Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for SS-31 and NMN: Two Paths to Improve Metabolism and Function in Aged Hearts (Study ST001329)

HILIC UNSPECIFIED ION MODE (Analysis AN002215)

Metabolite	Structure	F1	F2	F3	F4	F5
Serotonin	ME309612	0.58	0.43	0.63	3.73	0.41
DCMP	ME309504	0.79	1.09	0.37	2.28	0.89
Reduced glutathione	ME309604	0.75	0.88	0.45	2.36	0.97
1-methylnicotinamide	ME309455	1.57	0.69	0.69	1.73	0.56
Anserine	ME309479	0.85	0.95	0.77	0.78	1.55
Carnosine	ME309492	0.74	0.89	0.70	0.83	1.74
Trimethylamine-N-oxide (TMAO)	ME309625	1.11	1.04	1.34	1.07	0.47
Cystine	ME309502	0.97	1.58	1.17	0.83	0.49
methionine sulfoxide	ME309563	1.08	1.19	1.42	0.54	0.65
L-Kynurenine	ME309556	1.17	0.81	1.08	1.30	0.71
3-Indoxyl Sulfate	ME309463	1.35	1.04	0.83	1.26	0.65
Lactose/Trehalose	ME309552	1.09	1.14	0.99	1.26	0.63
Erythrose-4-phosphate	ME309514	1.07	1.21	0.96	1.23	0.64
G1P/G6P/F6P/F1P	ME309520	1.07	1.19	0.98	1.25	0.63
Glucose	ME309523	1.05	1.08	0.78	1.34	0.88
Mannose	ME309561	1.13	1.11	0.86	1.23	0.77
N-Acetyl-aspartyl-glutamate (naag)	ME309570	0.78	1.32	0.93	0.96	1.03
Sedoheptulose 7-phosphate	ME309610	0.94	1.02	1.21	1.06	0.78
Pipecolate	ME309596	0.97	1.18	1.14	1.02	0.71
Putrescine	ME309599	1.06	1.16	1.13	1.02	0.67
Glycerol-3-P	ME309528	1.18	1.01	1.01	0.96	0.84
2/3-Phosphoglyceric Acid	ME309456	1.10	1.05	0.96	1.04	0.88
Indole-3-Lactate	ME309545	1.12	1.06	0.96	1.07	0.83
1/3-Methylhistidine	ME309451	1.12	1.14	1.03	0.99	0.75
Orotate	ME309587	1.08	1.07	1.10	0.92	0.82
cAMP	ME309490	1.11	1.19	0.89	0.94	0.89
D-GA3P	ME309507	1.16	1.27	0.92	0.99	0.71
DHAP	ME309508	1.15	1.24	0.91	1.01	0.75
N-AcetylGlycine	ME309571	1.10	0.87	0.77	1.37	1.00
Methylmalonate	ME309564	0.85	1.05	0.76	1.31	1.13
n-isobutyrylglycine	ME309583	0.88	1.07	0.83	1.28	1.04
NADPH	ME309578	0.99	1.12	0.87	1.15	0.93
2-hydroxybutyrate	ME309459	1.04	0.91	0.88	1.26	0.98
6-phosphogluconic acid	ME309468	0.98	1.03	0.86	1.17	1.03
Glycerophosphocholine	ME309529	1.02	0.97	0.90	1.16	1.00
Guanidinoacetate	ME309533	1.06	0.95	0.88	1.13	1.03
Acetylcarnitine	ME309470	0.95	0.82	0.97	1.18	1.11
isoValeric Acid /4-oxobutanoate/acetoacetate	ME309549	0.90	0.92	0.86	1.15	1.20
Thiamine pyrophosphate	ME309620	0.88	1.03	0.91	1.10	1.12
Ergocalciferol	ME309512	1.26	0.75	1.03	0.83	1.06
mannitol	ME309560	1.17	0.85	1.07	0.87	0.99
Sorbitol	ME309613	1.17	0.91	1.03	0.81	1.01
NADP	ME309577	1.17	0.90	0.90	0.88	1.10
