Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses (Study ST001289)

Several methods (Analysis AN002142)

Metabolite	Structure	F1	F2	F3	F4
24S-Hydroxycholesterol	ME301863	3.15	0.35	0.20	0.13
Zymosterol	ME302119	3.13	0.38	0.15	0.17
CE(14:0)	ME301882	2.88	0.12	0.77	0.02
EPA	ME301936	2.68	0.29	0.92	0.12
Cholestenone	ME301913	2.39	NA	0.89	0.79
Desmosterol	ME301931	2.36	0.47	0.52	0.55
PG(34:2)	ME302038	2.47	0.40	0.69	0.44
15-Deoxy-delta-12,14-PGJ2	ME301857	1.89	1.90	0.10	0.11
CE(14:1)	ME301883	1.59	0.03	0.58	0.01
CL(68:5)	ME301917	1.13	NA	0.94	0.35
CL(68:4)	ME301916	0.95	NA	1.05	NA
CL(72:4)	ME301921	1.00	NA	1.00	NA
CE(20:4)	ME301893	1.30	1.16	1.45	0.09
PI(38:2)	ME302063	1.15	0.56	1.72	0.57
PS(40:7)	ME302094	1.17	0.68	1.55	0.60
CE(20:0)	ME301890	1.30	0.63	1.86	0.21
CL(70:5)	ME301919	1.44	0.50	1.67	0.39
CE(16:1)	ME301885	2.32	0.28	1.35	0.05
CE(16:2)	ME301886	2.33	0.18	1.47	0.02
GlcCer(d18:0/26:0)	ME301944	1.64	0.28	1.03	0.36
7,10,13,16,19-Docosapentaenoic acid	ME301869	1.81	0.62	1.24	0.33
Myristic acid	ME301960	1.84	0.55	1.20	0.41
PE(32:1)	ME302013	1.78	0.53	1.19	0.50
Lauric acid	ME301955	1.93	0.37	1.11	0.59
Stearidonic acid	ME302116	1.97	0.47	1.08	0.42
CE(16:0)	ME301884	2.29	0.56	0.95	0.19
CE(18:2)	ME301889	1.88	0.82	1.20	0.10
CE(20:2)	ME301892	1.92	0.84	1.11	0.14
CE(20:1)	ME301891	1.90	0.63	1.35	0.12
CE(22:1)	ME301894	1.96	0.57	1.38	0.09
CE(18:0)	ME301887	2.05	0.63	1.18	0.15
CE(18:1)	ME301888	2.09	0.54	1.28	0.09
CE(22:6)	ME301895	2.15	0.54	1.26	0.05
10Z-Heptadecenoic acid	ME301847	2.24	0.38	1.24	0.14
Palmitoleic acid	ME301981	2.04	0.46	1.25	0.25
Pentadecylic acid	ME302037	2.06	0.39	1.27	0.28
GlcCer(d18:0/24:0)	ME301942	1.48	0.23	1.05	0.95
PG(38:5)	ME302045	1.61	0.96	0.55	0.87
PG(40:8)	ME302050	1.56	0.92	0.52	1.00
PG(38:2)	ME302042	1.70	0.51	0.93	0.85
PG(38:3)	ME302043	1.65	0.60	0.86	0.88
Cer(d18:0/26:0)	ME301902	1.81	0.58	0.81	0.59
Lanosterol	ME301954	1.89	0.63	0.89	0.79
PG(38:4)	ME302044	1.80	0.68	0.79	0.74
PG(36:1)	ME302039	2.14	0.37	0.84	0.66
Cholesterol	ME301914	1.99	0.78	0.62	0.61
PG(40:7)	ME302049	2.05	0.58	0.69	0.68
PA(32:1)	ME301964	1.66	0.57	1.23	0.53
Sphinganine	ME302111	1.49	0.67	1.19	0.62
PC(32:2)	ME301984	1.54	0.60	1.25	0.60
PE(32:2)	ME302014	1.49	0.59	1.33	0.59
Palmitic acid	ME301980	1.44	0.82	1.13	0.61
PC(32:1)	ME301983	1.45	0.77	1.15	0.63
Cer(d18:0/24:1)	ME301901	1.55	0.76	1.08	0.61
