Data for (Study ST002097)

(Analysis AN003426)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6
2,4-Diaminobutyric acid 1.1883 0.7670 1.0080 0.7275 1.3783 0.9309
2-Aminoimidazole 0.8966 0.9846 1.0714 1.1154 1.2527 0.6793
2-Deoxyadenosine 1.4477 0.6191 1.1675 0.8080 1.0228 0.9348
2^-Deoxycytidine 5^-monophosphate 0.8197 1.5182 0.7673 0.8465 1.2382 0.8101
2-Deoxyguanosine 0.8315 1.4406 0.9335 1.1863 0.9716 0.6364
3-Guanidinopropionic acid? 1.4844 1.1929 1.1434 1.1728 0.6315 0.3750
3-Phenylpropionylglycine 0.9359 1.2070 1.4274 1.1491 0.7780 0.5025
5-Aminolevulinic acid 1.0108 1.1086 1.0359 1.1454 1.0808 0.6185
5-aminosalicylic acid 1.3153 0.6909 0.9357 0.7978 1.0951 1.1652
5-Methylcytidine 0.8350 0.9959 0.3956 0.9264 0.7913 2.0558
6-Aminocaproic acid 0.9416 1.1352 1.1006 1.2079 1.0422 0.5725
Acetylcarnitine 1.2066 0.2971 1.0388 0.9260 1.7355 0.7960
Acetylcholine 0.6258 1.4966 0.9850 1.3416 0.9992 0.5518
Adenine 1.4983 0.5544 1.2375 0.9048 1.1726 0.6324
Adenosine 1.3024 0.7748 1.1434 0.9085 1.1704 0.7005
Adenosine 5^-monophosphate 1.3769 0.9019 1.0913 0.8926 1.1594 0.5778
Adenylosuccinic acid 1.0010 0.7700 1.1445 0.9742 1.7262 0.3841
Alanine 0.7811 1.4566 0.9338 1.1059 0.9916 0.7311
Aminoadipic acid 0.2308 1.0305 0.7010 0.9740 2.1943 0.8694
Betaine 0.8195 0.9175 1.6145 0.9080 1.1131 0.6274
Beta-Sitosterol 0.9083 1.1119 0.9448 1.0387 0.9709 1.0253
Biotin 1.3930 0.7973 1.1156 0.9280 1.1166 0.6495
Choline 1.1037 1.0605 0.7008 0.9541 0.9147 1.2662
Creatine 0.9057 1.1766 1.0967 1.1533 1.0654 0.6022
Cytidine 0.1776 1.3700 0.6922 1.3015 0.9486 1.5101
Cytidine monophosphate 0.5159 1.4047 0.9038 1.1181 1.1142 0.9433
Cytosine 0.2841 1.4413 0.7898 1.3136 0.9334 1.2378
Deoxycytidine 0.4815 1.2927 0.7114 1.4406 0.9751 1.0988
Dephospho-CoA 1.6007 1.2392 1.4899 0.7791 0.5725 0.3187
Dopamine 1.2331 0.7184 0.9559 0.8440 1.0253 1.2233
Gamma-Aminobutyric acid 0.2599 2.4928 0.5230 1.2206 0.6515 0.8522
Guanidineacetic acid 0.6714 1.2589 0.9702 1.1398 0.9191 1.0406
Guanosine 5^-monophosphate 1.1653 1.0052 0.9324 0.9254 1.3988 0.5728
Hexanoylcarnitine 1.3722 0.5795 1.9718 0.8747 0.8692 0.3325
Hippuric acid 1.0421 1.0269 1.1321 1.1822 0.9303 0.6864
his 0.7652 1.3254 0.7083 0.9378 1.0302 1.2332
Histamine 0.2885 1.4503 0.7596 1.3121 0.9436 1.2458
Indole-3-acetic acid 0.3622 1.2708 1.0571 1.1041 0.9279 1.2780
Inosine 1.0993 0.9329 0.9912 0.9908 1.0679 0.9181
Inosine-5^-monophosphate 1.2766 0.9884 0.9089 1.2388 1.1598 0.4274
Isoleucine 0.8366 1.1469 1.0257 1.1738 0.9002 0.9168
Isonicotinic acid 1.2398 0.7416 0.9165 0.9353 1.0435 1.1232
L-Arginine 0.7813 1.2348 1.2885 1.1443 1.0804 0.4708
L-Ascorbic acid 1.6251 1.2582 1.1996 0.6512 0.9717 0.2942
L-Carnitine hydrochloride 1.1448 0.9710 1.2195 1.1037 1.0685 0.4925
L-Citrulline 0.9905 0.9132 0.8156 0.7902 1.3888 1.1016
