Clustering data with hclust algorithm for Diet, genetics and gut microbiome drive dynamic changes in plasma metabolites [cecal] (Study ST000880)
HILIC NEGATIVE ION MODE (Analysis AN001434)Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Xanthurenic acid | ME227332 | 0.10 | 0.16 | 0.11 | 1.87 | 0.94 | 0.53 | 4.80 | 0.83 | 0.97 | 0.27 | 0.81 | 0.39 |
Fructose-6-phosphate | ME227301 | 4.86 | 4.26 | 0.62 | 0.04 | 0.03 | 0.09 | 0.04 | 0.10 | 0.06 | 0.02 | 0.05 | 0.04 |
Glucuronic acid | ME227297 | 0.31 | 0.36 | 0.26 | 0.44 | 0.87 | 0.39 | 0.15 | 0.08 | 0.11 | 4.27 | 0.81 | 3.75 |
Sorbitol | ME227322 | 1.13 | 1.40 | 1.07 | 0.41 | 0.17 | 0.31 | 0.26 | 0.14 | 0.16 | 4.54 | 0.14 | 2.30 |
Guanosine | ME227300 | 1.27 | 0.48 | 1.34 | 0.18 | 0.07 | 0.18 | 0.42 | 0.28 | 0.39 | 2.74 | 0.18 | 4.55 |
Orotic acid | ME227315 | 0.95 | 1.19 | 1.93 | 0.67 | 1.31 | 0.39 | 0.18 | 0.08 | 0.68 | 0.86 | 1.35 | 2.63 |
Citric acid | ME227285 | 2.12 | 0.96 | 2.30 | 0.26 | 0.41 | 0.37 | 0.44 | 0.51 | 0.69 | 1.73 | 0.45 | 2.09 |
Cytidine | ME227288 | 1.72 | 1.03 | 1.17 | 0.10 | 0.04 | 0.08 | 0.82 | 0.78 | 1.25 | 1.55 | 0.20 | 3.30 |
Uridine | ME227330 | 1.79 | 0.90 | 1.89 | 0.39 | 0.24 | 0.42 | 0.69 | 0.61 | 0.69 | 1.13 | 0.25 | 3.22 |
Uric acid | ME227329 | 0.55 | 0.37 | 1.24 | 2.33 | 0.32 | 2.69 | 0.28 | 0.40 | 0.36 | 1.13 | 0.26 | 2.14 |
taurodeoxycholate-taurochenodeoxycholate | ME227326 | 0.51 | 0.20 | 0.02 | 0.65 | 0.92 | 1.08 | 1.38 | 1.95 | 2.94 | 0.54 | 0.82 | 0.73 |
3-hydroxykynurenate | ME227268 | NA | NA | NA | 0.74 | 1.05 | 0.95 | 1.66 | 0.49 | 1.76 | 0.92 | 0.90 | 0.40 |
Taurocholic acid | ME227325 | 0.21 | 0.16 | 0.01 | 1.40 | 1.59 | 1.44 | 1.11 | 0.76 | 0.99 | 1.21 | 1.53 | 1.33 |
Alpha-hydoxy butyric acid | ME227278 | 0.93 | 1.19 | 0.82 | 0.74 | 3.16 | 0.45 | 0.67 | 0.53 | 0.87 | 0.83 | 0.83 | 0.92 |
Folic acid | ME227293 | 0.56 | NA | NA | 1.10 | 1.43 | 0.78 | NA | NA | NA | 1.06 | 0.74 | 1.00 |
Isocitric acid | ME227306 | 0.57 | 0.73 | 0.56 | 1.17 | 1.87 | 0.87 | 0.21 | 0.57 | 0.18 | 2.01 | 1.21 | 1.85 |
Lactic acid | ME227308 | 0.54 | 1.34 | 0.61 | 1.50 | 1.45 | 0.86 | 0.66 | 0.45 | 0.56 | 1.48 | 0.60 | 1.86 |
beta-hydroxybutyric acid | ME227281 | 0.57 | 0.48 | 0.19 | 2.85 | 1.74 | 0.30 | 0.26 | 0.11 | 0.10 | 2.39 | 1.21 | 1.39 |
Indoxyl sulfate | ME227304 | 0.01 | 0.13 | NA | 2.01 | 1.66 | 0.04 | 0.68 | 0.66 | NA | 1.48 | 1.74 | 0.03 |
Cholic acid | ME227284 | 0.69 | 2.57 | 0.26 | 0.12 | 0.36 | 0.21 | 1.02 | 1.77 | 2.56 | NA | 0.00 | NA |
Glycocholic Acid | ME227298 | 0.64 | 1.87 | 0.26 | 0.34 | 0.30 | 0.65 | 0.99 | 1.62 | 3.75 | 0.30 | 0.37 | 0.73 |
3-hydroxybenzoate | ME227267 | 1.24 | 0.84 | 1.13 | 0.05 | 0.13 | 0.05 | 2.53 | 0.69 | 2.59 | 0.60 | 1.05 | 0.90 |
