Data for (Study ST002431)

(Analysis AN003957)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
11a-Hydroxyprogesterone 1.3076 0.6641 0.9015 1.0845
1 3-Dimethyluric acid 0.2326 0.0828 1.7516 0.4347
1-Methylimidazole acetic acid 0.1110 0.2514 1.4732 0.7997
2 2-dimethylsuccinic acid 1.2695 0.6960 1.0721 0.9337
3-Cresotinic acid 1.0603 0.9078 0.9177 1.0876
3-Phenylbutyric acid 0.8234 1.0120 0.9215 1.1059
3-Phosphoglycerate 0.3234 0.1708 1.6700 0.5810
3-Phosphoserine 0.2778 0.0179 2.1928 0.0912
4-Aminobutyrate 0.6649 2.0700 0.7311 1.1464
4-Guanidinobutanoic acid 0.1605 0.8421 0.1910 1.9753
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) 0.0452 0.0768 1.9370 0.5300
5-Aminoimidazole-4-carboxamide ribonucleotide 0.2592 NA 1.7585 0.1532
5-Hydroxylysine NA 0.7283 0.1142 1.1628
5-Methylcytosine 0.1696 0.2684 0.2200 2.0403
5- Methylthioadenosine 0.0860 0.5398 0.2403 1.9887
6-Phosphogluconate 0.5039 0.0330 1.9690 0.0792
Acetyl-arginine 0.5377 0.2753 1.3315 0.8663
Acetyl CoA 1.0228 0.1539 1.5324 0.6048
Acetyllysine 0.0504 0.2510 1.6269 0.6562
Acetyl-Methionine 3.0055 0.6467 1.0135 0.8647
Acetyl-Phenylalanine 0.9011 1.0806 0.9274 1.0756
Acetyl proline 0.8842 1.1357 0.8996 1.0971
Aconitate 1.0181 0.7760 1.0492 0.9851
Adenine 0.2679 1.2306 0.1458 1.9378
Adenosine 0.2627 1.2136 0.5494 1.5379
ADP 0.3674 0.6685 0.7987 1.3620
ADP-D-Glucose 0.1229 NA 1.6486 0.0927
Alanine 0.5204 1.2099 0.7731 1.2624
AMP 0.1110 1.6938 0.3584 1.6742
Androstenedione 0.8223 0.8185 0.8138 1.2460
Arginine 0.0559 0.2795 0.1745 2.1030
Asparagine 0.1651 0.6718 0.5357 1.6581
Aspartate 0.2513 0.3582 1.9530 0.2787
ATP 0.6318 0.1544 1.2637 0.9386
Betaine 2.0530 0.7668 1.0120 0.8514
Butyryl CoA 0.0903 0.5937 0.1826 1.7539
Carnitine 0.7506 1.1433 0.9793 1.0383
CDP 0.6440 0.2546 1.3962 0.7874
CDP-Choline NA 1.1726 0.2167 1.0190
Citrulline 0.3296 0.0402 2.1331 0.1386
CMP 0.2069 1.2302 0.7243 1.3695
Coenzyme A 0.0786 0.4207 0.6889 1.5612
Creatinine 0.9095 0.7043 1.0492 1.0152
CTP 0.8238 0.0493 1.5566 0.5325
Cyclic AMP 0.0636 2.6227 0.5108 1.3748
Cystathionine 0.1332 0.0988 2.0738 0.2209
Cystine 0.6639 0.4696 1.1491 0.7952
Cytosine 0.2905 1.0260 0.8194 1.2945
Deoxyadenosine 0.4908 0.2514 1.5773 0.6011
Deoxyinosine 0.6456 1.3918 1.0386 0.9584
D-Glyceraldehyde-3-phosphate 0.6825 0.1924 1.8336 0.3258
Dihydroorotate 0.1025 0.0365 2.1009 0.0963
Dihydroxyacetone phosphate 0.3495 NA 1.1776 0.1696
