Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion (Study ST001747)

Reversed phase NEGATIVE ION MODE (Analysis AN002843)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7
2-Hydroxyglutarate/Citramalate	ME405132	0.85	1.44	0.53	0.63	0.76	2.01	0.54
Threonate	ME405156	0.86	0.99	0.64	0.81	1.03	1.98	0.49
2/3-Phospho-D-glycerate	ME405122	1.10	0.97	0.42	1.40	1.38	1.11	0.33
Thioredoxin disulfide	ME405161	0.67	0.81	1.33	1.17	1.00	0.89	1.30
N-Glycoloyl-neuraminate	ME405143	1.44	0.79	0.96	0.88	1.09	0.85	0.98
D-Glucose	ME405118	1.45	0.79	1.40	0.79	0.83	1.01	0.88
Ornithine	ME405140	1.12	0.90	1.31	0.92	0.77	0.94	1.20
D-Glucose 6-phosphate	ME405119	0.77	0.84	0.82	1.32	1.21	1.17	0.76
S-Glutathionyl-L-cysteine	ME405136	1.00	0.79	0.51	0.78	1.29	1.61	0.80
N-Succinyl-L-citrulline	ME405145	1.09	1.01	0.59	0.75	1.19	1.37	0.81
Sedoheptulose 7-phosphate	ME405134	1.07	0.90	0.63	0.90	1.11	1.37	0.88
Sodium glucuronate	ME405158	0.56	0.97	0.89	0.97	0.98	1.54	1.04
D-Ribitol 5-phosphate	ME405160	0.81	0.81	0.79	0.98	1.05	1.48	1.00
Lactate	ME405123	0.83	0.92	0.74	0.96	1.19	1.41	0.83
L-2-Aminoadipate	ME405155	1.10	1.25	0.66	0.89	0.86	1.35	0.74
Ascorbate	ME405137	1.16	0.95	1.10	0.87	0.95	1.08	0.92
Fumarate	ME405129	1.17	0.92	0.97	0.89	0.98	1.14	0.91
AMP	ME405112	0.86	1.04	1.15	1.00	0.96	1.05	1.01
Ethanolamine phosphate	ME405152	1.05	0.91	1.11	0.94	0.93	0.99	1.12
3-Phosphonooxypyruvate	ME405139	1.04	1.03	1.12	0.91	0.93	1.01	1.02
Serotonin	ME405150	1.11	1.02	1.21	0.89	0.95	0.92	0.97
sn-Glycerol 3-phosphate	ME405151	1.10	1.08	0.70	1.03	1.11	1.11	0.72
2-Oxoglutaramate	ME405127	1.20	0.95	0.88	1.03	1.01	1.04	0.82
L-Selenomethionine	ME405148	1.03	1.03	0.97	1.00	1.02	0.98	0.96
2-Oxoglutarate	ME405126	1.06	0.99	0.94	1.07	0.97	1.02	0.91
Oxaloacetate	ME405131	1.02	1.01	0.97	1.05	0.99	1.03	0.90
N-Methylethanolamine phosphate	ME405153	0.97	1.03	0.92	1.09	1.05	0.99	0.91
Thymine	ME405115	1.01	1.03	0.90	1.05	1.02	1.02	0.93
Succinate	ME405128	1.11	1.06	0.92	1.07	1.00	0.95	0.85
Maleamate	ME405157	1.03	1.05	0.81	1.09	1.04	1.05	0.84
Mercaptopyruvate	ME405147	1.03	1.04	0.90	1.07	1.04	1.04	0.83
Sedoheptulose 1-phosphate	ME405133	0.82	0.94	0.96	0.93	0.98	1.19	1.18
sn-glycero-3-Phosphoethanolamine	ME405154	0.92	0.97	0.92	0.98	1.05	1.16	0.97
D-Glyceraldehyde 3-phosphate	ME405121	0.88	1.00	0.81	1.00	1.01	1.20	1.03
Urate	ME405141	0.78	1.03	0.88	1.00	1.03	1.24	0.98
D-Fructose 6-phosphate	ME405120	0.78	0.89	0.89	1.14	1.05	1.15	1.06
Pentose phosphates (isobars)	ME405135	0.89	0.95	0.86	1.05	0.99	1.08	1.13
N-Acetylneuraminate	ME405142	1.01	0.91	0.82	0.92	1.18	1.10	1.00
Catechin	ME405159	1.16	0.87	0.77	0.89	1.12	1.15	0.94
Hydroxyacetone phosphate	ME405162	1.13	0.83	0.88	0.86	1.15	1.22	0.88
Malate	ME405130	1.10	0.84	0.85	0.85	1.08	1.30	0.90
Citrate	ME405125	0.95	0.96	0.90	0.77	1.04	1.42	0.91
UMP	ME405114	0.98	1.12	1.01	0.84	0.94	1.18	0.93
Dehydroascorbate	ME405138	1.01	0.96	0.90	0.89	0.99	1.29	0.92
Diphosphate	ME405117	1.03	1.08	0.86	0.90	0.94	1.25	0.87
Orthophosphate	ME405116	1.02	1.07	0.83	0.97	0.94	1.18	0.91
3-Sulfino-L-alanine	ME405146	1.02	0.90	0.85	0.69	1.21	1.14	1.15
L-Cysteate	ME405149	0.94	0.88	1.16	0.68	0.99	1.25	1.19
(S)(+)-Allantoin	ME405113	3.72	1.30	0.57	0.23	0.25	0.46	0.22
D-Ribose	ME405124	2.47	0.83	1.30	0.67	0.66	0.63	0.51
L-Arabinose	ME405144	2.47	0.83	1.29	0.66	0.65	0.64	0.53

Factors:

F1	group:AKI \| time point:24h
F2	group:AKI \| time point:4h
F3	group:AKI \| time point:7d
F4	group:normal \| time point:24h
F5	group:sham \| time point:24h
F6	group:sham \| time point:4h
F7	group:sham \| time point:7d

Data matrix