Clustering data with hclust algorithm for Identification of Race-Associated Metabolite Biomarkers for Hepatocellular Carcinoma (Study ST000865)
GC POSITIVE ION MODE (Analysis AN001390)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D-threitol | ME224964 | 0.89 | 0.26 | 0.79 | 0.30 | 0.77 | 0.56 | 1.77 | 0.38 | 0.39 | 8.99 | NA | NA | NA | NA |
| tagatose 1 | ME225004 | 0.77 | 4.90 | 1.29 | 0.05 | 3.56 | 0.30 | 0.13 | 0.91 | 2.06 | 0.10 | NA | NA | NA | NA |
| L- sorbose 2 | ME224972 | 2.08 | 0.04 | 1.00 | 0.12 | 0.04 | 1.18 | 0.10 | 0.96 | 1.86 | 0.15 | NA | NA | NA | NA |
| lactulose 1 | ME224990 | 1.90 | 1.61 | 1.10 | 0.17 | 1.26 | 0.65 | 0.23 | 1.08 | 0.52 | 0.08 | NA | NA | NA | NA |
| L-alanine-2,3,3,3-d4 | ME224974 | 1.34 | 0.08 | 1.30 | 0.60 | 0.23 | 0.70 | 1.36 | 0.76 | 0.30 | 0.53 | NA | NA | NA | NA |
| 2-hydroxybenzyl alcohol | ME224954 | 0.97 | 1.81 | 1.01 | 0.98 | 1.19 | 0.90 | 0.97 | 1.04 | 0.94 | 0.82 | NA | NA | NA | NA |
| D-malic acid | ME224963 | 1.02 | 1.49 | 1.04 | 0.60 | 1.43 | 1.23 | 0.66 | 0.87 | 0.70 | 1.09 | NA | NA | NA | NA |
| lauric acid | ME224991 | 0.60 | 2.15 | 1.23 | 1.34 | 1.34 | 0.71 | 0.82 | 0.90 | 0.47 | 1.29 | NA | NA | NA | NA |
| tyramine | ME225006 | 0.74 | 1.53 | 1.19 | 1.20 | 1.80 | 0.86 | 0.36 | 1.00 | 0.36 | 0.96 | NA | NA | NA | NA |
| L-glutamic acid 2 | ME224976 | 1.83 | 0.26 | 0.80 | 1.42 | 0.81 | 1.44 | 0.80 | 0.91 | 0.43 | 0.63 | NA | NA | NA | NA |
| ribose | ME225002 | 1.53 | 0.25 | 1.17 | 1.15 | 0.43 | 1.01 | 0.53 | 0.72 | 0.79 | 0.93 | NA | NA | NA | NA |
| Creatinine | ME224961 | 1.87 | 0.59 | 1.09 | 0.66 | 1.18 | 1.17 | 0.55 | 0.70 | 0.47 | 0.43 | NA | NA | NA | NA |
| myo-inositol | ME224993 | 1.45 | 0.36 | 1.02 | 1.08 | 1.35 | 1.12 | 0.54 | 0.85 | 1.09 | 0.81 | NA | NA | NA | NA |
| ethanolamine | ME224968 | 0.90 | 0.56 | 1.03 | 0.76 | 0.91 | 1.75 | 0.67 | 0.78 | 0.67 | 0.78 | NA | NA | NA | NA |
| linoleic acid | ME224992 | 1.02 | 0.31 | 0.78 | 1.53 | 0.46 | 1.46 | 1.03 | 1.10 | 0.75 | 1.22 | NA | NA | NA | NA |
| L-valine 2 | ME224989 | 0.91 | 0.19 | 0.82 | 1.11 | 0.45 | 1.95 | 1.29 | 0.90 | 0.44 | 0.75 | NA | NA | NA | NA |
| L-homoserine 3 | ME224979 | 1.13 | 0.99 | 0.98 | 1.09 | 1.88 | 1.02 | 1.18 | 0.82 | 1.03 | 0.96 | NA | NA | NA | NA |
| Phenylalanine 1 | ME224998 | 0.69 | 0.57 | 1.22 | 1.01 | 2.01 | 1.03 | 0.75 | 0.71 | 1.03 | 1.14 | NA | NA | NA | NA |
| alpha-D-glucosamine 1-phosphate | ME224956 | 0.84 | 1.38 | 0.76 | 1.17 | 0.84 | 1.72 | 0.96 | 0.96 | 0.95 | 1.45 | NA | NA | NA | NA |
