Clustering data with hclust algorithm for Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion (Study ST001747)
Reversed phase POSITIVE ION MODE (Analysis AN002844)Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
---|---|---|---|---|---|---|---|---|
Creatinine | ME405214 | 2.93 | 0.99 | 0.61 | 0.54 | 0.78 | 0.58 | 0.35 |
N-Amidino-L-aspartate | ME405240 | 2.56 | 0.92 | 1.47 | 0.44 | 0.46 | 0.80 | 0.44 |
4-Aminobenzoate | ME405230 | 0.66 | 0.89 | 2.74 | 0.85 | 0.76 | 0.88 | 0.90 |
Indole-3-acetaldehyde | ME405221 | 0.38 | 0.64 | 0.97 | 0.85 | 0.75 | 1.88 | 1.50 |
Homocarnosine | ME405211 | 1.22 | 1.98 | 0.97 | 0.40 | 0.55 | 1.30 | 0.52 |
Peptide tryptophan | ME405231 | 0.78 | 1.45 | 1.01 | 0.52 | 0.81 | 1.62 | 0.79 |
Putrescine | ME405208 | 1.87 | 1.18 | 0.80 | 0.71 | 0.73 | 0.97 | 0.63 |
Pantothenol | ME405217 | 1.17 | 0.81 | 1.61 | 0.86 | 1.02 | 0.84 | 0.92 |
N6-Methyl-L-lysine | ME405236 | 1.59 | 0.86 | 1.48 | 0.77 | 0.78 | 0.95 | 0.74 |
Phosphocreatine | ME405212 | 1.73 | 0.84 | 1.42 | 0.81 | 0.82 | 0.74 | 0.79 |
L-Octanoylcarnitine | ME405227 | 1.27 | 0.86 | 0.61 | 1.40 | 1.38 | 0.77 | 0.50 |
6-Hydroxykynurenic acid | ME405222 | 1.15 | 0.76 | 0.26 | 0.75 | 1.57 | 1.57 | 0.60 |
Spermine | ME405210 | 0.77 | 0.85 | 1.48 | 0.98 | 0.75 | 0.93 | 1.48 |
aspartate | ME405166 | 0.70 | 0.67 | 1.45 | 1.06 | 1.18 | 0.89 | 1.26 |
O-Propanoylcarnitine | ME405225 | 0.56 | 0.69 | 1.21 | 1.10 | 1.00 | 1.00 | 1.58 |
5-6-Dihydrothymine | ME405188 | 1.12 | 1.01 | 1.34 | 0.91 | 0.90 | 0.96 | 0.88 |
tryptophan | ME405179 | 0.97 | 1.30 | 1.20 | 0.82 | 0.83 | 1.02 | 0.92 |
Purine | ME405196 | 1.09 | 1.08 | 0.99 | 1.11 | 0.92 | 0.90 | 0.89 |
L-Citrulline | ME405207 | 1.11 | 0.85 | 1.22 | 0.96 | 0.85 | 0.94 | 1.17 |
Succinyl sulfathiazole | ME405238 | 1.02 | 0.92 | 0.94 | 0.89 | 0.93 | 1.14 | 1.14 |
2-Deoxy-alpha-D-glucoside | ME405234 | 1.07 | 0.99 | 0.99 | 0.96 | 0.92 | 1.03 | 1.04 |
Taurine | ME405218 | 1.06 | 0.94 | 1.09 | 0.86 | 0.96 | 1.12 | 1.00 |
O-Butanoylcarnitine | ME405226 | 0.80 | 1.07 | 1.28 | 0.74 | 1.06 | 1.01 | 1.16 |
Tripeptide | ME405237 | 0.84 | 1.00 | 1.34 | 1.15 | 0.99 | 0.79 | 1.03 |
Hypotaurine | ME405219 | 0.39 | 1.11 | 0.75 | 0.78 | 1.11 | 1.38 | 1.42 |
