Data for (Study ST002473)

(Analysis AN004039)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8F9F10F11F12
1H-indole-3cetamide 1.1470 1.1924 1.0227 0.9251 0.9258 0.9647 0.9836 0.9598 1.0235 0.9766 0.9560 0.9228
1-methylguanosine 0.8123 0.7821 0.8123 1.0461 1.0537 1.1327 1.0519 1.0053 1.0983 1.0215 1.0473 1.1365
1-methylhistidine 1.0638 1.0193 0.9067 1.0228 1.0637 1.0620 0.9827 0.9039 0.9000 1.0045 1.1004 0.9700
2-deoxyadenosine 1.2097 1.2261 1.2286 0.8989 0.9381 0.9350 0.9171 0.8918 0.9376 0.9328 0.9117 0.9726
2-deoxycytidine 0.9073 0.9419 0.8764 1.0243 1.0411 1.0479 1.0415 0.9854 1.0333 1.0231 1.0234 1.0544
2-methylguanosine 0.9334 0.9661 0.9381 1.0000 0.9937 1.0410 1.0089 0.9871 1.0547 1.0159 0.9912 1.0697
3-methoxyanthranilate 0.8882 0.8737 0.8058 1.0296 0.9961 0.9787 1.1478 1.0715 1.1475 1.0887 0.8819 1.0905
3-methoxytyramine 1.2233 1.2105 1.1440 0.9962 0.7439 0.9861 1.0243 0.7698 1.0272 1.0185 0.8087 1.0475
3-methylhistidine 1.0592 1.0305 1.0327 0.9760 1.0485 1.0229 0.9719 0.9247 0.9404 0.9696 1.0994 0.9242
4-acetamidobutanoate 1.0215 1.0230 0.9575 0.9881 1.0384 1.0052 1.0013 0.9914 1.0077 0.9851 1.0243 0.9567
4-guanidinobutanoic acid 0.5294 0.5402 0.5133 1.1532 1.1116 1.1841 1.1796 1.1247 1.1558 1.1748 1.1824 1.1508
4-pyridoxate 0.8352 0.8187 0.7415 1.0513 1.0957 1.0720 1.0701 1.0642 1.0695 1.0427 1.0552 1.0839
5-hydroxytryptophan 1.0658 1.0016 0.9099 0.9627 1.0216 0.9947 0.9829 0.9940 0.9912 1.0132 1.0611 1.0012
5-hydroxytryptophol 1.4584 1.4289 1.4951 0.7468 1.0151 0.7382 0.7421 0.7878 0.8158 0.7800 1.1436 0.8483
5-methoxytryptophol 1.2873 1.2459 1.1267 0.9030 0.9961 0.9104 0.8742 0.9099 0.8569 0.9352 1.0681 0.8862
5-methylcytidine 0.9165 0.9558 0.9065 1.0112 1.0281 0.9921 1.0544 1.0008 1.0398 1.0245 1.0106 1.0596
5-methylcytosine 0.9173 0.9374 0.9193 1.0097 1.0222 1.0000 1.0407 1.0123 1.0440 1.0398 1.0153 1.0421
6-mercaptopurine 2.2397 0.6489 NA 0.6184 0.5930 NA 0.7734 0.7077 NA 1.5038 0.9152 NA
7-methylguanine 0.9435 0.9510 0.9283 1.0252 1.0044 1.0235 1.0051 0.9910 1.0418 1.0443 1.0087 1.0332
acetylcholine 0.9629 0.9936 0.9241 1.0295 1.0363 0.9965 1.0078 1.0097 1.0109 0.9986 1.0221 1.0080
acetyl-galactosamine 0.8475 0.8664 0.7857 1.0329 1.0805 1.1032 1.0421 1.0067 1.0713 1.0663 1.0743 1.0233
adenosine 1.0194 1.0230 1.0634 0.9613 0.9902 1.0271 0.9668 0.9429 1.0297 0.9656 0.9711 1.0393
