Clustering data with hclust algorithm for Metabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part I (Study ST001235)
HILIC POSITIVE ION MODE (Analysis AN002053)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|---|
| 2-deoxycytidine | ME291500 | 0.93 | 1.04 | 1.00 | 0.99 | 1.02 | 1.06 |
| quinolinic acid | ME291495 | 0.96 | 0.97 | 1.01 | 1.03 | 1.00 | 1.05 |
| anserine | ME291511 | 1.04 | 1.02 | 0.95 | 0.98 | 0.99 | 1.02 |
| cAMP | ME291519 | 0.98 | 1.00 | 1.03 | 0.99 | 0.98 | 1.03 |
| kynurenine | ME291493 | 0.99 | 0.97 | 1.02 | 1.00 | 1.03 | 0.99 |
| hydroxyproline | ME291537 | 1.00 | 0.99 | 1.01 | 1.03 | 0.99 | 0.98 |
| C22:6 carnitine | ME291595 | 1.00 | 1.00 | 1.02 | 1.00 | 1.01 | 0.96 |
| C14:2 carnitine | ME291586 | 1.01 | 1.01 | 1.02 | 0.99 | 1.01 | 0.97 |
| C18:1-OH carnitine | ME291590 | 1.01 | 1.01 | 1.02 | 0.98 | 1.01 | 0.97 |
| C12:1 carnitine | ME291583 | 1.01 | 1.00 | 1.02 | 0.98 | 1.01 | 0.97 |
| C14:1 carnitine | ME291585 | 1.01 | 1.00 | 1.02 | 0.98 | 1.01 | 0.97 |
| C10 carnitine | ME291580 | 1.01 | 1.00 | 1.02 | 0.98 | 1.00 | 0.98 |
| C6 carnitine | ME291577 | 1.01 | 1.00 | 1.01 | 0.99 | 1.01 | 0.98 |
| C12 carnitine | ME291582 | 1.01 | 1.00 | 1.02 | 0.99 | 1.01 | 0.98 |
| C14 carnitine | ME291584 | 1.00 | 1.00 | 1.02 | 0.99 | 1.01 | 0.98 |
| xanthosine | ME291568 | 1.03 | 0.98 | 1.01 | 1.00 | 1.00 | 0.99 |
| C18 carnitine | ME291589 | 0.99 | 0.99 | 1.01 | 1.00 | 1.01 | 0.99 |
| C18:1 carnitine | ME291592 | 0.99 | 1.00 | 1.01 | 0.99 | 1.01 | 0.99 |
| C16-OH carnitine | ME291588 | 1.00 | 1.00 | 1.01 | 0.99 | 1.01 | 0.99 |
| C4-OH carnitine | ME291573 | 1.00 | 1.00 | 1.01 | 0.99 | 1.01 | 0.99 |
| C10:2 carnitine | ME291581 | 1.01 | 1.01 | 1.01 | 0.98 | 1.00 | 0.99 |
| C9 carnitine | ME291579 | 1.01 | 1.00 | 1.00 | 0.99 | 1.00 | 0.99 |
| melatonin | ME291498 | 1.01 | 1.00 | 1.00 | 0.98 | 1.01 | 0.99 |
| C20:4 carnitine | ME291594 | 0.98 | 1.00 | 1.01 | 1.01 | 1.00 | 0.99 |
| triiodothyronine | ME291563 | 0.99 | 1.00 | 1.01 | 1.01 | 1.00 | 0.99 |
| 5-methylthioadenosine | ME291504 | 1.01 | 0.99 | 0.99 | 1.01 | 1.01 | 0.98 |
| beta-alanine | ME291516 | 1.01 | 1.00 | 0.99 | 1.01 | 1.01 | 0.99 |
| methionine sulfoxide | ME291543 | 1.00 | 0.98 | 1.00 | 1.01 | 1.00 | 1.00 |
| mevalonic acid | ME291544 | 1.00 | 0.99 | 1.00 | 1.01 | 1.00 | 0.99 |
| C7 carnitine | ME291578 | 1.01 | 0.99 | 1.01 | 1.00 | 1.00 | 0.99 |
| glutamate | ME291529 | 1.01 | 0.98 | 1.00 | 1.00 | 1.01 | 0.99 |
| argininosuccinate | ME291513 | 1.01 | 0.99 | 1.00 | 1.00 | 1.01 | 0.99 |
| aspartate | ME291515 | 1.01 | 0.99 | 1.00 | 1.00 | 1.01 | 0.99 |
| uracil | ME291566 | 1.00 | 1.00 | 0.98 | 1.01 | 1.01 | 1.00 |
| cotinine | ME291522 | 1.00 | 1.00 | 0.98 | 1.01 | 1.00 | 1.01 |
| 3-nitro-L-tyrosine | ME291501 | 1.00 | 1.00 | 0.99 | 1.01 | 0.99 | 1.01 |
| homocysteine | ME291536 | 1.00 | 1.00 | 0.99 | 1.01 | 0.99 | 1.01 |
| sarcosine | ME291554 | 0.99 | 0.99 | 1.01 | 1.00 | 1.01 | 1.01 |
| C3 carnitine | ME291571 | 1.00 | 0.99 | 1.00 | 1.00 | 1.00 | 1.01 |
| C5 carnitine | ME291574 | 1.00 | 0.99 | 1.00 | 1.00 | 1.01 | 1.01 |
| N-carbamoyl-beta-alanine | ME291545 | 1.00 | 0.98 | 1.01 | 1.00 | 1.01 | 1.00 |
| spermine | ME291557 | 1.00 | 0.98 | 1.01 | 1.01 | 1.00 | 1.01 |
| thyroxine | ME291562 | 1.00 | 1.00 | 1.01 | 1.00 | 1.00 | 0.99 |
| kynurenic acid | ME291492 | 1.00 | 1.00 | 1.01 | 1.00 | 1.00 | 1.00 |
| trimethylamine-N-oxide | ME291564 | 1.00 | 1.00 | 1.01 | 1.00 | 1.00 | 1.00 |
| C18:2 carnitine | ME291591 | 0.99 | 1.01 | 1.01 | 1.00 | 1.00 | 1.00 |
| 5-HIAA | ME291497 | 0.99 | 1.00 | 1.01 | 1.00 | 1.00 | 1.00 |
| C16 carnitine | ME291587 | 0.99 | 1.00 | 1.01 | 1.00 | 1.00 | 0.99 |
| adenine | ME291505 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 | 0.99 |
| C20 carnitine | ME291593 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 | 1.00 |
| aminoisobutyric acid | ME291510 | 1.00 | 0.99 | 1.01 | 1.00 | 1.00 | 1.00 |
| C5:1 carnitine | ME291575 | 1.00 | 0.99 | 1.01 | 1.00 | 1.00 | 1.00 |
| tryptophan | ME291491 | 1.00 | 0.99 | 1.00 | 1.00 | 1.00 | 1.00 |
| phenylalanine | ME291549 | 1.00 | 0.99 | 1.00 | 1.00 | 1.00 | 1.00 |
| C4 carnitine | ME291572 | 1.00 | 0.99 | 1.00 | 1.00 | 1.00 | 1.00 |
| dimethylglycine | ME291526 | 1.00 | 0.99 | 1.00 | 1.00 | 1.00 | 1.00 |
