Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Diet, genetics and gut microbiome drive dynamic changes in plasma metabolites [plasma] (Study ST000879)

HILIC NEGATIVE ION MODE (Analysis AN001430)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10	F11	F12
Hippuric acid	ME226908	0.82	5.14	0.53	0.77	0.75	0.66	0.57	0.66	0.30	0.62	0.60	0.46
Glutathione	ME226905	0.90	1.55	3.86	0.60	0.46	1.85	0.74	0.69	0.56	0.32	0.52	0.65
Indoxyl sulfate	ME226943	0.19	1.18	4.27	0.77	0.89	0.25	0.87	0.14	2.18	0.20	0.87	NA
Lactose	ME226914	0.88	0.05	0.12	0.52	0.06	4.16	2.62	1.46	1.28	0.44	0.07	0.13
Adenine	ME226884	1.49	0.46	0.81	1.34	0.52	1.86	1.09	0.58	2.94	0.63	0.90	0.19
6-Phosphogluconic acid	ME226947	1.30	0.20	0.25	1.49	0.36	0.96	1.81	1.15	0.34	2.83	0.67	0.45
Guanosine	ME226907	1.52	1.28	0.32	1.06	0.36	0.53	2.69	0.75	0.64	1.58	0.70	0.40
hexose diphosphate	ME226901	1.37	0.23	0.36	1.62	0.38	1.05	3.45	0.63	0.34	1.30	0.57	0.53
IMP	ME226910	1.80	0.03	0.19	1.38	0.08	1.39	3.68	0.35	0.46	1.44	0.54	0.33
UDP-glucuronic acid	ME226933	1.40	NA	0.46	1.06	0.34	0.78	2.05	1.50	0.95	1.28	0.60	0.65
adenylosuccinate	ME226885	0.67	NA	NA	1.30	0.20	0.86	2.28	1.37	0.33	1.49	0.46	0.31
GMP	ME226906	0.92	0.24	0.21	1.17	0.37	1.35	2.63	1.38	0.35	1.53	0.51	0.19
CDP	ME226891	0.77	NA	0.24	1.32	0.30	1.46	1.79	1.14	0.57	1.54	0.60	0.40
NADP+	ME226916	0.50	NA	0.38	1.20	0.65	1.05	1.72	1.14	0.43	1.68	0.49	1.01
2-Phosphoglyceric acid	ME226878	1.28	0.35	0.30	1.93	0.64	0.93	2.53	0.65	0.34	1.70	0.70	0.49
3-Phosphoglyceric acid	ME226879	1.22	0.39	0.28	1.87	0.62	0.92	2.68	0.64	0.30	1.78	0.63	0.50
DHAP/glyceraldehyde 3P	ME226897	1.34	0.40	0.61	1.44	0.57	1.09	1.98	0.98	0.65	1.34	0.60	0.61
Phosphoenolpyruvic acid	ME226920	1.18	0.52	0.48	1.43	0.80	0.87	2.41	0.85	0.50	1.28	0.94	0.60
AMP	ME226888	1.40	0.10	0.18	1.47	0.21	1.43	2.76	0.99	0.52	1.63	0.58	0.52
ADP	ME226889	1.39	0.16	0.31	1.42	0.21	1.78	2.64	0.74	0.63	1.48	0.52	0.54
GDP	ME226903	1.28	0.23	0.34	1.48	0.29	1.84	2.27	0.81	0.57	1.52	0.45	0.74
UDP-glucose	ME226932	1.08	0.22	0.37	1.23	0.51	1.94	2.48	1.04	0.48	1.52	0.39	0.58
Erythrose 4-phosphate	ME226898	1.20	0.30	0.46	1.35	0.40	1.62	2.76	0.80	0.49	1.53	0.56	0.38
Fructose-6-phosphate	ME226899	1.00	0.32	0.58	1.30	0.45	1.80	2.70	1.03	0.52	1.36	0.48	0.35
CMP	ME226894	1.03	0.08	0.32	1.37	0.27	1.18	2.96	1.01	0.62	2.45	0.30	0.24
UDP	ME226931	1.07	0.06	0.14	1.28	0.13	1.85	3.32	1.28	0.49	1.70	0.25	0.21
UMP	ME226930	1.11	0.07	0.21	1.18	0.17	1.53	3.01	1.31	0.48	1.78	0.25	0.28