PE(38:5)	ME302024	1.53	0.75	1.02	0.71
Cer(d18:0/16:0)	ME301896	1.46	0.80	1.08	0.67
PC(P-38:5)/PC(O-38:6)	ME302011	1.47	0.76	1.06	0.72
Cer(d18:1/26:1)	ME301911	1.66	0.70	0.99	0.65
Cer(d18:0/24:0)	ME301900	1.65	0.78	1.03	0.53
Margaric acid	ME301959	1.66	0.73	1.09	0.52
Behenic acid	ME301880	1.61	1.00	0.85	0.55
Lignoceric acid	ME301956	1.52	1.05	0.82	0.61
Nervonic acid	ME301961	1.55	1.02	0.82	0.61
alpha-Linolenic acid	ME301876	1.40	1.16	0.74	0.70
Cer(d18:0/20:0)	ME301898	1.50	1.13	0.72	0.64
25-Hydroxycholesterol	ME301864	1.62	0.76	0.68	0.38
Tricosanoic acid	ME302117	1.81	0.79	0.91	0.49
7alpha-Hydroxy-cholesterol	ME301870	1.76	0.89	0.84	0.51
Cer(d18:0/22:0)	ME301899	1.72	0.89	0.78	0.60
DHA	ME301932	1.69	0.85	0.99	0.47
Bishomo-gamma-linolenic acid	ME301881	1.63	0.93	0.90	0.53
gamma-Linolenic acid	ME301937	1.68	0.87	0.91	0.53
GlcCer(d18:0/22:0)	ME301941	1.34	0.68	0.97	0.97
PG(40:6)	ME302048	1.43	0.76	0.85	0.96
15-Deoxy-delta-12,14-PGD2	ME301856	1.35	0.98	0.67	1.00
Cer(d18:1/18:0)	ME301905	1.27	1.01	0.74	0.98
PG(36:3)	ME302041	1.27	0.93	0.80	1.00
27-Hydroxycholesterol	ME301865	1.40	0.87	0.68	0.83
Cer(d18:0/18:0)	ME301897	1.51	0.94	0.79	0.75
Cerotic acid	ME301912	1.44	1.01	0.81	0.74
Cer(d18:1/24:0)	ME301908	1.42	0.92	0.84	0.82
PE(38:6)	ME302025	1.47	0.85	0.88	0.77
PE(O-32:0)	ME302028	1.48	0.83	0.87	0.83
PC(36:1)	ME301990	1.22	0.94	1.02	0.81
Cer(d18:1/16:0)	ME301904	1.25	0.91	0.96	0.88
PC(38:5)	ME301997	1.21	0.92	1.00	0.87
LTE4	ME301958	1.22	0.82	1.01	0.95
Cer(d18:1/26:0)	ME301910	1.31	0.83	0.99	0.87
PA(40:6)	ME301979	1.25	0.84	1.01	0.89
SM(d18:0/24:0)	ME302099	1.20	1.02	0.87	0.91
Cer(d18:1/22:0)	ME301907	1.34	0.92	0.91	0.82
PC(38:6)	ME301998	1.28	0.96	0.93	0.83
PC(P-36:4)/PC(O-36:5)	ME302007	1.30	0.97	0.93	0.80
Cer(d18:1/20:0)	ME301906	1.32	0.95	0.85	0.87
PE(40:6)	ME302027	1.30	0.93	0.85	0.91
SM(d18:0/22:0)	ME302098	1.29	0.95	0.86	0.90
SM(d18:1/22:0)	ME302106	1.24	0.98	0.91	0.87
PC(34:3)	ME301988	1.28	0.92	0.92	0.89
SM(d18:1/20:0)	ME302105	1.28	0.94	0.91	0.87
cis-Erucic acid	ME301915	1.40	1.00	0.98	0.62
Cer(d18:0/26:1)	ME301903	1.29	1.00	1.01	0.70
Arachidic acid	ME301877	1.28	1.09	0.94	0.68
Stearic acid	ME302115	1.24	1.05	0.93	0.78
CL(70:6)	ME301920	1.34	0.71	1.16	0.79
PS(32:1)	ME302074	1.31	0.67	1.41	0.61
PI(36:5)	ME302061	1.35	0.66	1.33	0.66
