Data for (Study ST000271)
(Analysis AN000434)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 |
|---|---|---|---|---|---|---|---|---|---|---|
| 2 or 3-phosphoglycerate_13C_1 | NA | NA | NA | NA | 0.6726 | 1.6807 | NA | 0.6467 | NA | NA |
| 2 or 3-phosphoglycerate_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 2 or 3-phosphoglycerate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 2 or 3-phosphoglycerate_2PG/3PG | 1.1127 | 0.8272 | 0.3030 | 0.3789 | 1.6789 | 1.4455 | 1.3119 | 1.3195 | 0.7412 | 0.8813 |
| 3-Glycerophosphate | 0.8563 | 0.8131 | 1.0032 | 0.9178 | 1.1205 | 0.7000 | 0.7347 | 0.5837 | 1.7804 | 1.4902 |
| 3-Glycerophosphate_13C_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3-Glycerophosphate_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3-Glycerophosphate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3-phosphoglyceraldehyde | 0.9287 | 1.2165 | 0.8443 | 0.8720 | 0.9746 | 1.3085 | 0.7578 | 1.2049 | 1.0880 | 0.8048 |
| 3-phosphoglyceraldehyde_13C_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3-phosphoglyceraldehyde_13C_2 | NA | 0.7396 | NA | NA | 0.9312 | 1.8720 | 1.2058 | 0.2514 | NA | NA |
| 3-phosphoglyceraldehyde_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 6-Phosphogluconate | 1.4018 | 1.5289 | 0.5742 | 0.5278 | 1.0075 | 1.3218 | 1.2449 | 1.1729 | 0.6427 | 0.5775 |
| 6-Phosphogluconate_13C_1 | 0.8247 | 2.5127 | NA | 0.4741 | 1.0719 | 1.1652 | NA | 1.3144 | 0.2884 | 0.3487 |
| 6-Phosphogluconate_13C_2 | 1.7664 | NA | 0.3948 | 1.2089 | 0.7092 | 1.6757 | 0.5654 | 0.7158 | 1.6183 | 0.3456 |
| 6-Phosphogluconate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 1.0000 |
| 6-Phosphogluconate_13C_4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 6-Phosphogluconate_13C_5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 6-Phosphogluconate_13C_6 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Acetyl-CoA | 0.9945 | 0.7354 | 0.6800 | 0.3240 | 1.2249 | 1.1348 | 1.2568 | 1.0999 | 1.5156 | 1.0342 |
| Acetyl-CoA_13C_1 | NA | NA | NA | 0.2107 | NA | NA | NA | NA | NA | 1.7893 |
| Acetyl-CoA_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Adenosine diphosphate_13C_1 | NA | 0.6886 | NA | 0.2068 | 0.5253 | NA | 0.6374 | NA | 1.8798 | 2.0622 |
| Adenosine diphosphate_13C_2 | 0.6475 | 0.7387 | 0.9911 | 0.6633 | 0.8871 | 0.1530 | 1.4542 | 2.4838 | 0.9813 | NA |
| Adenosine diphosphate_13C_3 | 0.4689 | 0.0725 | NA | 0.3807 | 1.3245 | 0.9262 | 0.9825 | 1.6289 | 1.5867 | 1.6292 |
| Adenosine diphosphate_13C_4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Adenosine diphosphate_13C_5 | NA | NA | NA | NA | NA | 1.5419 | 0.1271 | 1.3310 | NA | NA |
| Adenosine monophosphate_13C_1 | 1.3162 | 1.1356 | 1.9225 | NA | NA | 0.1153 | NA | 0.5104 | NA | NA |
| Adenosine monophosphate_13C_2 | NA | NA | 1.2028 | 0.1032 | 1.9770 | 1.6386 | NA | NA | 0.5683 | 0.5100 |
| Adenosine monophosphate_13C_3 | NA | 0.2718 | 1.0678 | 0.1574 | 0.8032 | 0.6406 | 0.4068 | NA | 1.7646 | 2.8877 |
| Adenosine monophosphate_13C_4 | NA | NA | NA | NA | NA | NA | NA | 1.0000 | NA | NA |
| Adenosine monophosphate_13C_5 | NA | NA | NA | NA | 1.5101 | NA | NA | 0.5791 | 0.9108 | NA |
| Adenosine triphosphate_13C_1 | NA | 0.0613 | NA | NA | 2.0743 | 0.3872 | 1.8472 | 0.3331 | 1.3727 | 0.9243 |
