipecolic acid	ME167878	1.13	1.20	0.89	1.01	NA	0.71
Scyphostatin A	ME167916	0.90	1.30	1.00	1.20	NA	0.58
Tiletamine	ME167869	0.93	1.20	0.92	1.23	NA	0.71
8E-Heptadecenedioic acid	ME167903	1.16	1.16	1.00	0.99	NA	0.64
L-Glutamic acid n-butyl ester	ME167880	1.13	1.19	0.97	1.04	NA	0.62
L-Glutamic acid n-butyl ester + 1.5990624	ME167883	1.13	1.20	0.97	1.04	NA	0.62
1-L-Leucyl-L-Proline	ME167885	1.06	1.13	1.04	1.11	NA	0.64
Desmethylmianserin glucuronide	ME167843	1.02	1.14	1.06	1.13	NA	0.63
2-oxo-3-methylvaleric acid	ME167874	1.09	1.22	0.88	1.12	NA	0.65
Fexofenadine	ME167922	1.02	1.21	0.92	1.14	NA	0.69
5,7,3^,5^-Tetrahydroxy-3,6,8,4^-tetramethoxyflavone 3^-glucoside	ME167834	1.03	1.21	0.98	1.09	NA	0.67
5-Formiminotetrahydrofolic acid	ME167845	1.04	1.18	1.00	1.09	NA	0.67
3-Methyl-L-histidine	ME167829	1.01	1.04	1.22	1.00	NA	0.73
DL-2-Aminooctanoic acid	ME167876	1.05	1.01	1.10	1.12	NA	0.72
Urea	ME167860	0.99	1.02	1.14	1.11	NA	0.74
o-Methyldopamine (3-methoxytyramine)	ME167891	1.09	1.06	1.05	0.99	NA	0.80
Valdecoxib	ME167827	1.04	1.12	1.05	1.07	NA	0.71
(+)-12a-Hydroxyerythynone	ME167839	1.10	1.07	1.02	1.05	NA	0.74
Phe Phe Thr	ME167850	1.07	1.06	1.04	1.10	NA	0.73
Lysine	ME167817	1.18	0.92	1.00	1.33	NA	0.58
Hippuric acid	ME167895	1.15	1.03	1.03	1.17	NA	0.61
Trp Phe	ME167865	1.07	1.12	1.06	1.23	NA	0.52
N,N-Diethylglycine	ME167889	0.99	0.85	1.24	1.15	NA	0.82
Caproic acid	ME167882	0.94	0.88	1.22	1.09	NA	0.93
Caproic acid + 1.6348685	ME167884	0.93	0.88	1.20	1.12	NA	0.92
DL-?-Leucine	ME167886	1.11	1.10	0.88	0.98	NA	0.89
L-Valine	ME167859	1.06	1.13	0.88	0.93	NA	0.97
N-Acetylputrescine	ME167814	1.10	1.07	0.93	0.91	NA	0.95
Myxothiazol Z	ME167851	1.05	0.89	1.12	1.03	NA	0.93
Azaserine	ME167934	1.08	0.93	1.02	1.14	NA	0.84
Uridine	ME167875	1.10	0.88	1.08	1.09	NA	0.87
(E)-2-Methylglutaconic acid	ME167846	0.98	1.02	0.94	1.15	NA	0.92
5,7,4^-Trihydroxyflavanone 7-sulfate	ME167826	1.01	1.13	0.98	1.04	NA	0.82
1,6-Anhydro-?-D-glucose	ME167847	1.06	1.07	0.93	1.05	NA	0.88
2-Amino-3-methyl-1-butanol	ME167857	1.08	1.09	0.96	1.02	NA	0.83
7-hydroxy-5-heptynoic acid	ME167812	1.04	1.04	1.00	1.00	NA	0.91
edetate	ME167831	1.02	1.05	0.97	1.02	NA	0.93
Senecivernine	ME167841	1.05	1.05	0.95	1.02	NA	0.91
C17 Sphinganine	ME167906	1.02	0.98	1.03	1.04	NA	0.93
3-Isochromanone	ME167915	1.00	1.01	1.03	1.02	NA	0.94
