Data for (Study ST000157)
(Analysis AN000448)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| 2 or 3-phosphoglycerate_13C_1 | NA | NA | NA | NA | NA | NA |
| 2 or 3-phosphoglycerate_13C_2 | NA | NA | NA | NA | NA | NA |
| 2 or 3-phosphoglycerate_13C_3 | NA | NA | NA | NA | NA | NA |
| 2 or 3-phosphoglycerate_2PG/3PG | NA | NA | NA | NA | NA | NA |
| 3-Glycerophosphate | 1.1749 | 1.6248 | 1.1268 | 0.9494 | 0.4042 | 0.7163 |
| 3-Glycerophosphate_13C_1 | NA | NA | 1.4031 | NA | NA | 0.1939 |
| 3-Glycerophosphate_13C_2 | NA | NA | 0.5925 | 1.2037 | NA | NA |
| 3-Glycerophosphate_13C_3 | NA | NA | 1.6574 | NA | 0.3426 | NA |
| 3-phosphoglyceraldehyde | 1.4144 | 2.3912 | 0.5910 | 1.2932 | 0.6581 | 0.0979 |
| 3-phosphoglyceraldehyde_13C_1 | NA | NA | NA | 0.1640 | 1.8360 | NA |
| 3-phosphoglyceraldehyde_13C_2 | 1.1679 | 2.1793 | 0.9514 | 1.2400 | 0.3596 | 0.5352 |
| 3-phosphoglyceraldehyde_13C_3 | NA | NA | NA | NA | NA | NA |
| 6-Phosphogluconate | 1.1220 | 1.7787 | 0.7907 | 1.1487 | 0.9180 | 0.5802 |
| 6-Phosphogluconate_13C_1 | NA | 0.0277 | NA | 1.4862 | NA | NA |
| 6-Phosphogluconate_13C_2 | NA | 0.9417 | NA | 1.0583 | NA | NA |
| 6-Phosphogluconate_13C_3 | NA | NA | NA | NA | NA | NA |
| 6-Phosphogluconate_13C_4 | NA | NA | NA | NA | NA | NA |
| 6-Phosphogluconate_13C_5 | NA | NA | NA | NA | NA | NA |
| 6-Phosphogluconate_13C_6 | NA | NA | NA | NA | NA | NA |
| Acetyl-CoA | 1.1406 | 0.5505 | 1.4185 | 1.0477 | 0.4573 | 0.1095 |
| Acetyl-CoA_13C_1 | NA | NA | 1.0000 | NA | NA | NA |
| Acetyl-CoA_13C_2 | 0.7290 | NA | NA | 1.2710 | NA | NA |
| Adenosine diphosphate | 1.6407 | 1.3822 | 1.0042 | 1.3602 | 0.3829 | 0.2623 |
| Adenosine diphosphate_13C_1 | 0.4960 | 0.5259 | 1.8584 | 2.6834 | 0.1661 | 0.5551 |
| Adenosine diphosphate_13C_2 | 0.2800 | 0.8109 | 1.0545 | 3.6665 | 0.1736 | 0.2668 |
| Adenosine diphosphate_13C_3 | 0.4636 | 0.6054 | 1.3300 | 3.6772 | 0.0915 | 0.4931 |
| Adenosine diphosphate_13C_4 | 0.1293 | 0.7731 | 0.6871 | 3.9530 | NA | 0.2822 |
| Adenosine diphosphate_13C_5 | NA | NA | 0.2108 | 1.7892 | NA | NA |
| Adenosine monophosphate | 1.5147 | 1.7486 | 0.8327 | 1.0458 | 0.6371 | 0.3701 |
| Adenosine monophosphate_13C_1 | 0.4720 | 0.5923 | 1.7192 | 2.2037 | 0.2874 | 0.9269 |
| Adenosine monophosphate_13C_2 | 0.2949 | 1.3405 | 1.1242 | 3.3396 | 0.1134 | 0.8116 |
| Adenosine monophosphate_13C_3 | 0.4275 | 0.9281 | 1.2333 | 3.0191 | 0.1997 | 0.9318 |
| Adenosine monophosphate_13C_4 | 0.1698 | 1.3894 | 0.8114 | 4.1324 | 0.0353 | 0.4804 |