| Adenosine triphosphate_13C_2 | 1.0652 | 1.2027 | 0.5289 | 0.5293 | 1.1772 | 1.1445 | 1.5481 | 1.2226 | 0.7823 | 0.7993 |
| Adenosine triphosphate_13C_3 | 1.3103 | 0.9533 | 0.7114 | 0.5182 | 1.5632 | 0.9592 | 1.5504 | 1.1767 | 0.7689 | 0.4886 |
| Adenosine triphosphate_13C_4 | 1.5521 | NA | 0.3672 | NA | 0.5868 | 1.6854 | NA | NA | NA | 0.8085 |
| Adenosine triphosphate_13C_5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| ADP | 0.8549 | 0.7693 | 0.7884 | 0.7252 | 1.0817 | 1.2033 | 1.0352 | 1.0595 | 1.2291 | 1.2533 |
| AMP | 0.4738 | 0.4141 | 0.7510 | 0.8797 | 1.2141 | 0.7363 | 1.0059 | 0.7800 | 1.9858 | 1.7592 |
| Aspartate | 0.9767 | 1.0317 | 0.6082 | 0.6285 | 1.3032 | 1.5166 | 1.0587 | 1.2318 | 0.7668 | 0.8778 |
| Aspartate_13C_1 | 0.7560 | 1.4040 | 0.2961 | 0.6679 | 1.0568 | 1.9485 | 0.8264 | 1.7293 | 0.4235 | 0.8915 |
| Aspartate_13C_2 | 0.8978 | 1.7511 | 0.0379 | 1.3466 | 0.7035 | 1.7811 | 0.4338 | 1.5984 | 0.0978 | 1.3518 |
| Aspartate_13C_3 | NA | NA | NA | NA | 1.2757 | 0.3617 | NA | NA | 0.1387 | 2.2238 |
| Aspartate_13C_4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| ATP | 1.1143 | 1.1298 | 0.7901 | 0.6984 | 1.0405 | 1.1106 | 1.0129 | 1.1884 | 0.9778 | 0.9372 |
| Citrate or Isocitrate | 0.6876 | 0.7552 | 0.9211 | 0.6465 | 1.0113 | 0.9184 | 0.6592 | 0.7160 | 2.2050 | 1.4797 |
| Citrate or Isocitrate_13C_1 | 0.3935 | 0.9982 | 0.3662 | 0.9741 | 0.6101 | 1.3300 | 0.4234 | 1.1570 | 1.2600 | 2.4874 |
| Citrate or Isocitrate_13C_2 | 0.2115 | 1.2800 | 0.0662 | 1.4903 | 0.3578 | 1.4013 | 0.1568 | 1.6616 | 0.3257 | 3.0488 |
| Citrate or Isocitrate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Citrate or Isocitrate_13C_4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Citrate or Isocitrate_13C_5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Citrate or Isocitrate_13C_6 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Erythrose 4-phosphate | 0.5622 | 0.9815 | NA | 0.3101 | 1.3889 | 1.3050 | 1.3245 | 1.4413 | NA | 0.6864 |
| Erythrose 4-phosphate_13C_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Erythrose 4-phosphate_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Erythrose 4-phosphate_13C_3 | NA | NA | NA | NA | NA | NA | 0.7734 | 1.2266 | NA | NA |
| Erythrose 4-phosphate_13C_4 | NA | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA |
| Fructose 1,6-bisphosphate | 1.0388 | 1.1344 | 0.8283 | 0.8309 | 0.9400 | 1.0588 | 0.9370 | 1.1740 | 1.0402 | 1.0175 |
| Fructose 1,6-bisphosphate_13C_1 | 0.7070 | 2.1426 | 0.1219 | 0.1952 | 1.0245 | 2.1944 | 0.6443 | 1.7305 | 0.9142 | 0.3254 |
| Fructose 1,6-bisphosphate_13C_2 | 0.4728 | 1.1216 | 0.5012 | 1.4484 | 2.0089 | 0.6489 | 1.0965 | 1.2986 | 0.7713 | 0.6317 |
| Fructose 1,6-bisphosphate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Fructose 1,6-bisphosphate_13C_4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Fructose 1,6-bisphosphate_13C_5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Fructose 1,6-bisphosphate_13C_6 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Glucose 6-phosphate or fructose-6-phosphate | 1.0151 | 1.1357 | 0.7555 | 0.7328 | 1.2879 | 1.1174 | 0.8978 | 1.1556 | 0.9613 | 0.9409 |