Dihydroxybenzeneacetic acid 0.8838 0.9140 0.9335 1.1002
Dimethylglycine 0.8192 0.8292 0.9827 1.0759
D-sedoheptulose-1 7-phosphate 1.5896 0.1421 1.4269 0.3595
FAD 0.0877 0.7544 0.6083 1.5847
Fructose-1 6-bisphosphate 0.9184 0.0793 2.0172 0.1499
Fructose-6-phosphate 0.4842 0.0208 1.8237 0.3732
GDP 0.5289 0.4331 1.4230 0.7500
Glucose-6-phosphate 0.6990 0.0102 2.1100 0.1052
Glutamate 0.7384 0.0374 2.0521 0.1519
Glutamine 0.7328 0.0432 2.0639 0.1401
Glutathione 0.0140 0.1707 1.3449 0.9577
Glutathione disulfide 0.2573 0.2967 1.6632 0.5779
Glycerol-3-phosphate 0.5381 0.2307 1.8460 0.3592
Glycerophosphocholine 0.6825 0.9772 1.0004 1.0563
GMP 0.1428 1.7040 0.6696 1.3560
GTP 0.6314 0.0814 1.6114 0.6031
Guanidinoacetate 0.8138 1.5302 0.5798 1.4915
Guanine 0.1197 2.0384 0.2821 1.6916
Guanosine 0.9553 0.9229 0.9276 1.0927
Histidine 0.0940 0.5003 0.2293 2.0050
Homocitrulline 0.1814 0.0565 1.2485 0.9973
Homocysteine 0.2841 0.2226 1.4689 0.2105
Hydroquinone 0.8953 1.0165 0.9311 1.0836
Hydroxyindoleacetic acid 0.8600 0.9453 0.9466 1.0859
Hydroxymandelic acid 0.7725 1.0354 0.9243 1.1078
Hydroxyphenyllactic acid 0.7688 1.0406 0.9323 1.0995
Hypoxanthine 0.0122 0.2115 0.0308 2.2653
IMP 0.0694 0.0111 1.8418 0.2050
Indole 1.0072 0.9430 0.9570 1.0513
Inosine 0.2838 0.0810 0.6643 1.5875
Isoleucine 0.4222 0.4776 0.9236 1.2597
Itaconic acid 0.6641 0.0252 1.7657 0.1701
L-arginino-succinate 0.2859 0.0261 2.1930 0.0883
Leucic acid 0.6184 0.8108 0.9918 1.1033
Leucine 0.7463 0.3749 0.8072 1.3393
L-Octanoylcarnitine 0.7128 0.9887 0.8222 1.2276
L-Palmitoylcarnitine 0.5453 0.2616 1.7569 0.4419
Lysine 0.0547 0.7882 0.0959 2.0970
Malonyl-CoA 0.3448 NA 1.5462 0.1459
Mandelic acid 1.0334 0.8779 0.9836 1.0312
Mannose-6-phosphate 0.6592 0.0107 2.0337 0.1097
Methionine 0.1121 0.6497 0.9352 1.2711
Methylnicotinamide 0.7778 0.7147 0.9681 1.1165
N-Acetylaspartate 0.5738 0.4587 1.1663 0.9950
N-acetyl-glutamate 0.1162 0.0448 2.2508 0.0557
N-acetyl-glutamine 1.2149 0.0369 1.9039 0.2208
N-acetyl-L-ornithine 0.3552 0.7676 1.2733 0.8729
N-Acetylputrescine 0.2863 1.2803 0.5818 1.4905
N-Acetyltyrosine 1.0689 0.9612 0.9788 1.0162
NAD+ 0.0708 0.6239 0.3737 1.8438
NADH 0.1079 0.5145 0.8007 1.4289
NADP+ 0.1308 0.5940 0.4804 1.7321
NADPH 0.2850 0.1591 1.4896 0.7697
N-carbomoyl-L-aspartate 0.1485 0.0748 2.1682 0.1280
Nicotinamide ribotide 0.1201 0.7105 0.5442 1.6507
Nicotinate 0.6406 1.0243 0.8319 1.2239
