Data for (Study ST002163)
(Analysis AN003544)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| 10-Camphorsulfonic acid (IS) | 0.9794 | 0.6529 | 1.0882 | 0.9069 | 1.1562 | 1.1789 |
| 2,3-BPG | 1.4222 | 0.8889 | NA | 0.7778 | NA | 0.9111 |
| 2-Dehydrogluconate | 0.7342 | 1.4247 | NA | 0.4164 | NA | 1.4247 |
| 2-Ethylhexanoic acid | 1.0933 | 0.8267 | NA | 1.0400 | NA | 1.0400 |
| 2-Hydroxy glutaric acid | 1.6842 | 0.5614 | NA | 1.1930 | NA | 0.5614 |
| 2-Hydroxyisobutyric acid | 0.9171 | 0.5659 | NA | 1.1317 | NA | 1.3854 |
| 2-Hydroxyisovaleric acid | 1.1429 | 0.7143 | NA | 1.4286 | NA | 0.7143 |
| 2KG | 1.0500 | 0.9500 | NA | 0.9000 | NA | 1.1000 |
| 2-Methyl-3-Hydroxybutyric acid | 0.9552 | 0.9552 | NA | 0.8358 | NA | 1.2537 |
| 2-Methylhippuric acid | 0.6926 | 0.6061 | NA | 0.5368 | NA | 2.1645 |
| 2-Propylglutaric acid | 0.9697 | 0.9697 | NA | 0.8485 | NA | 1.2121 |
| 3-Hydroxybutyric acid | 1.1143 | 1.0000 | NA | 0.9143 | NA | 0.9714 |
| 3-Hydroxymethylglutaric acid | 1.0909 | 0.7792 | NA | 0.9870 | NA | 1.1429 |
| 3-Hydroxypropionic acid | 1.1954 | 1.0115 | NA | 0.7356 | NA | 1.0575 |
| 6PG | 1.5721 | 0.5590 | NA | 1.2227 | NA | 0.6463 |
| Acetyl-Gly | 1.1429 | 0.8000 | NA | 0.8571 | NA | 1.2000 |
| ADP | 1.1429 | 0.9286 | NA | 0.7857 | NA | 1.1429 |
| ADP-Glc | 1.1628 | 0.8372 | NA | 0.6977 | NA | 1.3023 |
| ADP-Rib | 1.1073 | 1.1073 | NA | 0.8166 | NA | 0.9689 |
| AICARP | 0.9828 | 0.9828 | NA | 0.7568 | NA | 1.2776 |
| Allantoic acid | 1.0667 | 0.8000 | NA | 0.8667 | NA | 1.2667 |
| Allantoin | 1.0169 | 0.9266 | NA | 0.8588 | NA | 1.1977 |
| AMP | 1.0118 | 1.0353 | NA | 0.8941 | NA | 1.0588 |
| Arabinose | 1.0196 | 1.0588 | NA | 0.7843 | NA | 1.1373 |
| Arabitol | 1.1000 | 0.9750 | NA | 0.9500 | NA | 0.9750 |
| ATP | 1.1139 | 0.9114 | NA | 0.8608 | NA | 1.1139 |
| Beta-Lactose | 0.8395 | 1.0864 | NA | 0.6914 | NA | 1.3827 |
| CDP | 1.5130 | 0.6957 | NA | 1.0261 | NA | 0.7652 |
| cis-Aco | 1.2482 | 0.8085 | NA | 0.8085 | NA | 1.1348 |
| Cit | 1.1064 | 0.9362 | NA | 0.7660 | NA | 1.1915 |
| CoA | 1.0000 | 1.0000 | NA | 1.0000 | NA | 1.0000 |
| Creatine phosphate | 0.7558 | 1.0138 | NA | 0.5714 | NA | 1.6590 |
| CTP | 1.6308 | 0.4205 | NA | 1.2308 | NA | 0.7179 |
| Cysteic acid | 1.5484 | 0.5806 | NA | 1.1613 | NA | 0.7097 |