b-Glucose	ME167849	1.02	1.02	1.00	1.01	NA	0.94
2-Iodophenol	ME167819	1.01	1.01	1.00	1.02	NA	0.95
Cetraxate	ME167837	1.01	1.01	1.01	1.02	NA	0.96
DL-?-Lipoic Acid	ME167946	1.02	0.98	1.09	1.02	NA	0.90
Heptanoic acid, 2-amino-, (R)-; (R)-2-Aminoheptanoic acid	ME167870	1.04	1.02	1.02	1.04	NA	0.87
Symmetric Dimethylarginine	ME167871	1.05	1.05	1.00	1.04	NA	0.86
Creatinine	ME167867	1.03	1.00	1.06	1.04	NA	0.88
Uric acid	ME167877	1.03	1.00	1.05	1.07	NA	0.85
3?,11?-Dihydroxy-12-oxo-5?-cholan-24-oic Acid	ME167949	0.73	0.95	1.12	1.02	NA	1.24
5-Methylcytidine	ME167836	0.90	0.79	0.91	1.01	NA	1.43
Isobutyronitrile	ME167866	0.97	0.96	0.88	0.89	NA	1.30
PE(21:0/20:1(11Z))	ME167945	0.92	1.00	0.87	0.89	NA	1.32
4-Oxoproline	ME167881	1.02	0.92	0.92	0.86	NA	1.27
Gly Pro	ME167854	0.98	0.89	0.91	0.95	NA	1.29
3-(Pyrazol-1-yl)-L-alanine	ME167824	1.02	0.92	1.00	0.99	NA	1.08
Quinaprilat	ME167852	0.97	0.98	0.91	0.94	NA	1.20
Indoleacrylic acid	ME167892	0.96	0.93	0.96	0.99	NA	1.17
L-Arginine	ME167825	0.97	0.93	0.92	1.00	NA	1.18
2-Oxo-10-methylthiodecanoic acid	ME167862	0.94	0.99	0.95	0.99	NA	1.15
THTC	ME167879	0.98	0.96	0.96	0.96	NA	1.14
3-Butynoate	ME167842	1.11	0.94	0.77	1.07	NA	1.10
3^-Methoxy-E,E-dienoestrol	ME167942	0.91	1.11	0.83	1.02	NA	1.12
AMPA	ME167832	0.97	1.13	0.67	0.98	NA	1.21
Lys Asn Pro	ME167939	1.07	1.28	0.81	0.72	NA	1.04
S-(2-Methylpropionyl)-dihydrolipoamide-E	ME167872	1.28	0.98	0.81	0.84	NA	1.04
Corey PG-Lactone Diol + 6.739769	ME167899	1.36	1.12	0.57	0.96	NA	0.89
HBA	ME167855	1.16	1.18	0.62	0.92	NA	1.03
1-Methyladenosine	ME167938	0.66	1.07	1.26	1.80	NA	0.33
Trans-2, 3, 4-Trimethoxycinnamate	ME167947	0.81	1.01	1.60	1.59	NA	0.11
13S-hydroperoxy-9Z,11E,14Z-octadecatrienoic acid	ME167948	0.83	1.30	0.83	1.64	NA	0.42
3-O-Methyl-myo-inositol	ME167893	1.20	1.15	1.01	1.39	NA	0.23
AFMK	ME167894	1.04	1.15	1.10	1.33	NA	0.38
N-Hydroxymethylnicotinamide	ME167887	0.82	1.28	1.20	1.38	NA	0.36
Glycerophospho-N-Arachidonoyl Ethanolamine	ME167919	0.83	1.11	1.24	1.29	NA	0.58
LysoPE(0:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	ME167917	0.89	1.09	1.21	1.34	NA	0.51

Factors:

F1	group:Old-Curcumin \| Time point:Post
F2	group:Old-Curcumin \| Time point:Pre
F3	group:Old-Placebo \| Time point:Post
F4	group:Old-Placebo \| Time point:Pre
F5	group:young \| Time point:Baseline
F6	group:young \| Time point:Pre

Data matrix