Data for (Study ST002352)
(Analysis AN004097)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| 135.036@6.09, provisional ID = Homocysteine | 1.0120 | 1.0510 | 0.8266 | 0.9721 | 1.0826 | 1.0557 |
| 1-Methyladenosine | 1.0939 | 1.1392 | 0.6084 | 0.7100 | 1.2301 | 1.2183 |
| 1-Methylnicotinamide | 0.9929 | 1.0314 | 0.8663 | 0.9517 | 1.0865 | 1.0712 |
| 299.2813@1.17, provisional ID = SPB 18:1;O2 | 0.6645 | 0.4599 | 1.8076 | 1.8534 | 0.6178 | 0.5968 |
| 323.2824@1.13, provisional ID = NAE 18:2 | 0.7575 | 1.0586 | 1.3108 | 1.0114 | 0.8779 | 0.9838 |
| 325.2973@1.13, provisional ID = NAE 18:1 | 0.7221 | 0.8594 | 1.4469 | 1.0817 | 0.9246 | 0.9653 |
| 367.2674@7.75, provisional ID = CAR 14:2 | 0.9313 | 1.1421 | 0.9403 | 0.9305 | 0.8610 | 1.1948 |
| 3-Methylhistamine | 0.9568 | 0.9832 | 0.9843 | 0.9852 | 1.0392 | 1.0512 |
| 3-Methylhistidine | 1.0526 | 1.0834 | 0.8904 | 0.7154 | 1.1574 | 1.1008 |
| 441.355@7.97, provisional ID = CAR 18:1-0H | 0.0061 | 0.2988 | 3.0564 | 2.6014 | 0.0185 | 0.0189 |
| 4-Aminobutyric Acid | 1.1038 | 1.1658 | 0.7658 | 0.9636 | 1.0040 | 0.9971 |
| 4-Guanidinobutyric Acid | 0.9860 | 1.0447 | 0.8549 | 0.9862 | 1.0493 | 1.0790 |
| 4-Imidazoleacetic Acid | 1.0189 | 0.9537 | 0.9550 | 1.0488 | 1.0413 | 0.9823 |
| 526.4679@1.14, provisional ID = DG(29:0) | 0.6903 | 0.6850 | 0.8610 | 0.8447 | 1.3208 | 1.5982 |
| 538.3788@7.87, provisional ID = PC O-20:0 | 0.0090 | 0.0090 | 3.2340 | 2.7298 | 0.0090 | 0.0090 |
| 5-Aminopentanoic Acid | 0.9965 | 1.0761 | 0.8059 | 0.9413 | 1.0807 | 1.0995 |
| 5^-Methylthioadenosine | 0.9312 | 1.0513 | 0.8511 | 0.9913 | 1.0500 | 1.1251 |
| Adenine | 0.9153 | 0.9968 | 1.0382 | 1.4170 | 0.7349 | 0.8979 |
| Adenosine | 1.0147 | 0.8808 | 1.0132 | 1.0439 | 1.2841 | 0.7633 |
| Alanine | 1.0617 | 1.0501 | 0.8159 | 0.9015 | 1.1047 | 1.0660 |
| Arginine | 1.1181 | 0.9181 | 1.0836 | 1.0311 | 0.8879 | 0.9612 |
| Betaine | 1.0013 | 1.0374 | 0.9036 | 0.9713 | 1.0365 | 1.0499 |
| Bilirubin | 0.2817 | 0.2484 | 2.8084 | 1.9089 | 0.3605 | 0.3921 |
| CAR 12:0 | 0.0191 | 0.0191 | 3.3984 | 2.5251 | 0.0191 | 0.0191 |
| CAR 14:1 | 0.0316 | 0.0679 | 3.1574 | 2.6919 | 0.0076 | 0.0437 |
| CAR 16:0 | 0.2539 | 0.2423 | 2.5025 | 2.4180 | 0.3200 | 0.2633 |
| CAR 16:0;O | 0.1322 | 0.2651 | 3.1817 | 2.3143 | 0.0510 | 0.0556 |
| CAR 16:1 | 0.1391 | 0.1749 | 2.8052 | 2.5010 | 0.2102 | 0.1696 |
| CAR 16:1;O | 0.0068 | 0.0068 | 3.6173 | 2.3224 | 0.0397 | 0.0068 |
| CAR 18:0 | 0.2608 | 0.3848 | 2.4684 | 2.3007 | 0.3183 | 0.2671 |