O-Butanoylcarnitine 0.7873 0.9830 0.9171 1.1212
O-Decanoyl-L-carnitine 0.8969 0.7942 1.0144 1.0371
O-Propanoylcarnitine 0.7557 0.9996 0.8911 1.1497
Ornithine 0.7920 0.5760 1.2974 0.8079
Pantothenate 0.0479 0.0775 0.1196 2.1929
Phenylacetylglycine 0.7975 0.9576 0.9714 1.0694
Phenylalanine 0.5606 0.8520 0.6450 1.4529
Phenylethanolamine 0.7717 1.0020 0.8804 1.1574
Phenyllactic acid 0.9343 1.0133 0.9460 1.0627
Phosphocholine 0.7111 0.7787 1.0488 1.0363
Phosphoenolpyruvate 0.1018 0.4862 0.9173 1.3180
Pipecolic acid 0.0426 0.2142 0.0722 2.2184
PosIS_Alanine-2H4-15N 1.2020 1.1239 0.9947 0.9510
PosIS_Glutamine-2H5-15N2 1.0878 0.9848 1.0186 0.9693
PosIS_Inosine-15N4 1.0716 0.9002 1.0116 0.9931
PosIS_Lysine-2H8 0.6241 1.0350 0.9462 1.1106
PosIS_Serine-13C3-15N1 1.0146 0.9582 1.0288 0.9757
Proline 0.0676 0.0949 0.1734 2.1328
Propionyl CoA NA 0.1278 0.6187 1.4501
Pterin 0.0284 0.0835 0.2921 2.0226
Pyridoxamine 0.9704 0.5553 1.4401 0.6390
Pyridoxamine 5-phosphate 0.1870 0.9188 0.4896 1.6594
Ribulose-5-phosphate 0.5685 0.0283 1.8498 0.1247
S-adenosyl-L-homocysteine 0.0792 0.3242 0.5352 1.7626
S-adenosyl-L-methionine 0.0803 0.4841 0.2049 2.0343
Serine 0.3787 0.3690 1.8598 0.3489
Spermine 0.8300 1.6660 0.8856 1.0318
Succinyl-CoA 0.1895 NA 1.7313 0.1057
Tetrahydrocortisone 0.9283 0.9287 0.9249 1.0989
Thiamine 0.8380 1.2146 1.0072 0.9840
Thiamine pyrophosphate 0.1123 0.5905 0.4371 1.7791
Threonine 0.3316 0.1283 1.8591 0.3976
Thymidine 0.2444 0.4282 0.6105 1.5937
Trehalose-6-phosphate 0.0673 NA 1.4409 0.4942
Tryptamine 0.8070 1.3433 0.7338 1.2411
Tryptophan 0.1923 1.0589 0.9549 1.1699
Tyrosine 0.0604 0.6844 0.2600 1.9492
UDP 0.7443 0.0175 2.0303 0.1760
UDP-D-Glucose 0.5299 0.0165 1.4778 0.2180
UDP-N-acetyl-glucosamine 0.5922 0.0353 1.9945 0.2342
UMP 0.0917 1.7282 0.5566 1.4734
Uracil 0.9588 0.9810 0.9470 1.0630
Uridine 0.8104 1.2104 0.7495 1.2471
Urocanic acid 0.7934 0.8244 1.1695 0.8942
UTP 0.5778 0.0716 1.7741 0.4510
Valine 1.0367 0.2872 1.2757 0.8370
Xanthosine NA 0.5852 0.0583 1.4568
Xanthosine-5-phosphate 0.1643 0.4254 1.7427 0.4551
Xylose-5-phosphate 0.6362 0.1056 1.7092 0.1949
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Factors:

F1age:ancestral | growth_phase:exponential
F2age:ancestral | growth_phase:stationary
F3age:evolved | growth_phase:exponential
F4age:evolved | growth_phase:stationary
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