ADMA 1.0296 0.9927 0.9111 1.0179 1.0182 1.0437 0.9820 0.9456 0.9769 1.0203 1.0718 0.9902
agmatine 0.9205 0.9154 0.8837 1.0215 1.0257 1.0280 1.0160 0.9960 1.0336 1.0504 1.0626 1.0466
alanine 0.9724 0.9524 0.9154 1.0085 1.0407 1.0396 1.0102 1.0026 0.9836 1.0305 1.0486 0.9955
allopurinol 0.0103 0.0108 0.0260 1.1830 1.0809 1.0128 1.2836 1.1910 1.1719 1.7151 1.5596 1.7549
allopurinol riboside NA NA NA 1.2565 1.2670 1.8263 0.8739 0.8691 1.1019 0.5807 0.5938 0.6308
alpha-glycerophosphocholine 0.9937 1.0015 0.9436 1.0059 1.0334 0.9955 1.0050 0.9845 1.0269 0.9937 1.0060 1.0102
anthranilic acid 0.9903 0.9660 0.8670 1.0163 1.0153 0.9817 1.0940 0.9738 1.0022 1.1337 0.9784 0.9813
arginine 1.0096 0.9811 0.9576 1.0048 1.0060 1.0024 1.0033 0.9898 0.9928 0.9983 1.0267 1.0277
asparagine 1.2495 1.2333 1.1544 0.9479 0.9700 0.9539 0.9072 0.9072 0.9000 0.9349 0.9307 0.9111
aspartate 4.0390 3.9645 3.7295 0.0285 0.0379 0.0276 0.0360 0.0312 0.0292 0.0220 0.0331 0.0216
atenolol 0.8546 0.9426 0.6787 1.0157 1.1350 1.0187 1.0997 0.9345 1.0446 1.0206 1.1498 1.1055
azathioprine NA 3.9083 NA NA 0.0472 NA NA 0.0323 NA NA 0.0122 NA
betaine 0.9879 0.9867 0.9659 1.0121 1.0088 0.9997 1.0111 0.9950 1.0124 1.0012 1.0161 1.0029
butyrobetaine 1.0046 0.9946 0.9487 0.9938 1.0274 1.0100 1.0036 0.9848 1.0030 1.0153 1.0223 0.9919
C2 carnitine 1.0130 0.9944 0.9259 0.9894 1.0154 1.0385 0.9867 0.9898 0.9773 1.0442 1.0379 0.9874
C3 carnitine 1.3537 1.1953 1.1435 0.9606 0.9596 0.9185 0.9249 0.9338 0.9496 0.9080 0.8772 0.8753
cadaverine 0.6235 0.6322 0.5939 1.0890 1.0394 1.1823 1.0949 0.9417 1.1665 1.2963 1.1269 1.2133
carnitine 0.9855 1.0195 0.9412 1.0099 1.0207 0.9987 1.0052 0.9849 1.0109 1.0108 1.0097 1.0029
choline 1.0027 0.9926 0.9482 1.0019 1.0171 0.9971 1.0040 0.9937 1.0159 1.0122 1.0110 1.0035
citrulline 1.0578 1.0466 1.0204 0.9941 1.0070 0.9900 0.9812 0.9755 0.9791 0.9782 1.0000 0.9701
creatine 1.0584 1.0812 1.1235 0.9736 0.9542 0.9521 0.9895 0.9630 0.9798 0.9743 0.9695 0.9809
creatinine 0.9970 0.9883 0.9336 0.9991 1.0087 1.0238 1.0179 0.9760 1.0048 1.0207 1.0213 1.0087
cyclohexylamine 0.9372 0.9372 1.0438 1.0249 0.9595 1.0808 1.0838 0.9631 0.9894 1.0453 0.9606 0.9743
cytidine 0.9257 0.9778 0.9733 1.0182 0.9824 0.9930 1.0389 1.0182 1.0402 0.9996 0.9902 1.0425
cytosine 0.9028 0.9206 0.8904 1.0362 0.9948 1.0214 1.0487 0.9848 1.0597 1.0441 1.0168 1.0796
dethiobiotin 1.1974 1.1852 1.1563 1.0058 1.0369 1.0072 0.8734 0.8467 0.8826 0.9418 0.9352 0.9316
