Data for (Study ST001170)
(Analysis AN001935)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3-Phosphoglyceric acid | 1.3881 | 1.0228 | 1.5708 | 0.7306 | 0.7306 | 1.6804 | 0.5114 | 1.2055 | 1.0959 | 0.4384 | 0.7306 | 1.0228 | 0.3653 | 0.7306 | NA |
| Acetyl-CoA | NA | NA | 0.9091 | NA | NA | 0.9091 | NA | 1.3131 | 0.9091 | 0.9091 | 0.9091 | 0.9091 | 0.9091 | 0.9091 | NA |
| Aconitate | 0.5404 | 0.2895 | 0.8492 | 1.4282 | 0.3088 | 1.1966 | 0.4053 | 1.2931 | 1.7949 | 0.4825 | 1.2545 | 1.6984 | 0.7913 | 1.5247 | NA |
| ADP | 0.6294 | 0.8025 | 0.8229 | 0.7180 | 0.5367 | 0.9828 | 0.3707 | 1.0525 | 1.2414 | 0.3809 | 1.3565 | 1.7577 | 1.2985 | 2.1743 | NA |
| Alanine | 0.2509 | 0.2770 | 0.7057 | 0.7422 | 0.2248 | 1.1238 | 0.1934 | 1.7066 | 1.2911 | 0.2770 | 1.3956 | 2.7494 | 1.0506 | 1.5995 | NA |
| Aspartate | 1.1072 | 1.0401 | 1.2727 | 1.0828 | 0.5038 | 1.7105 | 0.5038 | 1.3855 | 1.5683 | 0.4327 | 0.8004 | 1.2026 | 0.2844 | 0.4469 | NA |
| ATP | 0.9963 | 1.0195 | 1.1029 | 1.0549 | 0.6790 | 1.1075 | 0.5436 | 1.3146 | 1.2418 | 0.5997 | 1.3121 | 1.1150 | 0.6629 | 0.8326 | NA |
| CDP | 1.1849 | 1.1396 | 1.2391 | 1.4200 | 0.9949 | 1.1396 | 0.5155 | 1.1894 | 1.3024 | 0.3256 | 0.9859 | 1.0492 | 0.3889 | 0.6964 | NA |
| Citrate | 0.5376 | 0.2555 | 0.8904 | 1.4174 | 0.3275 | 1.1504 | 0.3819 | 1.2025 | 1.7717 | 0.5024 | 1.1136 | 1.9863 | 0.8879 | 1.4819 | NA |
| CTP | 1.3798 | 1.6122 | 1.4477 | 1.3798 | 1.1546 | 1.0795 | 0.6363 | 0.9741 | 1.4727 | 0.3718 | 0.5684 | 0.8972 | 0.1859 | 0.4182 | NA |
| Cytidine | 1.4928 | 1.1495 | 1.3435 | 1.1227 | 1.2043 | 1.3027 | 0.8699 | 1.1003 | 1.0366 | 0.7492 | 0.3343 | 0.8811 | 0.3724 | 0.5971 | NA |
| dCDP | 0.9054 | 0.9054 | 0.9054 | 1.2676 | 0.9054 | 0.9054 | 0.9054 | 1.0865 | 1.0865 | NA | 0.9054 | 1.2676 | 0.9054 | 0.9054 | NA |
| dCMP | 1.3465 | 1.0495 | 0.9307 | 1.1683 | 0.6733 | 1.2673 | 0.8317 | 1.1485 | 1.2673 | 0.6139 | 1.0297 | 1.1485 | 0.3168 | 1.1287 | NA |
| dCTP | 1.1348 | 1.3050 | 1.1915 | 1.1915 | 0.7376 | 1.2482 | 0.5674 | 1.0780 | 1.3617 | 0.3972 | 1.1915 | 1.1915 | 0.3404 | 0.7943 | NA |
| dGDP | 0.6325 | 0.8066 | 0.8270 | 0.7216 | 0.5394 | 0.9877 | 0.3726 | 1.1704 | 1.2477 | 0.3828 | 1.0573 | 1.7666 | 1.3050 | 2.1853 | NA |
