Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Metabolomic and Transcriptomic Signatures of Prenatal Excessive Methionine in Mice (Study ST001413)

HILIC POSITIVE ION MODE (Analysis AN002363)

Metabolite	Structure	F1	F2	F3	F4
Phenylacetylglutamine	ME325577	NA	1.86	NA	0.14
Phenylacetyl-L-glutamine	ME325578	NA	1.87	NA	0.13
Benzyldimethyltetradecylammonium cation	ME325529	NA	1.94	NA	0.06
Turanose	ME325544	NA	1.91	NA	0.09
5^-Methylthioadenosine	ME325518	NA	2.04	NA	0.09
3.alpha.-Galactobiose	ME325512	NA	1.99	NA	0.01
Palmitamide	ME325574	NA	1.99	NA	0.01
Benzyldimethylstearylammonium cation	ME325528	NA	1.44	NA	0.56
Kynurenine	ME325556	NA	1.71	NA	0.29
Sucrose	ME325590	NA	1.58	NA	0.42
Adenine	ME325522	1.40	0.62	1.37	0.80
Betaine aldehyde cation	ME325531	1.13	0.65	1.29	1.04
Propionylcarnitine	ME325582	0.90	0.96	1.19	0.97
Inosine	ME325554	0.97	0.97	1.05	1.02
Guanosine	ME325550	0.99	0.87	1.15	1.02
Nicotinamide	ME325571	1.08	0.92	1.09	0.95
4-Guanidinobutyric acid	ME325516	0.43	1.57	0.44	1.28
(2R)-3-Hydroxyisovaleroylcarnitine	ME325502	0.66	0.91	0.68	1.58
Ergothioneine	ME325545	0.71	0.86	0.62	1.64
3-Hydroxybutyrylcarnitine	ME325514	0.83	1.16	0.72	1.17
Pantothenic acid	ME325576	0.51	1.13	0.75	1.42
Guanine	ME325549	0.73	1.17	0.47	1.43
Choline cation	ME325535	0.70	1.13	0.71	1.31
Carnitine	ME325533	0.61	1.27	0.61	1.31
Taurine	ME325591	0.66	1.17	0.60	1.38
Malonyl-carnitine	ME325559	NA	0.12	NA	1.88
Creatine	ME325537	0.07	1.60	0.06	1.81
Creatinine	ME325538	NA	1.18	NA	0.82
5-Cholesten-3-beta-7-alpha-diol	ME325517	NA	1.15	NA	0.85
Methylglycinate	ME325565	NA	1.12	NA	0.88
Trigonelline	ME325593	NA	1.33	NA	0.67
Stachydrine	ME325588	NA	1.26	NA	0.74
Tyrosine	ME325558	NA	1.27	NA	0.73
2^-Fucosyllactose	ME325509	NA	0.61	NA	1.39
Pro-Gln	ME325580	NA	0.67	NA	1.33
1-Methylhistamine	ME325506	NA	0.69	NA	1.31
H-gamma-glutamyl-glutamine	ME325552	NA	0.70	NA	1.30
D9-Crotonobetaine iSTD	ME325499	NA	1.00	NA	1.00
4-Acetamidobutyric acid	ME325515	NA	1.00	NA	1.00
D3-DL-Alanine iSTD	ME325490	NA	1.00	NA	1.00
2-Propanamidoacetic acid	ME325511	NA	1.02	NA	0.98
D3-Creatine iSTD	ME325488	NA	1.02	NA	0.98
Adenosine 5^-monophosphate	ME325524	NA	1.01	NA	0.99
D3-AC(2:0) iSTD	ME325487	NA	1.01	NA	0.99
Val-Tyr-Val iSTD	ME325501	NA	0.99	NA	1.01
Nudifloramide	ME325573	NA	0.99	NA	1.01
D9-Butyrobetaine iSTD	ME325497	NA	0.99	NA	1.01
15N2-L-Arginine iSTD	ME325484	NA	0.99	NA	1.01
D3-L-Carnitine iSTD	ME325494	NA	0.99	NA	1.01
D9-TMAO iSTD	ME325500	NA	0.98	NA	1.02
D9-Choline Istd	ME325498	NA	0.98	NA	1.02
D5-L-Glutamine iSTD	ME325495	NA	0.98	NA	1.02
D3-DL-Glutamic acid iSTD	ME325492	NA	0.98	NA	1.02
