Data for (Study ST002033)
(Analysis AN003305)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|
10-Formyltetrahydrofolate | 0.5753 | 0.7089 | 1.1537 | 0.6338 | 1.0718 | 0.4890 | 2.3485 | 0.8980 | 2.0807 | 0.8951 | 0.7161 | 0.8935 |
3-methyldioxyindole | 0.2256 | 0.6568 | 1.3524 | 2.9980 | 0.4553 | 0.4204 | 2.3048 | 0.7091 | 1.6020 | 1.0087 | 0.2678 | 0.2259 |
4-Acetamidobutanoate | 0.8221 | 0.9437 | 1.0932 | 0.9712 | 0.9555 | 0.8546 | 1.3972 | 0.9023 | 1.2074 | 1.0818 | 0.9208 | 0.9637 |
4-Pyridoxate | 0.8714 | 1.1638 | 0.9701 | 0.9460 | 0.9413 | 1.0101 | 1.1263 | 0.9697 | 1.0059 | 0.9998 | 1.0087 | 1.0167 |
5-6-Dihydrouracil | 1.3401 | 1.2308 | 1.4877 | 0.9884 | 2.0262 | 1.1009 | 0.8250 | 0.4451 | 0.9517 | 0.5745 | 0.4581 | 0.4086 |
5-Guanidino-2-oxopentanoate | 0.7636 | 0.9594 | 1.1160 | 1.0821 | 0.9864 | 1.0173 | 1.3212 | 0.7578 | 0.8932 | 1.0612 | 1.1665 | 0.8979 |
5-Hydroxyisourate | 0.3831 | 0.7889 | 1.3539 | 0.6220 | 0.3881 | 1.3422 | 1.3109 | 0.6965 | 1.5568 | 1.5111 | 0.9314 | 1.3609 |
(5-L-Glutamyl)-L-glutamine | 0.8357 | 1.0623 | 1.0662 | 1.0080 | 1.0295 | 0.9717 | 1.2301 | 0.9734 | 0.9782 | 0.9957 | 1.0004 | 0.8632 |
5-Oxoproline | 0.4414 | 0.7942 | 1.4658 | 0.7455 | 0.9047 | 0.9311 | 1.9544 | 0.8359 | 1.4995 | 1.0875 | 0.7634 | 0.8340 |
5-Phosphoribosylamine | 1.0743 | 0.9316 | 0.7569 | 0.7639 | 0.9461 | 0.9423 | 0.9143 | 0.9435 | 1.2989 | 0.8484 | 1.0195 | 1.7537 |
5^-Phosphoribosyl-N-formylglycinamide | 0.6833 | 1.1992 | 1.3152 | 1.0880 | 0.7159 | 0.9333 | 1.3291 | 0.6921 | 1.1559 | 1.2017 | 0.8850 | 0.8727 |
6-Hydroxykynurenic acid | 1.0296 | 1.0591 | 1.1395 | 1.3951 | 0.8723 | 1.1665 | 0.9018 | 0.8434 | 1.1051 | 0.8687 | 0.8594 | 0.7013 |
Acetylcholine | 0.8698 | 0.9857 | 1.0502 | 0.8648 | 0.9361 | 0.9797 | 1.0691 | 0.9764 | 1.0464 | 1.1653 | 1.0958 | 0.9799 |
acyl-C12:1 (O-dodecenoyl-carnitine) | 0.7540 | 0.5809 | 0.6821 | 0.7307 | 0.3120 | 1.0989 | 1.0107 | 0.6823 | 2.6779 | 0.9982 | 1.1639 | 1.8076 |
acyl-C12 (O-dodecanoyl-carnitine) | 0.9278 | 1.0212 | 0.8681 | 0.8862 | 1.0378 | 0.8486 | 1.1162 | 0.9803 | 1.0990 | 1.0048 | 1.1585 | 1.1183 |