Thymine	ME226929	0.77	0.47	1.45	0.97	0.53	1.03	2.08	0.69	1.64	0.87	0.43	1.20
Hypoxanthine	ME226909	1.72	1.33	0.94	2.16	0.36	1.26	1.35	0.72	0.56	0.77	0.48	0.31
Inosine	ME226911	1.73	1.57	1.27	1.45	0.21	1.10	1.54	0.84	0.69	1.00	0.40	0.27
Sucrose	ME226928	0.64	0.30	0.39	1.04	1.38	1.98	1.36	1.03	0.98	0.47	1.37	0.91
Glycerol 3-phosphate	ME226880	1.12	1.04	1.50	1.25	0.68	1.33	1.37	0.83	0.57	1.12	0.75	0.56
Myo-inositol	ME226951	1.36	1.27	1.25	1.37	0.73	1.12	1.36	0.64	0.63	0.95	0.71	0.65
3-methyladipate/pimelate	ME226946	1.52	1.19	0.94	1.24	0.97	0.82	0.87	0.72	0.50	1.12	1.03	0.75
Xanthine	ME226937	1.26	1.36	0.75	1.53	0.88	1.06	1.20	0.95	0.42	0.90	0.97	0.65
glycodeoxycholate/glycochenodeoxycholate	ME226941	0.59	1.06	0.83	0.72	1.24	1.05	0.87	1.12	1.28	0.83	1.48	0.90
Oxoglutaric acid	ME226887	0.86	1.16	1.35	0.90	1.57	0.87	0.66	0.86	0.86	0.64	1.32	1.04
Kynurenine	ME226912	0.92	1.08	0.77	1.17	0.96	0.99	1.17	1.08	0.69	1.53	0.89	0.69
Oxalic acid	ME226918	0.94	1.01	0.87	1.07	0.83	1.05	1.18	1.19	0.89	1.18	0.91	0.85
phosphotyrosine	ME226921	1.42	0.73	1.10	1.07	1.15	1.07	0.88	0.96	0.89	1.01	1.01	0.77
Uridine	ME226936	1.07	0.88	0.84	1.59	0.92	1.22	0.95	1.08	0.75	0.87	1.14	0.66
Methylmalonic acid	ME226927	1.15	1.03	0.83	1.24	1.02	1.42	0.84	1.08	0.66	0.77	1.07	0.81
Succinic acid	ME226926	1.10	1.16	1.05	1.21	0.93	1.16	0.84	0.94	0.80	0.82	1.10	0.90
3^,5^ cyclic AMP	ME226890	0.69	0.99	1.25	1.35	1.24	0.72	1.14	0.91	1.03	0.77	1.01	0.94
Alpha-hydoxy butyric acid	ME226948	0.60	0.79	0.96	1.06	0.87	1.25	0.85	0.95	1.25	0.99	1.15	1.27
5-methyl-THF	ME226882	1.04	1.03	1.22	0.82	1.07	0.93	0.85	1.38	0.95	0.80	0.92	1.05
Cytidine	ME226896	1.04	0.93	0.77	1.06	1.11	0.79	1.17	0.77	0.98	1.10	1.06	1.16
Citric acid	ME226892	0.94	0.93	0.99	1.16	1.22	0.95	0.99	0.82	0.97	1.00	1.01	1.01
Trans-Aconitic acid	ME226883	0.94	0.88	0.91	1.24	1.33	0.99	0.93	0.84	0.89	1.03	1.05	0.94
glycocholate-d4 (internal standard)	ME226876	0.84	1.11	1.29	0.84	0.94	1.21	0.77	0.91	1.09	0.82	0.93	1.31
inosine-15N4 (internal standard)	ME226875	1.00	1.02	0.95	1.05	0.98	1.03	1.00	0.97	0.97	1.03	0.98	1.01
thymine-d4 (internal standard)	ME226874	1.07	1.12	1.15	0.98	0.97	0.95	0.99	0.88	1.06	0.93	0.99	0.96
Lactic acid	ME226913	0.92	1.11	1.15	1.01	1.13	1.19	0.83	0.86	1.11	0.72	1.02	0.99
Hexose	ME226900	0.99	1.02	1.05	1.00	0.95	1.15	0.88	0.95	1.09	0.89	0.96	1.07
Sorbitol	ME226925	0.93	1.07	0.96	1.12	1.03	1.22	0.83	0.96	1.08	0.86	0.96	0.97
Propionic acid	ME226922	1.08	0.85	0.72	1.28	1.42	0.49	0.84	0.86	1.22	1.30	1.30	0.52
