Data for (Study ST002098)

(Analysis AN003428)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6
2,4-Diaminobutyric acid 0.9977 0.6406 0.7333 0.5736 1.5740 1.4808
2-Aminoimidazole 0.8833 0.8216 0.5064 0.6024 1.7345 1.4518
2-Methylhippuric acid 1.2236 0.9591 1.1112 0.8585 1.1260 0.7217
3-Guanidinopropionic acid? 1.1258 0.8255 0.8743 0.9516 1.2040 1.0187
3-Phenylpropionylglycine 1.4278 1.2396 1.5719 0.8399 0.6282 0.2926
5-aminosalicylic acid 1.2321 0.7243 0.8003 0.6464 1.4279 1.1690
5-Hydroxy-L-tryptophan 0.9022 1.0854 1.1255 0.9159 1.0362 0.9347
5-Methylcytidine 1.5038 0.8047 0.8002 0.6589 1.3339 0.8985
6-Aminocaproic acid 1.1028 0.7908 0.8423 0.8465 1.3335 1.0842
Acetylcarnitine 1.0286 0.5477 1.0002 0.9307 1.1529 1.3399
Acetylcholine 1.0407 0.8608 0.8531 1.0401 1.1653 1.0400
Adenosine 3.1846 0.5851 0.9368 0.2401 0.5891 0.4644
Alanine 0.7416 0.7713 0.7721 0.6262 1.5132 1.5757
Aminoadipic acid 0.6250 1.0285 0.6708 0.7066 1.6647 1.3044
Arachidonic acid 0.9622 0.5043 0.5627 0.5894 1.7428 1.6385
Betaine 0.3453 0.8907 0.5695 0.5514 1.3177 2.3256
Beta-Sitosterol 2.2833 0.1186 0.4317 0.3919 1.5960 1.1785
Biotin 0.9306 0.8835 1.6262 1.6380 0.5705 0.3511
Choline 1.1371 0.7335 0.6893 0.5818 1.5912 1.2670
Creatine 1.0577 0.8437 0.9124 0.8295 1.2686 1.0881
Creatinine 1.3125 0.7016 0.7186 0.6138 1.6545 0.9989
Cytidine 1.6716 0.5089 0.8185 0.5769 1.4297 0.9944
Cytosine 1.5129 0.7364 0.9570 1.0236 0.8361 0.9340
Daidzein 0.7776 0.8491 1.1971 0.8747 1.3201 0.9814
Deoxycytidine 1.1507 0.6351 0.7519 0.7426 1.6839 1.0357
Dopamine 1.2120 0.7594 0.5976 0.5492 1.3845 1.4973
Guanidineacetic acid 0.8403 0.8492 0.9294 0.8417 1.3027 1.2367
Hexanoylcarnitine 1.2766 0.7338 1.0619 0.9868 0.8942 1.0468
Hippuric acid 0.8254 1.5702 1.3220 1.2822 0.6942 0.3060
Histamine 1.5129 0.7364 0.9570 1.0236 0.8361 0.9340
Hypoxanthine 5.4297 0.0815 0.1489 0.0955 0.1264 0.1180
Indole-3-acetic acid 0.5672 1.1599 0.9597 0.8618 1.2771 1.1742
Indole-3-propionic acid 0.6103 1.8507 1.3368 1.3127 0.4549 0.4345
Indolepyruvic acid 0.4335 1.4686 0.7680 0.7925 1.2019 1.3355
Inosine 3.6325 0.5181 0.9025 0.2360 0.4037 0.3073
Isoleucine 0.6371 1.2056 1.1253 1.1186 0.8603 1.0532
Isonicotinic acid 0.9924 0.5868 0.5979 0.5431 1.7767 1.5031
L-Arginine 3.0387 0.6518 0.6087 0.7850 0.4869 0.4289
L-Carnitine hydrochloride 0.9290 0.7948 0.9505 1.0829 1.1166 1.1261
L-Citrulline 0.8297 1.0055 0.8936 1.0586 1.2369 0.9757
L-Cysteic acid 1.5057 0.6582 0.8649 0.7020 1.1252 1.1439
L-Glutamate 0.3052 1.1349 0.5601 0.6665 1.4994 1.8339