acyl-C14:1 (Tetradecenoyl Carnitine) | 1.0774 | 0.4884 | 1.3375 | 0.4299 | 0.7836 | 0.9852 | 0.9965 | 1.6435 | 0.8997 | 0.6234 | 2.0055 | 0.6358 |
acyl-C14 (O-tetradecanoyl-L-carnitine) | 1.0935 | 0.4760 | 0.9756 | 0.5000 | 0.8082 | 1.4484 | 1.0264 | 1.7247 | 0.9589 | 0.5373 | 1.6369 | 0.7640 |
acyl-C16:1 (Hexadecenoyl-carnitine) | 1.1142 | 0.6011 | 1.2768 | 0.5709 | 0.9395 | 1.1390 | 1.0326 | 1.7277 | 0.6413 | 0.5287 | 1.6619 | 0.6265 |
acyl-C16 (L-Palmitoylcarnitine) | 1.1714 | 0.8319 | 1.0505 | 0.5728 | 1.1028 | 1.2950 | 0.9206 | 1.3033 | 0.8707 | 0.6930 | 1.3925 | 0.6924 |
acyl-C18:1 (O-octadecenoyl-L-carnitine) | 1.0341 | 0.8083 | 1.1437 | 0.6601 | 1.1683 | 1.1886 | 1.0932 | 1.3904 | 0.7566 | 0.7426 | 1.2772 | 0.6336 |
acyl-C2 (acetyl-carnitine) | 0.9121 | 1.1429 | 0.9678 | 0.9863 | 0.9249 | 1.5976 | 0.9635 | 0.8744 | 0.8499 | 0.9202 | 0.8721 | 0.9388 |
acyl-C3 (propionyl-carnitine) | 0.8745 | 1.3994 | 1.0386 | 1.0763 | 1.0115 | 1.0494 | 1.0807 | 0.9877 | 0.8788 | 0.9471 | 0.7296 | 0.8979 |
acyl-C4 (butanoyl-l-carnitine) | 0.9865 | 1.1436 | 1.0306 | 1.0932 | 1.1457 | 0.9431 | 1.1638 | 0.9130 | 0.9071 | 1.0739 | 0.7554 | 0.8229 |
acyl-C4-DC | 0.9646 | 1.2902 | 1.0180 | 1.1116 | 0.9731 | 0.9746 | 1.1626 | 0.9942 | 0.8643 | 0.9260 | 0.8036 | 0.9033 |
acyl-C4-OH (Hydroxybutyrylcarnitine) | 2.3337 | 0.3755 | 0.3697 | 0.3768 | 0.3450 | 0.4577 | 0.2202 | 0.4118 | 1.1790 | 1.0243 | 0.9223 | 4.5799 |
acyl-C5:1 (Tiglylcarnitine) | 0.8429 | 1.1359 | 1.1356 | 1.0795 | 1.0640 | 1.0053 | 1.0029 | 0.9367 | 0.8720 | 1.0550 | 0.9938 | 0.8142 |
acyl-C5 (isovalerylcarnitine) | 0.9022 | 1.0240 | 0.9431 | 0.9530 | 0.9784 | 1.0179 | 0.9639 | 0.9233 | 0.9930 | 1.0434 | 1.3395 | 0.8870 |
acyl-C5-OH | 0.9733 | 1.1037 | 0.9741 | 1.1787 | 1.2091 | 1.1531 | 1.1447 | 0.8741 | 0.8734 | 0.7828 | 0.8925 | 0.8050 |
acyl-C6-DC | 0.8864 | 0.9512 | 1.0033 | 0.9888 | 1.0008 | 1.0679 | 0.9942 | 0.9515 | 1.1019 | 1.1096 | 1.0411 | 0.9032 |
acyl-C6 (hexanoyl-l-carnitine) | 1.1609 | 0.8407 | 0.9423 | 0.6827 | 0.9922 | 1.3297 | 1.0789 | 1.1289 | 1.2159 | 0.8337 | 1.0054 | 0.8096 |