Tetrahydrobiopterin	ME309618	1.21	0.89	0.81	1.00	1.09
3HBA	ME309461	1.11	0.86	0.88	1.03	1.12
Ethylmalonic acid	ME309516	1.11	0.88	0.85	0.95	1.18
Linoleic Acid	ME309554	1.13	0.99	0.87	1.04	0.99
Linolenic Acid	ME309555	1.16	0.96	0.86	1.04	0.99
Adenylosuccinate	ME309473	1.15	1.04	0.75	1.03	1.06
AMP	ME309478	1.04	1.02	0.76	1.09	1.12
Cystathionine	ME309501	0.78	1.05	1.05	0.87	1.19
Aspartic Acid	ME309485	0.97	1.02	1.00	0.78	1.17
Citrulline	ME309496	0.95	0.91	0.92	1.02	1.18
5^-methylthioadenosine	ME309466	0.91	0.94	0.91	0.97	1.24
S-adenosylmethionine (SAM)	ME309608	0.92	1.00	0.92	0.95	1.19
Glutamic acid	ME309524	0.93	0.95	1.04	0.90	1.13
Mevalonate	ME309565	0.92	0.95	1.00	0.93	1.15
ADP	ME309474	0.93	0.92	0.97	0.94	1.20
Cholesteryl sulfate	ME309494	0.92	0.87	1.00	0.93	1.23
indole-3-carboxylic acid	ME309544	0.86	0.97	1.15	1.13	0.91
phosphocreatine	ME309594	0.90	0.87	1.16	1.11	0.98
Deoxyguanosine	ME309506	0.96	1.17	1.03	0.91	0.93
riboflavin	ME309605	1.05	1.15	0.98	0.83	0.97
N-Carbamoyl-B-Alanine	ME309579	1.04	0.88	1.08	1.07	0.94
n-glycylproline	ME309581	1.11	0.88	1.03	1.09	0.91
3-hydroxyisovaleric acid	ME309462	1.13	0.82	1.04	1.04	0.97
isovalerylcarnitine	ME309550	1.11	0.87	1.10	0.98	0.92
Urate	ME309632	1.11	0.85	1.09	1.05	0.90
Ornithine	ME309586	0.92	0.96	1.15	0.93	1.00
Oxidized glutathione	ME309588	0.93	0.95	1.18	0.89	1.00
gamma-Aminobutyrate	ME309521	0.94	0.92	1.17	1.02	0.94
2-aminoisobutyric acid	ME309457	0.94	0.95	1.19	0.97	0.93
Hypoxanthine	ME309542	0.93	0.93	1.17	0.97	0.96
1-methylguanidine	ME309453	0.98	0.88	1.07	0.95	1.08
ethanolamine	ME309515	0.90	0.91	1.11	1.00	1.06
Argininosuccinate	ME309483	0.92	0.95	1.09	0.99	1.04
Betaine Aldehyde	ME309489	0.91	0.95	1.08	0.96	1.07
Choline	ME309495	0.92	0.93	1.11	0.95	1.06
Pyroglutamic Acid	ME309602	1.02	0.95	1.00	0.85	1.11
1-Methyladenosine	ME309452	1.01	0.93	1.07	0.89	1.05
SAH	ME309609	0.95	0.97	1.09	0.88	1.06
arabitol/xylitol	ME309480	1.06	1.07	0.97	0.93	0.96
Palmitic Acid	ME309589	1.08	1.02	0.93	0.97	1.00
dimethylarginine (A/SDMA)	ME309509	1.07	0.97	0.97	0.97	1.01
Glycerate	ME309527	1.06	1.00	0.97	1.01	0.97
Phosphoadenosine phosphosulfate	ME309593	0.95	0.91	1.03	1.07	1.05
Inositol	ME309547	0.96	0.97	1.00	1.03	1.04
ATP	ME309486	0.96	0.93	1.03	1.03	1.05
N6-Trimethyllysine	ME309568	0.94	0.95	1.03	1.00	1.06
Tryptophan	ME309626	1.01	0.94	1.05	0.99	1.00