| putrescine | ME225000 | 0.69 | 0.49 | 1.22 | 0.89 | 1.02 | 1.06 | 1.01 | 0.75 | 1.42 | 0.84 | NA | NA | NA | NA |
| citric acid | ME224960 | 0.90 | 1.03 | 1.11 | 1.00 | 1.19 | 0.92 | 0.68 | 0.87 | 1.01 | 1.65 | NA | NA | NA | NA |
| N-acetyl-5-hydroxytryptamine 1 | ME224995 | 0.96 | 1.00 | 0.99 | 1.20 | 1.20 | 1.00 | 0.75 | 1.02 | 0.86 | 1.29 | NA | NA | NA | NA |
| L-tyrosine-3,3-d2 2 | ME224987 | 0.75 | 1.00 | 1.06 | 1.16 | 1.10 | 0.96 | 0.95 | 1.01 | 1.03 | 1.04 | NA | NA | NA | NA |
| tyrosine 2 | ME225007 | 0.58 | 0.93 | 1.09 | 1.30 | 0.88 | 1.07 | 0.91 | 0.97 | 1.12 | 1.03 | NA | NA | NA | NA |
| D-glucose 2 [17.625] / [24749] D-glucose 1 | ME224962 | 0.95 | 1.19 | 0.97 | 1.13 | 0.85 | 0.94 | 0.86 | 1.04 | 1.23 | 1.36 | NA | NA | NA | NA |
| Myristic Acid d27 | ME224994 | 0.89 | 0.82 | 1.01 | 1.02 | 0.98 | 0.96 | 0.96 | 1.00 | 1.20 | 1.34 | NA | NA | NA | NA |
| arachidic acid | ME224958 | 0.92 | 0.64 | 1.03 | 0.95 | 0.78 | 1.28 | 0.76 | 0.99 | 1.06 | 0.64 | NA | NA | NA | NA |
| alpha tocophereol | ME224955 | 0.82 | 0.68 | 1.01 | 1.20 | 0.96 | 1.22 | 0.96 | 1.00 | 0.95 | 0.67 | NA | NA | NA | NA |
| stearic acid | ME225003 | 0.89 | 0.85 | 0.95 | 1.26 | 0.94 | 1.17 | 0.91 | 1.05 | 1.11 | 0.92 | NA | NA | NA | NA |
| arabitol | ME224957 | 1.30 | 0.76 | 1.17 | 0.68 | 1.18 | 0.94 | 0.76 | 0.80 | 0.62 | 0.79 | NA | NA | NA | NA |
| glycine-d5 deuterated | ME224971 | 1.09 | 1.37 | 1.01 | 0.96 | 1.07 | 0.98 | 0.88 | 0.99 | 0.85 | 0.90 | NA | NA | NA | NA |
| glycine | ME224970 | 0.98 | 1.11 | 1.18 | 1.07 | 1.09 | 0.90 | 0.83 | 0.86 | 0.86 | 0.67 | NA | NA | NA | NA |
| L-(+) lactic acid | ME224973 | 1.10 | 1.02 | 1.06 | 0.86 | 0.88 | 1.09 | 0.79 | 0.94 | 0.92 | 0.81 | NA | NA | NA | NA |
| L-glutamic acid-2,3,3,4,4-d5 2 | ME224977 | 0.95 | 0.85 | 1.09 | 0.90 | 1.18 | 1.01 | 0.91 | 0.88 | 0.86 | 1.17 | NA | NA | NA | NA |
| L-phenylalanine-phenyl-d5-2,3,3-d3 2 | ME224981 | 0.84 | 0.76 | 1.11 | 0.93 | 1.14 | 1.00 | 0.98 | 0.87 | 0.95 | 1.17 | NA | NA | NA | NA |
| L-pyroglutamic acid/ glutamic acid | ME224983 | 1.04 | 0.56 | 1.16 | 0.93 | 1.06 | 1.02 | 0.84 | 0.82 | 0.82 | 0.86 | NA | NA | NA | NA |
| L-threonine 2 | ME224986 | 1.01 | 0.78 | 1.05 | 0.95 | 1.17 | 1.13 | 0.96 | 0.92 | 0.76 | 0.70 | NA | NA | NA | NA |
| cholesterol | ME224959 | 1.02 | 0.85 | 1.02 | 1.02 | 1.10 | 1.10 | 0.78 | 0.98 | 0.83 | 0.90 | NA | NA | NA | NA |
| L-glutamic acid-2,3,3,4,4-d5 3 (dehydrated) | ME224978 | 0.98 | 0.80 | 1.05 | 0.90 | 1.27 | 1.14 | 0.78 | 0.93 | 0.83 | 0.88 | NA | NA | NA | NA |
