Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for A Metabolomic Signature of Glucagon Action in Healthy Individuals with Overweight/Obesity Humans (Study ST001515)

Reversed phase POSITIVE ION MODE (Analysis AN002512)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10	F11	F12	F13	F14	F15	F16	F17	F18
heme	ME365100	0.52	0.28	0.25	0.25	0.27	0.32	4.29	0.25	0.23	2.95	0.63	1.20	0.38	0.36	0.31	3.22	0.78	0.87
piperine	ME365120	0.62	0.79	0.38	0.76	0.49	1.12	0.73	0.81	0.38	0.81	0.47	1.31	1.72	1.74	1.11	1.29	1.30	2.53
solanidine	ME365123	2.07	1.71	1.25	1.76	1.46	1.42	0.85	0.84	0.95	0.90	0.54	0.62	0.60	0.75	0.67	0.46	0.53	0.56
delta-tocopherol	ME365092	0.93	1.60	0.73	0.69	1.02	0.92	1.07	1.67	0.77	0.64	1.02	1.30	0.87	1.80	0.84	0.56	0.74	0.89
biliverdin	ME365082	1.04	0.43	0.64	0.65	0.63	0.78	2.00	0.75	0.92	1.31	1.15	1.45	1.04	0.64	0.79	1.33	1.22	0.97
cetirizine	ME365088	0.89	0.89	0.89	0.89	0.89	0.89	1.67	0.94	0.92	1.72	0.89	0.98	0.89	0.89	0.89	0.89	0.89	0.89
4-cholesten-3-one	ME365070	0.77	0.90	0.76	1.20	0.94	0.98	0.89	0.88	1.24	1.07	0.95	1.09	0.68	1.23	1.06	1.37	0.96	1.07
dihomo-linolenoyl-choline	ME365094	1.08	0.88	0.56	1.46	0.47	0.89	1.00	1.12	0.85	1.48	0.58	1.08	0.91	1.04	1.22	1.27	0.87	1.21
docosahexaenoylcholine	ME365097	0.90	0.88	0.89	1.37	0.77	0.67	0.73	0.98	0.88	1.10	0.58	0.74	1.17	1.26	1.37	1.31	1.21	1.38
linoleoylcholine*	ME365105	0.92	1.05	0.87	1.23	0.77	0.79	0.75	1.09	0.98	1.02	0.67	0.85	0.98	1.35	1.38	1.10	1.15	1.25
arachidonoylcholine	ME365076	0.81	0.80	0.69	1.24	0.65	0.70	0.83	1.06	0.95	1.21	0.72	0.84	1.07	1.25	1.48	1.28	1.21	1.37
oleoylcholine	ME365115	1.01	0.97	0.78	1.33	0.64	0.75	0.82	1.02	0.92	1.15	0.64	0.83	1.04	1.17	1.40	1.24	1.11	1.33
palmitoylcholine	ME365118	0.91	0.93	0.75	1.25	0.68	0.76	0.77	1.11	0.97	1.16	0.70	0.89	1.05	1.27	1.36	1.19	1.10	1.30
stearoylcholine*	ME365128	0.93	0.92	0.75	1.35	0.67	0.73	0.78	1.08	0.91	1.19	0.65	0.87	1.00	1.27	1.44	1.20	1.15	1.30
3-hydroxyoleoylcarnitine	ME365069	1.01	1.12	1.12	0.39	1.15	0.74	1.07	0.96	1.28	0.62	1.27	0.97	1.21	0.64	0.78	1.66	1.06	0.92
myristoleoylcarnitine (C14:1)*	ME365107	1.31	1.21	0.90	0.51	1.32	0.92	1.22	0.83	1.10	0.61	1.26	0.83	1.22	0.71	0.83	1.45	0.99	0.78
4-methylnonanoylcarnitine	ME365071	1.56	0.65	0.71	1.14	0.70	0.87	1.22	0.65	0.77	1.01	0.56	1.00	1.31	1.07	1.23	1.26	1.21	1.21