| CAR 18:1 | 0.1837 | 0.1849 | 2.7592 | 2.4329 | 0.2477 | 0.1915 |
| CAR 18:2 | 0.1597 | 0.1428 | 2.7854 | 2.5354 | 0.2136 | 0.1632 |
| CAR 18:3 | 0.0036 | 0.0036 | 3.2175 | 2.7682 | 0.0036 | 0.0036 |
| CAR 2:0 | 0.9996 | 1.1042 | 0.7604 | 0.9018 | 1.0949 | 1.1392 |
| CAR 3:0 | 0.9987 | 1.0926 | 0.7787 | 0.9152 | 1.0793 | 1.1355 |
| CAR 4:0 | 1.0031 | 1.1034 | 0.7637 | 0.9073 | 1.0840 | 1.1386 |
| CAR 4:1;O2 | 1.0185 | 1.0952 | 0.7708 | 0.8985 | 1.0986 | 1.1184 |
| CAR 5:0 | 1.0711 | 0.8123 | 0.8164 | 0.9602 | 1.1674 | 1.1727 |
| CAR 6:0 | 1.0178 | 1.0804 | 0.8010 | 0.9198 | 1.0835 | 1.0975 |
| Carnitine | 1.0133 | 1.0964 | 0.7745 | 0.9071 | 1.0823 | 1.1263 |
| Choline | 0.9813 | 1.1374 | 0.8167 | 0.9636 | 1.0182 | 1.0828 |
| Citrulline | 0.9953 | 0.9543 | 1.0163 | 1.0249 | 1.0069 | 1.0023 |
| Creatinine | 1.0083 | 1.0924 | 0.8116 | 0.9451 | 1.0507 | 1.0919 |
| Cytidine | 0.6105 | 1.8575 | 0.2578 | 0.7726 | 1.0923 | 1.4092 |
| Deoxycarnitine | 1.0096 | 1.0899 | 0.7667 | 0.9235 | 1.0863 | 1.1240 |
| Dimethylarginine | 1.0088 | 0.9961 | 0.8900 | 0.9983 | 1.0427 | 1.0642 |
| Glycerophosphocholine | 1.0062 | 1.0684 | 0.7835 | 0.9146 | 1.0994 | 1.1278 |
| Guanidinosuccinic Acid | 1.0128 | 1.0749 | 0.7806 | 0.9359 | 1.1053 | 1.0904 |
| Guanine | 0.9579 | 1.0730 | 0.8242 | 0.9895 | 1.0325 | 1.1229 |
| Guanosine | 0.9614 | 1.0558 | 0.8078 | 1.0241 | 1.0361 | 1.1148 |
| Histamine | 0.7482 | 1.0579 | 0.6721 | 0.6781 | 1.5006 | 1.3432 |
| Histidine | 1.0469 | 1.1397 | 0.8430 | 0.7009 | 1.1215 | 1.1481 |
| Hypotaurine | 1.0969 | 1.1489 | 0.6608 | 0.7046 | 1.2199 | 1.1689 |
| Inosine | 1.0091 | 1.0759 | 0.7996 | 0.9234 | 1.0764 | 1.1156 |
| L-Monomethylarginine | 1.0598 | 1.0142 | 0.9264 | 0.9244 | 1.0469 | 1.0283 |
| LPC 16:0 | 0.1875 | 0.1716 | 2.7080 | 2.4752 | 0.2520 | 0.2057 |
| LPC 16:1 | 0.1456 | 0.1002 | 2.9270 | 2.4535 | 0.2287 | 0.1450 |
| LPC 18:0 | 0.2541 | 0.2093 | 2.6094 | 2.3251 | 0.3479 | 0.2542 |
| LPC 18:1 | 0.2109 | 0.1862 | 2.6902 | 2.4083 | 0.2860 | 0.2185 |
| LPC 18:2 | 0.1977 | 0.1597 | 2.8418 | 2.3442 | 0.2687 | 0.1879 |
| LPC 18:3 | 0.0771 | 0.2260 | 3.0376 | 2.3522 | 0.1581 | 0.1491 |
| LPE 18:2 | 0.0877 | 0.4432 | 2.8152 | 2.4879 | 0.0278 | 0.1382 |
| Lysine | 0.9809 | 1.0709 | 0.8664 | 0.9775 | 1.0390 | 1.0652 |
| N1-Acetylspermidine | 0.9724 | 1.0563 | 0.8622 | 0.9592 | 1.0512 | 1.0987 |
| Nicotinamide | 1.0298 | 1.0451 | 0.8217 | 0.9343 | 1.0791 | 1.0899 |