Orotic acid	ME226917	1.09	1.03	0.80	1.03	1.67	0.74	0.91	0.92	0.80	1.08	1.18	0.71
fumarate/maleate	ME226902	0.94	0.97	0.74	1.22	1.46	0.66	1.07	1.16	0.58	1.09	1.31	0.75
Malic acid	ME226915	0.88	1.00	0.70	1.21	1.56	0.62	1.10	1.18	0.56	1.05	1.30	0.77
4-Hydroxybenzaldehyde	ME226953	1.08	0.88	0.84	1.09	1.41	1.03	0.70	1.24	0.63	1.19	1.02	0.85
Isocitric acid	ME226893	1.12	0.51	0.68	1.39	1.49	0.96	0.96	0.97	0.78	1.17	1.04	0.85
Adipic acid	ME226886	1.22	0.91	0.64	1.90	1.07	0.58	1.37	0.94	0.41	1.36	1.05	0.45
beta-hydroxybutyric acid	ME226949	0.79	0.55	0.77	1.70	0.80	0.54	1.79	0.85	0.72	1.84	0.60	1.00
pentose monophosphate	ME226924	1.42	0.57	0.91	1.52	0.56	1.24	1.37	0.94	0.79	1.47	0.54	0.66
Phosphocreatine	ME226945	1.02	0.49	0.64	1.24	0.95	1.46	1.51	0.64	0.84	1.42	0.79	0.91
Uracil	ME226934	1.13	0.58	0.78	1.53	0.84	1.08	1.29	0.75	1.10	1.22	0.80	0.84
mevalonate 5-phosphate	ME226952	0.44	0.39	1.23	0.82	0.96	1.29	0.66	NA	0.90	1.23	0.75	1.30
Quinolinic acid	ME226923	0.70	1.26	1.81	0.69	1.12	0.93	0.82	0.94	1.28	0.95	0.91	0.81
2-hydroxyglutaric acid	ME226950	0.80	0.60	1.94	0.71	0.90	1.57	0.63	0.52	1.36	0.60	0.70	1.89
4-Pyridoxic acid	ME226881	1.16	1.17	1.43	1.00	0.68	1.29	0.58	0.78	1.36	0.78	0.76	1.10
Pantothenic acid	ME226919	0.78	0.90	1.52	0.94	1.02	1.76	0.58	0.78	1.15	0.57	0.83	1.31
Cystathionine	ME226895	0.73	1.22	1.29	0.77	1.39	0.81	0.72	0.77	NA	0.18	1.36	0.84
Glucuronic acid	ME226904	1.46	1.82	1.99	1.20	1.00	0.58	0.96	0.80	0.42	0.75	0.71	0.56
Uric acid	ME226935	0.03	0.02	4.33	3.05	0.03	0.04	0.17	0.03	5.00	0.09	0.02	0.02
Glycocholic Acid	ME226939	3.32	0.26	6.88	0.93	0.26	0.29	0.23	0.19	0.43	0.33	0.14	0.36
Taurocholic acid	ME226940	2.68	0.01	6.12	2.90	0.00	0.04	0.23	0.01	0.01	0.94	0.01	0.34
taurodeoxycholate/taurochenodeoxycholate	ME226942	2.52	0.01	6.83	1.93	0.00	0.03	0.15	0.01	0.03	0.49	0.01	0.23

Factors:

F1	Diet:Chow \| Treatment:none \| Strain:129Jax
F2	Diet:Chow \| Treatment:none \| Strain:129Tac
F3	Diet:Chow \| Treatment:none \| Strain:B6Jax
F4	Diet:HFD \| Treatment:metronidazole \| Strain:129Jax
F5	Diet:HFD \| Treatment:metronidazole \| Strain:129Tac
F6	Diet:HFD \| Treatment:metronidazole \| Strain:B6Jax
F7	Diet:HFD \| Treatment:placebo \| Strain:129Jax
F8	Diet:HFD \| Treatment:placebo \| Strain:129Tac
F9	Diet:HFD \| Treatment:placebo \| Strain:B6Jax
F10	Diet:HFD \| Treatment:vancomycin \| Strain:129Jax
F11	Diet:HFD \| Treatment:vancomycin \| Strain:129Tac
F12	Diet:HFD \| Treatment:vancomycin \| Strain:B6Jax

Data matrix