undecenoylcarnitine (C11:1)	ME365129	1.34	0.67	0.51	1.09	0.74	1.05	1.11	0.65	0.66	1.19	0.75	1.01	1.42	0.97	1.16	1.34	1.18	1.26
3-decenoylcarnitine	ME365067	1.33	0.88	0.79	0.59	0.94	0.98	1.06	0.78	0.79	0.69	0.96	0.91	1.50	1.22	1.21	1.20	1.24	1.13
3-hydroxydecanoylcarnitine	ME365068	1.35	0.88	0.92	0.57	1.14	0.88	1.15	0.73	0.81	0.56	1.08	0.88	1.48	1.07	1.06	1.43	1.19	0.99
5-dodecenoylcarnitine (C12:1)	ME365072	1.36	0.76	0.81	0.58	0.98	0.94	1.30	0.77	0.99	0.70	1.17	0.93	1.36	0.87	1.01	1.44	1.11	0.95
laurylcarnitine (C12)	ME365101	1.38	0.81	0.76	0.63	1.02	0.96	1.34	0.73	0.98	0.68	1.15	0.93	1.40	0.85	0.96	1.39	1.07	0.95
cis-4-decenoylcarnitine (C10:1)	ME365090	1.22	0.78	0.67	0.57	0.85	0.87	1.43	0.83	0.84	0.77	1.07	0.92	1.32	1.34	1.07	1.34	1.25	0.98
decanoylcarnitine (C10)	ME365091	1.53	0.65	0.60	0.51	0.94	0.96	1.58	0.63	0.81	0.64	1.07	0.93	1.59	0.92	1.13	1.37	1.16	1.04
nonanoylcarnitine (C9)	ME365110	1.30	0.63	0.71	0.64	0.74	0.95	1.52	0.72	0.94	0.77	1.04	1.03	1.39	1.00	1.14	1.26	1.20	1.05
octanoylcarnitine (C8)	ME365113	1.36	0.65	0.65	0.48	0.82	0.95	1.58	0.66	0.88	0.70	1.09	0.99	1.50	1.04	1.07	1.35	1.22	1.04
1-stearoyl-2-oleoyl-GPS (18:0/18:1)	ME365066	1.26	1.28	1.26	1.61	0.94	1.15	0.72	0.91	0.95	0.92	0.70	0.87	0.90	0.86	1.20	0.81	0.83	0.89
octadecanedioylcarnitine (C18-DC)*	ME365111	0.95	1.12	1.06	1.01	0.94	0.73	1.07	1.20	1.23	1.15	1.08	0.88	0.97	0.95	0.88	0.97	0.90	0.81
octadecenedioylcarnitine (C18:1-DC)*	ME365112	0.89	1.43	1.08	0.78	0.91	0.71	0.97	1.26	1.19	0.98	1.10	0.93	0.95	0.96	0.86	1.22	0.94	0.82
linolenoylcarnitine (C18:3)*	ME365103	1.11	1.29	0.93	0.55	0.92	0.98	1.10	1.13	1.03	0.67	1.05	0.97	1.18	1.16	1.00	1.05	1.05	0.89
linoleoylcarnitine (C18:2)*	ME365104	1.05	1.22	0.99	0.65	1.11	0.96	1.04	1.01	0.97	0.79	1.00	0.96	1.10	1.08	0.92	1.18	1.08	0.96
arachidonoylcarnitine (C20:4)	ME365075	1.20	1.03	0.96	0.91	1.02	1.05	1.09	0.80	0.90	0.80	0.90	0.95	1.17	0.96	0.97	1.21	1.19	0.96
adrenoylcarnitine (C22:4)*	ME365073	1.21	0.90	0.92	0.77	1.06	1.21	1.18	0.83	0.97	0.78	0.89	0.99	1.20	0.92	0.94	1.11	1.15	0.97
dihomo-linolenoylcarnitine (C20:3n3 or 6)*	ME365093	1.24	0.99	0.98	0.83	0.96	1.19	1.15	0.85	0.97	0.90	0.94	1.06	1.10	0.89	0.90	1.11	1.00	0.92
palmitoleoylcarnitine (C16:1)*	ME365116	1.17	0.93	0.98	0.53	1.14	0.93	1.20	0.82	1.15	0.76	1.19	1.03	1.18	0.72	0.86	1.43	1.01	0.93
