Clustering data with hclust algorithm for Metabolite changes in human plasma before and after YF17D vaccination in symptomatic and asymptomatic subjects (Study ST001176)
Other UNSPECIFIED ION MODE (Analysis AN001952)| Metabolite | Structure | F1 | F2 | F3 | F4 |
|---|---|---|---|---|---|
| Inosine | ME281202 | 0.15 | NA | NA | 1.85 |
| Glyoxylic acid | ME281191 | 1.38 | NA | 0.64 | 0.59 |
| Hypoxanthine | ME281199 | 1.35 | 1.53 | 0.55 | 0.69 |
| Asp | ME281148 | 0.69 | 1.50 | 0.60 | 1.24 |
| β-Ala | ME281241 | 1.53 | 0.93 | 0.75 | 0.86 |
| 3-Hydroxybutyric acid | ME281136 | 0.67 | 1.27 | 1.04 | 1.01 |
| Cys | ME281165 | 0.67 | 1.36 | 1.13 | 0.95 |
| Met | ME281209 | 0.81 | 1.23 | 0.95 | 1.02 |
| Tyramine | ME281234 | 0.78 | 1.40 | 0.92 | 0.97 |
| Glu | ME281181 | 1.00 | 1.25 | 0.85 | 0.94 |
| Succinic acid | ME281228 | 1.01 | 1.29 | 0.96 | 0.87 |
| Lactic acid | ME281204 | 1.25 | 1.15 | 0.79 | 0.86 |
| Creatine | ME281162 | 1.18 | 1.21 | 0.85 | 0.82 |
| Malic acid | ME281207 | 1.13 | 1.30 | 0.82 | 0.86 |
| Sarcosine | ME281223 | 1.21 | 1.05 | 0.96 | 0.82 |
| Isocitric acid | ME281203 | 1.24 | 1.03 | 0.91 | 0.90 |
| cis-Aconitic acid | ME281157 | 1.22 | 0.95 | 0.94 | 0.89 |
| Citric acid | ME281158 | 1.19 | 0.96 | 0.94 | 0.93 |
| Pyruvic acid | ME281219 | 0.77 | 1.05 | 1.16 | 0.98 |
| Betaine | ME281150 | 0.93 | 0.95 | 1.08 | 1.03 |
| Ser | ME281225 | 0.89 | 1.01 | 1.02 | 1.07 |
| 2-Oxoisovaleric acid | ME281134 | 0.90 | 1.06 | 1.05 | 0.99 |
| Choline | ME281156 | 0.91 | 1.13 | 1.02 | 0.95 |
| 2-Hydroxybutyric acid | ME281132 | 0.82 | 1.09 | 1.07 | 1.01 |
| 2-Oxoglutaric acid | ME281133 | 0.85 | 1.10 | 1.05 | 1.10 |
| Hydroxyproline | ME281198 | 1.01 | 0.87 | 1.01 | 1.09 |
| Pro | ME281216 | 1.03 | 0.92 | 0.99 | 1.06 |
| Uridine | ME281238 | 0.98 | 1.13 | 1.04 | 0.87 |
| Ala | ME281143 | 1.15 | 1.09 | 0.86 | 0.94 |
| Gly | ME281187 | 1.07 | 1.11 | 0.91 | 0.94 |
| Ornithine | ME281213 | 1.07 | 1.06 | 0.91 | 0.97 |
| Leu | ME281205 | 0.97 | 1.11 | 0.94 | 0.99 |
| Lys | ME281206 | 0.93 | 1.09 | 0.95 | 1.04 |
| Thr | ME281229 | 0.95 | 1.08 | 0.92 | 1.05 |
| Val | ME281240 | 0.96 | 1.07 | 0.96 | 1.02 |
| Phe | ME281214 | 0.95 | 1.05 | 0.98 | 1.02 |
| Trp | ME281232 | 0.94 | 1.04 | 0.99 | 1.03 |
| Asn | ME281147 | 1.00 | 1.04 | 0.94 | 1.03 |
| Tyr | ME281233 | 1.03 | 1.03 | 0.92 | 1.03 |
| Arg | ME281146 | 1.00 | 1.11 | 0.86 | 1.04 |
| Ile | ME281200 | 1.00 | 1.08 | 0.90 | 1.04 |
| Gluconic acid | ME281182 | 1.10 | 0.97 | 1.00 | 0.93 |
| Gln | ME281180 | 1.02 | 0.99 | 0.99 | 1.00 |
| His | ME281196 | 0.99 | 1.02 | 1.00 | 0.99 |
| N,N-Dimethylglycine | ME281210 | 0.98 | 0.99 | 1.01 | 1.01 |
| Citrulline | ME281159 | 1.03 | 1.04 | 1.00 | 0.93 |
| Creatinine | ME281163 | 1.04 | 1.02 | 0.98 | 0.97 |
Factors:
| F1 | Outcome:Asymptomatic | Day post-vaccination:day 0 |
| F2 | Outcome:Asymptomatic | Day post-vaccination:day 1 |
| F3 | Outcome:Symptomatic | Day post-vaccination:day 0 |
| F4 | Outcome:Symptomatic | Day post-vaccination:day 1 |