dimethylglycine 1.0154 1.0094 1.0137 1.0022 1.0310 0.9962 0.9945 0.9905 0.9875 0.9889 0.9911 0.9798
ectoine 0.9582 1.0068 0.9684 1.0385 1.0328 0.9700 1.0192 1.0271 0.9943 0.9911 0.9831 1.0105
GABA 1.4665 1.4194 1.3966 0.8635 0.8630 0.8668 0.8380 0.8104 0.8400 0.8801 0.8972 0.8586
glutamate 2.6702 2.6543 2.5691 0.4925 0.6263 0.4543 0.3920 0.4652 0.3798 0.4715 0.4302 0.3948
glutamine 2.5074 2.4872 2.4052 0.5194 0.5706 0.5300 0.4931 0.5159 0.5017 0.4881 0.5055 0.4758
glycine 0.8462 0.8414 0.8000 1.0541 1.0442 1.0691 1.0385 1.0385 1.0379 1.0806 1.0843 1.0653
guanidinoacetic acid 1.4007 1.3401 1.3149 0.8592 0.9112 0.8962 0.8647 0.8673 0.8748 0.9019 0.8654 0.9036
guanosine 0.9832 0.9828 0.9269 0.9954 1.0151 1.0438 1.0082 0.9849 1.0255 1.0190 0.9998 1.0154
hippurate 1.0497 1.0244 1.0160 0.9545 0.9812 0.9589 0.9953 0.9945 1.0226 1.0093 0.9745 1.0192
histamine 0.7856 0.7900 0.7811 1.0889 1.0343 1.0984 1.0548 1.0198 1.0862 1.1016 1.0863 1.0729
histidine 1.0025 0.9447 0.8810 1.0374 1.0414 1.0783 0.9879 0.9727 0.9388 1.0147 1.1205 0.9800
histidinol 0.9958 0.9487 0.9132 1.0056 1.0306 1.0394 1.0164 0.9919 0.9809 1.0224 1.0540 1.0011
homoarginine 0.9870 0.9921 0.9351 0.9946 1.0301 1.0225 1.0265 0.9898 0.9626 1.0037 1.0288 1.0272
homocitrulline 1.0315 0.9983 0.9917 1.0116 1.0267 1.0082 0.9761 0.9955 0.9851 0.9961 1.0141 0.9653
hydroxyproline 1.1515 1.1737 1.1673 0.9121 0.9712 0.9748 0.9529 0.8962 0.9385 0.9824 0.9359 0.9435
imidazoleacetic acid 0.9186 1.0065 0.9555 1.0063 1.0898 1.0431 0.9483 0.9006 1.0595 1.0247 0.9788 1.0684
inosine 0.6279 0.6282 0.7037 0.9886 1.0248 1.2555 1.1248 1.1032 1.3583 0.9955 1.0383 1.1512
isoleucine 0.9626 0.9450 0.8548 1.0206 1.0300 1.0316 1.0205 1.0115 1.0121 1.0426 1.0649 1.0039
kynurenic acid 0.9012 0.9118 0.9167 0.9833 1.0110 1.0906 1.0432 0.9543 1.1344 0.9974 0.9789 1.0771
L-alpha-glutamyl-L-lysine 1.0936 1.0625 1.0560 0.9980 0.9796 0.9686 0.9684 0.9768 0.9526 0.9211 0.9942 1.0288
leucine 1.0002 0.9915 0.9354 0.9949 1.0345 1.0162 0.9986 0.9933 0.9974 1.0199 1.0221 0.9961
leu-gly 1.9053 1.8937 1.8369 0.7358 0.8381 0.7374 0.6767 0.7313 0.6854 0.6723 0.6548 0.6324
linoleoyl ethanolamide 1.3375 0.8318 1.0024 0.7886 0.8869 1.4619 0.8528 0.6746 0.7893 1.4468 0.9469 0.9739
lysine 1.0380 1.0318 0.9873 1.0018 0.9993 0.9997 0.9775 1.0004 0.9746 0.9773 1.0169 0.9953