22R-Hydroxycholesterol	ME301861	1.31	0.69	1.27	0.63
PI(38:6)	ME302067	1.30	0.75	1.30	0.65
PC(P-36:0)/PC(O-36:1)	ME302003	1.20	0.66	1.34	0.80
PE(P-38:1)/PE(O-38:2)	ME302034	1.21	0.70	1.29	0.79
PE(P-36:0)/PE(O-36:1)	ME302029	1.27	0.66	1.32	0.75
PG(36:2)	ME302040	1.30	0.68	1.26	0.75
PI(38:3)	ME302064	1.16	0.77	1.31	0.76
PS(38:5)	ME302088	1.18	0.75	1.34	0.73
PC(36:0)	ME301989	1.20	0.82	1.23	0.75
PI(38:5)	ME302066	1.23	0.77	1.26	0.74
PI(36:0)	ME302056	1.05	0.83	1.28	0.84
PI(40:6)	ME302071	1.08	0.85	1.26	0.81
CL(70:4)	ME301918	1.04	0.85	1.32	0.80
PI(40:7)	ME302072	1.01	0.84	1.36	0.80
PC(P-38:1)/PC(O-38:2)	ME302008	1.06	0.74	1.25	0.95
PE(P-36:2)/PE(O-36:3)	ME302031	1.04	0.75	1.28	0.94
PE(P-36:1)/PE(O-36:2)	ME302030	1.14	0.70	1.29	0.87
PC(P-36:1)/PC(O-36:2)	ME302004	1.18	0.75	1.18	0.89
PS(36:3)	ME302081	1.14	0.79	1.24	0.84
Dolichol-19	ME301934	1.10	0.92	1.18	0.79
Sphingosine	ME302113	1.18	0.88	1.14	0.79
Dolichol-18	ME301933	1.25	0.86	1.17	0.72
PC(40:6)	ME302002	1.25	0.81	1.12	0.82
GlcCer(d18:1/22:0)	ME301949	1.03	1.02	1.03	0.91
PA(40:5)	ME301978	1.03	1.02	1.05	0.90
PS(34:1)	ME302076	1.03	0.91	1.10	0.96
PC(34:0)	ME301985	1.06	0.95	1.05	0.95
PE(34:0)	ME302015	1.06	0.95	1.07	0.92
Oleic acid	ME301962	1.13	0.96	1.08	0.83
CL(72:6)	ME301923	1.13	0.87	1.08	0.92
PE(34:1)	ME302016	1.15	0.89	1.08	0.89
SM(d18:0/18:0)	ME302096	1.12	0.90	1.04	0.94
SM(d18:1/18:0)	ME302104	1.13	0.95	1.01	0.92
Dolichol-20	ME301935	1.01	1.01	1.16	0.82
PS(40:6)	ME302093	1.00	0.96	1.21	0.83
Sphinganine-1-phosphate	ME302112	1.04	0.95	1.20	0.80
PE(P-38:2)/PE(O-38:3)	ME302035	1.03	0.86	1.17	0.94
PI(34:1)	ME302054	1.07	0.89	1.16	0.88
11-HETE	ME301849	0.70	1.30	1.08	0.92
GlcCer(d18:0/18:0)	ME301939	0.66	1.17	1.46	0.87
CL(72:5)	ME301922	0.73	1.11	1.15	1.01
PS(38:2)	ME302085	0.73	1.04	1.13	1.10
PS(40:2)	ME302089	0.78	1.05	1.29	0.87
GlcCer(d18:1/18:0)	ME301947	0.85	0.99	1.22	0.93
PS(38:0)	ME302083	0.84	1.00	1.25	0.91
PS(36:0)	ME302078	0.80	1.03	1.25	0.92
PS(40:5)	ME302092	0.84	1.03	1.25	0.88
PI(40:5)	ME302070	0.93	0.90	1.22	0.95
PA(36:0)	ME301968	0.86	0.90	1.23	1.02
PA(38:2)	ME301973	0.81	0.89	1.21	1.09
Linoleic acid	ME301957	1.03	1.43	0.61	0.93
PC(36:4)	ME301993	1.10	1.18	0.65	1.07
PE(38:4)	ME302023	1.02	1.15	0.67	1.16
SM(d18:0/20:0)	ME302097	1.13	1.01	0.93	0.93
PC(34:1)	ME301986	1.17	0.97	0.92	0.95
PE(36:1)	ME302018	1.14	0.98	0.89	0.99
