Data for (Study ST000575)

(Analysis AN000885)

Values for each metabolite have been scaled by dividing by the mean across all factors

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Metabolite	F1	F2
1,5-Anhydroglucitol	0.9875	1.0125
2-Aminoadipic acid	1.0002	0.9998
2-Hydroxypyridine	0.9862	1.0138
3-Phosphoglyceric acid	0.9768	1.0232
Adenine	0.9925	1.0075
Adenosine/Inosine	0.9723	1.0277
Alanine	0.9960	1.0044
alpha-Monopalmitin	0.9954	1.0046
alpha-Monostearin	0.9943	1.0057
Aminomalonic acid	0.9734	1.0266
Arachidic acid/ 1-Heneicosanol	0.9901	1.0110
Arachidonic acid (also Eicosapentaenoic acid)	0.9882	1.0106
Aspartic acid	0.9907	1.0093
Benzoic acid	0.9909	1.0091
beta-Hydroxybutyric acid	0.9816	1.0184
beta-Monopalmitin	0.9868	1.0132
beta-Monostearin	0.9955	1.0045
C10 hydrocarbon	1.0071	0.9921
C11 hydrocarbon	1.0256	0.9681
C12 hydrocarbon	0.9914	1.0096
C13 hydrocarbon	0.9895	1.0116
C14 Hydrocarbon	0.9976	1.0027
C15 hydrocarbon	0.9982	1.0018
C17 hydrocarbon	0.9901	1.0099
C19 hydrocarbon	0.9984	1.0014
C21 Hydrocarbon	0.9943	1.0057
C22 hydrocarbon	0.9872	1.0160
C23 Hydrocarbon	0.9753	1.0247
Campesterol	0.9859	1.0141
Cholesterol	0.9922	1.0078
Citric acid/isocitric acid	0.9874	1.0126
Creatinine	1.0127	0.9873
Dehydroalanine (possibly from cysteine)	0.9790	1.0189
Dehydroascorbic acid (possibly alpha-ketoglutarate)	0.9930	1.0070
deuterated Myristic Acid (RTL std)	0.9955	1.0045
Disaccharide	0.9905	1.0085
Docosahexaenoic acid	0.9879	1.0121
Fructose-6-phosphate	0.9932	1.0068
Fructose or similar ketohexose	0.9963	1.0037
Fumaric acid	0.9953	1.0047
Glucose-6-phosphate or similar	0.9900	1.0100
Glucose and other aldohexoses	0.9888	1.0112
Glutamic acid	0.9942	1.0065
Glutamine	0.9916	1.0105
Glycerol 1-phosphate	0.9834	1.0166
Glycine	0.9786	1.0214
Heptadecanoic acid/Octadecanol	0.9899	1.0101
Hexitols	0.9946	1.0054
Homoserine	0.9945	1.0055
Hypotaurine	0.9508	1.0437
Isoleucine/Leucine	0.9880	1.0120
Lactic acid	0.9972	1.0028
Linoleic acid	0.9905	1.0086
Lysine	1.0044	0.9956
Malic acid	0.9986	1.0014
Methionine	0.9868	1.0118
MSTFA artifact	0.9577	1.0470
Myoinositol	0.9898	1.0102
Myoinositol-2-phosphate	0.9895	1.0105
Myristic acid or Pentadecanol	0.9946	1.0054
Oleic acid	0.9914	1.0086
O-Methylphosphate	0.9910	1.0090
Palmitic acid	0.9952	1.0048
Palmitoleic acid	0.9692	1.0308
Pantothenic acid	0.9888	1.0112
Pentadecanoic acid/Hexadecanol	0.9867	1.0133
Pentitols	1.0041	0.9959
Phenylalanine	0.9989	1.0011
Phosphoric acid	0.9979	1.0021
Prunetin or similar isoflavone	0.9878	1.0122
Pyrophosphate	0.9610	1.0433
Pyruvic acid	0.9815	1.0185
Serine	0.9967	1.0033
Siloxanes	0.9869	1.0148
Squalene	0.9911	1.0089
Stearic acid	0.9964	1.0036
Succinic acid	0.9904	1.0096
Taurine	0.9617	1.0426
Tetradecanedioic acid	0.9829	1.0171
Threonine	0.9923	1.0077
Tryptamine/Norepinephrine	0.9869	1.0118
Tyrosine	0.9879	1.0121
Unknown-possibly propylene glycol	0.9899	1.0112
Urea	0.9968	1.0032
Valine	0.9982	1.0018

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Factors:

F1	Vehicle (PBS) Control Treatment:30 mg/kg Sorafenib Treatment
F2	Vehicle (PBS) Control Treatment:Vehicle (PBS) Control Treatment