eicosenoylcarnitine (C20:1)*	ME365098	1.01	1.01	1.18	0.64	1.16	0.87	1.05	0.86	1.03	0.83	0.98	0.94	1.17	0.86	0.97	1.31	1.16	1.03
dihomo-linoleoylcarnitine (C20:2)*	ME365095	1.08	1.07	1.06	0.63	1.18	1.05	1.09	0.93	0.98	0.81	0.97	0.98	1.07	0.92	0.91	1.26	1.08	0.98
oleoylcarnitine (C18)	ME365114	1.12	0.99	1.10	0.61	1.15	0.96	1.12	0.87	1.08	0.80	1.11	1.00	1.13	0.78	0.91	1.28	1.03	0.95
stearoylcarnitine (C18)	ME365127	1.07	0.93	1.16	0.84	1.20	1.01	1.13	0.82	1.05	0.99	0.98	1.02	1.06	0.73	0.88	1.10	1.02	0.99
margaroylcarnitine (C17)*	ME365106	1.06	0.83	1.09	0.66	1.07	0.98	1.19	0.78	1.11	0.89	1.06	1.08	1.17	0.71	0.98	1.19	1.06	1.05
myristoylcarnitine (C14)	ME365108	1.17	0.93	1.03	0.69	1.03	1.04	1.15	0.85	1.05	0.85	1.05	0.99	1.19	0.73	0.91	1.31	0.93	1.06
palmitoylcarnitine (C16)	ME365117	1.13	0.91	1.07	0.72	1.05	1.04	1.13	0.85	1.06	0.91	0.99	1.09	1.10	0.79	0.94	1.18	0.97	1.04
beta-sitosterol	ME365080	1.03	1.15	1.44	1.02	1.28	0.97	0.82	0.90	0.99	0.83	0.86	0.88	0.95	1.15	0.94	0.86	1.05	1.01
campesterol	ME365083	1.14	1.08	1.31	0.99	1.19	1.03	0.82	0.77	0.96	0.83	0.89	0.89	1.02	1.25	0.98	0.83	1.23	0.95
beta-cryptoxanthin	ME365079	1.20	1.04	1.27	1.16	1.24	1.14	0.87	0.97	1.09	0.95	1.00	0.91	0.88	0.83	0.87	0.79	0.87	0.87
carotene diol (3)	ME365086	1.22	1.04	1.21	1.15	1.16	1.21	0.94	0.91	0.84	0.92	0.96	1.05	0.96	0.92	0.85	0.88	0.91	0.86
carotene diol (1)	ME365084	1.24	1.04	1.16	1.18	1.16	1.17	0.91	0.85	0.88	0.90	0.88	0.95	1.03	1.01	0.93	0.87	0.96	0.91
carotene diol (2)	ME365085	1.26	1.17	1.15	1.20	1.18	1.19	0.92	0.90	0.82	0.85	0.90	0.93	1.00	0.90	0.94	0.94	0.90	0.88
bilirubin (E,Z or Z,E)*	ME365081	1.10	0.74	0.83	0.99	0.87	1.00	1.02	1.00	1.21	1.16	1.11	0.92	1.14	0.94	1.00	1.12	0.90	0.87
sphingadienine	ME365124	1.02	0.85	0.98	1.45	0.81	1.17	1.09	1.05	0.98	1.24	0.75	0.99	1.15	0.91	0.93	0.74	0.72	1.05
sphinganine	ME365125	1.12	0.99	1.03	1.12	0.87	1.07	1.08	0.95	1.02	1.02	0.79	1.05	1.10	0.93	1.06	0.90	0.82	1.06
sphingosine	ME365126	1.15	1.00	1.07	1.14	0.88	1.13	1.15	0.98	0.94	1.08	0.73	1.04	1.12	0.84	1.00	0.84	0.77	1.07
behenoylcarnitine (C22)*	ME365078	1.06	1.25	1.08	1.16	1.00	1.01	0.83	0.90	0.82	0.85	0.83	0.83	1.13	1.00	1.18	0.92	1.39	0.87
retinal	ME365121	1.05	0.92	0.90	0.93	0.77	0.85	1.20	0.91	0.85	0.93	1.03	0.93	1.16	1.18	1.18	1.10	1.07	1.09
alpha-tocopherol	ME365074	1.02	0.96	1.07	0.99	1.02	0.99	0.84	0.92	1.01	0.87	0.97	0.93	1.13	1.13	1.11	1.01	1.10	1.00
