Data for (Study ST001652)

(Analysis AN002699)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6
1_3-diphopshateglycerate 0.2944 1.3055 1.0637 1.7668 0.8779 0.0113
2_3-Diphosphoglyceric acid 0.2510 1.3160 1.0716 1.7817 0.8853 0.0114
2-Aminooctanoic acid 0.9860 0.8993 0.6566 1.1911 1.1965 1.5552
3-methylphenylacetic acid 1.3872 1.1695 0.8534 1.3598 0.4592 0.4593
3-phosphoglycerate 2.3678 1.0192 0.5497 0.7206 0.5488 0.8319
3-phospho-serine 1.0692 1.0837 1.1232 0.9145 0.7914 0.9312
4-aminobutyrate 1.0193 1.0044 1.0699 0.9957 0.9052 0.9465
4-Pyridoxic acid 1.0391 0.9841 1.1366 1.0222 0.8067 0.8974
5-phosphoribosyl-1-pyrophosphate 1.0584 0.5520 1.1432 1.2695 1.0106 0.7555
6-phospho-D-gluconate 1.2863 0.8603 0.9098 1.2301 0.7898 0.8617
7-methylguanosine 0.9780 0.9509 1.1472 0.9989 0.9308 0.8357
acetoacetate 1.0245 1.0868 1.0269 0.9351 0.9150 1.0080
acetyl-CoA 0.9988 1.0217 0.9058 0.5166 1.4786 1.3298
aconitate 0.9837 1.1382 0.9474 0.9242 1.0543 0.9095
adenine 1.0623 0.7345 1.1437 1.2634 0.8683 0.6397
adenosine 5^-phosphosulfate 1.0709 1.0768 1.1464 0.7249 0.9050 1.0814
ADP 0.9303 1.0499 1.0737 0.8163 1.0568 1.1452
ADP-D-glucose 1.8266 0.8841 0.8131 0.9456 0.6387 0.8629
a-ketoglutarate 0.9581 0.9988 1.1779 1.0034 0.7899 1.0377
aminoimidazole carboxamide ribonucleotide 2.3747 0.9052 0.8995 0.6232 0.2930 0.8137
AMP 1.0539 0.9514 1.0689 1.0699 0.8278 1.0152
aspartate 0.8199 1.1061 1.2807 0.7480 0.9469 1.0144
ATP 0.5933 0.9922 1.4714 1.3144 0.6535 0.4540
Atrolactic acid 1.0006 0.9701 0.8224 1.1250 1.1122 1.0865
CDP 0.7719 1.1338 1.1845 0.7091 1.1177 1.0644
CDP-choline 1.0840 1.0267 1.1138 1.0595 0.7176 0.8812
CDP-ethanolamine 1.0645 1.0343 1.1058 0.9482 0.8299 0.9461
cholesteryl sulfate 1.0431 0.9438 1.0510 0.9282 1.0012 1.0469
Cholic acid 0.9964 1.0224 1.0416 0.9583 0.9822 0.9559
Citraconic acid 1.5291 0.9331 0.9278 0.8724 0.7248 1.1107
citrate 0.9778 1.0301 1.0835 0.8626 1.0298 0.9655
citrate/isocitrate 0.9778 1.0301 1.0835 0.8626 1.0298 0.9655
CMP 1.1540 0.9577 1.0713 1.0770 0.7364 0.9395
coenzyme A 0.8658 0.5308 1.4321 0.9290 1.1705 0.7835
CTP 1.4687 0.2623 0.8121 1.9968 0.7946 0.1847
cyclic-AMP 0.9682 1.0683 1.1242 0.8298 0.9599 1.0245
dAMP 1.2077 0.7861 1.0515 1.4684 0.5061 0.8890
dATP 1.2578 0.7294 1.1269 0.8626 1.0184 0.8880
dCDP 1.0958 0.8705 1.0389 1.3924 0.6400 0.8482
dCMP 1.2421 0.9041 1.0560 1.2237 0.5893 0.8985
dCTP 1.3866 0.1614 1.3073 0.7942 1.5222 0.1778
Deoxycholic acid 1.0646 0.6206 0.6610 1.3931 1.1867 1.5610
D-erythrose-4-phosphate 1.3898 0.9368 0.8766 1.0863 0.8020 0.8489
D-gluconate 1.1266 0.9146 1.1003 1.0258 0.8142 0.9552
dGMP 1.0539 0.9514 1.0689 1.0699 0.8278 1.0152
dihydroorotate 0.0871 0.0245 1.0205 2.2473 0.0880 5.5777
dihydroxy-acetone-phosphate 2.9286 0.8746 0.4333 0.5874 0.5080 0.5707
dimethylglycine 1.0575 0.9997 1.0481 0.9826 0.9155 0.9415
D-sedoheptulose-1/7-phosphate 1.6054 0.5955 0.8043 1.8430 0.3738 0.5298
dTDP 0.9215 1.0069 1.1555 0.9146 0.8900 1.1790
dTMP 1.2270 0.8180 1.0462 1.4431 0.4951 0.8654
dTTP 1.2449 0.5037 1.0478 1.2476 1.0434 0.6900
FAD 0.9986 1.0037 1.1390 0.8453 0.9094 1.1731
FMN 0.9315 1.1329 1.1397 0.8233 0.9074 1.0557
folate 0.8544 0.6935 1.3166 1.0196 1.0417 0.9065
fructose-1-6-bisphosphate 1.7734 1.0231 0.7188 0.8101 0.7901 0.9342
fumarate 1.2725 0.8684 0.8983 1.2455 0.7865 0.8880
GDP 0.7869 1.1137 1.1027 0.7495 1.1551 1.1738
glucono-δ-lactone 2.9131 0.9145 0.4390 0.7504 0.2585 0.7345
