Clustering data with hclust algorithm for Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. Part 2:Plasma (Study ST000916)
Core G Fatty acids/Eicosanoids (Analysis AN001491)| Metabolite | Structure | F1 | F2 | F3 | F4 |
|---|---|---|---|---|---|
| FA(22:3) | ME231511 | 0.55 | 2.75 | 0.23 | 0.99 |
| 20oh PGE2 | ME231449 | 0.32 | 0.80 | 1.07 | 1.53 |
| 2,3 dinor TXB2 | ME231487 | 0.65 | 0.71 | 1.38 | 1.32 |
| FA(26:0) | ME231519 | 0.40 | 1.48 | 0.57 | 1.66 |
| 10 HDoHE | ME231465 | 1.00 | 1.54 | 0.55 | 0.81 |
| 16 HDoHE | ME231455 | 0.87 | 1.52 | 0.82 | 0.83 |
| 12-HEPE | ME231468 | 0.43 | 1.51 | 0.88 | 1.28 |
| 12-HETE | ME231467 | 0.49 | 1.51 | 0.78 | 1.40 |
| 12-HHTrE | ME231452 | 0.48 | 1.41 | 1.03 | 1.08 |
| 11 HDoHE | ME231470 | 0.62 | 1.42 | 0.83 | 1.09 |
| PGE2 | ME231445 | 0.57 | 1.47 | 0.91 | 1.12 |
| FA(23:0) | ME231516 | 0.66 | 1.75 | 0.68 | 1.11 |
| 14 HDoHE | ME231469 | 0.42 | 1.83 | 0.80 | 0.96 |
| TxB2 | ME231444 | 0.33 | 1.66 | 0.94 | 1.03 |
| FA(22:1) | ME231509 | 1.18 | 1.33 | 0.62 | 1.09 |
| FA(18:4) | ME231499 | 1.24 | 1.11 | 0.91 | 0.73 |
| 11-HETE | ME231453 | 1.30 | 1.08 | 0.81 | 0.89 |
| 18-HETE | ME231475 | 1.33 | 0.94 | 0.82 | 0.88 |
| 13-HOTrE | ME231462 | 1.40 | 1.21 | 0.72 | 0.72 |
| FA(22:2) | ME231510 | 1.37 | 1.19 | 0.67 | 0.95 |
| HXB3 | ME231472 | 0.75 | 1.21 | 0.74 | 1.36 |
| FA(22:0) | ME231508 | 0.79 | 1.24 | 0.87 | 1.20 |
| FA(24:0) | ME231517 | 0.92 | 1.27 | 0.79 | 1.16 |
| FA(22:4) | ME231512 | 1.20 | 0.96 | 0.88 | 1.03 |
| dhk PGD2 | ME231448 | 1.14 | 1.04 | 0.84 | 1.07 |
| FA(24:1) | ME231518 | 1.20 | 0.99 | 0.83 | 1.09 |
| FA(18:1) | ME231495 | 1.05 | 1.09 | 0.94 | 0.93 |
| FA(20:0) | ME231500 | 1.06 | 1.13 | 0.86 | 1.04 |
| FA(20:3 N3) | ME231503 | 1.01 | 1.15 | 0.89 | 1.03 |
| FA(17:0) | ME231492 | 0.90 | 0.93 | 1.06 | 1.10 |
| FA(18:0) | ME231494 | 0.81 | 0.97 | 1.06 | 1.14 |
| FA(20:5) | ME231507 | 0.87 | 1.10 | 1.00 | 1.04 |
| FA(18:2) | ME231496 | 0.99 | 1.01 | 0.99 | 1.02 |
| FA(20:3 N6) | ME231504 | 0.95 | 1.01 | 1.00 | 1.05 |
| FA(20:4) | ME231506 | 0.91 | 1.04 | 1.01 | 1.05 |
| 16-HETE | ME231476 | 1.01 | 0.82 | 1.12 | 1.01 |
| FA(18:3 N3) | ME231497 | 1.05 | 0.96 | 1.05 | 0.90 |