| Cysteinesulfinic acid | 1.7582 | 0.5495 | NA | 1.3187 | NA | 0.3736 |
| F1P | 0.9254 | 1.1311 | NA | 0.6067 | NA | 1.3368 |
| F6P | 0.7218 | 1.4135 | NA | 0.4812 | NA | 1.3835 |
| FAD | 0.9565 | 1.1014 | NA | 0.7536 | NA | 1.1884 |
| FBP | 1.6000 | 0.6000 | NA | 1.0800 | NA | 0.7200 |
| Fum | 0.6824 | 0.5307 | 1.2889 | 0.9520 | 1.5164 | 1.0952 |
| G1P | 0.6950 | 1.2355 | NA | 0.5251 | NA | 1.5444 |
| G6P | 0.6653 | 1.3306 | NA | 0.5073 | NA | 1.4969 |
| Ga1P | 0.8649 | 1.1892 | NA | 0.6486 | NA | 1.2973 |
| GDP | 1.1321 | 0.9057 | NA | 0.9811 | NA | 0.9811 |
| GDP-Man | 1.0526 | 1.0175 | NA | 0.7719 | NA | 1.1579 |
| Glucaric acid | 1.0476 | 0.9524 | NA | 0.9524 | NA | 1.0476 |
| Gluconic acid | 1.0667 | 1.1429 | NA | 0.7619 | NA | 1.0286 |
| Glucosamine 1P | 1.3793 | 0.8276 | NA | 0.8276 | NA | 0.9655 |
| Glucose | 0.9778 | 1.0667 | NA | 0.8000 | NA | 1.1556 |
| Glucuronic acid | 0.8767 | 1.1507 | NA | 0.7671 | NA | 1.2055 |
| Glutaric acid | 1.5652 | 0.9275 | NA | 0.9855 | NA | 0.5217 |
| GMP | 1.1250 | 1.0000 | NA | 0.8750 | NA | 1.0000 |
| GTP | 1.1503 | 0.9150 | NA | 0.8627 | NA | 1.0719 |
| Hippuric acid | 0.7173 | 1.2042 | NA | 0.4660 | NA | 1.6126 |
| Homocysteic acid | 1.3125 | 0.9688 | NA | 0.9688 | NA | 0.7500 |
| IMP | 0.8615 | 1.1077 | NA | 0.6769 | NA | 1.3538 |
| IsoCit | 0.9263 | 1.0526 | NA | 0.6737 | NA | 1.3474 |
| IsovalerylGly | 1.1656 | 1.2883 | NA | 0.6258 | NA | 0.9202 |
| M6P | 0.8788 | 1.1818 | NA | 0.6061 | NA | 1.3333 |
| Mal | 1.0619 | 0.9440 | NA | 0.6962 | NA | 1.2979 |
| Maltotetraose | 0.5416 | 1.2379 | NA | 0.4410 | NA | 1.7795 |
| N-Acetyl-Ala | 2.0114 | 0.2743 | NA | 1.3714 | NA | 0.3429 |
| N-Acetyl-Asn | 1.3451 | 0.9204 | NA | 0.8850 | NA | 0.8496 |
| N-Acetyl-Asp | 2.0308 | 0.2769 | NA | 1.1692 | NA | 0.5231 |
| N-Acetyl-galactosamine | 0.8119 | 1.1287 | NA | 0.6733 | NA | 1.3861 |
| N-Acetyl-Gln | 1.0714 | 0.8571 | NA | 0.8571 | NA | 1.2143 |
| N-Acetyl-Glu | 1.1130 | 1.2174 | NA | 0.9391 | NA | 0.7304 |
| N-Acetyl-glucosamine-1P | 1.2174 | 0.8261 | NA | 0.8696 | NA | 1.0870 |
| N-Acetyl-glucosamine-6P | 1.2525 | 0.9293 | NA | 0.8889 | NA | 0.9293 |
| N-Acetyl-Leu | 1.3018 | 1.0651 | NA | 0.7101 | NA | 0.9231 |
| NAD | 0.8462 | 1.1795 | NA | 0.7179 | NA | 1.2564 |