Adenosine | ME405192 | 0.56 | 0.82 | 1.01 | 0.71 | 1.09 | 1.47 | 1.38 |
Cytidine | ME405187 | 0.75 | 0.86 | 0.79 | 0.82 | 1.02 | 1.51 | 1.19 |
S-Adenosyl-L-methionine | ME405206 | 0.81 | 0.79 | 1.01 | 0.83 | 1.17 | 1.32 | 1.08 |
Guanine | ME405184 | 0.78 | 0.85 | 0.87 | 0.89 | 1.18 | 1.26 | 1.15 |
alanine | ME405163 | 0.77 | 0.80 | 0.88 | 0.99 | 1.28 | 1.16 | 1.06 |
cis-p-Coumarate | ME405235 | 0.75 | 0.77 | 0.97 | 0.92 | 1.27 | 1.21 | 1.12 |
tyrosine | ME405180 | 0.73 | 0.79 | 0.89 | 0.93 | 1.27 | 1.23 | 1.14 |
Cys-Gly | ME405220 | 0.83 | 0.88 | 1.10 | 0.78 | 1.24 | 1.07 | 1.16 |
Glutathione | ME405198 | 0.78 | 0.84 | 1.13 | 0.76 | 1.29 | 1.08 | 1.20 |
cysteine | ME405167 | 0.91 | 0.89 | 0.92 | 0.83 | 1.31 | 1.03 | 1.08 |
glycine | ME405170 | 0.97 | 0.86 | 0.99 | 0.95 | 1.13 | 1.03 | 1.07 |
D-O-Phosphoserine | ME405204 | 0.59 | 0.62 | 1.21 | 0.90 | 1.40 | 1.10 | 1.31 |
glutamate | ME405168 | 0.67 | 0.72 | 1.13 | 1.07 | 1.24 | 1.05 | 1.18 |
L-Adrenaline | ME405223 | 0.50 | 0.88 | 1.10 | 1.16 | 1.09 | 1.03 | 1.33 |
L-Carnitine | ME405224 | 0.62 | 0.86 | 0.98 | 1.11 | 1.12 | 1.11 | 1.21 |
Guanosine | ME405193 | 0.59 | 0.67 | 0.71 | 0.84 | 1.38 | 1.39 | 1.35 |
Inosine | ME405194 | 0.76 | 0.77 | 0.63 | 0.96 | 1.19 | 1.31 | 1.26 |
methionine | ME405174 | 0.91 | 0.73 | 0.74 | 1.03 | 1.38 | 1.16 | 0.94 |
gamma-L-Glutamyl-D-alanine | ME405201 | 0.88 | 0.65 | 0.68 | 0.82 | 1.45 | 1.42 | 0.96 |
Hypoxanthine | ME405182 | 0.83 | 0.81 | 0.61 | 0.91 | 1.27 | 1.40 | 1.02 |
2-3-Bisphosphoglycerate | ME405197 | 1.06 | 1.57 | 0.58 | 0.73 | 0.83 | 1.27 | 0.77 |
asparagine | ME405165 | 1.25 | 1.27 | 0.66 | 0.66 | 0.91 | 1.29 | 0.80 |
4-Pyridoxate | ME405189 | 1.27 | 1.21 | 0.62 | 0.92 | 0.84 | 1.24 | 0.72 |
Allantoate | ME405185 | 1.25 | 1.28 | 0.72 | 0.95 | 0.75 | 1.05 | 0.88 |
(5-L-Glutamyl)-L-glutamine | ME405202 | 1.03 | 0.93 | 0.57 | 0.66 | 1.31 | 1.58 | 0.71 |
Glutathione disulfide | ME405199 | 1.00 | 0.78 | 0.61 | 0.69 | 1.34 | 1.60 | 0.81 |
5-Hydroxyisourate | ME405186 | 0.97 | 1.08 | 0.67 | 0.64 | 1.12 | 1.60 | 0.77 |
glutamine | ME405169 | 1.00 | 1.16 | 0.64 | 0.67 | 1.10 | 1.53 | 0.74 |
3-Oxalomalate | ME405233 | 0.99 | 1.30 | 0.64 | 0.74 | 0.98 | 1.42 | 0.76 |
histidine | ME405171 | 1.13 | 1.17 | 0.67 | 0.76 | 0.96 | 1.43 | 0.73 |