methionine 1.0087 1.0153 0.9248 0.9875 1.0187 1.0079 1.0081 0.9873 0.9946 1.0231 1.0302 0.9939
methionine sulfoxide 0.9781 0.9148 0.8382 1.0259 1.0566 1.0721 0.9688 1.0092 1.0096 1.0346 1.0834 1.0088
methylguanidine 0.9107 0.9616 0.8957 1.0112 1.0699 0.9990 1.0398 0.9496 0.9952 1.0693 1.0965 1.0015
methylthioadenosine 4.1105 3.9305 3.8529 0.0130 0.0254 0.0118 0.0086 0.0125 0.0071 0.0104 0.0082 0.0093
myristoleate 0.9682 1.1200 1.1134 1.0721 1.0148 0.9823 1.0242 1.0121 0.9425 0.8789 0.9351 0.9367
N1-acetylspermidine 1.0065 0.9771 0.9089 1.0001 1.0316 1.0182 1.0063 0.9829 1.0110 1.0244 1.0390 0.9940
N1-acetylspermine 1.0228 0.9683 0.8895 1.0316 0.9847 0.9237 1.0096 1.0517 1.0136 1.0136 1.0524 1.0385
N1-methyl-2-pyridone-5-carboxamide 0.8395 0.8197 0.7561 1.0874 1.0152 1.0248 1.0855 1.0471 1.0948 1.0574 1.0345 1.1380
N2,N2-dimethylguanosine 0.8605 0.8547 0.8335 1.0388 1.0192 1.0687 1.0695 1.0117 1.0687 1.0673 1.0195 1.0878
N6-acetyllysine 1.0711 1.0501 1.0318 0.9860 0.9989 0.9830 0.9782 0.9725 0.9858 0.9824 0.9947 0.9656
N6-methyllysine 1.0467 1.0137 0.9430 1.0207 1.0189 1.0354 0.9717 0.9595 0.9545 0.9982 1.0465 0.9912
N6,N6-dimethyllysine 0.9598 0.9416 0.8663 1.0509 1.0493 1.0593 1.0129 0.9664 0.9800 1.0287 1.0652 1.0197
N6,N6,N6-trimethyllysine 1.0322 0.9753 0.8891 1.0209 1.0459 1.0552 0.9780 0.9395 0.9807 1.0315 1.0524 0.9992
N-acetylalanine 1.0231 0.9984 0.9639 1.0208 1.0095 1.0042 1.0084 0.9857 1.0006 1.0023 0.9821 1.0009
N-acetylaspartic acid 0.6684 0.7194 0.6770 0.9845 1.3744 1.1342 1.0040 1.0131 1.0476 1.0763 1.2849 0.9355
N-acetylglutamine 0.9989 0.9797 0.8902 0.9604 1.0611 1.0095 1.0190 0.9944 0.9987 1.0245 1.0456 1.0180
N-acetylhistidine 0.8942 0.9114 0.9013 1.0342 1.0237 1.0152 1.0444 1.0250 1.0700 1.0335 1.0141 1.0329
N-acetylleucine 0.9806 0.9285 0.8909 1.0002 1.0542 1.0451 0.9975 1.0100 1.0089 1.0267 1.0699 0.9876
N-acetylmethionine 1.0244 1.0109 0.9711 1.0231 1.0412 0.9862 0.9876 0.9737 0.9945 1.0019 0.9915 0.9939
N-acetylornithine 1.0892 1.0861 1.0383 0.9913 1.0047 0.9920 0.9584 0.9661 0.9543 0.9672 0.9964 0.9558
N-acetylphenylalanine 0.9784 0.9938 0.9210 1.0042 1.0278 1.0381 1.0080 0.9881 0.9993 1.0086 1.0372 0.9954
N-acetylputrescine 0.9857 0.9980 0.9429 1.0222 1.0119 1.0150 1.0128 1.0004 1.0053 1.0020 1.0162 0.9876
N-acetylserine 1.0731 1.0918 1.0793 0.9433 1.0380 0.9581 1.0506 0.9860 0.9686 0.9226 0.9966 0.8918