| Adenosine monophosphate_13C_5 | 0.1113 | 0.5045 | 0.5711 | 3.9501 | NA | 0.2918 |
| Adenosine triphosphate | 1.5358 | 0.9931 | 1.2101 | 1.6482 | 0.3142 | 0.2639 |
| Adenosine triphosphate_13C_1 | 0.4359 | 0.2385 | 1.3883 | 2.0023 | 0.0530 | 0.8430 |
| Adenosine triphosphate_13C_2 | 0.1556 | 0.3031 | 1.0309 | 2.9170 | NA | NA |
| Adenosine triphosphate_13C_3 | 0.2451 | 0.1482 | 1.2659 | 3.3682 | 0.0527 | 0.3816 |
| Adenosine triphosphate_13C_4 | NA | 0.1515 | 0.3951 | 3.1150 | NA | 0.0381 |
| Adenosine triphosphate_13C_5 | NA | NA | NA | 1.0000 | NA | NA |
| Aspartate | 1.1683 | 0.7352 | 1.5172 | 0.6770 | 0.7821 | 0.6959 |
| Aspartate_13C_1 | 0.3687 | 0.1751 | 2.4939 | 0.6218 | 0.2649 | 0.8453 |
| Aspartate_13C_2 | 0.5109 | 0.4186 | 2.3053 | 1.1430 | 0.1452 | 1.0882 |
| Aspartate_13C_3 | 0.1955 | 0.0313 | 1.8846 | 1.2297 | NA | 0.3720 |
| Aspartate_13C_4 | NA | NA | NA | NA | NA | NA |
| Citrate or Isocitrate | 1.2840 | 0.8009 | 1.0557 | 0.6423 | 0.9565 | 0.9617 |
| Citrate or Isocitrate_13C_1 | 0.9218 | NA | 1.2592 | 0.4314 | 1.3352 | NA |
| Citrate or Isocitrate_13C_2 | 1.6735 | 0.8706 | 1.3172 | 1.4299 | 0.2094 | 0.2692 |
| Citrate or Isocitrate_13C_3 | 0.3005 | 2.3448 | 0.6519 | 0.9603 | 0.0937 | NA |
| Citrate or Isocitrate_13C_4 | NA | NA | NA | NA | NA | NA |
| Citrate or Isocitrate_13C_5 | 0.0370 | NA | 2.1455 | NA | 1.3790 | 1.0075 |
| Citrate or Isocitrate_13C_6 | 0.5834 | 0.8001 | 1.0380 | 0.5936 | 1.5594 | 1.3496 |
| Erythrose 4-phosphate | 1.2954 | 2.4206 | 0.6547 | 1.2603 | 0.7231 | 0.2228 |
| Erythrose 4-phosphate_13C_1 | NA | NA | 1.2517 | 1.1888 | 0.5594 | NA |
| Erythrose 4-phosphate_13C_2 | 0.3345 | 0.9690 | 0.1153 | 2.7484 | 0.0002 | NA |
| Erythrose 4-phosphate_13C_3 | NA | NA | NA | 1.0000 | NA | NA |
| Erythrose 4-phosphate_13C_4 | NA | NA | NA | NA | 1.0000 | NA |
| Fructose 1,6-bisphosphate | 1.0063 | 3.1180 | 0.9514 | 0.9932 | 0.4759 | 0.1731 |
| Fructose 1,6-bisphosphate_13C_1 | NA | 1.4882 | 0.8232 | 0.8654 | NA | NA |
| Fructose 1,6-bisphosphate_13C_2 | 0.3158 | 3.2843 | 0.3724 | 2.7694 | 0.0467 | NA |
| Fructose 1,6-bisphosphate_13C_3 | NA | 0.2388 | 0.0923 | 2.2540 | 0.1609 | NA |
| Fructose 1,6-bisphosphate_13C_4 | 0.0187 | 1.0744 | 0.0339 | 1.8993 | NA | NA |
| Fructose 1,6-bisphosphate_13C_5 | NA | NA | NA | NA | NA | NA |
| Fructose 1,6-bisphosphate_13C_6 | NA | 1.2097 | NA | 0.5806 | NA | NA |
| Glucose 6-phosphate or fructose-6-phosphate | 1.6520 | 2.6678 | 0.5130 | 0.6558 | 0.7396 | 0.1579 |
| Glucose 6-phosphate or fructose-6-phosphate_13C_1 | 0.5769 | 2.1635 | 0.8677 | 2.1116 | 0.4897 | 0.6009 |
