Clustering data with hclust algorithm for Disruption of Redox Balance Enhances the Effects of BRAF-inhibitors in Melanoma (Study ST001339)
HILIC NEGATIVE ION MODE (Analysis AN002233)| Metabolite | Structure | F1 | F2 | F3 | F4 |
|---|---|---|---|---|---|
| L-Cystine | ME310460 | NA | 0.06 | NA | 1.94 |
| GMP | ME310453 | 0.41 | 0.71 | 1.15 | 1.74 |
| L-Cysteine | ME310458 | 0.25 | 0.69 | 0.81 | 2.24 |
| NADH | ME310446 | NA | NA | 1.66 | 0.34 |
| GSH | ME310443 | 1.40 | 1.27 | 1.21 | 0.13 |
| NAD | ME310455 | 1.74 | 1.41 | 0.48 | 0.36 |
| Adenosine | ME310448 | 1.19 | 1.55 | 0.70 | 0.56 |
| L-Serine | ME310457 | 1.25 | 1.63 | 0.76 | 0.37 |
| UMP | ME310454 | 0.35 | 1.16 | 1.43 | 1.06 |
| AMP | ME310456 | 0.64 | 1.35 | 1.16 | 0.85 |
| GSSG | ME310445 | 0.72 | 1.05 | 1.09 | 1.14 |
| ATP | ME310444 | 1.32 | 0.66 | 1.30 | 0.73 |
| GDP | ME310449 | 1.37 | 0.58 | 1.43 | 0.63 |
| ADP | ME310452 | 1.10 | 0.79 | 1.33 | 0.78 |
| NADP | ME310450 | 1.27 | 0.92 | 1.11 | 0.71 |
| GTP | ME310459 | 1.77 | 0.44 | 1.23 | 0.57 |
| UDP | ME310451 | 1.40 | 0.46 | 1.68 | 0.46 |
| UTP | ME310447 | 1.52 | 0.44 | 1.59 | 0.46 |
Factors:
| F1 | genotype:resistant | treatment:DMSO |
| F2 | genotype:resistant | treatment:PLX4720 |
| F3 | genotype:sensitive | treatment:DMSO |
| F4 | genotype:sensitive | treatment:PLX4720 |