acyl-C8:1 (octenoyl-l-carnitine) | 0.9911 | 1.1246 | 0.9089 | 0.9526 | 1.0422 | 1.0794 | 1.0290 | 0.9064 | 1.1261 | 1.0236 | 0.9406 | 0.8830 |
Adenosine | 0.8103 | 0.9165 | 1.3210 | 0.8726 | 0.7027 | 1.2547 | 1.5282 | 0.5249 | 1.4810 | 0.9864 | 0.9733 | 0.7876 |
Allantoate | 1.1582 | 1.1826 | 1.2904 | 1.1207 | 1.7194 | 1.2404 | 0.7282 | 0.6347 | 0.8831 | 0.4415 | 0.6768 | 0.8079 |
AMP | 0.6422 | 0.7562 | 1.5232 | 1.0359 | 0.8591 | 1.8763 | 1.1747 | 0.4036 | 1.2157 | 0.8801 | 0.8314 | 0.8497 |
Anthranilate | 0.9557 | 0.9701 | 0.7071 | 0.8714 | 0.8008 | 0.7610 | 1.2037 | 1.2159 | 1.3694 | 1.2319 | 1.0051 | 1.0281 |
Argininosuccinate | 0.9723 | 1.0807 | 1.0933 | 1.1436 | 1.1473 | 0.8785 | 1.0729 | 0.7907 | 0.7085 | 0.9352 | 1.0086 | 1.1559 |
Carnosine | 0.8789 | 1.3507 | 1.0935 | 0.9385 | 0.8012 | 1.5086 | 1.1673 | 0.9916 | 0.6324 | 1.0436 | 0.6971 | 0.8204 |
Choline | 0.7571 | 0.8686 | 1.3544 | 0.9039 | 0.9527 | 1.2339 | 0.8631 | 1.1378 | 1.0899 | 0.8256 | 1.1008 | 0.8784 |
Creatinine | 0.9186 | 1.0474 | 0.8621 | 1.0617 | 1.0768 | 0.9200 | 1.1076 | 1.0796 | 1.0220 | 0.9859 | 0.9591 | 0.9812 |
Cystathionine | 0.6586 | 0.9775 | 0.9808 | 1.0836 | 1.0005 | 1.6165 | 1.0550 | 0.9156 | 1.0003 | 0.8713 | 0.9549 | 0.8705 |
Cytidine | 0.8393 | 0.8588 | 1.0854 | 0.6911 | 0.7677 | 0.8894 | 1.5332 | 1.0831 | 1.2819 | 1.0609 | 1.2132 | 0.8237 |
Cytosine | 0.9427 | 1.3657 | 1.5750 | 0.6809 | 1.1154 | 0.9489 | 0.6369 | 0.9343 | 0.7244 | 0.8935 | 0.8734 | 1.2265 |
dAMP | 0.7784 | 0.9435 | 1.2902 | 0.7795 | 0.7211 | 1.2072 | 1.9566 | 0.8140 | 1.1445 | 0.8936 | 0.4735 | 1.2174 |
Dihydrofolate | 0.4961 | 1.2390 | 1.1116 | 0.7701 | 1.0205 | 0.9724 | 1.4259 | 0.9216 | 1.6106 | 0.8932 | 0.9519 | 0.6700 |
Dimethylglycine | 0.7628 | 0.7854 | 1.1468 | 0.8985 | 1.1282 | 0.9047 | 1.9650 | 0.8490 | 1.2991 | 1.0270 | 0.7527 | 0.6668 |
Dopamine | 0.9000 | 1.1127 | 1.0538 | 1.0008 | 0.9959 | 0.7795 | 1.1655 | 1.0163 | 0.9918 | 1.0715 | 1.0321 | 0.8896 |
Ectoine | 1.0578 | 0.8955 | 0.9684 | 0.8946 | 0.9210 | 1.2250 | 1.0550 | 1.0156 | 1.0740 | 0.9036 | 0.8320 | 1.2290 |