hydroxyphenylacetate | ME227302 | 1.31 | 1.10 | 1.53 | 0.88 | 0.49 | 0.22 | 3.29 | 1.72 | 0.75 | 0.19 | 0.30 | 0.16 |
Erythrose 4-phosphate | ME227291 | 1.52 | 1.80 | 0.24 | NA | NA | 0.12 | NA | NA | 0.04 | NA | 0.06 | 0.05 |
phosphotyrosine | ME227319 | 2.16 | 1.29 | NA | 0.44 | NA | NA | 0.51 | NA | 0.71 | 0.51 | NA | NA |
Chenodeoxycholic Acid | ME227283 | 1.42 | 1.34 | 0.80 | NA | NA | 0.02 | 0.65 | 1.54 | 1.92 | NA | 0.01 | NA |
NAD+ | ME227312 | 1.10 | 0.50 | 1.96 | NA | NA | NA | 0.72 | 0.23 | 0.91 | NA | NA | NA |
4-Hydroxyphenylpyruvic acid | ME227271 | 1.73 | 0.86 | 0.91 | NA | NA | NA | 0.74 | 1.03 | 0.59 | NA | NA | NA |
Lithocholic acid | ME227310 | 1.25 | 0.98 | 1.01 | NA | NA | NA | 0.51 | 0.47 | 1.28 | NA | NA | NA |
Oxoglutaric acid | ME227279 | 1.68 | 0.74 | 1.22 | NA | NA | NA | 0.66 | 0.57 | 1.05 | NA | NA | NA |
Quinolinic acid | ME227321 | 0.69 | 1.54 | 2.82 | 1.13 | 0.82 | 0.41 | 0.90 | 0.60 | 0.81 | 1.17 | 1.02 | 0.53 |
Succinic acid | ME227323 | 0.90 | 2.61 | 1.65 | 1.21 | 1.46 | 0.65 | 1.03 | 0.50 | 0.87 | 0.13 | 1.05 | 0.10 |
4-Hydroxybenzaldehyde | ME227270 | 2.91 | 1.42 | 0.95 | 0.37 | 0.57 | 0.38 | 0.84 | 1.07 | 1.26 | 0.63 | 0.43 | 1.16 |
Cystathionine | ME227287 | 1.09 | 1.80 | 0.80 | 0.53 | 0.60 | 0.59 | 0.94 | NA | 0.86 | 1.06 | 0.54 | 1.79 |
Sucrose | ME227324 | 2.32 | 1.68 | 0.91 | 0.59 | 0.64 | 0.56 | 0.47 | 0.51 | 0.47 | 1.71 | 0.76 | 1.34 |
Adenine | ME227274 | 1.99 | 1.65 | 1.50 | 1.24 | 0.78 | 1.81 | 0.86 | 0.62 | 0.59 | 0.48 | 0.35 | 0.26 |
Guanine | ME227299 | 1.35 | 1.79 | 1.66 | 1.20 | 0.13 | 0.94 | 1.22 | 0.91 | 1.25 | 0.69 | 0.20 | 0.83 |
Aminoadipic acid | ME227265 | 1.47 | 1.22 | 1.71 | 0.56 | 0.45 | 0.82 | 1.61 | 0.59 | 1.77 | 0.36 | 0.48 | 0.52 |
Oxalic acid | ME227316 | 1.75 | 1.20 | 1.36 | 0.58 | 1.16 | 0.42 | 1.78 | 0.75 | 1.22 | 0.45 | 0.90 | 0.51 |
Kynurenine | ME227307 | 1.06 | 1.05 | 0.67 | 0.84 | 0.84 | 0.59 | 0.94 | 0.79 | 1.53 | 1.43 | NA | 0.96 |
inosine-15N4 (Internal standard) | ME227263 | 0.77 | 0.95 | 0.58 | 1.09 | 1.27 | 1.15 | 0.69 | 1.01 | 0.95 | 1.15 | 1.20 | 1.08 |
glycocholate-d4 (Internal standard) | ME227264 | 1.12 | 1.10 | 0.94 | 0.97 | 1.09 | 0.97 | 0.88 | 1.04 | 1.08 | 0.92 | 0.92 | 0.94 |
thymine-d4 (Internal standard) | ME227262 | 0.95 | 0.98 | 0.80 | 0.98 | 1.25 | 1.05 | 0.81 | 1.03 | 1.01 | 1.02 | 1.12 | 0.95 |
Adipic acid | ME227275 | 1.58 | 1.10 | 1.36 | 0.82 | 0.97 | 0.73 | 0.89 | 0.84 | 1.02 | 0.98 | 0.96 | 0.77 |
Propionic acid | ME227320 | 1.22 | 1.05 | 1.49 | 0.78 | 1.20 | 0.52 | 0.71 | 0.66 | 1.14 | 0.59 | 1.56 | 0.95 |
Lactose | ME227309 | 2.29 | 3.18 | 1.84 | 0.22 | 0.20 | 0.19 | 0.18 | 0.19 | 0.20 | 1.65 | 0.33 | 1.73 |
