Clustering data with hclust algorithm for A comprehensive plasma metabolomics dataset for a cohort of mouse knockouts within the International Mouse Phenotyping Consortium (Study ST001154)
Reversed phase NEGATIVE ION MODE/Ion trap (Analysis AN001947)Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 | F19 | F20 | F21 | F22 | F23 | F24 | F25 | F26 | F27 | F28 | F29 | F30 | F31 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cholic acid | ME280503 | 0.03 | 0.12 | 0.14 | 0.04 | 0.09 | 0.03 | 0.27 | 0.10 | 0.06 | 0.29 | 1.18 | 0.18 | 0.63 | 0.20 | 0.23 | 18.96 | 0.41 | 0.10 | 0.13 | 0.21 | 0.04 | 1.03 | 0.15 | 0.10 | 0.83 | 0.10 | 0.12 | 0.25 | 0.27 | 0.18 | 8.73 |
?-Muricholic acid | ME280495 | 0.01 | 0.02 | 0.56 | 0.01 | 0.02 | 0.13 | 0.01 | 0.01 | 0.02 | 0.01 | 0.43 | 0.03 | 0.37 | 0.01 | 0.02 | 2.21 | 0.01 | 0.02 | 0.30 | 1.70 | 0.01 | 0.47 | 1.46 | 0.03 | 0.72 | 0.01 | 0.16 | 1.28 | 11.91 | 0.01 | 3.82 |
Ursodeoxycholic acid | ME280504 | NA | 0.01 | 0.01 | NA | 0.01 | 0.00 | NA | NA | 0.00 | 0.00 | 0.03 | 0.01 | NA | 0.00 | 0.00 | 0.08 | 0.00 | 0.00 | NA | 2.48 | 0.03 | 5.72 | 0.01 | 0.01 | 0.03 | 0.02 | 8.95 | 0.04 | 0.01 | 0.01 | 0.10 |
testosterone | ME280467 | 0.65 | 2.44 | 3.08 | 0.25 | 0.39 | 0.60 | 2.22 | 0.22 | 1.33 | 0.11 | 3.13 | 3.06 | 0.34 | 0.10 | 0.09 | 0.14 | 0.68 | 0.11 | 0.19 | 0.35 | 3.81 | 2.16 | 0.41 | 0.32 | 4.39 | 0.13 | NA | 0.31 | 0.36 | 0.40 | 0.18 |
androstanediol | ME280478 | 0.81 | 0.54 | 1.09 | NA | NA | 0.69 | 0.47 | 0.59 | 0.65 | NA | 0.55 | 1.03 | 1.06 | NA | NA | NA | 7.07 | 0.60 | NA | 0.77 | 0.60 | NA | NA | NA | NA | 0.70 | 0.68 | 0.56 | 0.79 | 2.07 | NA |
progesterone | ME280463 | 1.04 | 0.66 | 1.16 | 4.44 | 0.91 | 0.39 | 1.20 | 0.26 | 0.46 | 1.28 | 3.11 | 1.55 | 0.73 | 1.72 | 0.35 | 0.89 | 0.73 | 0.77 | 0.43 | 0.80 | 0.31 | 1.52 | 0.60 | 1.27 | 1.23 | 0.84 | 0.62 | 1.12 | 0.29 | 0.59 | 0.59 |
Lithocholic acid | ME280511 | 0.39 | 0.67 | 0.09 | 0.14 | 1.16 | 1.31 | 0.98 | 0.58 | 0.83 | NA | 0.52 | 0.92 | 0.63 | 0.45 | 0.48 | 0.89 | 1.81 | 0.46 | 0.99 | 1.29 | 1.10 | 1.66 | 0.85 | 0.71 | 0.60 | 0.21 | 0.16 | 3.03 | 0.07 | 2.15 | 3.04 |
