Clustering data with hclust algorithm for Diet, genetics and gut microbiome drive dynamic changes in plasma metabolites [plasma] (Study ST000879)
Reversed phase NEGATIVE ION MODE (Analysis AN001431)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Taurocholic acid | ME226990 | 0.15 | 0.05 | 0.01 | 0.42 | 0.04 | 0.09 | 2.81 | 0.07 | 0.05 | 7.18 | 0.07 | 0.42 |
| Hyodeoxycholic acid/Ursodeoxycholic acid | ME226982 | 0.33 | 1.61 | 0.97 | 3.51 | 0.04 | 1.66 | 0.76 | 1.05 | 0.47 | 0.15 | 0.34 | 0.15 |
| Deoxycholic acid | ME226981 | 1.14 | 1.48 | 1.45 | 1.04 | 0.20 | 1.33 | 1.70 | 0.93 | 1.69 | 0.36 | 0.28 | 0.31 |
| 8.11.14-Eicosatrienoic acid | ME226968 | 0.84 | 0.38 | 0.76 | 2.95 | 0.59 | 0.76 | 0.98 | 0.76 | 0.77 | 1.64 | 0.70 | 0.81 |
| Arachidonic acid | ME226967 | 0.74 | 0.38 | 0.90 | 2.38 | 0.70 | 1.05 | 1.16 | 0.95 | 0.83 | 1.17 | 0.74 | 0.97 |
| Adrenic Acid | ME226971 | 0.50 | 0.26 | 0.44 | 1.52 | 0.81 | 1.03 | 1.32 | 1.07 | 1.13 | 1.62 | 0.92 | 1.25 |
| Stearic acid | ME226965 | 0.68 | 0.24 | 0.43 | 2.08 | 0.69 | 0.80 | 1.47 | 1.04 | 0.76 | 2.00 | 0.86 | 0.80 |
| DHA | ME226969 | 1.46 | 1.41 | 1.66 | 1.13 | 0.55 | 0.95 | 0.80 | 0.78 | 0.91 | 0.90 | 0.60 | 1.01 |
| PGE2-d4 (internal standard) | ME226954 | 0.99 | 1.01 | 1.00 | 0.97 | 1.00 | 1.04 | 1.00 | 1.00 | 0.99 | 0.97 | 1.01 | 1.02 |
| Sphingosine-1-phosphate | ME226979 | 0.97 | 1.10 | 0.79 | 1.13 | 1.11 | 0.87 | 0.91 | 1.18 | 0.79 | 1.00 | 1.24 | 0.88 |
| Gamma-linolenic acid | ME226962 | 1.26 | 0.53 | 0.93 | 1.85 | 0.59 | 1.00 | 0.95 | 0.76 | 0.95 | 1.51 | 0.61 | 1.04 |
| Linoleic acid | ME226963 | 1.31 | 0.29 | 0.86 | 2.18 | 0.53 | 0.97 | 0.97 | 0.66 | 0.82 | 1.87 | 0.51 | 1.00 |
| Oleic acid | ME226964 | 1.20 | 0.24 | 0.86 | 1.79 | 0.55 | 1.08 | 0.93 | 0.74 | 0.96 | 1.93 | 0.56 | 1.11 |
| Myristoleic acid | ME226958 | 1.11 | 0.74 | 1.49 | 1.62 | 0.73 | 0.69 | 0.83 | 0.93 | 1.02 | 1.31 | 0.57 | 1.09 |
| DPA | ME226970 | 1.68 | 0.87 | 1.41 | 1.65 | 0.44 | 0.86 | 0.88 | 0.61 | 0.90 | 1.30 | 0.47 | 1.05 |
| Myristic acid | ME226959 | 1.77 | 0.51 | 1.08 | 1.43 | 0.59 | 1.14 | 0.92 | 0.62 | 1.00 | 1.36 | 0.46 | 1.14 |
| Palmitic acid | ME226961 | 1.37 | 0.53 | 1.03 | 1.33 | 0.66 | 1.08 | 1.01 | 0.80 | 0.91 | 1.59 | 0.63 | 1.08 |
| Palmitoleic acid | ME226960 | 2.51 | 0.44 | 1.01 | 1.58 | 0.37 | 0.83 | 0.87 | 0.59 | 0.74 | 1.83 | 0.30 | 0.92 |
| PGE2 | ME226977 | 2.09 | 0.70 | 0.80 | 0.96 | 0.78 | 0.93 | 1.18 | 0.66 | 0.79 | 1.44 | 0.85 | 0.77 |
| LTB4 | ME226976 | 0.92 | NA | 0.26 | 0.80 | NA | 0.65 | 1.77 | NA | NA | 1.06 | NA | NA |
| 11-HETE | ME226973 | 1.96 | 0.05 | 0.10 | 1.65 | 0.38 | 0.80 | 3.24 | 0.11 | 0.08 | 1.82 | 0.41 | 0.10 |