1-Methylhistamine	ME309454	1.04	0.93	1.02	0.97	1.02
Tyrosine	ME309627	1.05	0.97	1.02	0.96	0.99
Histidine	ME309537	1.00	0.98	1.05	1.00	0.98
Inosine	ME309546	0.97	0.99	1.04	1.00	1.00
Glutamine	ME309525	0.99	1.00	1.03	0.99	0.98
Creatine	ME309498	0.99	0.99	1.02	0.99	1.00
Taurine	ME309616	1.00	1.00	1.01	0.98	1.01
lactate	ME309551	0.99	1.00	0.98	1.05	0.99
Ribose-5-P	ME309606	1.01	1.02	0.98	1.00	0.99
N-Ac-L-Glutamine	ME309573	1.06	0.94	0.93	1.03	1.04
Niacinamide	ME309582	1.01	0.99	0.92	1.04	1.06
NAD	ME309575	1.00	0.96	0.95	1.05	1.05
Pyridoxal-5-P	ME309600	1.01	0.97	0.95	1.06	1.02
FAD	ME309518	0.97	1.00	0.96	0.99	1.07
Alanine	ME309475	0.98	0.97	0.99	1.00	1.05
homoarginine	ME309538	0.98	0.96	0.98	0.99	1.08
Fumaric Acid	ME309519	1.02	1.00	0.93	0.99	1.07
Histamine	ME309536	1.01	0.99	0.98	1.00	1.02
Carnitine	ME309491	1.01	0.98	0.96	1.00	1.05
Malate	ME309558	1.01	0.98	0.96	1.00	1.05
Creatinine	ME309499	0.99	1.04	0.98	0.95	1.03
Hydroxyproline	ME309540	0.99	1.03	0.96	0.96	1.05
Betaine	ME309488	1.01	0.99	0.95	0.93	1.09
Thiamine	ME309619	1.01	0.97	1.00	0.94	1.06
Aminolevulinate	ME309477	0.99	0.99	0.99	0.96	1.06
CDP	ME309493	0.98	1.00	0.99	0.95	1.07
Arachidonate	ME309481	1.05	1.06	0.82	1.05	1.05
GMP	ME309531	1.02	1.05	0.89	1.01	1.05
UMP	ME309630	1.03	1.11	0.86	0.98	1.04
Uridine	ME309633	0.97	1.07	0.85	1.03	1.10
IMP	ME309543	0.94	1.05	0.91	1.06	1.07
Deoxycarnitine	ME309505	0.97	1.03	0.92	0.99	1.09
succinylcarnitine	ME309614	0.96	1.01	0.94	1.03	1.06
NADH	ME309576	1.00	1.03	0.88	0.93	1.13
CMP	ME309497	0.97	0.98	0.94	0.97	1.13
glutarylcarnitine	ME309526	0.96	1.07	0.94	0.94	1.08
Phosphotyrosine	ME309595	0.95	1.03	0.96	0.94	1.10
xylonate	ME309637	0.99	1.06	1.10	1.00	0.86
Uracil	ME309631	0.99	1.03	1.14	0.93	0.88
Proline	ME309597	0.96	1.04	1.16	0.97	0.86
Serine	ME309611	0.96	1.07	1.13	0.96	0.87
Xanthosine	ME309636	0.95	1.06	1.12	0.92	0.93
Guanosine	ME309535	0.96	1.05	1.11	0.94	0.92
Threonine	ME309622	0.95	1.04	1.11	0.93	0.94
Pentothenate	ME309590	0.98	1.10	1.07	0.93	0.91
Pyridoxamine	ME309601	0.99	1.08	1.10	0.87	0.93
CTP	ME309500	1.02	1.07	0.97	1.03	0.93
Ribulose 5-phosphate	ME309607	1.04	1.02	1.04	1.00	0.91
Allantoin	ME309476	0.98	1.05	1.04	0.98	0.95
Cytidine	ME309503	1.00	1.07	1.02	0.99	0.93
Guanine	ME309534	1.02	1.05	1.02	0.97	0.94
Glycine	ME309530	0.92	1.05	1.03	0.98	1.01
2^-deoxycytidine	ME309458	0.98	1.02	1.05	0.94	0.99
Asparagine	ME309484	0.99	1.04	1.05	0.89	1.00