cortexone | ME280469 | 1.54 | 0.61 | 1.60 | 0.77 | 0.78 | 0.23 | 1.17 | 0.61 | 0.44 | 0.85 | 2.42 | 1.19 | 1.57 | 0.25 | 2.18 | 2.99 | 1.04 | 1.00 | 0.21 | 0.85 | 0.19 | 1.34 | 0.33 | 2.18 | 0.37 | 0.47 | 1.59 | 0.95 | 1.30 | 0.76 | 0.60 |
corticosterone | ME280462 | 1.36 | 0.73 | 1.48 | 1.08 | 1.09 | 0.69 | 1.09 | 0.53 | 0.76 | 0.47 | 1.14 | 1.14 | 2.29 | 0.42 | 1.53 | 1.30 | 1.82 | 0.93 | 0.64 | 0.90 | 0.39 | 0.95 | 0.82 | 1.69 | 0.32 | 0.75 | 1.13 | 1.07 | 1.57 | 0.81 | 0.69 |
17-OH pregnenolone | ME280475 | 0.81 | NA | NA | 1.03 | 1.02 | 1.41 | 1.64 | 1.29 | 0.70 | 1.27 | 0.76 | NA | 0.85 | 0.64 | 1.16 | 0.87 | 1.51 | 0.52 | NA | 1.09 | 0.92 | 0.92 | NA | 1.22 | 0.93 | 0.76 | 0.78 | 0.54 | NA | 1.10 | 0.83 |
cortisol | ME280459 | 1.00 | 1.00 | 0.99 | 1.01 | 0.99 | 1.04 | 0.99 | 0.99 | 1.00 | 0.99 | 0.99 | 0.98 | 1.00 | 0.99 | 0.97 | 0.99 | NA | 1.01 | 0.99 | 1.00 | 1.00 | 1.03 | 0.99 | 1.01 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.08 | 1.00 |
pregnenolone | ME280486 | NA | 0.98 | NA | NA | 1.15 | NA | NA | NA | 0.65 | 0.67 | NA | 0.74 | 0.69 | 0.73 | 0.63 | 0.69 | 1.08 | 2.66 | 1.33 | 0.86 | 0.79 | 0.98 | NA | NA | 1.30 | 1.41 | 1.56 | NA | NA | NA | 0.77 |
20-hydroxyprogesterone | ME280476 | NA | 0.90 | 0.97 | NA | 1.61 | NA | 0.69 | NA | 0.78 | NA | NA | 0.88 | 1.20 | NA | 0.88 | NA | 0.95 | 0.77 | 0.68 | 1.36 | NA | NA | 0.76 | 0.80 | NA | NA | NA | 1.42 | NA | 0.74 | NA |
Taurodehydrocholate | ME280489 | NA | 0.99 | 1.43 | NA | 1.05 | 1.11 | 0.99 | NA | 1.00 | 0.93 | 1.03 | 0.94 | NA | NA | 0.96 | NA | 0.80 | 0.90 | NA | 1.04 | 0.89 | NA | NA | NA | 0.93 | 1.07 | NA | NA | NA | 1.02 | NA |
dehydroepiandrosterone sulfate | ME280468 | 1.29 | 1.01 | NA | NA | 1.57 | 0.91 | NA | 0.57 | NA | 0.48 | 0.29 | NA | NA | 0.35 | 1.66 | NA | NA | NA | NA | 0.58 | NA | 1.41 | NA | 0.62 | NA | 0.96 | 1.04 | 0.73 | 0.53 | NA | 3.14 |
Glycolithocholic acid | ME280510 | 1.89 | 0.75 | NA | NA | 0.98 | NA | 0.67 | 1.50 | 1.09 | 0.35 | 0.37 | 1.05 | NA | NA | 0.33 | 0.95 | NA | NA | 1.14 | 0.58 | 2.12 | NA | NA | 0.92 | 0.75 | 1.86 | 0.73 | NA | NA | NA | NA |
