Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Pharmacometabolomic analysis of rat hippocampus and plasma in response to chronic stress and albiflorin treament (Study ST000903)

HILIC POSITIVE ION MODE (Analysis AN001470)

Metabolite	Structure	F1	F2	F3	F4
Homoarginine	ME230474	0.58	0.68	1.82	0.82
Serotonin	ME230443	0.88	0.32	1.31	1.46
2-Arachidonylglycerol	ME230374	1.59	0.88	0.84	0.71
Cysteine-S-sulfate	ME230469	1.42	1.04	0.55	1.06
Hypotaurine	ME230471	0.58	1.63	0.89	0.91
7-ketocholesterol	ME230363	1.19	1.15	1.18	0.46
L-Kynurenine	ME230454	0.81	0.76	0.99	1.44
5-Hydroxyindoleacetic acid	ME230466	0.70	0.86	0.83	1.64
N-alpha-Acetylarginine	ME230473	0.76	0.97	0.72	1.58
5,6-trans-25-Hydroxyvitamin D3	ME230361	0.80	1.03	1.29	0.84
L-Histidinol	ME230409	0.88	0.88	1.31	0.89
Linoleylcarnitine	ME230396	0.90	0.98	0.76	1.38
1-Methylhistidine	ME230434	0.83	1.10	0.83	1.26
Alanine	ME230440	0.85	1.09	0.87	1.20
Sarcosine	ME230441	0.86	1.08	0.89	1.19
Corticosterone	ME230380	0.96	0.87	0.91	1.27
Octadecanoylcarnitine	ME230392	0.98	0.90	0.90	1.23
Acetylcholine	ME230427	0.87	0.93	0.97	1.22
Retinol	ME230357	0.84	0.91	0.97	1.28
CoQ9	ME230355	1.04	0.96	1.26	0.71
Trimethylamine-N-oxide	ME230404	1.03	1.05	1.16	0.74
Isovalerylcarnitine	ME230400	1.10	0.89	1.08	0.92
Adenosine	ME230414	1.03	0.99	1.13	0.83
CoQ9H2	ME230356	1.01	0.97	1.14	0.85
Alpha-Tocopherol	ME230358	0.98	1.05	1.09	0.88
Propionylcarnitine	ME230406	0.94	1.06	1.09	0.89
LysoPC(16:0)	ME230393	0.98	1.04	1.04	0.94
L-Serine	ME230450	1.01	1.01	0.99	0.99
Cysteamine	ME230397	1.01	1.03	0.98	0.98
Epinephrine	ME230465	1.00	1.03	0.99	0.97
Cer(d18:1/22:0 OH)	ME230364	1.04	1.03	0.99	0.94
Adenine	ME230421	1.04	1.00	1.02	0.94
L-Carnitine	ME230428	1.02	1.00	1.01	0.97
3-Hydroxyisovaleryl Carnitine	ME230413	1.06	0.94	1.01	0.99
Cer(d18:1/24:1)	ME230368	1.00	0.96	1.06	0.98
Spermidine	ME230461	1.04	0.95	1.07	0.93
L-Phenylalanine	ME230422	0.96	0.97	1.04	1.02
Pipecolic acid	ME230447	0.93	0.98	1.05	1.03
Dimethylglycine	ME230424	0.92	0.98	1.08	1.01
Lysine	ME230458	0.93	1.00	1.08	0.99
L-leucine	ME230423	0.96	0.95	1.07	1.00
Purine	ME230425	0.94	0.96	1.09	1.00
L-Asparagine	ME230445	0.90	1.03	1.05	1.01
L-Glutamine	ME230446	0.95	1.02	1.04	0.99
Cer(d18:1/23:0)	ME230372	0.95	0.99	1.01	1.05
Cer(d18:1/24:2)	ME230369	0.95	0.97	1.01	1.07
Glycine	ME230455	0.93	1.02	1.02	1.04
Cer(d18:1/24:0)	ME230367	0.96	1.03	0.99	1.02
L-Acetylcarnitine	ME230410	0.97	1.01	1.00	1.03
Creatine	ME230354	0.96	1.00	0.94	1.10
Cer(d18:1/25:0)	ME230370	0.97	1.00	0.97	1.06
Ethanolamine	ME230418	1.00	1.01	0.96	1.04
Cer(d18:1/22:0)	ME230366	0.97	1.03	0.95	1.05
Urea	ME230398	0.98	1.03	0.96	1.04
L-Glutamic acid	ME230462	0.80	0.88	1.12	1.19
L-Tyrosine	ME230451	0.80	0.94	1.09	1.17
Indole	ME230438	0.95	0.86	1.11	1.06
Hydroxykynurenine	ME230417	0.84	1.01	1.10	1.04
Histidine	ME230457	0.85	0.98	1.07	1.09
Cysteine	ME230448	0.88	0.96	1.09	1.05
L-Tryptophan	ME230435	0.88	0.93	1.11	1.07