PE(36:4)	ME302021	1.15	0.98	0.89	0.97
PE(34:2)	ME302017	1.17	0.92	0.94	0.97
Cer(d18:1/24:1)	ME301909	1.10	0.94	0.99	0.96
PE(36:3)	ME302020	1.12	0.94	0.95	0.99
SM(d18:0/16:0)	ME302095	1.10	0.97	0.96	0.98
SM(d18:1/16:0)	ME302103	1.06	1.04	0.94	0.96
PC(P-38:4)/PC(O-38:5)	ME302010	1.11	1.03	0.84	1.02
PE(32:0)	ME302012	1.07	1.03	0.88	1.02
SM(d18:1/24:0)	ME302107	1.08	1.06	0.87	0.99
GlcCer(d18:0/16:0)	ME301938	1.10	1.04	0.86	0.99
SM(d18:0/24:1)	ME302100	1.10	1.03	0.87	1.00
PC(P-36:2)/PC(O-36:3)	ME302005	1.08	0.98	0.90	1.04
PE(36:2)	ME302019	1.07	0.98	0.94	1.00
4beta-Hydroxy-cholesterol	ME301866	0.90	1.12	0.94	1.03
PC(38:3)	ME301995	0.98	1.05	0.86	1.11
SM(d18:1/24:1)	ME302108	0.98	1.11	0.88	1.03
PI(38:4)	ME302065	0.96	1.09	0.89	1.06
PS(36:4)	ME302082	0.99	1.07	0.89	1.05
SM(d18:0/26:1)	ME302102	0.94	1.10	0.87	1.09
SM(d18:1/26:0)	ME302109	0.97	1.10	0.84	1.09
PC(32:0)	ME301982	0.99	1.10	0.85	1.06
SM(d18:1/26:1)	ME302110	0.98	1.10	0.85	1.07
PC(P-36:3)/PC(O-36:4)	ME302006	1.10	1.13	0.73	1.04
SM(d18:0/26:0)	ME302101	1.01	1.14	0.81	1.04
20-HETE	ME301860	1.07	1.16	0.77	1.00
PI(36:4)	ME302060	1.05	1.15	0.81	1.00
PC(34:2)	ME301987	1.09	1.05	0.75	1.10
PE(38:3)	ME302022	1.06	1.06	0.80	1.08
PE(40:5)	ME302026	1.03	1.08	0.81	1.07
PC(36:3)	ME301992	1.02	1.08	0.75	1.15
PC(38:4)	ME301996	1.04	1.02	0.74	1.20
PC(38:2)	ME301994	1.05	0.83	1.08	1.04
PA(34:1)	ME301966	1.00	0.80	1.08	1.12
PA(36:3)	ME301971	1.00	0.78	1.08	1.14
PC(P-38:2)/PC(O-38:3)	ME302009	0.97	0.91	1.04	1.08
PA(38:3)	ME301974	1.02	0.94	1.04	1.00
PS(34:2)	ME302077	1.01	0.93	1.03	1.03
PA(34:2)	ME301967	1.01	0.86	1.00	1.13
PA(36:1)	ME301969	0.98	0.93	0.94	1.15
GlcCer(d18:1/24:1)	ME301951	0.87	1.08	1.03	1.02
PE(P-36:3)/PE(O-36:4)	ME302032	0.85	1.03	1.08	1.04
GlcCer(d18:1/16:0)	ME301946	0.94	1.04	1.04	0.98
PS(36:1)	ME302079	0.95	1.04	1.00	1.02
PI(34:2)	ME302055	0.97	1.01	1.01	1.01
PS(38:1)	ME302084	0.98	1.01	1.01	1.01
PI(36:1)	ME302057	0.93	0.98	1.11	0.99
PS(38:3)	ME302086	0.94	1.03	1.11	0.93
Sphingosine-1-phosphate	ME302114	0.97	1.00	1.09	0.95
Arachidonoyl-EA	ME301879	1.00	1.18	0.91	0.91
GlcCer(d18:1/24:0)	ME301950	1.03	1.11	0.93	0.92
Arachidonic acid	ME301878	0.98	1.12	1.04	0.86
GlcCer(d18:1/20:0)	ME301948	0.90	1.15	1.06	0.89
PA(34:0)	ME301965	1.04	0.97	0.65	1.35
PG(40:5)	ME302047	0.99	0.92	0.70	1.38
CL(74:8)	ME301928	0.76	1.12	0.73	1.39
PA(32:0)	ME301963	0.89	1.05	0.73	1.33