| dGTP | 1.0130 | 1.0366 | 1.1214 | 1.0726 | 0.6904 | 1.1260 | 0.5527 | 1.2336 | 1.4167 | 0.6097 | 0.9231 | 1.1337 | 0.6739 | 1.0417 | NA |
| dTDP | 0.8840 | 0.8840 | 0.8840 | 1.4144 | 0.4420 | 0.7072 | 0.5304 | 1.0608 | 2.2983 | 0.5304 | 0.8840 | 1.7680 | 0.4420 | 1.3260 | NA |
| Fructose 1,6-bisphosphate | 1.3696 | 1.1319 | 1.3253 | 0.8137 | 2.4250 | 0.9990 | 1.0393 | 0.8842 | 0.7654 | 0.5277 | 0.6203 | 1.0232 | 0.3343 | 0.5317 | NA |
| Fumarate | 1.2237 | 0.6969 | 1.4200 | 1.3742 | 0.5955 | 1.3448 | 0.5661 | 1.0339 | 1.6589 | 0.4646 | 0.7918 | 1.3644 | 0.3010 | 0.7100 | NA |
| Glucose-6-phosphate | 1.1888 | 1.0011 | 1.0726 | 1.1620 | 0.8223 | 1.1620 | 0.6436 | 1.0279 | 1.3140 | 0.6436 | 0.8581 | 1.3676 | 0.3218 | 1.3140 | NA |
| Glutamate | 0.7750 | 0.7066 | 1.1124 | 1.3486 | 0.6239 | 0.9764 | 0.5484 | 1.1870 | 1.5080 | 0.4513 | 1.0627 | 1.7346 | 0.6287 | 1.0369 | NA |
| Glutamine | 1.5127 | 1.6086 | 1.2154 | 1.3938 | 0.7527 | 1.0089 | 0.6651 | 1.1083 | 1.3422 | 0.5784 | 0.4259 | 1.0716 | 0.3955 | 0.5973 | NA |
| Glyceraldehyde-3-phosphate | 0.7937 | 0.8355 | 1.2533 | 1.7546 | 1.2115 | 0.8773 | 0.6684 | 1.1279 | 1.5457 | 0.5431 | 0.9608 | 1.0026 | 0.3342 | 0.7102 | NA |
| Glycine | 0.9797 | 1.2382 | 1.1961 | 1.1360 | 0.6371 | 1.2622 | 0.4087 | 1.4756 | 1.1660 | 0.4147 | 0.8174 | 0.9557 | 0.6311 | 1.0098 | NA |
| Histidine | 0.7286 | 0.9388 | 0.9722 | 0.8982 | 0.5709 | 1.2517 | 0.4467 | 1.5706 | 1.0534 | 0.4873 | 1.6291 | 1.0152 | 0.9507 | 0.9436 | NA |
| Homocysteine | 1.3454 | 0.7245 | 1.3765 | 1.4282 | 0.6210 | 1.3454 | 0.6210 | 1.2316 | 1.3040 | 0.5175 | 0.8486 | 1.0970 | 0.2691 | 0.6624 | NA |
| Homoserine | 0.8218 | 0.8977 | 1.0358 | 0.7251 | 0.5179 | 1.6297 | 0.5248 | 1.7609 | 0.9944 | 0.5870 | 1.1670 | 1.0151 | 0.5801 | 0.9461 | NA |
| Hypoxanthine | 1.8375 | 1.6271 | 1.1329 | 0.9845 | 0.5899 | 0.7628 | 0.2893 | 0.9037 | 3.8027 | 0.1804 | 0.5524 | 0.8380 | 0.0902 | 0.3720 | NA |
| Lactic acid | 0.6293 | 0.4288 | 1.1123 | 0.5742 | 0.3837 | 1.5932 | 0.4063 | 2.1426 | 1.5136 | 0.3147 | 0.8252 | 1.2606 | 0.4952 | 1.0655 | NA |
