Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition (Study ST001709)

HILIC POSITIVE ION MODE (Analysis AN002783)

Metabolite	Structure	F1	F2	F3	F4	F5	F6
glycine M0	ME398080	0.85	0.84	4.12	4.20	0.28	0.29
alanine M3	ME397990	0.84	0.87	2.26	3.64	0.19	0.08
NAD+ M5	ME398130	0.36	0.38	2.52	3.46	0.31	0.33
3-hydroxy-trimethyllysine M0	ME397944	NA	NA	2.27	2.79	0.32	0.14
alanine M2	ME397989	0.12	0.07	2.54	3.01	0.14	0.04
asparagine / N-carbamoylsarcosine M0	ME397998	0.18	0.19	3.19	3.87	0.11	0.08
citrulline M0	ME398038	0.21	0.16	3.48	2.93	0.24	0.25
lysine M1	ME398102	NA	NA	1.92	NA	0.45	0.71
adenosine M0	ME397976	0.25	0.19	1.36	1.84	1.52	1.13
NAD+ M6	ME398131	0.25	NA	0.87	2.01	0.82	1.15
CDP-choline M0	ME398017	0.26	0.46	0.94	0.79	1.46	1.48
arginine M1	ME397992	NA	NA	1.01	0.86	0.59	1.48
lysine M0	ME398101	NA	NA	1.79	1.12	0.89	0.88
NAD+ M4	ME398129	NA	NA	1.55	1.06	0.69	0.70
glycine M1	ME398081	NA	0.17	1.23	0.99	1.26	1.07
gamma-butyrobetaine M0	ME398063	NA	NA	0.93	1.16	1.11	0.86
adenosine M2	ME397978	NA	NA	1.31	0.98	0.86	0.85
NADP+ M4	ME398151	NA	NA	1.08	1.10	0.81	1.01
riboflavin M0	ME398225	NA	NA	1.18	1.00	0.80	1.02
arginine M0	ME397991	NA	NA	2.36	1.08	0.79	0.85
NAD+ M9	ME398134	0.32	0.29	2.02	1.56	0.63	0.57
NAD+ M7	ME398132	NA	NA	1.19	1.77	0.49	0.38
N-trimethyllysine M0	ME398176	NA	NA	1.99	2.61	0.92	0.43
NADP+ M5	ME398152	0.16	0.27	1.85	2.49	0.47	0.48
ornithine M1	ME398187	NA	NA	1.91	2.09	0.27	0.37
NADP+ M12	ME398159	0.17	1.98	NA	NA	1.08	0.77
alanine M1	ME397988	0.03	0.11	0.76	0.87	2.58	1.35
S-adenosyl-methionine M8	ME398234	1.02	0.99	NA	NA	0.87	1.11
propionyl-carnitine M1	ME398215	1.02	0.65	NA	NA	1.26	1.29
betaine M0	ME398003	0.75	0.71	0.13	0.14	1.33	1.38
S-adenosyl-methionine M6	ME398232	0.81	0.77	NA	NA	1.00	1.42
S-adenosyl-methionine M7	ME398233	0.81	0.78	NA	NA	1.02	1.40
betaine M2	ME398005	0.69	0.70	NA	NA	1.17	1.26
CDP-choline M3	ME398020	0.69	0.85	NA	NA	1.21	1.17
propionyl-carnitine M3	ME398217	0.74	0.30	NA	NA	1.76	1.21
asparagine / N-carbamoylsarcosine M2	ME398000	0.79	0.79	0.04	0.06	1.71	1.66
5^-methylthioadenosine M0	ME397954	0.49	0.57	0.13	0.13	1.40	1.51
5^-methylthioadenosine M4	ME397958	0.44	0.69	NA	NA	1.50	1.37
betaine M1	ME398004	0.52	0.73	0.40	NA	1.53	0.86
acetyl-carnitine M0	ME397966	0.42	0.53	0.41	0.54	1.23	1.56