PS(38:4)	ME302087	0.79	1.34	0.76	1.12
PS(32:0)	ME302073	0.69	1.22	0.81	1.29
PS(34:0)	ME302075	0.69	1.22	0.84	1.25
PA(38:4)	ME301975	0.86	1.18	0.79	1.17
PI(40:3)	ME302068	0.85	1.07	0.84	1.25
PS(36:2)	ME302080	0.80	1.14	0.81	1.26
CL(74:6)	ME301926	0.83	1.02	0.83	1.11
PI(36:2)	ME302058	0.81	1.16	0.91	1.12
PI(36:3)	ME302059	0.82	1.14	0.87	1.17
GlcCer(d18:1/26:1)	ME301953	0.80	1.08	1.00	1.12
PE(P-36:4)/PE(O-36:5)	ME302033	0.86	1.08	0.96	1.10
PA(36:4)	ME301972	0.85	1.10	0.92	1.13
PE(P-38:4)/PE(O-38:5)	ME302036	0.83	1.11	0.93	1.13
PA(36:2)	ME301970	0.77	0.97	0.94	1.33
PC(40:3)	ME301999	0.79	1.02	0.88	1.32
GlcCer(d18:0/24:1)	ME301943	0.95	0.93	0.86	1.30
GlcCer(d18:1/26:0)	ME301952	0.91	0.98	0.92	1.19
PC(40:5)	ME302001	0.90	0.94	0.94	1.23
2,3-Dinor-TXB2	ME301859	0.87	1.68	0.79	0.59
13,16,19-Docosatrienoic acid	ME301853	1.25	1.23	0.82	0.70
5,8,11-Eicosatrienoic acid	ME301867	1.12	1.33	0.82	0.73
PI(38:1)	ME302062	0.39	0.92	1.48	1.14
TXB2	ME302118	0.37	0.95	1.55	1.13
GlcCer(d18:0/26:1)	ME301945	0.52	0.96	1.13	1.26
PC(36:2)	ME301991	0.44	1.08	1.19	1.28
8-HETE	ME301874	0.68	0.97	1.84	0.51
5-HETE	ME301868	0.53	0.92	1.80	0.76
GlcCer(d18:0/20:0)	ME301940	0.71	0.73	1.89	0.68
15S-HETE	ME301858	0.17	1.20	1.87	0.75
PGD2	ME302051	0.33	1.37	1.56	0.74
PGE2	ME302052	0.25	1.95	1.05	0.75
CL(72:8)	ME301925	0.43	1.43	0.35	1.79
PS(40:4)	ME302091	0.34	1.80	0.47	1.39
CL(74:7)	ME301927	0.48	1.64	0.53	1.35
PA(40:4)	ME301977	0.48	1.61	0.48	1.44
12-HETE	ME301851	0.54	1.87	0.63	0.96
13Z,16Z-Docosadienoic acid	ME301854	0.56	1.95	0.35	1.14
11Z,14Z-Eicosadienoic acid	ME301850	0.65	1.80	0.40	1.16
Adrenic acid	ME301875	0.65	1.87	0.42	1.05
PC(40:4)	ME302000	0.62	1.19	0.70	1.49
CL(72:7)	ME301924	0.72	1.23	0.65	1.40
PA(40:3)	ME301976	0.69	1.26	0.68	1.37
CL(74:9)	ME301929	0.66	1.30	0.56	1.48
PI(40:4)	ME302069	0.55	1.39	0.61	1.44
Coenzyme Q9	ME301930	0.53	1.37	0.94	1.16
PS(40:3)	ME302090	0.57	1.58	0.80	1.04
14(15)-EpETE	ME301855	0.75	0.91	NA	1.31
11(12)-EpETE	ME301848	0.69	1.09	NA	1.22
12-Oxo-ETE	ME301852	0.81	1.11	NA	1.05
PG(40:4)	ME302046	1.36	1.66	0.39	0.81
24,25-Epoxycholesterol	ME301862	1.39	1.26	0.32	1.04
PGJ2	ME302053	1.14	1.30	0.30	1.27

Factors:

F1	Genotype:LDLR-KO \| Diet:High fat
F2	Genotype:LDLR-KO \| Diet:Normal
F3	Genotype:Wild type \| Diet:High fat
F4	Genotype:Wild type \| Diet:Normal

Data matrix