Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for K13 mutations driving artemisinin resistance rewrite Plasmodium falciparum’s programmed intra-erythrocytic development and transform mitochondrial physiology (Study ST001279)

Reversed phase NEGATIVE ION MODE (Analysis AN002120)

Metabolite	Structure	F1	F2	F3	F4
glucosamine	ME300706	0.89	0.44	0.96	4.85
DLS	ME300792	0.46	0.39	1.61	2.94
citrate/isocitrate	ME300734	0.88	0.85	0.98	3.23
Citraconic acid	ME300745	0.90	0.61	0.92	3.11
4-Pyridoxic acid	ME300722	1.00	0.67	1.02	3.24
acetyl-CoA	ME300715	1.00	0.61	1.01	3.31
UDP-D-glucuronate	ME300713	1.02	0.45	1.11	4.00
acetylphosphate	ME300712	1.02	0.49	1.04	3.65
IMP	ME300725	1.04	0.57	1.03	3.59
Acetyllysine	ME300784	0.79	0.47	1.74	0.46
UDP	ME300778	0.76	1.58	0.79	0.51
CDP	ME300777	0.78	1.37	0.85	NA
lactate	ME300783	0.88	1.25	0.89	NA
3-phosphoglycerate	ME300714	1.16	0.71	1.13	NA
fumarate	ME300775	1.15	0.68	1.17	NA
orotate	ME300779	1.02	1.07	0.92	NA
riboflavin	ME300742	0.88	0.90	1.21	NA
NAD+	ME300773	0.93	0.98	1.09	NA
GDP	ME300709	0.98	0.88	1.14	NA
Octoluse Bisphosphate	ME300769	1.04	0.89	1.08	NA
biotin	ME300735	0.89	0.86	1.10	2.23
Guanidoacetic acid	ME300730	0.99	0.80	1.03	2.26
Phenyllactic acid	ME300740	0.98	0.72	1.09	2.21
4-hydroxyphenyllactate	ME300710	0.95	0.73	0.99	2.20
cyclic-AMP	ME300762	0.94	0.75	1.02	2.18
Acetylcarnitine	ME300776	1.05	0.76	1.03	1.89
NADP+	ME300767	1.05	0.71	1.11	1.82
phenylpyruvate	ME300701	1.04	0.70	1.04	1.78
2-Hydroxy-2-methylbutanedioic acid	ME300708	1.04	0.57	1.11	1.98
aconitate	ME300705	1.03	0.55	1.13	2.00
Pyrophosphate	ME300721	0.98	0.83	1.03	2.01
acetyl-aspartate	ME300726	1.06	0.65	0.99	2.04
2,3-Diphosphoglyceric acid	ME300720	1.07	0.70	1.05	2.03
N-acetyl-glutamate	ME300760	1.09	0.72	1.04	2.00
2-oxo-4-methylthiobutanoate	ME300700	0.95	0.65	0.98	2.03
xylose/ribose	ME300718	1.00	0.69	1.03	1.99
tyrosine	ME300707	0.93	0.76	1.16	1.51
glutathione disulfide	ME300717	1.06	0.67	1.08	1.62
Kynurenic acid	ME300727	1.06	0.73	1.03	1.62
ADP-D-glucose	ME300702	1.13	0.64	1.13	1.54
fructose-1,6-bisphosphate	ME300703	1.11	0.60	1.16	1.65
guanine	ME300747	0.94	1.02	0.84	1.83
IDP	ME300699	0.95	1.00	0.97	1.73
folate	ME300744	0.86	0.90	1.00	1.89
leucine/isoleucine	ME300736	0.97	0.85	0.93	1.80
pyridoxine	ME300737	1.03	0.86	0.96	1.65
UDP-N-acetyl-glucosamine	ME300770	0.97	0.89	0.99	1.55
indole	ME300728	0.93	0.87	1.11	1.65
LD	ME300750	0.88	0.78	1.13	1.78
PE	ME300789	0.60	0.84	1.22	2.26
phosphoenolpyruvate	ME300716	1.12	0.58	1.08	2.40
Sedoheptoluse bisphosphate	ME300704	1.07	0.57	1.15	2.40
glycodeoxycholic acid	ME300738	0.91	0.85	0.97	2.72
hypoxanthine	ME300746	0.97	0.79	0.97	2.63
pantothenate	ME300732	0.93	0.80	1.04	2.66
dGTP	ME300724	1.00	0.72	1.03	2.46
a-ketoglutarate	ME300759	0.94	0.77	0.91	2.40
N-carbamoyl-L-aspartate	ME300749	0.87	0.75	0.98	2.51
4-phosphopantothenate	ME300761	0.83	0.84	1.02	2.88
dGDP	ME300723	1.01	0.70	1.00	2.79
malate	ME300711	1.09	0.59	1.06	2.78
DLH	ME300786	0.57	0.46	1.74	1.43
PEE	ME300788	0.72	0.48	1.61	1.55
N-acetyl-L-ornithine	ME300785	0.70	0.52	1.70	1.16
PVNF	ME300787	0.58	0.30	1.80	1.16
PD	ME300790	0.77	0.70	1.38	1.47
SD	ME300791	0.64	0.62	1.49	1.84
xanthine	ME300743	0.74	1.09	1.07	1.34
6-phospho-D-gluconate	ME300719	1.11	0.74	1.09	1.13
xanthosine-5-phosphate	ME300780	0.99	0.92	1.07	1.13
methionine	ME300729	0.96	0.88	1.10	1.17
valine	ME300731	0.98	0.87	1.08	1.20
FAD	ME300766	1.00	0.86	1.08	1.38
UDP-D-glucose	ME300771	0.98	0.89	1.01	1.44
pyruvate	ME300781	0.98	0.97	1.01	1.29
proline	ME300733	0.99	0.90	1.04	1.26
hydroxyproline	ME300757	1.00	0.93	1.00	1.27
Inositol	ME300764	1.01	0.92	0.99	1.27
aspartate	ME300763	1.05	0.89	0.94	1.30
ornithine	ME300748	0.99	0.96	0.93	1.33
arginine	ME300751	0.90	1.07	0.99	1.18
asparagine	ME300753	0.99	1.03	0.97	1.07
glutamine	ME300752	0.96	1.07	0.97	1.03
histidine	ME300755	0.98	0.99	1.03	1.00
serine	ME300754	1.03	0.95	1.00	1.07
threonine	ME300756	1.03	0.93	1.02	1.05
2-dehydro-D-gluconate	ME300698	1.18	0.85	1.01	0.81
N-acetyl-glutamine	ME300772	1.23	0.90	0.86	0.94
tryptophan	ME300741	0.95	0.82	1.29	0.69
DL-Pipecolic Acid	ME300758	1.02	0.91	1.10	0.77
Pyroglutamic acid	ME300768	0.98	0.94	1.11	0.68
uridine	ME300782	0.88	1.19	1.02	0.60
dihydroorotate	ME300774	1.16	0.85	1.22	0.32
taurine	ME300793	1.10	0.98	1.01	0.44
D-sedoheptulose-1/7-phosphate	ME300739	1.00	1.02	1.15	0.38
phenylalanine	ME300765	1.04	0.89	1.14	0.38

Factors:

F1	Treatment:350nM DHA
F2	Treatment:70nM DHA
F3	Treatment:DMSO
F4	Treatment:None

Data matrix