Data for (Study ST002220)

(Analysis AN003629)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
2/3-phosphoglycerate 1.2505 1.1026 0.6019 1.0450
2-hydroxyglutarate_m+0 0.9926 1.0960 1.0867 0.8247
2-hydroxyglutarate_m+1 0.9944 1.1104 1.0939 0.8013
2-hydroxyglutarate_m+2 1.1306 1.5075 1.1943 0.1676
2-hydroxyglutarate_m+3 0.7517 1.1956 1.0038 NA
2-oxoglutarate_m+0 1.1026 1.1410 1.0423 0.7142
2-oxoglutarate_m+1 1.1083 1.1569 1.0482 0.6865
2-oxoglutarate_m+2 1.3173 1.5326 1.1076 0.0425
2-oxoglutarate_m+3 0.9074 1.1514 0.9412 NA
4-hydroxyproline 0.7120 0.8224 0.6809 1.7847
6-phosphogluconate 0.4255 1.4418 0.6467 1.4860
aconitate_m+0 1.2282 1.0147 1.0345 0.7226
aconitate_m+1 1.2691 1.0319 1.0404 0.6586
aconitate_m+2 1.3071 0.9839 0.7089 NA
aconitate_m+3 1.6384 0.8575 0.5041 NA
adenine 0.8233 0.6905 0.3794 2.1069
adenosine 0.6964 0.7308 1.1627 1.4101
ADP 1.3807 0.8920 0.8156 0.9117
alanine 0.7841 0.7729 0.6999 1.7431
AMP 1.1616 0.9731 0.8963 0.9690
arginine 1.2103 0.9090 1.0318 0.8489
argininosuccinate 1.7545 1.4351 0.0088 0.8015
Asparagine 0.9689 0.9732 0.8282 1.2296
aspartate_m+0 1.0844 1.1352 0.8112 0.9691
aspartate_m+1 1.1036 1.1603 0.8133 0.9229
aspartate_m+2 1.3903 1.5302 0.8937 0.1857
aspartate_m+3 1.0854 1.2193 0.6952 NA
ATP 1.2498 0.8916 0.7671 1.0915
betaine 0.6701 0.6863 0.7111 1.9324
carnitine 1.1037 0.9943 1.1058 0.7961
carnitine C14 0.6959 0.6384 0.7181 1.9476
carnitine C16 0.8490 0.5198 0.6660 1.9653
carnitine C18 1.3388 1.0670 1.3062 0.2880
carnitine C18:1 0.9270 0.9102 0.9062 1.2566
carnitine C2_m+0 1.1540 0.9314 0.9438 0.9708
carnitine C2_m+1 1.1569 0.9312 0.9369 0.9750
carnitine C2_m+2 1.5083 1.2752 1.0593 0.1572
carnitine C3_m+0 0.9527 0.9037 0.6809 1.4627
carnitine C3_m+1 0.9633 0.9167 0.6818 1.4382
carnitine C3_m+2 1.4688 1.5793 0.7724 0.1795
carnitine C3_m+3 1.5493 1.5102 0.8040 0.1364
carnitine C4_m+0 1.0164 0.9960 0.7973 1.1903
carnitine C4_m+1 1.0291 1.0103 0.7949 1.1657
carnitine C4_m+2 1.3903 1.3935 0.8144 0.4017
carnitine C4_m+3 1.2545 1.7347 0.6213 0.2368
carnitine C5_m+0 1.2184 1.1738 0.8960 0.7119
carnitine C5_m+1 1.2577 1.1930 0.9271 0.6222
carnitine C5_m+3 0.9117 1.4427 0.5570 NA
carnitine C5_m+4 1.6133 1.4946 0.8195 0.0726
carnitine C5_m+5 1.4352 1.3420 0.8874 0.1693
carnitine C5_m+6 1.2612 1.1298 0.6090 NA
CDP 1.2221 0.8485 0.8044 1.1250
citrate_m+0 1.1844 1.0455 0.9383 0.8319
citrate_m+1 1.2081 1.0583 0.9423 0.7914
citrate_m+2 1.2589 1.0286 0.7125 NA
citrate_m+3 1.2360 1.0000 0.7641 NA