| urea | ME225008 | 0.93 | 0.96 | 0.96 | 1.19 | 1.36 | 1.23 | 1.02 | 0.91 | 1.36 | 0.71 | NA | NA | NA | NA |
| L-proline 2 | ME224982 | 0.82 | 0.94 | 1.07 | 1.06 | 1.49 | 1.00 | 0.70 | 1.05 | 0.76 | 0.76 | NA | NA | NA | NA |
| 2,3-butanediol 2 | ME224953 | 0.91 | 1.14 | 1.10 | 1.10 | 1.49 | 0.99 | 0.91 | 0.93 | 0.80 | 0.52 | NA | NA | NA | NA |
| glyceric acid | ME224969 | 0.82 | 1.34 | 1.03 | 1.24 | 1.36 | 1.03 | 0.92 | 1.02 | 0.94 | 0.56 | NA | NA | NA | NA |
| phosphoric acid | ME224999 | 1.10 | 0.96 | 1.00 | 1.29 | 0.63 | 1.04 | 0.99 | 1.06 | 0.61 | 0.55 | NA | NA | NA | NA |
| DL-isoleucine 2 | ME224967 | 0.95 | 1.53 | 0.81 | 1.31 | 0.80 | 1.34 | 1.16 | 1.11 | 0.71 | 0.82 | NA | NA | NA | NA |
| L-leucine 1 | ME224980 | 1.02 | 1.26 | 0.78 | 1.53 | 0.47 | 1.41 | 1.32 | 1.09 | 0.47 | 0.83 | NA | NA | NA | NA |
| oxalic acid | ME224996 | 1.19 | 0.58 | 0.93 | 1.33 | 0.97 | 1.01 | 1.16 | 0.99 | 0.77 | 1.12 | NA | NA | NA | NA |
| DL-isoleucine 1 | ME224966 | 0.92 | 0.86 | 0.89 | 1.33 | 0.83 | 1.44 | 1.28 | 0.94 | 0.77 | 0.68 | NA | NA | NA | NA |
| L-valine 1 | ME224988 | 0.79 | 0.60 | 0.79 | 1.65 | 1.00 | 1.43 | 1.41 | 1.09 | 0.74 | 0.76 | NA | NA | NA | NA |
| palmitic acid | ME224997 | 0.85 | 0.83 | 0.96 | 1.71 | 0.78 | 1.09 | 0.99 | 1.04 | 1.01 | 1.03 | NA | NA | NA | NA |
| L-serine 1 | ME224984 | 0.57 | 1.00 | 0.93 | 1.65 | 1.23 | 1.00 | 1.16 | 1.20 | 1.11 | 0.73 | NA | NA | NA | NA |
| L-threonine 1 | ME224985 | 0.89 | 1.01 | 0.99 | 1.67 | 1.24 | 1.17 | 1.13 | 0.89 | 0.76 | 0.85 | NA | NA | NA | NA |
| L-cystine 3 | ME224975 | 0.62 | 1.04 | 1.06 | 0.54 | 1.14 | 1.02 | 0.66 | 1.05 | 0.79 | 1.92 | NA | NA | NA | NA |
| trans-aconitic acid | ME225005 | 0.78 | 0.78 | 1.26 | 0.90 | 0.33 | 1.03 | 0.56 | 0.83 | 0.61 | 1.48 | NA | NA | NA | NA |
| diglycerol 2 | ME224965 | 1.09 | 0.40 | 1.33 | 0.58 | 0.92 | 0.80 | 0.43 | 0.82 | 0.52 | 1.04 | NA | NA | NA | NA |
| ribitol | ME225001 | 1.34 | 0.51 | 1.26 | 0.64 | 0.84 | 0.81 | 0.64 | 0.71 | 0.56 | 1.35 | NA | NA | NA | NA |
Factors:
| F1 | Patient group:CIRR | RACE:AA |
| F2 | Patient group:CIRR | RACE:Asian |
| F3 | Patient group:CIRR | RACE:EA |
| F4 | Patient group:CIRR | RACE:Hisp |
| F5 | Patient group:CIRR | RACE:Other |
| F6 | Patient group:HCC | RACE:AA |
| F7 | Patient group:HCC | RACE:Asian |
| F8 | Patient group:HCC | RACE:EA |
| F9 | Patient group:HCC | RACE:Hisp |
| F10 | Patient group:HCC | RACE:Other |
| F11 | Patient group:Pool CIRR | RACE:- |
| F12 | Patient group:Pool HCC | RACE:- |
| F13 | Patient group:POSSIBLE CASE | RACE:- |
| F14 | Patient group:- | RACE:- |