glycerophosphocholine M0	ME398071	0.30	0.36	0.32	0.23	1.52	1.51
NAD+ M0	ME398125	0.40	0.38	0.41	0.45	1.45	1.39
carnitine M0	ME398009	0.67	0.62	0.72	0.24	1.36	1.26
NADP+ M0	ME398147	0.66	0.46	0.37	0.44	1.45	1.07
glycerophosphocholine M1	ME398072	NA	NA	0.07	0.01	2.16	1.76
5^-methylthioadenosine M1	ME397955	NA	NA	0.06	NA	0.86	1.45
NAD+ M2	ME398127	NA	NA	0.55	0.54	1.43	1.47
ornithine M0	ME398186	NA	NA	0.36	0.28	1.28	1.18
NAD+ M3	ME398128	NA	NA	0.44	0.32	1.52	1.72
NAD+ M1	ME398126	0.17	0.19	0.30	0.30	1.61	1.86
S-adenosyl-methionine M0	ME398226	0.12	0.13	0.16	0.19	1.47	1.82
5^-methylthioadenosine M2	ME397956	NA	NA	0.03	0.02	1.54	1.76
NADP+ M1	ME398148	NA	NA	0.17	0.02	1.40	1.48
S-adenosyl-methionine M1	ME398227	NA	0.00	0.01	NA	1.23	1.43
proline M3	ME398211	1.41	1.21	0.45	0.70	0.83	0.98
NAD+ M10	ME398135	1.22	1.00	0.64	0.98	1.18	0.98
NADP+ M10	ME398157	1.34	1.16	0.41	0.88	1.23	0.98
phosphocholine M0	ME398202	0.96	0.73	0.72	0.89	1.24	1.01
alanine M0	ME397987	0.96	0.81	1.15	1.08	1.18	0.89
glycerophosphocholine M3	ME398074	0.67	0.81	1.28	1.00	1.33	0.91
phenylalanine M1	ME398193	1.20	1.27	0.40	0.05	0.18	1.90
NADP+ M2	ME398149	1.55	1.23	0.25	0.27	1.19	1.50
S-adenosyl-methionine M5	ME398231	0.85	1.10	0.30	0.44	0.95	1.85
acetyl-carnitine M2	ME397968	2.22	3.36	0.09	0.79	0.50	0.68
nicotinamide M0	ME398169	2.56	3.04	0.58	0.81	0.17	0.18
valine M2	ME398257	2.01	2.80	0.53	0.53	0.15	0.29
methioninesulfoxide M0	ME398119	2.24	2.44	0.34	0.26	0.31	0.37
valine M0	ME398255	2.24	2.48	0.66	0.33	0.44	0.45
kynurenine M0	ME398083	2.43	2.09	0.78	1.09	0.36	0.42
serine M2	ME398248	2.54	1.75	0.84	0.77	0.32	0.23
leucine / isoleucine M1	ME398095	1.60	2.20	0.83	0.03	0.11	0.31
5^-methylthioadenosine M5	ME397959	1.81	2.18	0.12	0.14	0.77	0.99
leucine / isoleucine M0	ME398094	1.77	1.93	0.48	0.21	0.72	0.76
nicotinamide M1	ME398170	1.50	2.04	0.39	0.72	0.18	0.18
methionine M0	ME398113	1.80	1.77	0.64	0.81	0.69	0.66
phenylalanine M0	ME398192	2.00	2.21	0.87	0.61	0.50	0.53
serine M3	ME398249	1.65	2.21	0.52	0.52	0.70	0.40
cystathionine M1	ME398056	2.91	1.40	NA	NA	0.11	0.16
cystathionine M3	ME398058	2.16	1.05	NA	NA	0.11	0.06
kynurenine M1	ME398084	0.82	2.17	NA	NA	NA	0.02
nicotinamide M2	ME398171	1.22	1.63	NA	NA	0.32	0.39
CDP-choline M5	ME398022	1.31	1.53	NA	NA	0.52	0.65
CDP-choline M7	ME398024	1.28	1.52	NA	NA	0.36	0.63