| alpha-glycerophosphocholine | ME291509 | 1.00 | 1.01 | 1.00 | 1.01 | 1.00 | 1.00 |
| valine | ME291567 | 1.00 | 1.00 | 1.00 | 1.01 | 1.00 | 1.00 |
| leucine | ME291540 | 1.00 | 1.00 | 1.00 | 1.01 | 1.00 | 1.00 |
| asparagine | ME291514 | 1.00 | 1.00 | 1.00 | 1.01 | 1.00 | 1.00 |
| isoleucine | ME291539 | 1.00 | 1.00 | 1.00 | 1.01 | 1.00 | 1.00 |
| GABA | ME291528 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.01 |
| pipecolic acid | ME291550 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 |
| pyroglutamic acid | ME291553 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 |
| hypoxanthine | ME291538 | 1.01 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| C5-DC carnitine | ME291576 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 | 1.00 |
| creatinine | ME291524 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 | 1.00 |
| tyrosine | ME291565 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| taurine | ME291558 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| serine | ME291556 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| SDMA | ME291555 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| proline | ME291551 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| NMMA | ME291547 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| lysine | ME291541 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| histidine | ME291535 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| guanine | ME291533 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| glycine | ME291531 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| epinephrine | ME291527 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| creatine | ME291523 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| citrulline | ME291521 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| choline | ME291520 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| carnitine | ME291569 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| C2 carnitine | ME291570 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| butyrobetaine | ME291518 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| betaine | ME291517 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| arginine | ME291512 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| alanine | ME291508 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| 1-methylhistamine | ME291499 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| ADMA | ME291507 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| threonine | ME291560 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 |
| methionine | ME291542 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 |
| histamine | ME291534 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 |
| 5-aminolevulinic acid | ME291503 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 |
| C26 carnitine | ME291596 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 |
| guanidinoacetic acid | ME291532 | 0.99 | 1.01 | 0.99 | 1.00 | 0.99 | 1.01 |
| adenosine | ME291506 | 1.00 | 1.02 | 0.99 | 1.00 | 0.99 | 1.00 |
| serotonin | ME291496 | 1.00 | 1.01 | 0.99 | 1.00 | 0.99 | 1.00 |
| glutamine | ME291530 | 1.00 | 1.01 | 0.99 | 1.00 | 1.00 | 1.00 |
| ornithine | ME291548 | 1.00 | 1.01 | 1.00 | 1.00 | 1.00 | 1.00 |
| cytosine | ME291525 | 1.00 | 0.98 | 0.99 | 1.02 | 1.00 | 1.02 |
| thiamine | ME291559 | 0.99 | 0.99 | 0.99 | 1.02 | 1.00 | 1.02 |
| S-adenosylhomocysteine | ME291502 | 0.98 | 0.99 | 1.00 | 1.01 | 1.02 | 1.01 |
| 3-hydroxyanthranilic acid | ME291494 | 0.99 | 0.99 | 0.99 | 1.00 | 1.00 | 1.02 |
| niacinamide | ME291546 | 0.99 | 1.00 | 0.99 | 0.99 | 1.01 | 1.01 |
| putrescine | ME291552 | 1.02 | 1.00 | 1.01 | 0.97 | 0.99 | 1.00 |
| thymidine | ME291561 | 1.01 | 1.00 | 1.01 | 1.00 | 0.97 | 1.00 |
Factors:
| F1 | Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- |
| F2 | Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 |
| F3 | Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- |
| F4 | Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 |
| F5 | Time point:week 6 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- |
| F6 | Time point:week 6 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 |
