Clustering data with heatmap algorithm for Metabolic responses to PD1 immune-checkpoint blockade and association with therapeutic benefits - Part II (Study ST001236)

This analysis uses the 'heatmap.2' function of gplots package in the R statistics environment


The rows are scaled to have mean=0 and standard deviation=1

Factors:

F1Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):0.3
F2Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):10
F3Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):2
F4Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):0.3
F5Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):10
F6Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):2
F7Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):0.3
F8Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):10
F9Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):2
F10Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):0.3
F11Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):10
F12Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):2
F13Time point:week 9 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):0.3
F14Time point:week 9 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):10
F15Time point:week 9 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):2
F16Time point:week 9 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):0.3
F17Time point:week 9 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):10
F18Time point:week 9 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):2
Data matrix
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