Data for (Study ST000546)

(Analysis AN000833)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
1-18:2-2-18:2-monogalactosyldiacylglycerol 0.8432 0.9093 0.8327 1.3111
1-Deoxy-D-altro-heptulose 7-phosphate 0.9708 0.8377 1.1915 NA
1-Sinapoyl-D-glucose 0.8741 0.8591 1.2045 1.0623
1-thio-beta-D-glucose 0.8990 0.8288 1.2722 NA
2-16:0-lysoPG 0.8736 0.8009 1.3255 NA
2,3-Bisphospho-D-glycerate 0.6059 0.4236 0.4500 2.1404
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate 0.3284 0.3328 0.4507 2.4161
2-C-Methyl-D-erythritol 4-phosphate 1.0014 0.6570 0.7892 1.4143
2-Dehydro-3-deoxy-D-gluconate 0.4060 0.4257 0.4329 2.3016
2-Deoxy-2,3-dehydro-N-acetylneuraminic acid 0.4744 0.3801 0.4001 2.3091
2-Hydroxy-1,3-dimethoxy-8,9-methylenedioxycoumestan 1.1306 1.0166 1.1047 0.8111
2-Oxoglutaramate 1.0268 1.4336 1.5400 0.2497
2-Oxoglutarate 0.9194 1.0255 0.6366 1.3139
3-beta-D-Galactosyl-sn-glycerol 0.4020 0.4266 0.4347 2.3025
3-Cyano-L-alanine 1.1258 1.2924 0.9570 0.7185
3-Oxopropanoate 0.8367 0.6150 0.7110 1.6279
3-Phospho-D-glycerate 0.8113 0.5372 0.5067 1.8586
4-Amino-4-deoxychorismate 0.7056 0.6173 0.6012 1.8070
4-Hydroxyphenylacetylglycine 0.7676 0.5488 0.5942 1.8170
4-Methyl-2-oxopentanoate 0.6151 0.6563 0.5582 1.8778
4-oxo-4-(3-pyridyl)-butanoate 0.4090 0.3174 0.4859 2.3407
5-Acetyl-2,4-dimethyloxazole 0.7374 0.6480 0.6306 1.7380
5-L-Glutamylglycine 1.0599 1.3282 1.0999 0.6340
6-Phospho-D-gluconate 1.3202 0.7805 0.8507 1.0365
7-Methyl-3-oxooctanoyl-CoA 0.7229 0.5155 0.5524 1.9069
Acetyl phosphate 0.8761 0.7781 0.4917 1.6406
ADP-ribose 1.1704 0.9388 0.8908 NA
Ala-Glu-Ala-Glu 0.8215 1.2371 0.9415 NA
Ala-Gly-Tyr 1.2665 1.1728 1.1876 0.0596
Ala-Lys-Asp-Pro 0.7232 1.3189 0.9579 NA
Ala-Ser 1.0593 1.7462 1.4017 0.0946
Allogibberic acid 0.3621 0.3382 0.3195 2.4852
AMCC 0.8580 0.8979 1.2441 NA
ancymidol 0.8096 0.7410 0.6897 1.5699
Arg-Cys-Cys-Tyr 1.1737 0.6486 1.1777 NA
Asn-Met-Thr-Asp 0.5897 0.5534 0.7317 1.8439
Asn-Ser 1.0320 1.1022 0.8658 NA
Asp-Gln 0.7434 1.0627 1.1939 NA
Asp-Phe-Pro-Tyr 1.3608 0.9244 0.7149 NA
Asp-Ser-Tyr-Tyr 1.3141 0.7913 0.8946 NA
Asp-Trp-Asp-Gln 0.3997 0.4796 0.4546 2.2496
Benzyl sulfate 0.8659 0.7057 0.8775 1.3796
Bergaptol 0.6572 0.5622 0.4526 1.9960
Betaine 0.3896 0.4193 0.3777 2.3600
Cholate 1.1220 1.0461 0.8455 1.0203
Cholesterolsulfate 0.6403 0.5413 0.4964 1.9915
cis-(homo)3aconitate 0.7284 0.6609 0.5272 1.8126
Citrate 0.3892 0.3230 0.3575 2.4478
CMP 0.9364 1.2377 0.8047 NA
CMP-2-aminoethylphosphonate 0.8066 0.8283 0.7653 1.4498
Cyclic 2,3-bisphospho-D-glycerate 0.5767 0.3774 0.4622 2.1877
Cyclic ADP-ribose 1.3175 1.2078 1.0242 0.5879
Cys-Leu-Cys-Tyr 1.2880 0.9820 0.8968 0.4996
Cys-Lys-Ser-Ser 1.0602 1.6374 1.2048 0.3232