L-Glutamate 0.3640 0.9730 0.7428 0.7658 0.9694 2.1850
L-Glutamine 1.1060 1.1890 0.8307 0.9983 0.7745 1.1015
L-Homocysteine 0.5369 1.6999 0.7444 0.9084 1.1308 0.9797
L-Homoserine 0.5442 1.6142 0.7208 1.1489 0.8662 1.1057
L-Kynurenine 0.7241 1.1537 0.9759 1.1761 0.7388 1.2314
L-Leucine 0.8376 1.1484 1.0269 1.1716 0.8974 0.9180
L-Lysine 1.1036 1.1520 0.8279 1.0409 0.7751 1.1006
L-Methionine 0.5206 1.2699 0.4839 1.3236 0.7731 1.6289
L-Norleucine 0.8538 1.1597 1.0171 1.1400 0.9220 0.9073
L-Ornithine 0.7877 1.1449 1.0595 1.2475 0.8384 0.9220
L-Phenylalanine 0.8316 1.2416 0.9943 1.1285 0.9088 0.8952
L-Proline 0.5524 1.6895 0.7760 1.2163 0.8932 0.8727
L-Threonine 0.5726 1.5765 0.7333 1.1755 0.8458 1.0964
L-Valine 0.6606 1.2573 0.9819 1.1468 0.9161 1.0372
N-Acetylglutamine 1.4217 0.8970 1.1481 1.1168 0.8000 0.6163
N-Acetyl-L-methionine 0.6447 1.3055 1.2781 1.1838 0.9060 0.6818
Nicotinic acid 1.2400 0.7422 0.9175 0.9379 1.0443 1.1181
Normetanephrine 2.5080 0.0955 1.3548 1.7555 0.1104 0.1760
Norvaline 0.6606 1.2573 0.9819 1.1468 0.9161 1.0372
Oxidized glutathione 0.8994 1.1429 0.9975 1.0656 0.9992 0.8954
Palmitoyl-l-carnitine 1.1143 0.4851 0.9725 0.8151 1.7569 0.8561
Phosphoenolpyruvic acid 0.8386 0.9487 0.4583 0.9527 0.6553 2.1464
Pipecolic acid 1.0919 0.9119 1.1355 0.9831 1.0540 0.8236
Putrescine 0.6959 1.1315 1.1242 0.7852 0.7769 1.4864
Pyridoxal 0.6065 1.5320 0.7584 1.4576 0.8089 0.8366
Pyroglutamic acid 1.1052 0.9142 1.0794 0.9686 1.0484 0.8843
Reduced glutathione 0.9524 1.1241 1.2605 1.0113 0.8783 0.7733
S-(5^-Adenosyl)-L-homocysteine 1.9869 0.4316 1.0153 0.5933 0.8971 1.0758
Sarcosine 0.7625 1.5061 0.9136 1.0965 1.0081 0.7131
Serotonin 0.6826 0.9722 0.9534 1.0491 0.9598 1.3829
Spermidine 0.9686 1.2063 1.1661 1.0485 1.1139 0.4967
Sphinganine 0.6318 0.9975 0.7986 0.6867 1.0715 1.8138
Taurine 2.0098 0.8588 0.6847 0.8809 0.9582 0.6076
Taurohyodeoxycholic acid 2.0772 0.2386 0.6501 0.4656 1.4272 1.1414
Taurolithocholic acid 1.9729 0.3539 0.6258 0.4448 1.4170 1.1856
Thiamine 1.8852 0.9116 0.8037 0.9705 0.7493 0.6798
Thymine 1.0860 0.8147 0.9560 1.0676 1.3977 0.6780
Trans-4-Hydroxy-L-proline 0.8376 1.1472 1.0270 1.1717 0.8983 0.9181
Tryptophan 0.7467 1.2719 1.0317 1.1004 0.9725 0.8769
Uracil 1.2359 1.0781 0.8427 0.6323 1.2718 0.9392
Uridine 5^-monophosphate 1.4935 0.8278 1.3381 0.7260 1.4214 0.1931
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Factors:

F1Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil)
F2Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil)
F3Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil)
F4Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil)
F5Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.
F6Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.
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