| FA(22:6) | ME231515 | 1.07 | 0.87 | 1.01 | 1.06 |
| FA(18:3 N6) | ME231498 | 1.09 | 0.96 | 0.99 | 0.95 |
| FA(22:5 N3) | ME231513 | 1.10 | 0.93 | 0.98 | 1.00 |
| FA(16:0) | ME231490 | 1.09 | 0.95 | 0.95 | 1.05 |
| FA(22:5 N6) | ME231514 | 1.09 | 0.96 | 0.96 | 1.02 |
| 9-HOTrE | ME231458 | 1.48 | 0.85 | 0.96 | 0.46 |
| PGFM | ME231450 | 1.17 | 0.86 | 1.21 | 0.55 |
| TXB1 | ME231446 | 1.36 | 1.18 | 1.15 | 0.48 |
| 8,9-diHETrE | ME231481 | 1.76 | 0.83 | 0.65 | 0.85 |
| 19,20 DiHDPA | ME231477 | 1.70 | 0.71 | 0.85 | 0.79 |
| 9,10 EpOME | ME231478 | 1.69 | 0.69 | 0.84 | 0.84 |
| 12,13 EpOME | ME231479 | 1.57 | 0.66 | 0.91 | 0.90 |
| FA(14:0) | ME231488 | 1.61 | 0.72 | 0.88 | 0.85 |
| 11,12-diHETrE | ME231482 | 1.64 | 0.90 | 0.72 | 0.86 |
| FA(16:1) | ME231491 | 1.61 | 0.81 | 0.82 | 0.83 |
| 14,15-diHETrE | ME231483 | 1.58 | 0.82 | 0.82 | 0.87 |
| 5-HETE | ME231457 | 1.57 | 0.81 | 0.84 | 0.84 |
| 6k PGF1a | ME231443 | 1.89 | 0.68 | 0.78 | 0.84 |
| 9-HODE | ME231471 | 1.71 | 0.78 | 0.85 | 0.69 |
| 13-HODE | ME231461 | 1.78 | 0.72 | 0.82 | 0.74 |
| 15-HETE | ME231460 | 1.78 | 0.72 | 0.82 | 0.72 |
| 12,13 diHOME | ME231485 | 1.77 | 0.67 | 0.88 | 0.71 |
| 15-HETrE | ME231463 | 1.78 | 0.67 | 0.86 | 0.70 |
| 9-oxoODE | ME231473 | 1.32 | 0.65 | 0.96 | 1.10 |
| 5,6-diHETrE | ME231480 | 1.34 | 0.81 | 0.78 | 1.28 |
| FA(20:1) | ME231501 | 1.22 | 0.82 | 0.87 | 1.18 |
| 13-oxoODE | ME231474 | 1.39 | 0.51 | 1.00 | 0.83 |
| 5-HETrE | ME231459 | 1.43 | 0.62 | 1.00 | 0.68 |
| FA(20:3 N9) | ME231505 | 1.49 | 0.79 | 0.89 | 0.88 |
| 8-HETE | ME231464 | 1.41 | 0.82 | 0.84 | 0.89 |
| FA(17:1) | ME231493 | 1.43 | 0.87 | 0.85 | 0.92 |
| FA(15:0) | ME231489 | 1.33 | 0.81 | 0.93 | 0.95 |
| FA(20:2) | ME231502 | 1.38 | 0.79 | 0.86 | 1.05 |
| 9,10 diHOME | ME231484 | 1.39 | 0.83 | 1.02 | 0.70 |
| 8-HETrE | ME231466 | 1.24 | 0.78 | 1.08 | 0.84 |
| dhk PGF2a | ME231447 | 1.32 | 0.76 | 0.98 | 0.84 |
| LTE4 | ME231456 | 1.64 | 0.28 | 0.31 | NA |
| tetranor 12-HETE | ME231451 | 2.08 | 0.61 | 0.72 | 0.62 |
| 20cooh AA | ME231486 | 2.24 | 0.72 | 0.58 | 0.65 |
| PGA2 | ME231454 | 2.08 | 0.87 | 0.55 | 0.56 |
Factors:
| F1 | Diagnosis:Cirrhosis |
| F2 | Diagnosis:NASH |
| F3 | Diagnosis:Normal |
| F4 | Diagnosis:Steatosis |