valine | ME405181 | 0.60 | 1.19 | 0.63 | 0.96 | 1.10 | 1.40 | 0.97 |
N-Carbamyl-L-glutamate | ME405242 | 1.28 | 0.87 | 0.89 | 0.76 | 1.02 | 1.11 | 1.03 |
S-Adenosyl-L-homocysteine | ME405205 | 1.19 | 0.88 | 0.91 | 0.85 | 1.00 | 1.14 | 0.99 |
N-N-Dimethylglycine | ME405203 | 1.15 | 0.99 | 0.83 | 0.85 | 1.07 | 1.20 | 0.82 |
Creatine | ME405213 | 1.28 | 0.87 | 0.82 | 0.75 | 1.13 | 1.24 | 0.83 |
Methylenediurea | ME405232 | 1.24 | 0.91 | 0.83 | 0.78 | 1.10 | 1.25 | 0.81 |
Guanidinoacetate | ME405215 | 0.83 | 1.06 | 0.90 | 0.74 | 0.91 | 1.49 | 1.04 |
Triacanthine | ME405229 | 0.86 | 1.08 | 0.85 | 0.77 | 0.97 | 1.37 | 1.05 |
phenylalanine | ME405175 | 0.95 | 1.04 | 0.91 | 0.80 | 0.98 | 1.36 | 0.91 |
trans-4-Hydroxy-L-proline | ME405216 | 0.80 | 1.07 | 1.05 | 0.82 | 1.01 | 1.36 | 0.90 |
Adenine | ME405191 | 0.91 | 0.93 | 0.89 | 0.99 | 1.09 | 1.18 | 0.97 |
Nicotinamide | ME405190 | 0.83 | 0.88 | 0.91 | 0.93 | 1.17 | 1.28 | 0.96 |
threonine | ME405178 | 1.01 | 0.96 | 0.76 | 0.90 | 1.10 | 1.20 | 0.97 |
Xanthine | ME405183 | 0.97 | 0.93 | 0.68 | 1.05 | 1.08 | 1.24 | 0.90 |
proline | ME405176 | 0.87 | 0.87 | 0.81 | 0.91 | 1.28 | 1.21 | 0.97 |
serine | ME405177 | 0.91 | 0.93 | 0.77 | 0.92 | 1.27 | 1.16 | 0.95 |
5-Oxoproline | ME405200 | 0.90 | 0.96 | 0.78 | 0.91 | 1.19 | 1.30 | 0.85 |
arginine | ME405164 | 1.00 | 0.95 | 0.72 | 0.95 | 1.24 | 1.20 | 0.82 |
leucine/isoleucine | ME405172 | 0.98 | 0.90 | 0.77 | 0.78 | 1.13 | 1.43 | 0.92 |
trans-Homoaconitate | ME405241 | 0.89 | 1.02 | 0.58 | 0.88 | 1.19 | 1.39 | 0.86 |
lysine | ME405173 | 0.85 | 1.14 | 0.70 | 0.94 | 1.17 | 1.32 | 0.75 |
2-Oxo-7-methylthioheptanoic acid | ME405243 | 0.85 | 1.17 | 0.80 | 1.01 | 1.13 | 1.13 | 0.80 |
Pyridoxamine | ME405239 | 0.86 | 1.18 | 0.74 | 0.97 | 1.07 | 1.24 | 0.82 |
Uracil | ME405195 | 1.00 | 0.99 | 0.59 | 1.14 | 1.12 | 1.27 | 0.71 |
Acetyl phosphate | ME405228 | 0.84 | 0.98 | 0.85 | 1.18 | 1.13 | 1.10 | 0.83 |
Spermidine | ME405209 | 0.98 | 1.00 | 0.76 | 1.18 | 1.07 | 1.11 | 0.79 |
Factors:
F1 | group:AKI | time point:24h |
F2 | group:AKI | time point:4h |
F3 | group:AKI | time point:7d |
F4 | group:normal | time point:24h |
F5 | group:sham | time point:24h |
F6 | group:sham | time point:4h |
F7 | group:sham | time point:7d |