glucose-1-phosphate 0.9630 0.9778 1.0417 1.0533 0.9494 1.0025
glucose-6-phosphate 0.9630 0.9778 1.0417 1.0533 0.9494 1.0025
glutamate 1.0777 1.0046 1.0324 0.9889 0.9097 0.9277
glutathione 0.9168 0.7344 1.2095 0.9742 1.0886 1.0204
glutathione disulfide 1.1703 1.0855 0.9559 1.0115 0.7855 1.0180
glycerate 1.6201 0.9815 0.8075 0.8431 0.7751 1.1108
GMP 0.8579 0.9879 1.1260 0.9414 1.0099 1.1044
GTP 0.9787 0.8610 1.1451 1.0957 1.0544 0.4503
guanosine 1.3056 0.8159 1.1412 1.1683 0.5678 0.8623
Hydroxyisocaproic acid 0.9250 1.2388 0.9511 1.0625 0.8602 0.9361
hydroxyphenylpyruvate 0.9929 0.9374 0.8480 1.1073 1.1251 1.1198
IDP 3.1211 0.7877 0.3572 0.8370 0.2436 0.6029
IMP 1.8712 0.7336 0.7120 1.4613 0.3810 0.8106
Indole-3-carboxylic acid 1.9573 NA 0.0427 NA NA NA
inosine 1.1447 0.9939 1.0611 1.1855 0.6123 0.9468
isocitrate 0.9778 1.0301 1.0835 0.8626 1.0298 0.9655
lactate 2.5238 0.9137 0.4600 0.8547 0.4874 0.8210
malate 1.2807 0.8459 0.9089 1.2339 0.8164 0.8336
myo-inositol 2.1459 0.9602 0.7483 0.7600 0.5350 0.8032
N-acetyl-glucosamine-1/6-phosphate 2.7268 0.5777 0.7365 0.6696 0.5041 0.6197
N-acetyl-glutamate 0.8562 1.0714 0.9969 1.1079 0.9618 1.0205
N-Acetyl-L-alanine 1.1343 0.9355 1.0201 1.0984 0.7601 1.1344
NADH 0.3634 0.1394 1.9668 0.5587 1.8471 0.4067
NADP+ 1.0783 1.0029 1.0352 1.0265 0.8378 1.0229
NADPH 0.2052 0.3259 1.8806 0.9253 1.5451 0.4728
N-carbamoyl-L-aspartate 0.1287 0.0570 1.0774 2.3512 0.2108 4.4471
NG-dimethyl-L-arginine 1.0764 1.0961 0.9773 1.0862 0.8536 0.7539
nicotinate 1.1424 0.7901 1.0530 1.3904 0.6175 0.9667
Octoluse Bisphosphate 0.8445 1.1272 1.0611 0.9105 1.0223 1.0420
orotate 0.7449 0.1006 0.8269 2.7897 0.0994 2.4889
pantothenate 2.6229 0.8209 0.5387 0.8292 0.4343 0.7234
phenylalanine 1.3807 1.0699 0.8499 1.0519 0.6808 1.0510
Phenyllactic acid 1.0006 0.9701 0.8224 1.1250 1.1122 1.0865
phosphoenolpyruvate 1.1450 1.0961 0.9807 1.1067 0.7310 0.8407
purine 1.3866 1.1331 0.9346 0.8654 0.7599 0.8264
Pyridoxamine 0.9723 0.7688 1.1292 1.0016 1.0793 1.0174
Pyroglutamic acid 1.2322 0.9764 0.9305 1.0359 0.8684 0.9393
pyruvate 1.2594 0.9172 1.0981 0.7303 0.8627 1.2989
S-adenosyl-L-homoCysteine 0.8581 0.9477 1.2467 0.9998 0.8810 0.9535
Sedoheptoluse bisphosphate 0.8971 1.0027 1.0596 1.0069 1.0089 1.0147
S-methyl-5^-thioadenosine 0.8107 1.0372 1.1541 0.8381 1.0672 1.1241
sn-glycerol-3-phosphate 1.5254 0.7681 0.7722 1.3235 0.7537 0.7991
succinate 1.0805 0.9678 1.0961 1.0002 0.7947 1.0863
Taurodeoxycholic acid 0.9222 0.9520 1.1778 1.0310 0.9240 0.8015
thymidine 1.3157 0.5757 1.0380 1.6846 0.4585 0.7445
tryptophan 1.8676 1.0339 0.6240 0.9140 0.7275 0.8753
UDP 0.7972 1.0904 1.1803 0.8135 0.9971 1.1840
UDP-D-glucose 1.1583 0.9762 1.0477 0.9682 0.8468 0.9604
UDP-D-glucuronate 1.3174 0.8967 1.0088 1.1649 0.6917 0.7525
UDP-N-acetyl-glucosamine 1.0780 0.9720 1.0692 0.9917 0.8688 0.9918
UMP 1.1083 0.9785 1.0408 1.0808 0.7692 1.0262
Uric acid 1.0471 0.5481 1.7479 0.7137 0.7915 2.2030
UTP 1.2404 0.5325 0.8228 1.8276 0.8224 0.4400
xanthosine-5-phosphate 1.0156 0.5905 0.9257 1.6787 0.8050 1.0282
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Factors:

F1Genotype:Drug Resistant | Treatment:Atovaquone
F2Genotype:Drug Resistant | Treatment:Control
F3Genotype:Drug Resistant | Treatment:DSM-1
F4Genotype:Wild-type | Treatment:Atovaquone
F5Genotype:Wild-type | Treatment:Control
F6Genotype:Wild-type | Treatment:DSM-1
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