D3-1-Methylnicotinamide iSTD	ME325486	NA	0.98	NA	1.02
CUDA iSTD	ME325485	NA	0.98	NA	1.02
5^-S-Methyl-5^-thioadenosine	ME325519	NA	0.98	NA	1.02
Adenosine-3-monophosphate	ME325525	NA	0.98	NA	1.02
1-Methyladenosine A	ME325504	NA	0.96	NA	1.04
Maltotetraose	ME325560	NA	0.96	NA	1.04
Thionin	ME325592	NA	0.97	NA	1.03
N-Acetylalanine	ME325567	NA	0.97	NA	1.03
1-Methylnicotinamide	ME325507	NA	0.97	NA	1.03
.beta.-Nicotinamide adenine dinucleotide	ME325503	NA	0.97	NA	1.03
2-Methylbutyryl-L-carnitine	ME325510	NA	1.08	NA	0.92
D3-DL-Aspartic acid iSTD	ME325491	NA	1.03	NA	0.97
D9-Betaine iSTD	ME325496	NA	1.04	NA	0.96
Tryptophan	ME325594	NA	1.04	NA	0.96
Indole-3-lactic acid	ME325543	NA	1.05	NA	0.95
D3-Histamine, N-methyl- iSTD	ME325493	NA	1.06	NA	0.94
Methioninesulfoxide	ME325564	NA	1.06	NA	0.94
Phenylalanine	ME325579	NA	0.80	NA	1.20
Citrulline	ME325536	NA	0.80	NA	1.20
gamma.-Glutamyl-L-glutamic acid	ME325557	NA	0.80	NA	1.20
Proline	ME325581	NA	0.82	NA	1.18
Norleucine	ME325572	NA	0.81	NA	1.19
Serine	ME325587	NA	0.81	NA	1.19
Methionine	ME325563	NA	0.76	NA	1.24
N,N,N trimethyllysine	ME325570	NA	0.78	NA	1.22
Isoleucine	ME325555	NA	0.78	NA	1.22
Betaine	ME325530	NA	0.78	NA	1.22
Cytidine 5^-diphosphocholine	ME325541	NA	0.78	NA	1.22
Glutamic acid	ME325547	NA	0.95	NA	1.05
D3-Creatinine iSTD	ME325489	NA	0.94	NA	1.06
1-Methylguanosine	ME325505	NA	0.93	NA	1.07
Pyrrole-2-carboxylic acid	ME325583	NA	0.93	NA	1.07
Urocanic acid	ME325598	NA	0.92	NA	1.08
N8-Acetylspermidine	ME325566	NA	0.92	NA	1.08
2^-Deoxycytidine	ME325508	NA	0.92	NA	1.08
Carnosine	ME325534	NA	0.92	NA	1.08
Cytidine 5^-monophosphate	ME325542	NA	0.91	NA	1.09
Glutamine	ME325548	NA	0.91	NA	1.09
Aspartic acid	ME325527	NA	0.89	NA	1.11
Uridine 5^-monophosphate	ME325596	NA	0.90	NA	1.10
Cytidine	ME325540	NA	0.90	NA	1.10
Uridine	ME325595	NA	0.90	NA	1.10
Cystathionine	ME325539	NA	0.85	NA	1.15
Threonine	ME325526	NA	0.84	NA	1.16
Biliverdin	ME325532	NA	0.84	NA	1.16
Ethylenediaminetetraacetic acid	ME325546	NA	0.84	NA	1.16
Guanosine 5^-tetraphosphate	ME325551	NA	0.86	NA	1.14
N-Acetylaspartylglutamic acid	ME325568	NA	0.86	NA	1.14
Uridine-5-diphosphoacetylglucosamine	ME325597	NA	0.87	NA	1.13
Succinic acid	ME325589	NA	0.87	NA	1.13
3-Aminoisobutyric acid	ME325513	NA	0.87	NA	1.13
SDMA	ME325586	NA	0.87	NA	1.13
N-Acetyl-Asp-Glu	ME325569	NA	0.88	NA	1.12
Methacholine cation	ME325562	NA	0.88	NA	1.12
7-Methylguanine	ME325520	NA	0.88	NA	1.12
Melibiose	ME325561	NA	0.88	NA	1.12
Erythromycin	ME325630	0.16	NA	1.84	NA
Erythromycin A enol ether	ME325631	0.22	NA	1.78	NA
N-Demethylerythromycin	ME325641	0.25	NA	1.75	NA
Histamine	ME325622	0.55	NA	1.45	NA
