Clustering data with hclust algorithm for Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability (Study ST001119)
HILIC NEGATIVE ION MODE (Analysis AN001831)Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 |
---|---|---|---|---|---|---|---|
Thymidine | ME268316 | 0.08 | 0.09 | 0.43 | 0.05 | 1.83 | 4.03 |
AMP | ME268287 | 2.63 | 0.65 | 1.09 | 0.35 | 0.79 | 0.18 |
GMP | ME268303 | 1.73 | 0.82 | 2.26 | 0.21 | 0.19 | 0.02 |
Uracil | ME268320 | 0.94 | 1.85 | 1.75 | 0.07 | 0.16 | 1.42 |
Aspartic acid | ME268290 | 0.98 | 1.49 | 1.81 | 0.06 | 0.23 | 1.36 |
glucose-1-phosphate/fructose-6 -hosphate | ME268299 | 0.86 | 1.56 | 1.91 | 0.03 | 0.10 | 1.58 |
Glucose-6-phosphate | ME268300 | 0.83 | 1.45 | 1.88 | 0.02 | 0.10 | 1.74 |
Xanthine | ME268321 | 1.40 | 2.08 | 1.25 | 0.00 | 0.41 | 0.83 |
3-Phosphoglyceric acid | ME268283 | 1.62 | 1.95 | 1.56 | 0.07 | 0.08 | 0.98 |
Glutamic acid | ME268301 | 1.36 | 2.04 | 1.43 | 0.07 | 0.12 | 1.43 |
Glyceric acid | ME268302 | 0.85 | 1.52 | 1.57 | 0.43 | 0.51 | 1.06 |
Malic acid | ME268306 | 1.23 | 1.82 | 1.21 | 0.64 | 0.35 | 1.18 |
Dihydroxyacetone phosphate | ME268295 | 0.83 | 1.31 | 1.58 | 0.04 | 0.33 | 2.62 |
Argininosuccinic acid | ME268288 | 1.06 | 1.13 | 1.14 | 0.41 | 0.37 | 1.76 |
Thiamine | ME268315 | 0.99 | 1.95 | 1.11 | 0.19 | 0.39 | 1.98 |
2-hydroxyglutaric acid | ME268278 | 1.40 | 1.99 | 0.59 | 0.72 | 0.54 | 1.51 |
Orotic acid | ME268309 | 1.68 | 1.79 | 0.56 | 0.45 | 0.80 | 0.55 |
N-6-trimethyllysine | ME268317 | 1.21 | 1.71 | 0.67 | 1.03 | 0.74 | 1.08 |
Ketoisovaleric acid | ME268281 | 1.40 | 1.47 | 0.75 | 0.67 | 0.89 | 0.89 |
Lactic acid | ME268305 | 1.39 | 1.68 | 0.64 | 0.69 | 0.86 | 0.91 |
3-Methyl-2-oxovaleric acid | ME268282 | 1.99 | 2.01 | 0.31 | 0.92 | 0.63 | 0.74 |
Sorbitol | ME268313 | 1.79 | 2.10 | 0.96 | 1.13 | 0.19 | 0.40 |
UDP-glucose | ME268319 | 2.13 | 2.23 | 0.69 | 0.06 | 0.13 | 0.26 |
UDP-N-acetylglucosamine | ME268318 | 2.21 | 1.96 | 1.16 | 0.04 | 0.09 | 0.56 |
Phosphoethanolamine | ME268308 | 1.64 | 2.51 | 1.28 | 0.07 | 0.09 | 0.58 |
5^-Methylthioadenosine | ME268307 | 1.12 | 2.58 | 0.99 | 0.12 | 0.27 | 0.40 |
Ribose-5-phosphate | ME268312 | 1.12 | 2.74 | 1.26 | 0.07 | 0.15 | 0.78 |
Allantoin | ME268286 | 0.80 | 1.96 | 0.75 | 0.59 | 1.10 | 0.43 |
Succinic acid | ME268314 | 0.78 | 1.22 | 0.69 | 0.19 | 1.56 | 0.72 |
Cis-Aconitic acid | ME268291 | 0.77 | 1.06 | 0.59 | 1.11 | 1.28 | 1.25 |
Citric acid | ME268292 | 0.88 | 1.11 | 0.80 | 0.98 | 1.05 | 1.39 |
beta-hydroxybutyric acid | ME268279 | 0.40 | 0.47 | 0.87 | 1.65 | 1.64 | 0.29 |
3-hydroxyisobutyric acid | ME268280 | 0.76 | 0.84 | 0.81 | 1.29 | 1.33 | 0.70 |
3-methyl pyruvic acid | ME268284 | 0.80 | 0.84 | 0.61 | 1.07 | 1.61 | 0.47 |
Pyruvic acid | ME268311 | 0.55 | 1.11 | 0.45 | 1.22 | 1.60 | 0.62 |
Glucose | ME268298 | 0.82 | 0.53 | 0.59 | 2.34 | 1.24 | 0.91 |
Itaconic acid | ME268304 | 1.38 | 1.77 | 0.51 | 1.74 | 0.59 | 0.82 |
Oxoglutaric acid | ME268285 | 0.89 | 1.65 | 0.35 | 2.37 | 0.79 | 0.79 |
Cysteic acid | ME268294 | 0.34 | 0.18 | 3.16 | NA | NA | 3.32 |
P-Aminobenzoic acid | ME268310 | NA | 0.02 | 1.07 | NA | 2.10 | 1.65 |
CTP | ME268293 | NA | 0.01 | 1.03 | NA | NA | 1.15 |
dTMP | ME268296 | 0.13 | 0.13 | 1.27 | NA | NA | 1.78 |
Fumaric acid | ME268297 | 0.20 | 0.36 | 1.47 | NA | 0.19 | 2.16 |
2-hydroxybutyric acid | ME268277 | 0.68 | 0.66 | 1.63 | 0.79 | 0.56 | 2.26 |
Vitamin C | ME268289 | 0.36 | 0.10 | 2.24 | NA | 0.55 | 2.36 |
Factors:
F1 | Sample Type:Keap1_mutant_lung_subcutaneous |
F2 | Sample Type:lung_subcutaneous |
F3 | Sample Type:pancreatic ductal adenocarcinoma |
F4 | Sample Type:pancreatic ductal adenocarcinoma plasma |
F5 | Sample Type:pancreatic ductal adenocarcinoma plasma cardiac puncture |
F6 | Sample Type:pancreatic ductal adenocarcinoma subcutaneous |