Taurolithocholic acid | ME280507 | 0.64 | NA | NA | NA | 0.69 | NA | 0.67 | 2.99 | 0.74 | 0.61 | 0.88 | 0.44 | NA | NA | NA | 1.23 | 0.64 | NA | NA | 0.55 | 0.46 | NA | NA | NA | 0.46 | 0.50 | NA | 0.51 | 0.46 | NA | 2.46 |
Taurochenodeoxycholic acid | ME280501 | 0.73 | 0.44 | 0.78 | 0.51 | 0.20 | 0.25 | 0.25 | 0.20 | 0.29 | 0.57 | 1.52 | 0.46 | 2.08 | 0.25 | 0.28 | 2.85 | 4.29 | 0.46 | 0.39 | 0.41 | 0.34 | 0.76 | 0.55 | 0.35 | 0.85 | 0.21 | 0.41 | 3.29 | 0.31 | 6.06 | 4.75 |
Taurodeoxycholic acid | ME280502 | 0.05 | 0.25 | 0.35 | 0.13 | 0.18 | 0.08 | 0.66 | 0.25 | 0.12 | 0.37 | 3.55 | 0.35 | 1.62 | 0.42 | 0.25 | 5.45 | 0.41 | 0.12 | 0.37 | 0.21 | 0.06 | 3.10 | 0.24 | 0.28 | 1.37 | 0.34 | 0.37 | 0.18 | 0.58 | 0.30 | 13.85 |
Tauroursodeoxycholic acid | ME280493 | 0.15 | 0.36 | 0.17 | 0.22 | 0.13 | 0.23 | 0.20 | 0.21 | 0.18 | 0.37 | 1.39 | 0.38 | NA | 0.25 | 0.78 | 5.98 | 0.20 | 0.16 | 0.21 | 0.51 | 0.27 | 1.86 | 0.16 | 0.51 | 2.49 | 0.21 | 0.23 | 5.32 | 0.33 | 0.27 | 7.04 |
Glycocholic acid | ME280499 | 0.09 | 0.20 | 0.19 | 0.13 | 0.20 | 0.13 | 0.23 | 0.42 | 0.17 | 0.27 | 1.72 | 0.49 | 0.38 | 0.22 | 0.20 | 5.13 | 0.28 | 0.23 | 0.29 | 0.25 | 0.11 | 2.05 | 0.05 | 0.17 | 2.26 | 0.15 | 0.24 | 2.84 | 0.81 | 0.17 | 8.04 |
Glycodeoxycholic acid | ME280506 | 0.10 | 0.15 | 0.27 | 0.11 | 0.09 | 0.12 | 0.43 | 0.15 | 0.10 | 0.30 | 3.50 | 0.32 | NA | 0.25 | 0.19 | 4.97 | 0.09 | 0.10 | 0.18 | 0.20 | 0.06 | 1.85 | 0.31 | 0.32 | 1.16 | 0.18 | 0.34 | 1.46 | 0.80 | 1.13 | 8.20 |
ß-Muricholic acid | ME280500 | 0.62 | 0.35 | 0.12 | 0.33 | 0.43 | 0.48 | 0.69 | 0.47 | 0.31 | 0.27 | 1.08 | 1.03 | 0.85 | 0.50 | 0.47 | 4.95 | 0.95 | 0.40 | 0.14 | 1.11 | 0.71 | 0.75 | 0.29 | 0.16 | 1.26 | 0.41 | 0.09 | 1.18 | 0.23 | 0.72 | 7.42 |
Deoxycholic acid | ME280509 | 0.21 | 0.43 | 0.59 | 0.36 | 0.30 | 0.22 | 0.62 | 0.46 | 0.22 | 0.53 | 2.23 | 0.79 | 1.86 | 0.66 | 0.60 | 3.91 | 1.18 | 0.37 | 0.48 | 0.45 | 0.27 | 2.76 | 0.46 | 0.70 | 1.20 | 0.59 | 0.51 | 1.62 | 0.71 | 1.14 | 7.59 |