arachidoylcarnitine (C20)*	ME365077	1.04	0.94	1.03	1.00	1.00	0.87	0.97	0.89	0.90	0.96	0.83	1.03	1.09	1.04	1.06	1.03	1.25	1.16
1-oleoyl-GPS (18:1)	ME365065	1.04	0.94	0.96	0.96	0.94	0.99	0.97	1.02	0.95	1.01	0.92	1.06	1.16	0.93	1.11	0.99	1.01	1.05
palmitoyl-sphingosine-phosphoethanolamine (d18:1/16:0)	ME365119	1.06	0.86	0.89	1.00	0.97	0.99	1.01	0.94	0.92	1.04	1.01	1.02	1.05	1.07	1.08	1.04	1.02	1.06
cholesterol	ME365089	1.07	0.89	0.99	1.01	0.96	0.99	0.98	0.87	0.92	0.97	0.90	1.00	1.17	1.08	1.04	1.07	1.10	1.05
retinol (Vitamin A)	ME365122	1.00	0.86	0.90	1.03	0.83	0.98	0.97	0.93	0.97	1.04	0.89	0.99	1.16	1.16	1.12	1.05	1.11	1.09
nervonoylcarnitine (C24:1)*	ME365109	1.30	0.98	0.97	1.08	0.88	1.18	0.96	0.72	0.74	0.87	0.67	0.77	1.30	0.94	1.10	1.35	1.15	1.17
lignoceroylcarnitine (C24)*	ME365102	1.13	1.09	1.02	1.14	0.93	1.08	0.90	0.82	0.77	0.91	0.77	0.91	1.14	1.09	1.05	1.07	1.17	1.16
cerotoylcarnitine (C26)*	ME365087	1.14	1.05	1.10	1.13	1.02	1.12	0.89	0.83	0.82	0.90	0.78	0.87	1.14	1.06	1.04	1.07	1.05	1.08
ximenoylcarnitine (C26:1)*	ME365130	1.20	1.06	1.06	1.19	0.97	1.13	0.90	0.81	0.79	0.96	0.75	0.86	1.11	1.08	1.03	1.09	1.08	1.01
docosahexaenoylcarnitine (C22:6)*	ME365096	1.36	1.25	0.85	0.92	0.99	1.10	0.81	0.97	0.72	0.61	0.72	0.63	1.19	1.11	1.16	1.50	1.35	0.97
gamma-tocopherol/beta-tocopherol	ME365099	1.01	1.05	0.78	0.85	0.93	1.01	0.88	1.04	0.74	0.76	0.91	0.99	1.24	1.60	1.08	1.06	1.10	1.19

Factors:

F1	Group:High-Dose \| TIMEPOINT:-0.5HR
F2	Group:High-Dose \| TIMEPOINT:+23HR POST INFUSION
F3	Group:High-Dose \| TIMEPOINT:+47HR POST INFUSION
F4	Group:High-Dose \| TIMEPOINT:+4HR POST INFUSION
F5	Group:High-Dose \| TIMEPOINT:+71HR POST INFUSION
F6	Group:High-Dose \| TIMEPOINT:BASELINE
F7	Group:Low-Dose \| TIMEPOINT:-0.5HR
F8	Group:Low-Dose \| TIMEPOINT:+23HR POST INFUSION
F9	Group:Low-Dose \| TIMEPOINT:+47HR POST INFUSION
F10	Group:Low-Dose \| TIMEPOINT:+4HR POST INFUSION
F11	Group:Low-Dose \| TIMEPOINT:+71HR POST INFUSION
F12	Group:Low-Dose \| TIMEPOINT:BASELINE
F13	Group:Placebo \| TIMEPOINT:-0.5HR
F14	Group:Placebo \| TIMEPOINT:+23HR POST INFUSION
F15	Group:Placebo \| TIMEPOINT:+47HR POST INFUSION
F16	Group:Placebo \| TIMEPOINT:+4HR POST INFUSION
F17	Group:Placebo \| TIMEPOINT:+71HR POST INFUSION
F18	Group:Placebo \| TIMEPOINT:BASELINE

Data matrix