| Glucose 6-phosphate or fructose-6-phosphate_13C_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Glucose 6-phosphate or fructose-6-phosphate_13C_2 | 0.8320 | 1.0043 | 0.6974 | 0.4731 | 1.3105 | 1.5274 | 1.0511 | 1.1856 | 0.9007 | 1.0178 |
| Glucose 6-phosphate or fructose-6-phosphate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Glucose 6-phosphate or fructose-6-phosphate_13C_4 | 1.0026 | NA | 1.1198 | NA | NA | NA | NA | NA | 1.1331 | 0.7445 |
| Glucose 6-phosphate or fructose-6-phosphate_13C_5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Glucose 6-phosphate or fructose-6-phosphate_13C_6 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Glutamate | 1.0704 | 0.8443 | 0.9141 | 0.7730 | 1.3151 | 1.0975 | 0.9961 | 0.9059 | 1.0403 | 1.0433 |
| Glutamate_13C_1 | 0.2815 | 1.4912 | 0.1431 | 0.9947 | 0.4339 | 1.9074 | 0.4218 | 2.2376 | 0.3273 | 1.7614 |
| Glutamate_13C_2 | 0.0512 | 1.7212 | 0.0023 | 1.1638 | 0.0624 | 1.7361 | NA | 2.3374 | 0.0892 | 1.8364 |
| Glutamate_13C_3 | NA | 0.4519 | NA | 0.5443 | NA | 0.2953 | NA | 2.5530 | NA | 1.1555 |
| Glutamate_13C_4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Glutamate_13C_5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Lactate | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Lactate_13C_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Lactate_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Lactate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Malate | 0.9038 | 1.1167 | 1.1139 | 1.2813 | 1.1513 | 0.9850 | 0.5882 | 0.7078 | 1.0241 | 1.1278 |
| Malate_13C_1 | 0.7995 | 1.5293 | 0.6095 | 1.5942 | 0.8628 | 1.2841 | 0.5667 | 1.0635 | 0.5754 | 1.1150 |
| Malate_13C_2 | 1.0002 | 1.2703 | 0.9574 | 1.4231 | 0.8781 | 1.0668 | 0.7692 | 0.8905 | 0.7420 | 1.0024 |
| Malate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Malate_13C_4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 1.0000 |
| Malonyl-CoA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Malonyl-CoA_13C_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Malonyl-CoA_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Malonyl-CoA_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Nicotinamide Adenine Dinucleotide oxidized | 0.8370 | 0.7878 | 0.6603 | 0.6465 | 1.2271 | 1.3123 | 1.2185 | 1.1865 | 1.0160 | 1.1081 |
| Nicotinamide Adenine Dinucleotide oxidized_13C_1 | 0.7686 | 1.5535 | 0.1185 | 0.0637 | 2.2916 | 1.8723 | 1.2067 | 0.7298 | 0.3127 | 1.0825 |
| Nicotinamide Adenine Dinucleotide oxidized_13C_2 | 0.9879 | 1.0232 | 0.7836 | 0.6759 | 1.5009 | 0.9821 | 1.5120 | 1.1565 | 0.6318 | 0.7461 |
| Nicotinamide Adenine Dinucleotide oxidized_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Nicotinamide Adenine Dinucleotide oxidized_13C_4 | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA |
| Nicotinamide Adenine Dinucleotide oxidized_13C_5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Nicotinamide Adenine Dinucleotide reduced | 1.2733 | 0.3179 | 1.1932 | 0.4743 | 0.1967 | 0.9918 | 1.6887 | 1.0910 | 1.8060 | 0.9671 |
| Nicotinamide Adenine Dinucleotide reduced_13C_1 | 1.6000 | NA | 0.5717 | 2.0056 | NA | 0.5125 | 1.4955 | 0.5961 | 0.4128 | 0.8058 |
| Nicotinamide Adenine Dinucleotide reduced_13C_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Nicotinamide Adenine Dinucleotide reduced_13C_3 | NA | NA | 0.9880 | NA | NA | 1.6373 | NA | 0.7444 | 0.6303 | NA |