citrulline 1.0485 1.0524 0.9894 0.9097
CMP-acetylneuraminate 0.9830 0.9035 0.7832 1.3303
creatine 0.9900 1.0727 0.7926 1.1447
CTP 1.3217 0.8355 0.7372 1.1057
cystathionine 1.0384 0.6005 1.0382 1.3229
deoxycarnitine 0.9597 0.8641 1.0407 1.1355
dihydroorotate 0.3807 0.7740 0.4247 2.4206
dihydroxyacetone phosphate 1.2885 1.0481 0.7647 0.8986
fructose bisphosphate 1.1040 1.0850 0.7515 1.0594
fumarate_m+0 0.9975 0.9003 0.8718 1.2304
fumarate_m+1 1.0195 0.9239 0.9081 1.1486
fumarate_m+2 1.4625 1.0753 0.7697 0.2312
fumarate_m+3 1.4276 0.8616 0.7108 NA
GDP 1.3963 0.7667 0.8777 0.9593
GDP fucose 1.0729 0.9252 0.7951 1.2067
glucose 0.5166 1.1133 0.4787 1.8914
glutamate_m+0 1.0849 1.0428 0.9727 0.8997
glutamate_m+1 1.0936 1.0532 0.9835 0.8697
glutamate_m+2 1.3140 1.3866 1.0709 0.2285
glutamate_m+3 1.0847 1.1114 0.9425 0.8614
glutamine_m+0 1.0271 1.2481 0.8953 0.8294
glutamine_m+1 1.0299 1.2477 0.8952 0.8273
glutamine_m+2 1.0289 1.2607 0.8831 0.8273
glutathione reduced_m+0 1.0554 1.0386 0.8838 1.0222
glutathione reduced_m+1 1.0563 1.0492 0.8825 1.0120
glutathione reduced_m+2 1.2457 1.6677 0.9841 0.1026
glutathione reduced_m+3 0.9327 1.5766 0.4772 NA
glyceraldehyde 3-phosphate 1.1271 0.8253 1.0796 0.9680
glycerate 0.9833 1.2408 0.8424 0.9335
glycerol 3-phosphate 1.1619 1.2735 0.9718 0.5928
glycerylphosphorylcholine 1.0677 1.2505 0.9648 0.7169
glycine 0.9194 0.9669 0.5571 1.5566
GTP 1.4717 0.8341 0.7692 0.9250
guanosine 1.3371 1.1468 0.9700 0.5462
hexose phosphate 0.7221 1.3501 0.9925 0.9352
histidine 1.0241 1.0821 0.9979 0.8958
homocitrulline 1.2380 1.1055 0.8648 0.7917
hypotaurine 1.0425 1.1426 1.2195 0.5954
hypoxanthine 0.8783 1.0092 0.8962 1.2163
inosine 0.8895 1.1942 0.9069 1.0095
Inositol 1.1256 1.0481 1.2870 0.5393
ketoleucine+ketoisoleucine_m+0 1.1164 1.1500 1.0226 0.7110
ketoleucine+ketoisoleucine_m+5 0.9747 1.3141 1.0026 0.7087
ketoleucine+ketoisoleucine_m+6 1.0067 1.2300 1.0157 0.7476
kynurenine 1.0640 1.0673 1.0396 0.8292
lactate 0.9384 1.2159 0.6854 1.1603
leucine+isoleucine_m+0 1.1384 1.1191 0.9812 0.7612
leucine+isoleucine_m+1 1.1454 1.1520 1.0105 0.6921
leucine+isoleucine_m+4 1.1274 1.2334 0.9210 0.7182
leucine+isoleucine_m+5 1.0908 1.1125 0.9339 0.8629
leucine+isoleucine_m+6 1.0888 1.1121 0.9319 0.8671
lysine 1.1578 1.0133 1.0768 0.7522
malate_m+0 0.9958 0.9092 0.8942 1.2008
malate_m+1 1.0124 0.9255 0.9087 1.1534
malate_m+2 1.3306 1.2884 1.0740 0.3071
malate_m+3 1.4624 1.3662 1.1185 0.0529
