Data for (Study ST002709)

(Analysis AN004391)

Values for each metabolite have been scaled by dividing by the mean across all factors

Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

MetaboliteF1F2F3F4F5F6F7F8
1-methylnicotinamide 0.8404 1.7095 1.1005 1.4542 0.6547 0.5186 0.5265 1.1956
3-hydroxy-trimethyllysine 1.0836 1.2260 0.9327 0.8617 1.0890 0.9142 0.6915 1.2014
4-aminobutyrate 0.9500 1.1571 0.7849 1.0100 1.0769 0.9563 0.7257 1.3392
5^-methylthioadenosine 0.8595 1.3297 0.7844 1.1155 0.9409 0.9723 0.7064 1.2914
6-phosphogluconic acid 0.8967 0.9554 0.6773 0.5275 1.8959 0.9082 0.9165 1.2224
acetyl-carnitine 0.8771 0.9231 0.9626 0.8946 1.0361 1.0880 1.1393 1.0792
acetyl-CoA 1.0013 1.2473 0.8247 0.8231 1.3174 0.9713 0.7412 1.0737
adenylosuccinic acid 0.3026 0.5131 0.2039 0.2654 2.4099 1.6280 0.9550 1.7221
ADP 1.0501 1.2518 0.7704 0.8054 1.2281 0.9980 0.6978 1.1983
AICAR 0.3406 3.3481 1.0637 1.8812 0.4594 0.2645 0.1443 0.4983
AIR 0.1416 0.1519 0.1121 0.1750 2.2660 1.5731 1.0459 2.5344
alanine 0.9216 1.0826 0.8968 0.8168 1.0579 1.1706 0.9271 1.1265
alpha-ketoglutarate 1.0596 1.6316 0.9729 1.3714 0.5549 0.8074 0.4429 1.1593
AMP 0.9478 1.2400 0.7905 0.8508 1.1880 1.0797 0.7700 1.1333
arachidic acid 0.9266 1.2163 0.8772 0.7311 1.1740 0.9035 1.0010 1.1703
arginine 0.8730 1.0563 0.7580 0.8538 1.2665 1.1436 1.0051 1.0437
argininosuccinate 0.1725 0.2188 0.1216 0.1053 2.4325 1.9169 1.2728 1.7596
ascorbate 2.1454 2.7087 1.1821 1.2786 0.2365 0.1897 0.1120 0.1470
asparagine 0.1794 0.2143 0.1518 2.4821 0.3584 0.2980 0.2491 4.0669
aspartate 1.7674 1.9737 1.3286 1.1463 0.6062 0.4149 0.3603 0.4026
ATP 0.9902 1.4205 0.8614 0.8143 1.2414 0.8878 0.5987 1.1856
betaine 1.3183 1.3526 1.2379 1.1344 0.7991 0.7052 0.6763 0.7762
CAIR NA 1.8337 0.1712 0.8845 NA 1.2770 0.2442 1.5893
carbamoyl-aspartate 1.7716 1.8697 1.3629 1.3620 0.4385 0.4138 0.3379 0.4435
carnitine 1.3883 1.6496 1.2082 1.1773 0.6709 0.6268 0.5146 0.7644
CDP 1.0143 1.4101 0.8128 0.8126 1.2213 0.9351 0.6341 1.1597
CDP-choline 1.3192 1.2938 0.6881 0.6504 1.4827 1.0000 0.5399 1.0258
CDP-ethanolamine 1.7234 2.0002 0.5550 0.7886 0.9454 0.9157 0.2958 0.7758
choline 1.3739 0.8833 0.5234 1.1065 1.3931 0.7511 0.6661 1.3026
cis-aconitate 1.3917 1.8140 1.2578 1.3029 0.4552 0.5368 0.2967 0.9448
citrate / isocitrate 1.2658 1.6634 1.1285 1.1707 0.6831 0.6600 0.3487 1.0799