| NADPH | 1.1667 | 1.1667 | NA | 0.7500 | NA | 0.9167 |
| N-Carbamoyl-Asp | 1.7627 | 0.7627 | NA | 1.0339 | NA | 0.4407 |
| O-Acetyl-homoSer | 1.1733 | 0.6933 | NA | 0.8533 | NA | 1.2800 |
| Oxalic acid | 1.1304 | 0.8696 | NA | 0.9565 | NA | 1.0435 |
| Pantothenate | 0.9818 | 0.9818 | NA | 0.8000 | NA | 1.2364 |
| PEP | 0.8116 | 1.2174 | NA | 0.4058 | NA | 1.5652 |
| PIPES (IS) | 0.9250 | 0.7805 | 1.0406 | 0.8993 | 1.1562 | 1.1723 |
| PropionylGly | 1.6933 | 0.8344 | NA | 0.7607 | NA | 0.7117 |
| PRPP | 1.3171 | 0.7561 | NA | 0.9024 | NA | 1.0244 |
| Pyr | 0.8571 | 1.1429 | NA | 0.5714 | NA | 1.4286 |
| Pyridoxal-5P | 0.9836 | 0.9836 | NA | 0.7432 | NA | 1.2896 |
| PyroGlu | 1.1525 | 0.8814 | NA | 0.9492 | NA | 1.0169 |
| Quinolinic acid | 1.6842 | 0.8772 | NA | 0.8596 | NA | 0.5789 |
| R5P | 1.2135 | 0.8989 | NA | 0.8989 | NA | 0.9888 |
| S7P | 0.6759 | 1.1034 | NA | 0.7034 | NA | 1.5172 |
| Sorbitol-6P | 0.8727 | 1.1636 | NA | 0.5818 | NA | 1.3818 |
| Suc | 1.2435 | 0.7876 | NA | 1.0363 | NA | 0.9326 |
| Succinyl AMP | 1.0492 | 1.0492 | NA | 0.7869 | NA | 1.1148 |
| Taurine | 1.2000 | 0.7333 | NA | 1.1333 | NA | 0.9333 |
| ThPP | 0.9825 | 0.9825 | NA | 0.7719 | NA | 1.2632 |
| Threonic acid | 1.1111 | 0.8889 | NA | 0.7778 | NA | 1.2222 |
| UDP | 1.2598 | 0.8976 | NA | 0.7402 | NA | 1.1024 |
| UDP-Galac | 1.0980 | 0.7373 | NA | 0.9098 | NA | 1.2549 |
| UDP-Glc | 1.2698 | 0.7619 | NA | 0.6984 | NA | 1.2698 |
| UDP-glucuronate | 1.0086 | 1.1003 | NA | 0.9971 | NA | 0.8940 |
| UDP-N-acetyl-glucosamine | 1.0503 | 0.9609 | NA | 0.9609 | NA | 1.0279 |
| UMP | 1.1111 | 0.9444 | NA | 0.8333 | NA | 1.1111 |
| Uracil | 0.1564 | 0.0695 | 2.1726 | 1.0356 | 1.8467 | 0.9222 |
| Uridine | 1.0149 | 0.9552 | NA | 1.0149 | NA | 1.0149 |
| UTP | 1.2549 | 0.7843 | NA | 0.8627 | NA | 1.0980 |
Factors:
| F1 | Genotype:NNMT KO | Sample group:4T1 | Sex:female | Treatment:No treatment |
| F2 | Genotype:NNMT KO | Sample group:Sham | Sex:female | Treatment:No treatment |
| F3 | Genotype:WT | Sample group:4T1 | Sex:female | Treatment:MNAM treatment |
| F4 | Genotype:WT | Sample group:4T1 | Sex:female | Treatment:No treatment |
| F5 | Genotype:WT | Sample group:Sham | Sex:female | Treatment:MNAM treatment |
| F6 | Genotype:WT | Sample group:Sham | Sex:female | Treatment:No treatment |