Inosine | ME227305 | 3.45 | 1.00 | 3.72 | 0.15 | 0.09 | 0.30 | 0.60 | 0.45 | 0.38 | 1.00 | 0.19 | 1.35 |
CMP | ME227286 | 2.42 | 1.42 | 2.49 | 0.38 | 0.48 | NA | 0.49 | 0.37 | 0.27 | 0.12 | 0.23 | NA |
dTMP | ME227290 | 3.15 | 0.83 | 1.98 | 0.17 | 0.49 | NA | 0.48 | 0.34 | 0.59 | NA | 0.30 | NA |
dCMP | ME227289 | 2.79 | 1.57 | 2.26 | 1.23 | 0.90 | 0.06 | 1.70 | 0.36 | 0.57 | 0.31 | 0.50 | 0.06 |
Hexose | ME227294 | 2.90 | 3.03 | 2.34 | 0.09 | 0.09 | 0.06 | 1.41 | 1.02 | 1.01 | 0.10 | 0.15 | 0.13 |
Uracil | ME227328 | 2.50 | 1.90 | 2.89 | 0.34 | 0.29 | 0.15 | 1.31 | 1.00 | 1.18 | 0.31 | 0.33 | 0.27 |
Hypoxanthine | ME227303 | 2.66 | 2.49 | 2.79 | 0.27 | 0.13 | 0.20 | 1.50 | 0.96 | 1.20 | 0.09 | 0.09 | 0.07 |
Nicotinic acid | ME227313 | 2.64 | 2.43 | 2.88 | 0.53 | 0.39 | 0.20 | 1.25 | 0.81 | 0.93 | 0.17 | 0.15 | 0.09 |
Thymine | ME227327 | 1.91 | 1.62 | 2.44 | 0.41 | 0.36 | 0.28 | 1.18 | 0.93 | 0.97 | 0.81 | 0.32 | 1.12 |
3-methyladipate-pimelate | ME227269 | 2.04 | 2.10 | 2.72 | 0.48 | 0.61 | 0.46 | 1.08 | 0.59 | 0.98 | 0.35 | 0.57 | 0.44 |
4-Pyridoxic acid | ME227272 | 2.45 | 2.05 | 2.59 | 0.66 | 0.57 | 0.39 | 0.87 | 0.51 | 0.74 | 0.47 | 0.66 | 0.43 |
Gentisic acid | ME227296 | 3.17 | 3.44 | 3.21 | 0.03 | 0.10 | 0.03 | 0.06 | 0.19 | 0.07 | NA | 0.02 | NA |
fumarate/maleate | ME227295 | 2.35 | 2.30 | 3.31 | 0.30 | 0.91 | 0.40 | 0.37 | 0.48 | 0.37 | 0.39 | 0.44 | 0.49 |
Malic acid | ME227311 | 2.89 | 3.04 | 3.81 | 0.18 | 0.52 | 0.17 | 0.31 | 0.38 | 0.35 | 0.30 | 0.31 | 0.43 |
Pantothenic acid | ME227317 | 1.57 | 2.27 | 3.92 | 0.30 | 0.27 | 0.21 | 0.88 | 1.19 | 1.50 | 0.14 | 0.29 | 0.20 |
Xanthine | ME227331 | 2.44 | 1.77 | 3.85 | 0.52 | 0.08 | 0.92 | 0.78 | 0.78 | 0.93 | 0.32 | 0.05 | 0.27 |
2-hydroxyglutaric acid | ME227266 | 3.14 | 1.58 | 4.52 | 0.10 | 0.38 | 0.05 | 1.10 | 0.66 | 1.16 | 0.03 | 0.13 | 0.04 |
Glycerol 3-phosphate | ME227277 | 2.38 | 1.47 | 4.39 | 0.55 | 0.49 | 0.05 | 0.78 | 0.73 | 0.28 | 0.13 | 0.17 | 0.03 |
Factors:
F1 | Diet:Chow | Treatment:none | Strain:129Jax |
F2 | Diet:Chow | Treatment:none | Strain:129Tac |
F3 | Diet:Chow | Treatment:none | Strain:B6Jax |
F4 | Diet:HFD | Treatment:metronidazole | Strain:129Jax |
F5 | Diet:HFD | Treatment:metronidazole | Strain:129Tac |
F6 | Diet:HFD | Treatment:metronidazole | Strain:B6Jax |
F7 | Diet:HFD | Treatment:placebo | Strain:129Jax |
F8 | Diet:HFD | Treatment:placebo | Strain:129Tac |
F9 | Diet:HFD | Treatment:placebo | Strain:B6Jax |
F10 | Diet:HFD | Treatment:vancomycin | Strain:129Jax |
F11 | Diet:HFD | Treatment:vancomycin | Strain:129Tac |
F12 | Diet:HFD | Treatment:vancomycin | Strain:B6Jax |