(-)-Epinephrine	ME325621	0.47	NA	1.53	NA
N-alpha-methylhistamine	ME325623	0.44	NA	1.56	NA
Homocysteine	ME325624	0.78	NA	1.22	NA
Valine	ME325648	0.78	NA	1.22	NA
DL-Norepinephrine	ME325620	0.65	NA	1.35	NA
TMAO	ME325645	0.70	NA	1.30	NA
Adenosine monophosphate	ME325629	1.38	NA	0.62	NA
1_D3-DL-Alanine iSTD	ME325605	0.92	NA	1.08	NA
3-Methoxytyramine	ME325619	0.91	NA	1.09	NA
Isovaleryl-L-carnitine	ME325634	0.91	NA	1.09	NA
3-Methylcrotonylglycine	ME325626	0.96	NA	1.04	NA
1_15N2-L-Arginine iSTD	ME325599	0.96	NA	1.04	NA
1_D5-L-Glutamine iSTD	ME325610	0.96	NA	1.04	NA
Tributylamine	ME325646	0.97	NA	1.03	NA
1_D9-Betaine iSTD	ME325611	0.97	NA	1.03	NA
1_D3-DL-Glutamic acid iSTD	ME325607	0.97	NA	1.03	NA
1_D3-AC(2:0) iSTD	ME325602	0.97	NA	1.03	NA
1_D3-Creatine iSTD	ME325603	0.97	NA	1.03	NA
Stearoyl-L-carnitine	ME325644	1.00	NA	1.00	NA
1_D9-TMAO iSTD	ME325616	1.00	NA	1.00	NA
1_D9-Choline iSTD	ME325614	1.00	NA	1.00	NA
1_CUDA iSTD	ME325600	1.00	NA	1.00	NA
1_D9-Butyrobetaine iSTD	ME325612	1.00	NA	1.00	NA
1_D3-1-Methylnicotinamide iSTD	ME325601	1.01	NA	0.99	NA
gamma-Aminobutyric Acid (GABA)	ME325632	1.01	NA	0.99	NA
1_Val-Tyr-Val iSTD	ME325617	0.99	NA	1.01	NA
1_D3-L-Carnitine iSTD	ME325609	0.99	NA	1.01	NA
1_D3-Histamine, N-methyl- iSTD	ME325608	0.99	NA	1.01	NA
1_D3-Creatinine iSTD	ME325604	0.99	NA	1.01	NA
1_D3-DL-Aspartic acid iSTD	ME325606	0.99	NA	1.01	NA
N-(15Z-Tetracosenoyl)-1-.beta.-galactosylsphing-4-enine	ME325637	0.98	NA	1.02	NA
1_D9-Caffeine iSTD	ME325613	0.98	NA	1.02	NA
1_D9-Crotonobetaine iSTD	ME325615	0.98	NA	1.02	NA
L-Arachidonoylcarnitine	ME325635	1.05	NA	0.95	NA
Oleoyl-L-carnitine	ME325642	1.06	NA	0.94	NA
Urea	ME325647	1.07	NA	0.93	NA
4-Aminomethylcyclohexanecarboxylic acid	ME325627	1.12	NA	0.88	NA
1-Methyladenosine B	ME325625	1.11	NA	0.89	NA
N-Acetyl-D-lactosamine	ME325638	1.11	NA	0.89	NA
Myristoyl-L-carnitine	ME325636	1.09	NA	0.91	NA
N-Acetyl-L-aspartic acid	ME325640	1.10	NA	0.90	NA
Serotonin	ME325643	1.23	NA	0.77	NA
Acetylcholine cation	ME325628	1.19	NA	0.81	NA
Glutathione (reduced)	ME325633	1.17	NA	0.83	NA
Dopamine	ME325618	1.16	NA	0.84	NA
N-Acetylhistidine	ME325639	1.16	NA	0.84	NA
S-(5^-Adenosyl)-L-homocysteine	ME325584	1.25	0.16	2.97	0.18
Hypoxanthine	ME325553	1.68	0.80	1.89	0.02
Adenosine	ME325523	2.25	0.05	2.26	0.07
Palmitoylcarnitine	ME325575	2.35	0.10	2.13	0.04
Acetylcarnitine	ME325521	2.02	0.26	1.94	0.27
S-Adenosyl-L-methionine	ME325585	2.07	0.28	1.72	0.38

Factors:

F1	Condition:Control \| Age:13 weeks
F2	Condition:Control \| Age:24 hour
F3	Condition:Methionine \| Age:13 weeks
F4	Condition:Methionine \| Age:24 hour

Data matrix