1-Methyladenine	ME230472	0.91	0.89	1.08	1.11
1-Methyladenosine	ME230412	0.88	0.94	1.06	1.11
L-Methionine	ME230429	0.91	0.97	1.01	1.11
Cytosine	ME230411	0.91	0.95	1.04	1.10
Histamine	ME230408	0.92	0.94	1.04	1.10
PC(16:0/18:2)	ME230385	0.88	1.17	1.11	0.83
PC(18:0/18:2)	ME230379	0.81	1.13	1.16	0.88
Choline	ME230381	0.96	1.10	0.97	0.98
Ornithine	ME230453	0.95	1.10	1.00	0.96
Cortisol	ME230470	0.95	1.15	1.00	0.90
PC(16:0/22:6)	ME230384	0.94	1.15	1.00	0.91
Dopamine	ME230460	0.90	1.14	1.03	0.93
PC(16:0/20:4)	ME230386	0.90	1.17	1.02	0.91
L-Valine	ME230430	0.86	1.00	1.15	0.96
Norepinephrine	ME230437	0.85	1.12	1.06	0.96
S-Adenosylmethionine	ME230449	0.88	1.06	1.08	0.96
Dihexosylcer(18:1/16:0)	ME230401	0.73	1.16	1.08	1.01
Glucosylceramide(18:1/16:0)	ME230389	0.74	1.12	1.11	1.03
Trihexosylcer(18:1/16:0)	ME230407	0.80	1.08	0.97	1.15
Metanephrine	ME230432	0.87	1.12	0.95	1.07
Nicotinamide N-oxide	ME230399	0.91	1.07	0.96	1.06
Normetanephrine	ME230416	0.87	1.11	1.00	1.02
PC(16:0/16:0)	ME230377	0.82	1.11	1.00	1.06
Suberylcarnitine	ME230436	0.83	1.07	1.03	1.07
N-oleoylethanolamine	ME230373	1.30	0.83	0.94	0.94
Glycerophosphocholine	ME230433	1.18	0.96	1.01	0.85
Cholesterol	ME230360	1.24	0.88	1.01	0.86
Dodecanoylcarnitine	ME230394	1.24	0.93	0.96	0.88
Malonylcarnitine	ME230419	0.98	0.98	0.89	1.16
Testosterone	ME230375	1.05	0.93	0.92	1.11
Cer(d18:1/18:0)	ME230365	1.16	1.02	0.86	0.97
Melatonin	ME230382	1.07	0.99	0.94	1.00
Biotin	ME230431	1.16	0.94	0.93	0.99
Myristoylcarnitine	ME230395	1.15	0.89	0.93	1.04
Dodecenoylcarnitine	ME230388	1.11	0.93	0.94	1.04
L-Palmitoylcarnitine	ME230390	1.12	0.93	0.90	1.06
Oleoylcarnitine	ME230391	1.07	0.89	0.79	1.27
Niacinamide	ME230383	1.00	1.07	0.79	1.17
Retinal	ME230362	1.10	1.02	0.76	1.14
Oxidized glutathione	ME230464	0.75	1.25	1.24	0.73
PC(16:0/18:1)	ME230378	0.97	1.25	1.04	0.73
Carnosine	ME230456	1.06	1.25	0.72	1.00
Butyrylcarnitine	ME230403	0.86	1.50	0.81	0.85
Saccharopine	ME230459	0.82	1.24	0.99	0.95
L-Glutarylcarnitine	ME230442	0.79	1.28	0.91	1.02
PC(20:4/P-16:0)	ME230387	0.85	1.21	0.92	1.02
3-Hydroxydodecanoylcarnitine	ME230426	0.94	1.18	0.91	0.97
Vitamin K2	ME230359	0.92	1.31	0.90	0.89
Methionine sulfoxide	ME230439	0.89	1.21	0.96	0.95
PC(22:6/P-18:0)	ME230376	0.92	1.25	0.94	0.90
Vitamin D3	ME230371	0.90	1.26	0.95	0.90
Gamma-Aminobutyric acid	ME230444	0.73	1.24	0.92	1.12
8-Hydroxy-deoxyguanosine	ME230463	0.73	1.34	0.94	1.00
Dihexosylcer(18:1/24:1)	ME230402	0.76	1.39	0.89	0.98
Phosphorylcholine	ME230452	0.61	1.06	1.06	1.25
5-Methyltetrahydrofolic acid	ME230468	0.44	1.14	1.17	1.23
Riboflavin	ME230415	0.43	1.13	1.23	1.18
Thiamine	ME230405	0.70	0.78	1.34	1.14
Adenosine monophosphate	ME230467	0.90	0.67	1.22	1.18
Cytidine	ME230420	0.76	0.80	1.15	1.28

Factors:

F1	Genotype:CUMS model \| Treatment:Albiflorin
F2	Genotype:CUMS model \| Treatment:Fluoxetine
F3	Genotype:CUMS model \| Treatment:Saline
F4	Genotype:Wild-type \| Treatment:Saline

Data matrix