| Glucose 6-phosphate or fructose-6-phosphate_13C_2 | 0.8472 | 2.2209 | 0.3469 | 3.7368 | 0.1944 | 0.2416 |
| Glucose 6-phosphate or fructose-6-phosphate_13C_3 | 0.0980 | 1.7211 | 0.2612 | 3.0738 | NA | 0.3326 |
| Glucose 6-phosphate or fructose-6-phosphate_13C_4 | 0.4183 | 2.2115 | 0.2633 | 3.6857 | 0.1567 | 0.1953 |
| Glucose 6-phosphate or fructose-6-phosphate_13C_5 | NA | 0.0614 | 0.0004 | 1.9691 | NA | NA |
| Glucose 6-phosphate or fructose-6-phosphate_13C_6 | 0.2927 | 0.7069 | 2.3797 | 0.9138 | NA | NA |
| Glutamate | 1.4517 | 1.5836 | 0.8695 | 1.1286 | 0.7020 | 0.3949 |
| Glutamate_13C_1 | 0.7554 | 0.4630 | 1.7960 | 1.7846 | 0.2945 | 0.5607 |
| Glutamate_13C_2 | 0.9506 | 1.0852 | 1.5476 | 1.8472 | 0.2433 | 0.4709 |
| Glutamate_13C_3 | 0.1252 | 0.1673 | 1.7749 | 2.1813 | NA | 0.4138 |
| Glutamate_13C_4 | NA | 0.1834 | 1.0915 | 2.0207 | NA | 0.2046 |
| Glutamate_13C_5 | NA | NA | NA | NA | NA | NA |
| Lactate | NA | NA | NA | NA | NA | NA |
| Lactate_13C_1 | NA | NA | NA | NA | NA | NA |
| Lactate_13C_2 | NA | NA | NA | NA | NA | NA |
| Lactate_13C_3 | NA | NA | NA | NA | NA | NA |
| Malate | 1.2630 | 1.6559 | 1.0990 | 1.0419 | 0.6266 | 0.4256 |
| Malate_13C_1 | 0.4019 | 0.4201 | 2.1783 | 1.5844 | 0.1452 | 0.6899 |
| Malate_13C_2 | 0.6641 | 1.0684 | 1.8337 | 1.9306 | 0.2003 | 0.4700 |
| Malate_13C_3 | 0.2609 | 0.2518 | 1.5584 | 1.5304 | NA | 0.0965 |
| Malate_13C_4 | 0.5290 | 1.2901 | 1.1777 | 2.5737 | 0.4885 | 0.6601 |
| Malonyl-CoA | NA | NA | NA | NA | NA | NA |
| Malonyl-CoA_13C_1 | NA | NA | NA | NA | NA | NA |
| Malonyl-CoA_13C_2 | NA | NA | NA | NA | NA | NA |
| Malonyl-CoA_13C_3 | NA | NA | NA | NA | NA | NA |
| Nicotinamide Adenine Dinucleotide oxidized | 1.9341 | 0.4751 | 1.9911 | 0.6809 | 0.0685 | 0.3547 |
| Nicotinamide Adenine Dinucleotide oxidized_13C_1 | NA | NA | 1.0000 | NA | NA | NA |
| Nicotinamide Adenine Dinucleotide oxidized_13C_2 | NA | NA | 1.0000 | NA | NA | NA |
| Nicotinamide Adenine Dinucleotide oxidized_13C_3 | NA | NA | 1.0000 | NA | NA | NA |
| Nicotinamide Adenine Dinucleotide oxidized_13C_4 | NA | NA | NA | NA | NA | NA |
| Nicotinamide Adenine Dinucleotide oxidized_13C_5 | NA | NA | NA | NA | NA | NA |
| Nicotinamide Adenine Dinucleotide reduced | 1.1697 | 0.8806 | 1.7796 | 0.9869 | 0.1098 | 0.1976 |
| Nicotinamide Adenine Dinucleotide reduced_13C_1 | NA | NA | 1.1641 | NA | NA | 0.6718 |
| Nicotinamide Adenine Dinucleotide reduced_13C_2 | NA | NA | 0.0674 | 1.9326 | NA | NA |