| 5-HETE | ME226972 | 1.27 | 0.39 | 0.38 | 1.86 | 0.77 | 0.96 | 3.06 | 0.46 | 0.45 | 1.06 | 0.59 | 0.59 |
| 12S-HETE | ME226974 | 2.75 | 0.02 | 0.71 | 1.47 | 0.07 | 0.96 | 2.60 | 0.27 | 0.18 | 1.63 | 1.08 | 0.18 |
| 15S-HETE | ME226975 | 3.62 | 0.03 | 0.30 | 1.18 | 0.32 | 0.78 | 3.18 | 0.05 | 0.11 | 1.24 | 0.26 | 0.06 |
| Alpha-muricholic acid | ME226955 | 3.43 | 0.63 | NA | 0.91 | 0.05 | NA | 0.06 | 0.20 | 1.97 | NA | 0.48 | NA |
| Beta-muricholic acid | ME226956 | 2.30 | 0.76 | 0.19 | 3.51 | 0.20 | 0.13 | 1.39 | 0.10 | 2.57 | 0.49 | 0.16 | 0.20 |
| tauromuricholic acid | ME226957 | 2.92 | 0.00 | 0.35 | 4.12 | 0.01 | 0.04 | 1.04 | 0.00 | 2.75 | 0.55 | 0.01 | 0.02 |
| Taurochenodeoxycholic acid | ME226994 | 2.09 | 0.01 | 7.81 | 2.95 | 0.00 | 0.03 | 0.14 | 0.01 | 0.01 | 0.54 | 0.01 | 0.12 |
| Glycochenodeoxycholic acid | ME226985 | 3.30 | 0.09 | 6.97 | 0.67 | 0.09 | 0.27 | 0.04 | 0.05 | 0.21 | 0.05 | 0.07 | 0.31 |
| Taurolithocholic acid | ME226993 | 2.79 | 0.22 | 8.14 | 0.76 | 0.21 | 0.08 | 0.58 | 0.14 | 0.08 | 0.54 | 0.17 | 0.08 |
| Taurohyodeoxycholic acid | ME226992 | 3.46 | 0.01 | 3.82 | 4.08 | 0.00 | 0.03 | 0.27 | 0.01 | 0.02 | 0.88 | 0.01 | 0.13 |
| Tauroursodeoxycholic acid | ME226989 | 3.46 | 0.01 | 3.82 | 4.08 | 0.00 | 0.03 | 0.27 | 0.01 | 0.02 | 0.88 | 0.01 | 0.13 |
| Glycocholic Acid | ME226988 | 4.39 | 0.02 | 5.03 | 0.78 | NA | 0.00 | 0.15 | 0.03 | 0.03 | 0.11 | 0.00 | 0.03 |
| Glycoursodeoxycholic acid | ME226987 | 5.27 | 0.01 | 3.28 | 0.97 | NA | 0.02 | 0.01 | NA | 0.01 | 0.03 | NA | 0.04 |
| Taurodeoxycholic acid | ME226991 | 5.20 | 0.03 | 3.68 | 0.01 | NA | 0.00 | 0.12 | 0.04 | 0.07 | 0.00 | 0.00 | 0.00 |
| Glycodeoxycholic acid | ME226986 | 2.14 | 0.42 | 2.92 | 0.70 | 0.28 | 0.80 | NA | 0.28 | 0.87 | 0.14 | 0.26 | 1.11 |
| Cholic acid | ME226980 | 2.50 | 2.39 | 3.75 | 0.11 | 0.01 | 0.01 | 0.06 | 0.61 | 0.04 | 0.04 | NA | NA |
| Eicosapentaenoic acid | ME226966 | 2.97 | 2.32 | 3.37 | 0.68 | 0.21 | 0.55 | 0.40 | 0.35 | 0.55 | 0.44 | 0.26 | 0.50 |
Factors:
| F1 | Diet:Chow | Treatment:none | Strain:129Jax |
| F2 | Diet:Chow | Treatment:none | Strain:129Tac |
| F3 | Diet:Chow | Treatment:none | Strain:B6Jax |
| F4 | Diet:HFD | Treatment:metronidazole | Strain:129Jax |
| F5 | Diet:HFD | Treatment:metronidazole | Strain:129Tac |
| F6 | Diet:HFD | Treatment:metronidazole | Strain:B6Jax |
| F7 | Diet:HFD | Treatment:placebo | Strain:129Jax |
| F8 | Diet:HFD | Treatment:placebo | Strain:129Tac |
| F9 | Diet:HFD | Treatment:placebo | Strain:B6Jax |
| F10 | Diet:HFD | Treatment:vancomycin | Strain:129Jax |
| F11 | Diet:HFD | Treatment:vancomycin | Strain:129Tac |
| F12 | Diet:HFD | Treatment:vancomycin | Strain:B6Jax |