L-Glutamine 0.8584 0.4590 0.6620 0.5204 1.4008 2.0994
L-Histidine 0.8247 0.5245 0.7185 0.5361 1.3869 2.0094
L-Homoserine 0.7356 0.8889 0.7457 0.7106 1.3540 1.5652
L-Kynurenine 0.4969 1.7140 1.2021 1.1044 0.8663 0.6164
L-Leucine 0.6617 1.1974 1.0897 1.1264 0.8807 1.0441
L-Lysine 0.7605 0.5325 0.7104 0.5735 1.3384 2.0848
L-Methionine 0.9224 0.6598 0.6640 0.5545 1.3180 1.8813
L-Norleucine 0.7444 1.0706 1.0608 1.0858 0.9735 1.0649
L-Ornithine 0.3345 1.0150 0.7692 1.4250 1.3995 1.0568
L-Phenylalanine 0.7017 1.1938 1.1258 1.2235 0.8764 0.8788
L-Proline 0.8306 0.8154 0.7366 0.7365 1.3637 1.5172
L-Threonine 0.6707 0.8653 0.7619 0.7199 1.4418 1.5404
L-Valine 0.8432 0.8641 0.9249 0.8326 1.2808 1.2543
N-Acetylglutamine 1.0384 1.1215 0.6284 0.7589 1.0955 1.3573
Nicotinic acid 0.9369 0.6448 0.5317 0.5161 1.8382 1.5323
Normetanephrine 0.5476 1.0503 0.7408 0.7002 1.6309 1.3302
Norvaline 0.8469 0.8642 0.9223 0.8278 1.2909 1.2479
Palmitoyl-l-carnitine 0.7754 0.5148 0.7434 0.4570 1.7636 1.7457
Phosphoenolpyruvic acid 0.7893 0.5451 0.8092 0.7480 1.3208 1.7876
Pipecolic acid 1.3720 0.7739 0.7613 0.6931 1.1394 1.2603
Putrescine 0.6986 0.9360 0.6798 0.7332 1.4325 1.5199
Pyrogallol 0.8623 1.4305 1.2952 1.2223 0.7991 0.3905
Pyroglutamic acid 1.2060 0.7687 0.8815 0.7010 1.0805 1.3622
Sarcosine 0.8272 0.6978 0.7712 0.5762 1.5012 1.6264
Serotonin 1.1335 1.1660 1.0113 0.9141 0.9985 0.7765
Spermidine 0.9211 0.7159 0.6317 0.5165 1.7484 1.4663
Sphinganine 0.8815 0.5497 0.4007 0.3646 1.9639 1.8396
Stearic acid 0.9882 0.2853 0.4159 0.3075 2.0662 1.9369
Taurine 1.2792 0.4696 0.6164 0.5018 1.5597 1.5734
Taurohyodeoxycholic acid 0.2289 0.4141 0.5529 0.6411 2.3476 1.8155
Taurolithocholic acid 0.2156 0.5886 0.6082 0.7383 2.0438 1.8056
Trans-4-Hydroxy-L-proline 0.6226 1.2198 1.1322 1.1378 0.8386 1.0489
Trimethylamine N-oxide 1.4621 0.5242 0.5464 1.3411 1.4583 0.6680
Tryptamine 0.0067 0.8345 0.1152 0.2696 2.8131 1.9609
Tryptophan 0.7721 1.1588 1.0515 0.8703 1.2310 0.9163
Uracil 1.1717 0.4426 0.4518 0.2743 2.0701 1.5895
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Factors:

F1Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil)
F2Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil)
F3Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil)
F4Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil)
F5Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.
F6Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.
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