| Nicotinamide Adenine Dinucleotide reduced_13C_3 | 1.1895 | NA | 1.1918 | 0.6186 | NA | NA |
| Nicotinamide Adenine Dinucleotide reduced_13C_4 | NA | NA | 0.5629 | 1.4371 | NA | NA |
| Nicotinamide Adenine Dinucleotide reduced_13C_5 | NA | NA | NA | NA | NA | NA |
| Phosphoenolpyruvate | NA | NA | NA | NA | NA | NA |
| Phosphoenolpyruvate_13C_1 | NA | NA | NA | NA | NA | NA |
| Phosphoenolpyruvate_13C_2 | NA | NA | NA | NA | NA | NA |
| Phosphoenolpyruvate_13C_3 | NA | NA | NA | NA | NA | NA |
| Ribose-5-phosphate or xylulose 5-phosphate | 1.5320 | 1.8938 | 0.9636 | 0.7069 | 0.6957 | 0.2429 |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_1 | 0.5819 | 0.8036 | 1.8580 | 1.3782 | 0.3050 | 0.6332 |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_2 | 0.5095 | 1.8841 | 1.2388 | 2.3951 | 0.1909 | 0.4379 |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_3 | 0.3575 | 0.9392 | 1.5979 | 1.9901 | 0.3211 | 0.4993 |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_4 | 0.1334 | 1.5327 | 1.0781 | 2.8859 | 0.0658 | 0.1921 |
| Ribose-5-phosphate or xylulose 5-phosphate_13C_5 | NA | NA | NA | NA | NA | NA |
| Sedoheptulose 7-phosphate | 1.4985 | 1.9817 | 0.8484 | 0.7309 | 0.7981 | 0.2644 |
| Sedoheptulose 7-phosphate_13C_1 | 0.6908 | 1.0167 | 1.8352 | 0.7518 | 0.3914 | 0.7881 |
| Sedoheptulose 7-phosphate_13C_2 | 0.1086 | 1.3624 | 1.1497 | 3.0346 | 0.0573 | 0.1667 |
| Sedoheptulose 7-phosphate_13C_3 | 0.0583 | 0.9144 | 0.9981 | 2.3352 | NA | 0.1813 |
| Sedoheptulose 7-phosphate_13C_4 | 0.1788 | 1.0058 | 0.2039 | 3.2425 | NA | 0.3690 |
| Sedoheptulose 7-phosphate_13C_5 | 0.1766 | 3.0646 | 0.3272 | 0.5186 | 0.0025 | NA |
| Sedoheptulose 7-phosphate_13C_6 | NA | 2.1603 | 0.2006 | 0.5736 | 0.7047 | NA |
| Sedoheptulose 7-phosphate_13C_7 | NA | 1.0000 | NA | NA | NA | NA |
| Sucrose | 1.4567 | 1.8331 | 0.7188 | 1.2121 | 0.7389 | 0.3303 |
| Sucrose_13C_1 | 0.8197 | NA | 1.1673 | 1.1483 | 0.0834 | 1.4787 |
Factors:
| F1 | Cell type:AMPKαfl/fl | Labeling time, min:5 | 1,2-13C2-labeled glucose concentration, g/L:0.2 |
| F2 | Cell type:AMPKαfl/fl | Labeling time, min:5 | 1,2-13C2-labeled glucose concentration, g/L:2 |
| F3 | Cell type:AMPKαfl/fl | Labeling time, min:60 | 1,2-13C2-labeled glucose concentration, g/L:0.2 |
| F4 | Cell type:AMPKαfl/fl | Labeling time, min:60 | 1,2-13C2-labeled glucose concentration, g/L:2 |
| F5 | Cell type:AMPKαΔ/Δ | Labeling time, min:5 | 1,2-13C2-labeled glucose concentration, g/L:0.2 |
| F6 | Cell type:AMPKαΔ/Δ | Labeling time, min:60 | 1,2-13C2-labeled glucose concentration, g/L:0.2 |