gamma-Glutamyl-gamma-aminobutyrate | 0.8982 | 0.9337 | 1.1237 | 0.9275 | 0.8409 | 1.0057 | 1.2715 | 0.9332 | 1.0985 | 1.0485 | 0.9747 | 1.0224 |
Guanidinoacetate | 0.8592 | 0.9475 | 0.5599 | 1.1693 | 0.4796 | 1.4877 | 0.8492 | 1.8319 | 1.1935 | 0.6829 | 0.9715 | 0.8604 |
Guanine | 1.0564 | 1.3789 | 0.7252 | 0.7184 | 0.8054 | 0.9148 | 1.0321 | 1.3022 | 1.0194 | 0.9104 | 1.0457 | 1.1268 |
Hydroxyindole-acetylglycine | 0.8365 | 1.0038 | 1.0935 | 0.8187 | 0.9027 | 1.2097 | 1.2852 | 0.8639 | 1.1231 | 1.0087 | 1.0008 | 0.9188 |
Hypoxanthine | 0.3375 | 0.7487 | 0.9843 | 0.9395 | 0.9602 | 0.4503 | 2.4045 | 1.0236 | 1.6261 | 1.3511 | 0.7242 | 0.8201 |
Indole | 0.8466 | 1.0153 | 0.8959 | 1.0264 | 1.0954 | 1.0283 | 1.0992 | 1.0555 | 0.9613 | 1.0036 | 0.9901 | 0.9930 |
Indole-3-acetaldehyde | 0.8178 | 1.3678 | 0.9305 | 0.9014 | 0.7826 | 0.9424 | 1.2377 | 0.9507 | 0.8927 | 1.2303 | 0.8969 | 1.0939 |
Indole-3-acetate | 0.6014 | 0.9632 | 1.0165 | 1.0216 | 0.7540 | 1.4142 | 1.2406 | 0.8808 | 1.0774 | 0.8990 | 1.0738 | 1.1515 |
Indolepyruvate | 0.4899 | 0.4521 | 0.6578 | 0.3824 | 0.4506 | 1.3184 | 1.6753 | 1.1275 | 1.6461 | 1.3350 | 1.3534 | 1.4699 |
Indoxyl | 0.3657 | 0.5169 | 1.3694 | 1.1743 | 1.0655 | 0.7666 | 1.9348 | 1.2305 | 1.1178 | 1.2485 | 0.8002 | 0.5256 |
kynurenine | 0.9389 | 1.0622 | 0.9721 | 1.0026 | 1.0459 | 0.9638 | 1.0888 | 0.9127 | 0.9901 | 0.9966 | 1.0537 | 0.9855 |
L-Adrenaline | 0.8983 | 1.2222 | 0.9108 | 1.0311 | 1.0434 | 0.8843 | 0.9795 | 1.0129 | 0.9292 | 1.0577 | 0.9693 | 1.0537 |
L-alanine | 0.7434 | 0.9998 | 1.3221 | 0.8658 | 0.9236 | 1.4634 | 0.7509 | 0.9239 | 0.8731 | 0.8593 | 0.9211 | 1.3480 |
L-arginine | 0.7285 | 0.9375 | 0.5920 | 0.7226 | 0.7208 | 1.1041 | 1.5316 | 0.8806 | 1.3005 | 0.9378 | 1.6464 | 1.0800 |
L-Carnitine | 0.9757 | 1.2978 | 1.1240 | 1.0579 | 0.9104 | 1.0101 | 0.9988 | 0.9382 | 0.9265 | 0.9621 | 0.8213 | 0.9530 |
L-Citrulline | 0.8202 | 1.1877 | 1.1260 | 1.0788 | 1.0791 | 0.8906 | 1.4360 | 1.0075 | 0.9944 | 0.9621 | 0.8092 | 0.6179 |
L-gamma-Glutamyl-L-hypoglycin | 0.8467 | 1.1521 | 0.9823 | 1.0381 | 0.9822 | 1.0698 | 0.9757 | 0.9882 | 0.9277 | 0.9582 | 1.0287 | 1.0389 |