methionine 0.9868 1.0383 0.9846 0.9903
N-acetylaspartate_m+0 0.1258 0.1505 0.2968 3.4269
N-acetylaspartate_m+1 0.1273 0.1551 0.3059 3.4116
N-acetylaspartate_m+2 0.7520 1.4003 1.6195 0.0351
N-acetylaspartate_m+3 0.3485 1.0733 1.5782 NA
N-acetylaspartylglutamate 0.0187 0.0203 0.0472 3.9138
N-acetylglutamate 0.6399 0.5453 0.6148 2.2000
N-acetylneuraminic acid 1.2165 1.2209 0.5851 0.9774
NAD 1.0820 0.9889 0.9355 0.9936
NADH 1.8373 0.5392 0.5226 1.1009
N-carbamoylaspartate 0.6508 0.6310 0.2104 2.5077
ornithine 0.9926 0.9240 1.0817 1.0016
orotate 0.4672 0.7257 0.2429 2.5642
oxidized glutathione 1.0421 0.9437 0.7719 1.2422
palmitate 1.1060 0.7646 0.8761 1.2534
pentose phosphate 0.8594 1.0672 0.5665 1.5068
phenylalanine 1.1341 1.1036 0.9909 0.7714
phosphocreatine 0.0887 0.0220 0.0084 3.8809
phosphoenolpyruvate 1.3239 1.0139 0.4941 1.1681
phosphorylcholine 0.4310 0.4881 0.5602 2.5207
proline_m+0 0.9568 0.9206 0.7873 1.3353
proline_m+1 0.9637 0.9274 0.7896 1.3193
proline_m+2 1.1808 1.2716 0.8396 0.7080
proline_m+3 0.9654 1.3314 0.7032 NA
pyroglutamate_m+0 0.9782 1.1662 0.8028 1.0529
pyroglutamate_m+1 0.9746 1.1681 0.8196 1.0377
pyroglutamate_m+2 1.0604 1.6157 0.9054 0.4185
pyruvate 0.8637 1.2158 0.7266 1.1939
S-(2-succinyl)cysteine 1.0446 0.8578 1.0961 1.0015
S-adenosylhomocysteine 1.1115 1.0329 0.7629 1.0928
S-adenosylmethionine_m+0 1.1058 1.1467 1.0329 0.7147
S-adenosylmethionine_m+1 1.1184 1.1588 1.0519 0.6708
S-adenosylmethionine_m+2 1.4236 1.4100 0.9703 0.1960
sedoheptulose 7-phosphate 0.7895 1.4524 0.6543 1.1039
serine 0.5824 0.6535 0.4897 2.2743
S-lactoylglutathione 1.3477 1.2130 0.9511 0.4882
S-Succinylglutathione 0.8557 0.6980 0.6139 1.8324
succinate 0.6094 0.8340 0.6486 1.9080
taurine 1.1318 1.0979 1.2488 0.5214
threonine 0.8289 0.8488 0.7269 1.5954
tryptophan 1.1704 1.1329 0.9672 0.7295
tyrosine 1.1570 1.1548 0.9203 0.7679
UDP 1.0848 0.9843 0.6632 1.2677
UDP-GlcNac 1.0346 1.0464 0.7983 1.1207
UDP-glucose 1.0195 0.9633 0.7901 1.2271
UMP 1.1731 0.9065 0.8040 1.1163
UTP 1.1921 0.9280 0.6746 1.2053
valine 1.1209 1.1868 1.0068 0.6855
xanthine 0.7630 1.1797 0.6331 1.4243
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Factors:

F1Cell line:786-M1A | Treatment:13C6-leucine+13C6-isoleucine
F2Cell line:786-M2A | Treatment:13C6-leucine+13C6-isoleucine
F3Cell line:786-O | Treatment:13C6-leucine+13C6-isoleucine
F4Cell line:HK2 | Treatment:13C6-leucine+13C6-isoleucine
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