N-acetyltryptophan 0.8158 0.8344 0.8529 1.0645 1.0352 1.0365 1.0543 1.0267 1.0505 1.0831 1.0409 1.1051
N-alpha-acetylarginine 1.0398 1.0406 1.0406 0.9862 0.9846 0.9809 0.9824 0.9718 0.9937 0.9877 0.9976 0.9940
N-carbamoyl-beta-alanine 0.9413 0.9060 0.9073 1.0293 1.0331 1.0376 1.0565 0.9935 0.9971 0.9920 1.0418 1.0646
niacinamide 4.0776 4.0559 3.8359 0.0035 0.0038 0.0034 0.0037 0.0036 0.0031 0.0026 0.0036 0.0034
nicotinate 0.4259 0.5723 0.6156 0.8572 1.2390 0.5075 1.6462 0.9871 1.4483 1.0929 1.1317 1.4763
nicotinuric acid 0.9112 0.9204 0.9317 1.0426 0.9819 1.0344 1.0658 1.0007 1.0462 0.9948 1.0109 1.0594
NMMA 0.8974 0.8791 0.8389 1.0600 1.0023 1.0622 1.0267 1.0042 1.0407 1.0527 1.0782 1.0575
ornithine 1.8830 1.8625 1.8243 0.7524 0.8104 0.7084 0.6998 0.8034 0.6615 0.6328 0.7153 0.6460
O-succinyl homoserine 1.2473 1.2320 1.1578 0.9190 0.9218 0.8906 0.9061 0.9347 0.9394 0.9342 0.9300 0.9873
pantothenate 1.3349 1.2726 1.2325 0.9193 0.9656 0.9117 0.9014 0.9078 0.9156 0.8957 0.8336 0.9093
phenylacetylglutamine 0.9119 0.9219 1.2063 0.8199 0.9507 1.2095 0.8996 0.7434 1.2432 1.0780 0.8323 1.1835
phenylalanine 1.0092 0.9881 0.9123 0.9886 1.0231 1.0029 1.0007 1.0008 1.0171 1.0252 1.0276 1.0043
phenylalanine-d8 1.0150 0.9809 1.0301 0.9855 0.9915 1.0128 0.9861 0.9914 0.9995 1.0077 1.0180 0.9816
phosphocholine 1.0270 1.0018 0.8988 0.9928 1.0482 1.0157 0.9898 0.9889 0.9837 1.0213 1.0418 0.9904
pipecolic acid 1.1435 1.1390 1.1081 0.9555 0.9671 0.9484 0.9457 0.9545 0.9475 0.9722 0.9689 0.9497
progesterone 1.0659 1.0412 0.9661 0.9720 0.9991 1.0058 0.9690 0.9769 0.9755 1.0131 1.0194 0.9961
pro-gly 1.1044 1.1058 1.1429 0.9917 0.9660 0.9327 0.9607 0.9539 0.9604 0.9719 0.9385 0.9711
proline 1.0255 1.0132 0.9756 0.9971 1.0120 0.9938 0.9987 0.9806 0.9941 0.9974 1.0126 0.9994
proline-betaine 0.9759 1.0527 0.9004 1.0002 1.0401 0.9986 1.0067 0.9849 0.9983 1.0627 1.0037 0.9758
pseudouridine 1.0245 0.9582 0.8629 1.0021 1.0286 0.9997 1.0406 1.0240 1.0086 1.0057 0.9984 1.0467
pterin 0.9773 0.9987 1.0647 0.9166 0.9516 1.1110 0.9263 0.8893 1.0606 0.9620 1.0029 1.1390
putrescine 0.0244 0.0249 0.0244 1.2931 1.2506 1.3338 1.3280 1.2242 1.3636 1.3822 1.3757 1.3751
pyridoxine 1.0031 0.9666 1.0764 0.9763 0.9075 0.8053 1.0199 1.0479 1.1440 1.0249 0.7589 1.2693
pyroglutamic acid 0.9121 0.9020 0.8400 1.0142 1.0594 1.0397 1.0376 1.0171 1.0462 1.0278 1.0680 1.0358