choline M1	ME398033	1.70	1.84	NA	NA	0.28	0.45
choline M2	ME398034	1.83	1.73	NA	NA	0.41	0.55
choline M0	ME398032	1.71	1.45	NA	NA	0.35	0.48
5^-methylthioadenosine M7	ME397961	1.48	1.61	NA	NA	0.49	0.43
5^-methylthioadenosine M6	ME397960	1.54	1.58	NA	NA	0.42	0.46
5^-methylthioadenosine M8	ME397962	1.54	1.60	NA	NA	0.35	0.51
acetyl-carnitine M3	ME397969	1.27	1.28	NA	NA	0.17	NA
CDP-choline M6	ME398023	1.26	1.33	NA	NA	0.32	0.25
adenosine M6	ME397982	0.98	1.34	0.05	NA	NA	NA
valine M3	ME398258	0.85	1.48	NA	NA	NA	0.29
cystathionine M0	ME398055	2.28	1.13	0.05	0.10	0.91	0.76
CDP-choline M8	ME398025	1.00	1.56	NA	NA	0.95	0.60
NADP+ M11	ME398158	1.40	1.37	NA	NA	0.81	0.42
propionyl-carnitine M0	ME398214	1.79	1.03	NA	NA	0.65	0.53
creatine M2	ME398047	1.58	1.08	NA	NA	0.99	0.68
NAD+ M12	ME398137	1.40	1.10	NA	NA	0.76	0.74
NAD+ M13	ME398138	1.52	1.12	NA	NA	0.79	0.61
NAD+ M11	ME398136	1.65	1.05	0.07	0.08	1.26	0.95
proline M5	ME398213	1.65	1.45	0.07	0.13	0.88	0.98
proline M0	ME398208	1.62	1.49	3.05	0.73	0.50	0.51
S-adenosyl-methionine M4	ME398230	0.77	1.66	2.57	0.32	0.43	0.66
creatine M1	ME398046	0.85	0.72	1.81	1.93	0.16	0.08
creatinine M1	ME398051	0.93	1.09	2.07	2.18	0.34	0.25
creatine M0	ME398045	1.11	0.75	1.72	2.15	0.82	0.79
asparagine / N-carbamoylsarcosine M1	ME397999	0.89	0.90	1.94	2.72	0.59	0.60
creatinine M0	ME398050	0.81	0.92	1.97	3.03	0.76	0.63
adenosine M5	ME397981	0.65	0.74	1.00	1.62	NA	NA
glycine M2	ME398082	0.86	0.91	1.07	1.17	NA	NA
threonine M1	ME398251	1.18	1.20	0.74	1.03	0.13	0.38
acetyl-carnitine M1	ME397967	0.70	1.69	1.22	1.25	0.38	0.40
proline M4	ME398212	1.35	1.60	0.92	1.53	0.35	0.35
serine M1	ME398247	1.39	1.91	1.03	1.12	0.62	0.56
serine M0	ME398246	1.10	1.40	1.49	0.99	0.84	0.79
proline M1	ME398209	1.68	1.45	1.60	1.76	0.50	0.60
threonine M0	ME398250	1.35	1.37	1.96	1.47	0.66	0.63
threonine M2	ME398252	1.48	1.53	2.08	1.64	0.56	0.50
proline M2	ME398210	2.19	1.97	1.42	1.96	0.29	0.29
valine M1	ME398256	1.42	1.86	0.24	2.20	0.64	0.42

Factors:

F1	Cell_type:HEK293T_ACE2 \| Sample_type:Mock
F2	Cell_type:HEK293T_ACE2 \| Sample_type:SARS-CoV-2
F3	Cell_type:NHBE-ALI \| Sample_type:Mock
F4	Cell_type:NHBE-ALI \| Sample_type:SARS-CoV-2
F5	Cell_type:Vero \| Sample_type:Mock
F6	Cell_type:Vero \| Sample_type:SARS-CoV-2

Data matrix