| Leucine | 1.0364 | 1.1449 | 1.0639 | 0.9474 | 0.6082 | 1.2258 | 0.5040 | 1.4084 | 1.1146 | 0.5359 | 1.3627 | 1.0613 | 0.6032 | 0.9108 | NA |
| Malate | 1.2154 | 0.6621 | 1.3957 | 1.5807 | 0.5333 | 1.2526 | 0.4694 | 1.0403 | 2.1588 | 0.3902 | 0.6439 | 1.2192 | 0.2633 | 0.7393 | NA |
| Methionine | 1.1462 | 1.1935 | 1.1285 | 0.9453 | 0.7090 | 1.2999 | 0.5672 | 1.3353 | 1.0399 | 0.5790 | 1.0517 | 0.9453 | 0.7208 | 0.8744 | NA |
| NAD+ | 0.7447 | 0.6890 | 1.3258 | 1.2249 | 0.6890 | 1.3084 | 0.4524 | 1.4371 | 1.2597 | 0.5011 | 0.8908 | 1.0718 | 0.6333 | 1.0091 | NA |
| NADH | 1.8230 | 2.1595 | 1.3742 | 0.3225 | 1.6827 | 2.3138 | 0.8273 | 0.9115 | 0.5329 | 0.6591 | 0.1683 | 0.2103 | 0.3786 | 0.3506 | NA |
| NADP+ | 0.6897 | 0.6897 | 0.9655 | 1.5172 | 0.6897 | 0.9655 | 0.6897 | 1.0345 | 1.3793 | 0.6897 | 0.6897 | 1.3793 | NA | 0.6897 | NA |
| NADPH | 1.6878 | 2.6329 | 1.5527 | 0.5401 | 0.7426 | 2.0253 | 0.4726 | 0.7426 | 1.2827 | 0.3376 | 0.3376 | 0.6751 | 0.3376 | 0.3376 | NA |
| Orotidine | 1.4022 | 0.8764 | 1.0517 | 1.4022 | 0.8764 | 1.0517 | 0.8764 | 1.0517 | 0.8764 | 0.8764 | 0.8764 | 0.8764 | 0.8764 | 0.8764 | NA |
| Oxaloacetate | 0.8169 | NA | 0.8169 | 0.8169 | 0.8169 | 0.8169 | NA | 0.8169 | 1.6338 | 0.8169 | 1.1437 | 1.6338 | 0.8169 | 0.9803 | NA |
| Oxidized glutathione | 1.5002 | 0.8658 | 1.0354 | 1.0155 | 0.8938 | 1.4743 | 0.8738 | 0.9387 | 0.9397 | 0.7222 | 0.7401 | 1.1232 | 0.8279 | 1.0753 | NA |
| Phenylalanine | 1.2125 | 1.3365 | 1.2314 | 1.0374 | 0.6602 | 1.3715 | 0.6251 | 1.3823 | 1.0077 | 0.6952 | 0.6009 | 0.9835 | 0.4850 | 0.7572 | NA |
| Pyruvic acid | 0.6780 | 0.4068 | 0.9153 | 0.6780 | 0.3390 | 1.2881 | 0.3390 | 2.5424 | 1.2881 | 0.3390 | 0.6780 | 1.0847 | 0.6102 | 1.3559 | NA |
| Reduced glutathione | 1.1338 | 0.8682 | 1.1765 | 1.5608 | 0.6120 | 1.2419 | 0.4646 | 1.1350 | 1.5961 | 0.3705 | 1.1440 | 1.1518 | 0.5626 | 0.6707 | NA |
| Serine | 1.1564 | 1.2361 | 1.2461 | 0.8972 | 0.7377 | 1.5651 | 0.8075 | 1.2312 | 1.0567 | 0.8474 | 0.4984 | 0.9470 | 0.3688 | 0.9271 | NA |
| Succinate | 0.6593 | 0.5146 | 1.2864 | 1.6402 | 0.4181 | 1.2060 | 0.3538 | 1.2221 | 2.0583 | 0.3055 | 0.8844 | 1.3508 | 0.6432 | 0.9487 | NA |