L-glutamate | 0.4483 | 0.8081 | 1.5092 | 0.7749 | 0.9491 | 0.8749 | 2.0118 | 0.8101 | 1.5155 | 1.0752 | 0.7115 | 0.7712 |
L-histidine | 0.9756 | 1.1370 | 1.0470 | 0.9050 | 1.1457 | 1.1273 | 0.9916 | 0.7748 | 1.1546 | 0.7953 | 1.0170 | 0.9479 |
L-leucine/L-isoleucine | 0.9672 | 1.0470 | 1.0804 | 0.8573 | 1.0201 | 0.8964 | 0.8878 | 1.0461 | 1.0943 | 0.9164 | 1.1401 | 1.0539 |
L-lysine | 0.8200 | 1.0265 | 1.1748 | 0.7877 | 1.1908 | 0.8408 | 1.5837 | 0.8251 | 1.2159 | 0.9163 | 0.9499 | 0.7855 |
L-methionine | 0.7131 | 1.1182 | 1.4687 | 1.0395 | 0.9816 | 0.7363 | 1.2420 | 0.9926 | 0.9775 | 1.0619 | 0.8478 | 0.8310 |
L-Methionine S-oxide | 0.6289 | 0.9092 | 1.9176 | 0.6808 | 0.6743 | 0.8258 | 1.2041 | 1.0818 | 1.3072 | 0.9857 | 0.9400 | 0.9336 |
L-phenylalanine | 0.8441 | 1.0308 | 1.1867 | 0.8179 | 1.0413 | 1.0138 | 0.8647 | 1.1686 | 0.8966 | 0.9744 | 1.0583 | 1.0686 |
L-proline | 0.9017 | 0.9235 | 0.9903 | 0.9237 | 0.9490 | 1.7738 | 0.7329 | 0.9325 | 1.0150 | 0.7659 | 1.1096 | 0.9147 |
L-threonine | 0.7850 | 0.9711 | 1.3186 | 0.8936 | 1.0722 | 0.9924 | 1.2448 | 0.8893 | 1.1813 | 0.9455 | 0.8181 | 0.9666 |
L-tryptophan | 0.7088 | 0.8138 | 1.0734 | 0.8238 | 0.8737 | 1.4358 | 1.2259 | 0.9335 | 1.2842 | 0.8526 | 1.2296 | 0.8086 |
L-tyrosine | 0.8199 | 1.1995 | 1.1139 | 0.9882 | 0.9749 | 0.9375 | 1.0619 | 0.9611 | 1.0178 | 0.9866 | 0.9885 | 0.9577 |
L-valine | 1.3403 | 0.6346 | 0.6879 | 0.3710 | 0.4631 | 2.1004 | 0.4772 | 0.8854 | 1.5815 | 0.5485 | 1.8659 | 1.0698 |
N-Acetylornithine | 0.6598 | 0.9759 | 1.7400 | 0.7770 | 1.0778 | 1.2128 | 1.2634 | 0.5682 | 1.3015 | 0.8427 | 0.6952 | 0.9982 |
N-formyl kynurenine | 1.2588 | 1.4615 | 0.6574 | 1.0163 | 0.8038 | 0.6414 | 0.4600 | 0.9756 | 0.8510 | 0.9869 | 1.3928 | 1.4460 |
Nicotinamide | 0.5180 | 0.5505 | 0.9724 | 0.6844 | 0.6769 | 2.6214 | 1.8975 | 0.5251 | 1.0195 | 0.9246 | 1.0077 | 0.7318 |
N-Succinyl-L-glutamate 5-semialdehyde | 0.6218 | 0.7907 | 0.9416 | 0.8386 | 0.7149 | 0.7739 | 1.2723 | 1.1378 | 1.3655 | 1.2190 | 1.2748 | 1.2207 |
Pantetheine | 0.5476 | 0.5980 | 0.6252 | 0.5263 | 0.6526 | 0.5446 | 4.4772 | 0.5903 | 1.3063 | 1.6844 | 0.5851 | 0.5238 |
