Data for (Study ST000576)

(Analysis AN000886)

Values for each metabolite have been scaled by dividing by the mean across all factors

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Metabolite	F1	F2
1,5-Anhydroglucitol	0.9857	1.0143
2-Aminoadipic acid	0.9953	1.0047
2-Hydroxypyridine	0.9839	1.0161
5^-Deoxy-5^-(methylthio) adenosine	1.0153	0.9847
6-Hydroxynicotinic acid	0.9751	1.0249
Adenine	0.9937	1.0063
Adenosine-5-monophosphate	0.9739	1.0261
Adenosine/Inosine	0.9818	1.0182
Alanine	0.9922	1.0078
alpha-Monopalmitin	0.9945	1.0055
alpha-Monostearin	0.9984	1.0016
alpha-Tocopherol	1.0141	0.9873
Arachidic acid/ 1-Heneicosanol	0.9889	1.0111
Arachidonic acid (also Eicosapentaenoic acid)	0.9768	1.0232
Aspartic acid	1.0066	0.9934
Benzoic acid	0.9900	1.0100
beta-Hydroxybutyric acid	0.9892	1.0108
beta-Monopalmitin	0.9818	1.0182
beta-Monostearin	0.9904	1.0096
beta-Sitosterol	0.9848	1.0135
C10 hydrocarbon	1.0038	0.9958
C11 hydrocarbon	0.9923	1.0077
C12 hydrocarbon	0.9906	1.0094
C13 hydrocarbon	0.9947	1.0053
C15 hydrocarbon	0.9951	1.0049
C17 hydrocarbon	0.9894	1.0106
C21 Hydrocarbon	0.9900	1.0100
Campesterol	0.9898	1.0102
Cholesterol	0.9938	1.0062
Citric acid/isocitric acid	0.9913	1.0087
Creatinine	1.0158	0.9842
Dehydroalanine (possibly from cysteine)	0.9534	1.0466
Dehydroascorbic acid (possibly alpha-ketoglutarate)	0.9962	1.0038
deuterated Myristic Acid (RTL std)	0.9954	1.0046
Disaccharide	0.9856	1.0144
Docosahexaenoic acid	0.9834	1.0166
Ethanolamine	0.9474	1.0526
Fructose or similar ketohexose	1.0156	0.9875
Fumaric acid	0.9680	1.0320
Glucose-6-phosphate or similar	0.9888	1.0112
Glucose and other aldohexoses	0.9955	1.0045
Glutamic acid	0.9983	1.0017
Glutamine	1.0538	0.9462
Glycerol 1-phosphate	0.9836	1.0164
Glycine	0.9876	1.0124
Heptadecanoic acid/Octadecanol	0.9856	1.0144
Hexitols	1.0219	0.9825
Homoserine	0.9909	1.0091
Hypotaurine	0.9551	1.0449
Hypoxanthine	0.9762	1.0211
Inosine/Adenosine	0.9664	1.0299
Isoleucine/Leucine	1.0047	0.9947
Lactic acid	0.9950	1.0050
Linoleic acid	0.9805	1.0195
Lysine	0.9997	1.0003
Malic acid	0.9985	1.0015
Methionine	1.0084	0.9916
MSTFA artifact	0.9616	1.0384
Myoinositol	0.9932	1.0068
Myoinositol-2-phosphate	0.9347	1.0653
Myristic acid or Pentadecanol	0.9911	1.0089
Nicotinamide	1.0031	0.9972
Oleic acid	0.9790	1.0210
O-Methylphosphate	0.9935	1.0058
O-Phosphocolamine	0.9076	1.0924
Palmitic acid	0.9929	1.0071
Pantothenic acid	0.9852	1.0148
Pentadecanoic acid/Hexadecanol	0.9983	1.0015
Pentitols	0.9963	1.0034
Phenol	1.0220	0.9802
Phenylalanine	1.0124	0.9876
Phosphoric acid	0.9948	1.0052
Prunetin or similar isoflavone	0.9947	1.0043
Pyrophosphate	0.9789	1.0211
Pyruvic acid	0.9867	1.0120
Serine	1.0101	0.9899
Siloxanes	0.9812	1.0150
Spermidine	1.0238	0.9810
Squalene	0.9877	1.0123
Stearamide	0.9546	1.0409
Stearic acid	0.9922	1.0078
Succinic acid	0.9864	1.0136
Taurine	0.9826	1.0174
Threonine	1.0147	0.9868
Tyrosine	0.9953	1.0047
Urea	0.9956	1.0044
Valine	1.0012	0.9989

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Factors:

F1	Vehicle (PBS) Control Treatment:30 mg/kg Sorafenib Treatment
F2	Vehicle (PBS) Control Treatment:Vehicle (PBS) Control Treatment