2-Hydroxyglutarate	ME309460	1.00	1.06	1.07	1.09	0.82
N-Acetylneuraminate	ME309572	1.05	1.01	0.97	1.09	0.93
7-methylguanine	ME309469	1.05	0.93	1.02	1.14	0.90
o-phosphoethanolamine	ME309585	1.06	0.97	1.00	1.14	0.88
Epinephrine	ME309511	1.04	0.99	1.06	1.03	0.90
Leucine /D-norleucine	ME309553	1.04	0.95	1.07	1.05	0.90
Phenylalanine	ME309592	1.03	0.97	1.09	1.03	0.89
Glucoronate	ME309522	1.05	0.95	1.11	1.05	0.85
Xanthine	ME309635	1.01	0.95	1.13	1.03	0.88
iso-Leucine /allo-isoleucine	ME309548	1.03	0.93	1.06	1.02	0.95
GTP	ME309532	1.03	0.96	1.01	1.05	0.96
Taurocyamine	ME309617	1.06	0.96	1.02	1.04	0.93
Arginine	ME309482	0.96	0.97	1.11	1.00	0.96
N-Ac-Alanine	ME309569	0.99	0.97	1.08	1.03	0.93
Valine	ME309634	1.00	0.97	1.08	1.02	0.93
Lysine	ME309557	1.00	0.97	1.08	0.99	0.95
N6-Acetyl-lysine	ME309567	0.99	0.99	1.08	0.97	0.96
pseudouridine	ME309598	0.99	1.00	1.05	1.06	0.92
UDP-GlcNAc	ME309628	0.94	0.99	1.05	1.08	0.96
Sucrose	ME309615	0.88	0.88	1.37	0.96	0.87
6-Methyladenosine	ME309467	0.98	0.87	1.27	0.73	1.04
Thymine	ME309623	0.92	1.00	1.30	0.78	0.92
Dimethylglycine	ME309510	1.03	0.98	1.16	0.85	0.92
trigonelline	ME309624	0.99	1.04	1.26	0.88	0.78
homocitrulline	ME309539	1.24	0.78	1.23	0.94	0.76
N-Ac-Methionine	ME309574	0.96	0.62	1.36	1.06	0.96
Pyruvate	ME309603	0.95	0.66	1.29	1.16	0.93
N2,N2-Dimethylguanosine	ME309566	1.14	0.63	1.20	0.97	1.01
5-methylcytidine	ME309465	0.89	0.79	1.28	0.97	1.02
Methionine	ME309562	1.00	0.73	1.24	1.01	0.98
PGE	ME309591	1.05	0.76	1.20	0.93	1.01
UDP-Glucose	ME309629	0.82	0.84	1.21	0.76	1.25
beta alanine	ME309487	0.99	0.81	0.77	0.91	1.45
Hypotaurine	ME309541	0.90	0.77	0.86	0.99	1.43
5-Aminovaleric Acid	ME309464	1.04	0.73	1.04	0.98	1.16
n-formylmethionine	ME309580	1.00	0.72	1.04	1.07	1.15
Adenine	ME309471	0.90	0.84	0.91	1.02	1.30
Malondialdehyde	ME309559	0.98	0.70	0.92	1.00	1.34
n-isovalerylglycine	ME309584	0.97	0.73	0.98	1.01	1.26
Adenosine	ME309472	1.51	0.84	0.77	0.78	1.05
F16BP/F26BP/G16BP	ME309517	1.37	1.36	0.86	0.85	0.60
erythronic acid	ME309513	1.16	1.25	0.85	0.68	1.01
threonic acid	ME309621	1.19	1.25	0.83	0.62	1.05

Factors:

F1	Age (Months):26 \| Treatment:NMN (300 mg/kg/day)
F2	Age (Months):26 \| Treatment:None
F3	Age (Months):26 \| Treatment:SS-31 (3 mg/kg/day)
F4	Age (Months):26 \| Treatment:SS-31 (3 mg/kg/day) + NMN (300 mg/kg/day)
F5	Age (Months):5-6 \| Treatment:None

Data matrix