| Ornithine | 0.9953 | 1.0580 | 0.8513 | 0.9618 | 1.0581 | 1.0754 |
| PC 34:2 | 0.3673 | 0.3010 | 2.2974 | 2.1692 | 0.4895 | 0.3756 |
| PC 36:2 | 0.3969 | 0.3268 | 2.2403 | 2.1001 | 0.5288 | 0.4071 |
| PC 36:4 | 0.3996 | 0.3227 | 2.2526 | 2.1017 | 0.5222 | 0.4012 |
| PC O-36:4 | 0.1741 | 0.0870 | 2.6120 | 2.5268 | 0.3555 | 0.2446 |
| Phosphocholine | 1.0050 | 1.0723 | 0.7820 | 0.9046 | 1.0929 | 1.1433 |
| Pipecolinic Acid | 1.0472 | 1.0855 | 0.8305 | 0.8820 | 1.0359 | 1.1188 |
| Proline Betaine | 1.0058 | 1.1009 | 0.7750 | 0.9189 | 1.0690 | 1.1304 |
| S-Adenosylmethionine | 0.9656 | 1.1757 | 0.6889 | 0.8620 | 1.1368 | 1.1710 |
| SM 36:1;O2 | 0.0603 | 0.0354 | 2.8416 | 2.8069 | 0.1855 | 0.0703 |
| SM 36:2;O2 | 0.0126 | 0.0126 | 3.0297 | 2.9198 | 0.0126 | 0.0126 |
| SM d34:0 | 0.0055 | 0.0055 | 3.0005 | 2.9776 | 0.0055 | 0.0055 |
| SM d34:1 | 0.2143 | 0.1439 | 2.5816 | 2.4883 | 0.3381 | 0.2337 |
| ST 21:4;O5 | 0.9152 | 0.6881 | 1.2830 | 1.1971 | 0.9346 | 0.9821 |
| Succinoadenosine | 1.1452 | 1.1265 | 0.5768 | 0.6463 | 1.2389 | 1.2662 |
| Succinylaminoimidazole carboxamide riboside | 1.0135 | 1.1622 | 0.7097 | 0.6298 | 1.3313 | 1.1535 |
| Thiamine | 0.9664 | 1.1114 | 0.7468 | 0.9408 | 1.1034 | 1.1312 |
| Trimethyllysine | 0.9945 | 1.0930 | 0.8089 | 0.9390 | 1.0807 | 1.0838 |
| Tyramine | 0.9994 | 0.9650 | 1.0401 | 1.0093 | 0.9761 | 1.0101 |
| Urea | 0.9511 | 1.0406 | 0.7672 | 0.8964 | 1.1990 | 1.1458 |
| Xanthine | 1.0029 | 1.0376 | 0.8679 | 0.9527 | 1.0536 | 1.0854 |
Factors:
| F1 | Protein:MED1 | RNA:150 nM | fraction:aqueous | Extraction from condensate:No heat step | timing of metabolite extract addition:standard |
| F2 | Protein:MED1 | RNA:150 nM | fraction:aqueous | Extraction from condensate:standard | timing of metabolite extract addition:Metabolites added after 10 min incubation |
| F3 | Protein:MED1 | RNA:150 nM | fraction:condensate | Extraction from condensate:No heat step | timing of metabolite extract addition:standard |
| F4 | Protein:MED1 | RNA:150 nM | fraction:condensate | Extraction from condensate:standard | timing of metabolite extract addition:Metabolites added after 10 min incubation |
| F5 | Protein:MED1 | RNA:150 nM | fraction:input | Extraction from condensate:No heat step | timing of metabolite extract addition:standard |
| F6 | Protein:MED1 | RNA:150 nM | fraction:input | Extraction from condensate:standard | timing of metabolite extract addition:Metabolites added after 10 min incubation |