| Nicotinamide Adenine Dinucleotide reduced_13C_4 | 3.9079 | 0.0117 | 0.2145 | NA | NA | 0.8861 | 0.5822 | 1.5864 | 0.2345 | 0.5767 |
| Nicotinamide Adenine Dinucleotide reduced_13C_5 | NA | 1.3054 | NA | NA | NA | 0.6946 | NA | NA | NA | NA |
| Phosphoenolpyruvate | 1.1293 | 0.7772 | 0.1614 | 0.3381 | 1.9254 | 1.4448 | 1.4331 | 1.3441 | 0.5810 | 0.8655 |
| Phosphoenolpyruvate_13C_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Phosphoenolpyruvate_13C_2 | NA | NA | NA | 0.8059 | NA | NA | 0.0199 | 0.2532 | 2.9209 | NA |
| Phosphoenolpyruvate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Ribose-5-phosphate or xylulose 5-phosphate | 0.8328 | 0.7130 | 0.7062 | 0.8150 | 1.3951 | 1.0938 | 0.9761 | 0.8374 | 1.3394 | 1.2911 |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_1 | NA | NA | 1.3631 | 0.2720 | 0.5999 | 0.4206 | NA | 1.2107 | 0.4222 | 2.7115 |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_2 | 1.0770 | 1.0019 | 0.8050 | 0.7515 | 1.1086 | 1.1482 | 0.8974 | 1.1291 | 1.0191 | 1.0623 |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_4 | NA | 0.7393 | NA | NA | NA | NA | 1.2088 | 1.0519 | NA | NA |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Sedoheptulose 7-phosphate | 1.0601 | 1.4910 | 0.4070 | 0.4957 | 0.8796 | 1.3575 | 1.1594 | 1.8409 | 0.6919 | 0.6169 |
| Sedoheptulose 7-phosphate_13C_1 | 0.7579 | 1.7308 | 0.1547 | 0.4280 | 0.7917 | 2.3567 | 0.8173 | 2.6366 | 0.2492 | 0.0772 |
| Sedoheptulose 7-phosphate_13C_2 | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA |
| Sedoheptulose 7-phosphate_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Sedoheptulose 7-phosphate_13C_4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Sedoheptulose 7-phosphate_13C_5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Sedoheptulose 7-phosphate_13C_6 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Sedoheptulose 7-phosphate_13C_7 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Sucrose | 0.8267 | 0.8428 | 0.5231 | 0.6194 | 1.3588 | 1.3437 | 1.0813 | 1.2434 | 1.1214 | 1.0393 |
| Sucrose_13C_1 | NA | 1.0550 | NA | 0.6329 | NA | 1.0355 | NA | 1.5242 | NA | 0.7523 |
| Sucrose_13C_2 | NA | 2.1273 | NA | NA | NA | NA | 0.2482 | 0.6246 | NA | NA |
| Sucrose_13C_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Sucrose_13C_4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Factors:
| F1 | Drug combination:Isoproterenol | 13C-label position in pyruvate:C1 |
| F2 | Drug combination:Isoproterenol | 13C-label position in pyruvate:C2 |
| F3 | Drug combination:Isoproterenol + Leelamine | 13C-label position in pyruvate:C1 |
| F4 | Drug combination:Isoproterenol + Leelamine | 13C-label position in pyruvate:C2 |
| F5 | Drug combination:None | 13C-label position in pyruvate:C1 |
| F6 | Drug combination:None | 13C-label position in pyruvate:C2 |
| F7 | Drug combination:Rosiglitazone | 13C-label position in pyruvate:C1 |
| F8 | Drug combination:Rosiglitazone | 13C-label position in pyruvate:C2 |
| F9 | Drug combination:Rosiglitazone + Leelamine | 13C-label position in pyruvate:C1 |
| F10 | Drug combination:Rosiglitazone + Leelamine | 13C-label position in pyruvate:C2 |