| Taurine | 0.7538 | 1.0348 | 1.0416 | 1.6511 | 0.7301 | 0.4669 | 0.2708 | 1.0938 | 1.4652 | 0.2258 | 1.2750 | 1.4253 | 0.9610 | 1.4694 | NA |
| Threonine | 0.8214 | 0.8973 | 1.0354 | 0.7248 | 0.5177 | 1.6290 | 0.5315 | 1.7601 | 0.9940 | 0.5867 | 1.1665 | 1.0147 | 0.5798 | 0.9456 | NA |
| Tryptophan | 1.2588 | 1.3380 | 1.1954 | 1.1084 | 0.7600 | 1.2825 | 0.6254 | 1.2588 | 1.0609 | 0.7125 | 0.6096 | 1.0134 | 0.5146 | 0.8075 | NA |
| TTP | 1.3366 | 1.0221 | 1.0418 | 1.5725 | 0.7076 | 0.8649 | 0.6290 | 0.9828 | 1.7690 | 0.5111 | 0.7862 | 1.4152 | 0.4324 | 0.9042 | NA |
| Tyrosine | 0.8324 | 1.0335 | 0.9260 | 0.9553 | 0.7123 | 1.0279 | 0.6229 | 1.3492 | 1.1201 | 0.6285 | 1.3408 | 1.1872 | 0.8352 | 1.1536 | NA |
| UDP | 0.9697 | 0.9750 | 1.1883 | 1.0863 | 0.4901 | 1.2267 | 0.2941 | 1.5724 | 1.3724 | 0.2676 | 1.3433 | 1.2770 | 0.3842 | 0.7922 | NA |
| Uracil | 0.5732 | 0.3261 | 0.8351 | 1.1760 | 0.3558 | 1.1563 | 0.3854 | 1.4280 | 1.5219 | 0.4744 | 1.8283 | 1.5318 | 0.7511 | 1.3935 | NA |
| UTP | 1.3835 | 1.2021 | 1.4119 | 1.1219 | 0.5309 | 1.2143 | 0.3439 | 1.1720 | 1.5872 | 0.2593 | 1.0006 | 1.4514 | 0.2493 | 0.4875 | NA |
| Valine | 1.0449 | 1.2646 | 1.0904 | 0.9591 | 0.8573 | 1.2163 | 0.7073 | 1.3771 | 1.0020 | 0.7555 | 0.6644 | 1.0074 | 0.6269 | 0.9591 | NA |
| α-Ketoglutarate | 0.8581 | 0.5536 | 1.3702 | 1.3841 | 0.3322 | 1.1626 | 0.3875 | 1.2042 | 2.3529 | 0.3322 | 0.8858 | 1.3841 | 0.4706 | 0.7474 | NA |
Factors:
| F1 | hours:12 | Doxorubicin dosage(μM):- |
| F2 | hours:12 | Doxorubicin dosage(μM):10 |
| F3 | hours:24 | Doxorubicin dosage(μM):- |
| F4 | hours:24 | Doxorubicin dosage(μM):0.1 |
| F5 | hours:24 | Doxorubicin dosage(μM):10 |
| F6 | hours:36 | Doxorubicin dosage(μM):- |
| F7 | hours:36 | Doxorubicin dosage(μM):10 |
| F8 | hours:48 | Doxorubicin dosage(μM):- |
| F9 | hours:48 | Doxorubicin dosage(μM):0.1 |
| F10 | hours:48 | Doxorubicin dosage(μM):10 |
| F11 | hours:72 | Doxorubicin dosage(μM):- |
| F12 | hours:72 | Doxorubicin dosage(μM):0.1 |
| F13 | hours:96 | Doxorubicin dosage(μM):- |
| F14 | hours:96 | Doxorubicin dosage(μM):0.1 |
| F15 | hours:- | Doxorubicin dosage(μM):- |