D-4^-Phosphopantothenate 0.9791 0.9190 1.1018 NA
deacetylcolchicine 0.7138 0.5884 0.4271 1.9530
D-Erythrose 0.3459 0.3856 0.5399 2.2964
D-Fructose 0.9195 0.7807 0.9002 1.2997
D-Gluconic acid 0.3509 0.3653 0.3698 2.4355
D-Glucosamine 0.2960 0.3655 0.3267 2.5088
D-Glucose 6-phosphate 1.2398 1.1432 0.9619 0.7414
D-Glucuronate 0.7204 0.5101 0.4958 1.9553
D-Glycerate 0.4795 0.5159 0.6456 2.0193
Dide-O-methylsimmondsin 0.3392 0.4096 0.3108 2.4554
D-Mannitol 1-phosphate 0.9957 0.8611 0.8179 1.2440
D-Ribose 5-phosphate 0.9983 0.4959 0.5019 1.7530
D-Sedoheptulose 7-phosphate 0.6471 0.4540 0.5088 2.0426
D-Sorbitol 0.2746 0.2963 0.2930 2.6021
D-Xylonate 0.2636 0.2277 0.2672 2.6811
D-Xylonolactone 0.8627 0.5799 0.4936 1.7978
FA(16:0) 0.9568 0.4685 0.5153 1.7945
[FA (18:1)] 9Z-octadecenoic acid 0.9096 0.8281 0.9917 1.2029
[FA (18:3)] 9Z,12Z,15Z-octadecatrienoic acid 0.9136 0.9401 1.0526 1.0703
FA (19:1) 0.7946 0.7797 0.8958 1.3975
FA (20:0) 0.9017 0.6306 0.5506 1.6878
[FA (20:1)] 11Z-eicosenoic acid 0.9257 0.8711 0.7454 1.3433
FA (20:4) 0.9755 0.8585 1.0964 1.0522
[FA (22:5)] 7Z,10Z,13Z,16Z,19Z-docosapentaenoic acid 0.8800 0.8444 0.8987 1.2826
FA hydroxy(10:0) 0.9550 0.7113 0.5108 1.6172
[FA trihydroxy(4:0)] 2,3,4-trihydroxy-butanoic acid 0.5009 0.5316 0.6302 2.0030
Fumarate 0.6818 0.5970 0.6468 1.8058
gamma-L-Glutamyl-D-alanine 0.7769 1.1284 1.0948 NA
Gln-Leu-Lys-Tyr 0.7601 0.6659 0.4914 1.8120
Gln-Met-Met-Thr 1.0517 0.8640 1.0843 NA
Glycerol 1.0900 1.2481 0.9143 0.8107
Glycochenodeoxycholate 1.0632 0.8854 0.9625 1.0825
Glycyl-Serine 0.9522 0.9240 1.1238 NA
Gravacridonetriol glucoside 0.6211 0.6240 0.4727 1.9616
HEPES 1.3855 1.0399 1.2039 0.5281
Histidinyl-Asparagine 0.7539 1.1587 1.0873 NA
Hydantoin-5-propionate 1.2819 1.7640 1.1539 0.1002
Hydroxymethylphosphonate 1.2179 0.8571 0.7515 1.1301
Icosadienoic acid 1.0177 0.6183 1.0548 1.4638
Icosatrienoic acid 0.9596 0.8867 1.0390 1.0860
Ile-His-Val 1.0919 0.8592 1.0489 NA
Ile-Thr 0.8644 1.2270 0.9086 NA
Imidazole-4-acetaldehyde 0.4546 0.4565 0.4851 2.2029
Kinobscurinone 0.9829 1.0357 1.0153 0.9746
LacCer(d32:1) 0.8829 0.9426 0.4900 1.5133
L-Aspartate 0.7074 0.6471 0.6520 1.7451
L-beta-aspartyl-L-serine 0.8880 1.6351 1.5874 0.1671
L-Cysteate 0.7980 0.7007 0.9150 1.4397
L-Cysteine 1.1348 0.7393 1.1259 NA
L-prolyl-L-glycine 1.2554 1.4445 0.9365 0.3636
LysoPA(16:0) 0.5263 0.5387 0.5185 2.0624
LysoPA(18:0) 0.5548 0.5311 0.3818 2.1493
LysoPE(18:0) 0.9216 0.8107 1.0044 1.1975
LysoPE(18:2) 0.7473 0.7245 1.0914 1.3276
LysoPE(18:3) 0.9249 0.8113 1.2638 NA
LysoPE(20:4) 0.6313 0.5668 0.5880 1.9104
LysoPE(20:5) 1.1949 0.9598 1.1532 0.6921
LysoPE(22:5) 0.9022 0.7272 0.8477 1.3921