Pantothenol | 0.6742 | 0.8544 | 0.9962 | 0.7455 | 1.2864 | 0.8509 | 1.3927 | 1.2212 | 1.0772 | 0.9764 | 1.0625 | 0.9453 |
Phosphocreatine | 0.7640 | 0.9760 | 0.4488 | 1.3042 | 0.5796 | 0.7952 | 0.9531 | 0.8619 | 0.8454 | 0.2991 | 3.2126 | 0.8205 |
Phosphoserine | 0.2722 | 0.6422 | 1.9326 | 0.7050 | 0.6804 | 0.8587 | 2.3038 | 0.5188 | 2.1015 | 1.3024 | 0.5244 | 0.5489 |
Putrescine | 1.5756 | 1.1286 | 1.0654 | 0.3815 | 0.4262 | 3.1483 | 0.1754 | 0.4280 | 0.7324 | 0.4052 | 1.2494 | 1.0821 |
Pyridoxal | 0.8823 | 1.1391 | 0.9555 | 0.9893 | 0.9648 | 0.8718 | 0.9820 | 1.0061 | 1.0396 | 1.0637 | 1.0642 | 1.0573 |
S-Adenosyl-L-homocysteine | 0.8646 | 1.0085 | 1.1102 | 0.9793 | 0.9358 | 1.0491 | 1.1008 | 0.8678 | 1.0191 | 1.0212 | 1.0940 | 0.9669 |
Serotonin | 0.9475 | 1.4013 | 1.0976 | 0.9019 | 0.8858 | 1.5316 | 0.9916 | 0.7683 | 0.7491 | 0.9311 | 0.8849 | 0.8218 |
Spermidine | 1.5448 | 1.0552 | 1.0534 | 0.8008 | 0.8893 | 0.9049 | 1.2583 | 1.3234 | 0.9277 | 0.6632 | 0.9315 | 0.6058 |
Spermine | 0.8914 | 0.3463 | 0.8722 | 0.5664 | 1.4717 | 0.4851 | 0.8656 | 1.9496 | 1.1476 | 0.7662 | 2.1385 | 0.3777 |
Tetrahydrofolate | 0.9166 | 0.9017 | 1.2040 | 1.0696 | 1.0223 | 0.6974 | 1.3364 | 0.9464 | 1.0660 | 1.1144 | 1.0223 | 0.7458 |
Urate | 0.8451 | 0.7140 | 1.7871 | 0.5618 | 1.1077 | 1.3014 | 1.0123 | 1.0130 | 1.2180 | 0.8215 | 0.9578 | 0.6327 |
Xanthine | 0.5917 | 0.7619 | 1.5150 | 0.7320 | 1.1715 | 0.6124 | 1.6771 | 1.3046 | 1.1091 | 1.1417 | 0.7669 | 0.7167 |
Factors:
F1 | Treatment:IV iron | Radiation Dose:Gy10 |
F2 | Treatment:IV iron | Radiation Dose:Gy11 |
F3 | Treatment:IV iron | Radiation Dose:Gy7 |
F4 | Treatment:IV iron | Radiation Dose:Gy8 |
F5 | Treatment:IV iron | Radiation Dose:Gy9 |
F6 | Treatment:IV iron | Radiation Dose:no irradiated |
F7 | Treatment:Saline | Radiation Dose:Gy10 |
F8 | Treatment:Saline | Radiation Dose:Gy11 |
F9 | Treatment:Saline | Radiation Dose:Gy7 |
F10 | Treatment:Saline | Radiation Dose:Gy8 |
F11 | Treatment:Saline | Radiation Dose:Gy9 |
F12 | Treatment:Saline | Radiation Dose:no irradiated |