S-adenosylhomocysteine 1.1064 1.1163 1.0309 1.0416 1.0312 1.0034 0.8635 0.9019 0.9337 0.9637 1.0169 0.9904
SDMA 1.0456 1.0052 0.9112 1.0184 1.0166 1.0419 0.9637 0.9471 0.9682 1.0104 1.0617 1.0101
serine 1.1863 1.1732 1.1104 0.9488 0.9740 0.9630 0.9444 0.9170 0.9183 0.9528 0.9868 0.9252
serotonin 1.1412 1.0739 1.1124 0.9723 0.9842 1.0288 1.0156 0.8602 0.9570 0.9932 0.9308 0.9303
S-methyl-L-cysteine-S-oxide 1.0333 1.0110 1.1060 1.0042 0.9758 0.9410 0.9660 1.0234 0.9546 0.9461 0.9766 1.0620
spermidine 0.9645 0.9107 0.8875 1.0379 1.0494 1.0343 0.9939 1.0337 0.9867 0.9920 1.0677 1.0417
taurine 0.9373 0.9448 0.8633 1.0178 1.0392 1.1145 1.0179 0.9877 0.9974 1.0240 1.0446 1.0115
thiamine 1.0533 1.0612 0.9736 0.9912 1.0191 0.9982 0.9786 0.9788 0.9811 0.9915 0.9898 0.9837
threonine 1.4079 1.4080 1.3496 0.8770 0.8653 0.8754 0.8699 0.8448 0.8493 0.8942 0.8869 0.8716
thymidine 1.0483 0.6908 1.1021 0.9948 1.0397 1.0758 1.0423 0.9903 1.0307 0.9433 1.0203 1.0217
trigonelline 0.9765 0.9732 0.9375 1.0057 1.0240 1.0058 1.0143 0.9953 1.0176 1.0138 1.0235 1.0129
tryptamine 1.0739 1.0974 1.0158 0.9838 0.9714 0.9874 0.9978 0.9489 0.9880 0.9734 0.9735 0.9887
tryptophan 0.9480 0.9817 0.8894 1.0040 1.0413 1.0247 1.0091 0.9812 1.0257 1.0238 1.0455 1.0256
tyramine 0.9449 0.9441 0.9250 1.0085 1.0031 1.0256 1.0201 0.9849 1.0362 1.0379 1.0252 1.0444
tyrosine 0.9829 0.9865 0.8950 0.9933 1.0373 1.0071 1.0220 0.9872 1.0088 1.0276 1.0306 1.0219
urocanic acid 0.7026 0.9776 1.4973 0.6484 0.5603 1.8854 1.1834 0.5961 0.6701 1.2258 0.8554 1.1975
valine 0.9202 0.9260 0.8709 1.0671 1.0276 1.0226 1.0251 0.9951 1.0279 1.0105 1.0464 1.0606
valine-d8 1.0104 1.0083 1.0911 0.9639 1.0146 1.0400 0.9787 0.9691 0.9569 0.9819 1.0289 0.9561
xanthine 1.7006 1.7076 1.6128 1.3387 1.4296 1.2392 0.0943 0.0534 0.0649 0.9248 0.9377 0.8962
xanthosine 0.9684 0.9722 0.9087 0.9931 1.1301 1.0703 0.9757 0.9696 1.0107 1.0171 1.0280 0.9560
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Factors:

F1Strain:None | Drug:6-mercaptopurine
F2Strain:None | Drug:Azathioprine
F3Strain:None | Drug:None
F4Strain:pucD | Drug:6-mercaptopurine
F5Strain:pucD | Drug:Azathioprine
F6Strain:pucD | Drug:None
F7Strain:WT | Drug:6-mercaptopurine
F8Strain:WT | Drug:Azathioprine
F9Strain:WT | Drug:None
F10Strain:xdhA | Drug:6-mercaptopurine
F11Strain:xdhA | Drug:Azathioprine
F12Strain:xdhA | Drug:None
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