Chenodeoxycholic acid | ME280508 | 0.25 | 0.44 | 1.11 | 0.33 | 0.55 | 0.48 | 1.10 | 0.53 | 0.45 | 1.03 | 2.69 | 0.62 | 1.12 | 0.65 | 0.56 | 3.25 | 1.12 | 0.39 | 0.47 | 0.60 | 0.58 | 1.03 | 0.52 | 0.40 | 1.03 | 0.60 | 0.82 | 1.67 | 0.93 | 0.58 | 7.38 |
Glycoursodeoxycholic acid | ME280496 | 0.15 | 0.52 | 0.50 | 0.18 | 0.34 | 0.22 | 1.10 | 0.53 | 0.22 | 0.99 | 2.43 | 0.95 | 1.07 | 1.02 | 0.41 | 3.23 | 0.75 | 0.30 | 0.44 | 0.91 | 0.41 | 1.62 | 0.51 | 0.38 | 1.17 | 0.54 | 0.44 | 0.69 | 1.66 | 0.37 | 7.83 |
Taurocholic acid | ME280494 | 0.18 | 0.10 | 0.10 | 0.12 | 0.08 | 0.11 | 0.07 | 0.06 | 0.07 | 0.11 | 2.85 | 0.20 | 3.46 | 0.10 | 0.08 | 7.51 | 4.28 | 0.14 | 0.10 | 0.29 | 0.09 | 2.94 | 0.11 | 0.10 | 2.72 | 0.10 | 0.09 | 2.54 | 0.14 | 1.74 | 6.79 |
Tauro-?-Muricholic acid | ME280490 | 0.21 | 0.19 | 0.15 | 0.19 | 0.12 | 0.09 | 0.17 | 0.15 | 0.10 | 0.22 | 1.37 | 0.25 | 3.67 | 0.18 | 0.10 | 4.62 | 3.29 | 0.16 | 0.22 | 0.63 | 0.15 | 2.21 | 0.19 | 0.17 | 4.68 | 0.20 | 0.13 | 1.67 | 0.30 | 2.15 | 6.09 |
Tauro-a-Muricholic acid | ME280491 | 0.08 | 0.08 | 0.04 | 0.05 | 0.09 | 0.08 | 0.08 | 0.05 | 0.05 | 0.10 | 1.48 | 0.18 | 0.70 | 0.09 | 0.07 | 8.97 | 2.75 | 0.08 | 0.09 | 0.23 | 0.06 | 2.25 | 0.04 | 0.09 | 6.18 | 0.08 | 0.09 | 1.84 | 0.07 | 0.77 | 9.05 |
Tauro-ß-Muricholic acid | ME280492 | 0.06 | 0.06 | 0.04 | 0.03 | 0.06 | 0.04 | 0.05 | 0.02 | 0.03 | 0.06 | 1.61 | 0.10 | 2.17 | 0.05 | 0.05 | 11.27 | 3.14 | 0.04 | 0.04 | 0.40 | 0.03 | 2.25 | 0.03 | 0.05 | 3.77 | 0.05 | 0.04 | 1.95 | 0.07 | 1.88 | 6.58 |
Factors:
F1 | Genotype:A2m |
F2 | Genotype:Ahcy |
F3 | Genotype:Atp5b |
F4 | Genotype:Atp6v0d1 |
F5 | Genotype:C8a |
F6 | Genotype:Cdk4 |
F7 | Genotype:Dhfr |
F8 | Genotype:Dync1li1 |
F9 | Genotype:G6pd2 |
F10 | Genotype:Galc |
F11 | Genotype:Gnpda1 |
F12 | Genotype:Idh1 |
F13 | Genotype:Iqgap1 |
F14 | Genotype:Lmbrd1 |
F15 | Genotype:Mfap4 |
F16 | Genotype:Mmachc |
F17 | Genotype:Mvk |
F18 | Genotype:Nek2 |
F19 | Genotype:Npc2 |
F20 | Genotype:Null |
F21 | Genotype:Pebp1 |
F22 | Genotype:Phyh |
F23 | Genotype:Pipox |
F24 | Genotype:Plk1 |
F25 | Genotype:Pmm2 |
F26 | Genotype:Ptpn12 |
F27 | Genotype:Pttg1 |
F28 | Genotype:Rock1 |
F29 | Genotype:Sra1 |
F30 | Genotype:Ulk3 |
F31 | Genotype:Ywhaz |