Maleamate 1.5182 1.1343 1.2399 0.3307
Melibiitol 0.6302 0.7825 0.7897 1.5981
melibionate 0.6088 0.4859 0.5138 2.0437
Met-Met-Ala 0.7321 1.2828 0.9851 NA
Met-Thr-Asp 1.1150 0.6202 0.5674 1.5230
Miroestrol 0.9553 0.7079 0.6255 1.5335
N2-Succinyl-L-ornithine 1.2148 1.6694 1.3764 0.0545
N-Acetyl-D-glucosaminate 0.4324 0.3766 0.3609 2.3725
N-Acetyl-D-glucosamine 6-phosphate 0.5644 0.5550 0.5254 2.0164
N-Acetyl-D-mannosaminolactone 0.9571 0.9795 1.1728 0.9179
N-Acetyl-L-citrulline 0.7336 1.2752 0.9912 NA
N-Acetyl-L-glutamate 1.3595 1.1992 1.0612 0.5350
N-Acetylmethionine 1.1297 1.2507 1.4362 0.3875
N-Amidino-L-glutamate 1.0326 0.9300 1.0374 NA
N-D-Glucosylarylamine 0.8091 0.6815 0.6415 1.6509
nonulose 9-phosphate 0.7797 0.5488 0.5090 1.8719
N-Succinyl-L-glutamate 0.8761 1.0725 1.0513 NA
octulose 8-phosphate 0.3455 0.3042 0.3996 2.4630
Orotate(Fragment) 1.3550 1.2324 1.4047 0.2560
Orotidine 0.5267 0.5346 0.4448 2.1204
Orthophosphate 0.7505 0.5900 0.4893 1.8777
[PA(16:0/18:1)] 1-hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-phosphate 0.8067 0.7574 0.6871 1.5616
PA(18:1(9Z)/0:0) 0.5912 0.6894 0.6508 1.8014
PA(34:2) 0.7151 0.6213 0.5574 1.8297
PA(36:3) 0.7091 0.6503 0.5551 1.8141
PA(36:4) 0.6344 0.6326 0.4968 1.9272
PE(14:0/20:2(11Z,14Z)) 1.1910 1.2055 0.9582 0.7340
[PE(18:1/16:0)] 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine 0.9916 1.2486 1.0470 0.7846
[PE(18:2/18:2)] 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine 0.8898 0.9598 0.8052 1.2589
PE(30:4) 0.7925 0.7907 0.6857 1.5483
PE(31:4) 0.7327 0.7167 0.6307 1.6899
PE(36:1) 1.1966 1.1563 1.1970 0.5876
PE(36:3) 0.6808 0.5817 0.5208 1.9125
PE(38:5) 0.6605 0.6267 0.4704 1.9318
PE(P-38:4) 0.3980 0.3494 0.2609 2.4939
PE(P-40:4) 0.4894 0.3536 0.2920 2.3987
[PG (18:0)] 1-octadecanoyl-sn-glycero-3-phospho-(1^-sn-glycerol) 0.8478 0.9312 1.2209 NA
[PG (18:1)] 1-(9E-octadecenoyl)-sn-glycero-3-phospho-(1^-sn-glycerol) 0.8887 0.8196 1.2916 NA
PG(33:1) 1.0021 0.8637 1.1342 NA
PG(34:1) 1.2278 1.1800 1.6249 0.2255
PG(34:2) 1.1001 1.0687 1.4642 0.0506
PG(34:3) 0.8640 0.8645 1.2715 NA
PG(36:1) 1.4047 1.2314 1.2611 0.3271
PG(36:2) 1.3419 1.2630 1.5831 0.1091
PG(36:3) 0.9321 0.8714 1.1966 NA
PG(36:4) 0.9989 1.0173 1.3058 0.0340
PG(36:5) 0.9349 0.9472 1.1179 NA
PG(38:6) 0.9057 0.9803 1.1140 NA
PG(40:5) 1.1400 0.9407 0.9193 NA
PG(40:6) 1.0235 0.9750 1.0015 NA
PG(54:0) 1.0691 1.1588 0.7721 NA
Phaeantharine 0.8227 0.9850 1.1923 NA
Phenolsulfonphthalein 1.1574 1.0469 1.0744 0.7909
Phosphocreatine 0.3835 0.4932 0.3442 2.3343
Phosphodimethylethanolamine 1.2598 1.2025 0.8594 0.0348
Phosphoenolpyruvate 0.7791 0.5552 0.5622 1.8276
Phosphoramidate 0.6136 0.5369 0.4467 2.0520
[PI(16:0)] 1-hexadecanoyl-sn-glycero-3-phospho-(1^-myo-inositol) 0.8585 1.0750 1.0665 NA
[PI(18:0)] 1-octadecanoyl-sn-glycero-3-phospho-(1^-myo-inositol) 0.8995 1.1788 0.9217 NA
[PI(18:0/20:4)] 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1^-myo-inositol) 1.0978 0.8131 0.7566 1.2494
PI(34:2) 0.8746 0.7653 0.7330 1.4703
PI(36:1) 1.5249 1.3756 1.2048 0.1710
PI(36:2) 1.3120 1.2444 1.2256 0.4135
PI(36:3) 1.1168 0.9893 1.0525 0.8811
PI(36:4) 0.6613 0.6478 0.6145 1.8073
PI(38:5) 1.1483 0.9849 0.8485 1.0137
PI(40:5) 1.5201 1.2481 1.0354 0.3973
PIP(36:1) 1.3045 1.1652 1.3063 0.4181
PS(18:0) 0.7368 0.7255 0.8090 1.5465
PS(18:0/18:1(9Z)) 1.4048 1.2234 1.1533 0.4140
[PS(18:1)] 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoserine 1.3322 1.2295 1.0967 0.5061
[PS(20:4)] 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine 0.7197 0.7295 0.5477 1.7523
PS(34:1) 1.2956 1.3143 0.9604 0.5723
PS(34:2) 1.4091 1.2039 0.8993 0.2316
PS(36:4) 1.1837 1.1039 0.9118 0.8504
PS(38:4) 0.6509 0.6042 0.4630 1.9614
PS(38:5) 1.2139 0.9618 0.7219 1.0768
PS(38:6) 1.0793 1.0265 0.7471 1.1103
PS(40:5) 0.7348 0.6700 0.5082 1.8152
Psychosine 0.2699 0.3908 0.4164 2.4421
Pyridoxine phosphate 1.3189 0.9439 0.7672 0.9099
Raffinose 0.3261 0.7310 0.3011 2.2313
(R,R)-Tartaric acid 0.7294 0.6115 0.5507 1.8313
Sambutoxin 0.8620 0.7264 0.9845 1.3204
Sanguinarine 0.5288 0.5782 0.6005 1.9694
(S)-ATPA 1.1259 1.6007 1.2525 0.2657
(S)-Dihydroorotate 1.4672 1.2048 1.5281 0.0999
Ser-Ser-Ser 1.0581 0.8764 0.9540 1.0836
Sinalbin 1.0782 0.9016 1.0202 NA
(S)-Lactate 0.6109 0.8091 0.9331 1.4851
(S)-Malate 1.1039 0.8795 1.0100 1.0050
sn-glycero-3-Phosphoethanolamine 0.6274 0.5250 0.5079 2.0047
sn-Glycerol 3-phosphate 0.3306 0.3511 0.3062 2.5091
[SP (16:0)] N-(hexadecanoyl)-sphing-4-enine 0.9463 0.7631 0.7519 1.4040
[SP] Sphing-4-enine-1-phosphate 0.6950 0.5673 0.4897 1.8598
Succinyladenosine 1.1890 1.0436 1.2794 0.4880
Sucrose monopalmitate 0.9284 1.0857 0.6053 1.5707
Sulfate 0.7100 0.5842 0.6757 1.7725
Sulfoacetaldehyde 1.1611 1.1404 1.5041 0.3958
Taurine 0.2843 0.3120 0.3291 2.5560
UDP-glucose 1.1970 0.7880 0.7442 1.2031
UDP-glucuronate 0.5275 0.3133 0.3598 2.3496
UDP-N-acetyl-D-galactosamine 0.8367 0.8635 0.7756 1.3932
Val-Pro 0.9108 1.0585 1.0307 NA
(Z)-4-Hydroxyphenylacetaldehyde-oxime 0.7374 0.7027 0.6596 1.6752
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Factors:

F1Artemisinin resistant:Resistant | PfKelch13 mutation:C580Y
F2Artemisinin resistant:Resistant | PfKelch13 mutation:R539T
F3Artemisinin resistant:Sensitive | PfKelch13 mutation:WT
F4Artemisinin resistant:Uinfected red blood cells | PfKelch13 mutation:Control
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