CMP 0.9188 1.0989 0.6640 0.7854 1.2469 1.1969 0.7827 1.3064
CoA 0.6886 1.5477 0.8180 0.8790 0.7390 1.1578 0.7376 1.4323
creatine 1.1680 1.1865 1.0651 1.1844 0.8284 0.7878 0.7418 1.0381
creatinine 0.9920 1.2602 1.0149 1.0319 0.9501 0.9353 0.8471 0.9685
CTP 1.0546 1.5987 0.8068 0.8067 1.2403 0.7810 0.5169 1.1951
cystathionine 0.7322 0.5902 0.6354 NA 1.0444 0.6247 1.1135 1.6322
cysteine 0.1849 NA NA 0.4371 0.5274 NA 0.1471 3.7035
cysteine-glutathione disulfide 2.6413 0.1514 0.5713 0.1256 3.1214 0.1649 1.0664 0.1577
cystine 1.9954 NA 0.3549 0.0494 1.8818 0.1071 0.6800 NA
cytidine 1.1788 NA NA NA 0.7318 NA NA NA
dAMP 1.3015 NA NA NA 0.6985 NA NA NA
dATP 1.2400 1.6693 0.6895 0.9280 1.2099 0.8044 0.4414 1.0175
dCTP 0.8860 1.9540 1.0684 0.6730 1.1528 0.7595 0.5754 0.9309
dihydroorotate 1.8307 2.0350 1.3561 1.1663 0.4939 0.3936 0.3456 0.3788
dihydroxyacetone-phosphate 0.7721 1.1088 0.7071 0.7371 1.2020 1.7802 0.7992 0.8934
dTMP 0.2959 2.3542 0.6992 1.1365 0.3746 1.2407 0.6148 1.2842
dTTP 1.1774 1.5937 0.8159 0.8232 1.1920 0.8314 0.5032 1.0633
FAICAR 0.3522 0.6839 NA 0.4843 1.8571 1.2372 1.0039 1.2107
FGAM 0.0881 0.1126 0.0523 0.0830 2.8941 1.5211 0.8825 2.3662
FGAR 0.2501 0.6661 0.3495 0.3624 1.6446 1.7375 1.0293 1.9605
folate 0.9682 1.3399 0.4278 0.9629 1.4440 1.2356 0.5669 1.0547
fructose 0.9272 1.1314 1.0056 0.7544 1.0809 1.0344 0.9666 1.0994
fructose-1;6-bisphosphate 0.8151 1.3168 0.6316 0.7540 1.3912 1.0891 0.6708 1.3313
fructose-1-phosphate 1.5345 2.1240 0.3687 1.3582 0.9774 0.6791 0.0986 0.8595
fructose-6-phosphate 0.8459 1.0492 0.7856 0.6516 1.3013 1.1633 0.8884 1.3147
fumarate 0.3538 0.4369 0.2693 0.2510 1.9459 1.6492 1.2758 1.8181
gamma-butyrobetaine 1.2240 1.4565 1.1720 1.1438 0.7786 0.7296 0.6615 0.8340
gamma-glutamylcysteine 2.1360 0.5108 1.8181 0.6269 1.0917 0.4056 0.6852 0.7255
GAR NA 1.8975 0.3101 1.1515 0.8733 0.4410 0.6571 1.2110
GDP 0.8440 1.1373 0.6802 0.6868 1.5090 1.0634 0.7198 1.3595
glucose 0.9182 1.1526 1.0122 0.7556 1.1550 1.0220 1.1792 0.8053
glucose-6-phosphate 0.9166 1.1812 0.8364 0.7263 1.2429 0.9636 0.9450 1.1880
glutamate 0.9458 1.1986 0.8125 0.9300 1.0936 1.0132 0.7764 1.2299
glutamine 0.7371 0.8783 0.5752 0.6633 1.6029 1.2830 0.9751 1.2851
glyceraldehyde-3-phosphate 0.6806 0.8274 0.4988 0.5535 1.7415 1.2672 0.8559 1.5752
glycerol-3-phosphate 0.8612 1.4482 0.7826 0.9135 1.1148 1.0428 0.7090 1.1278
glycerophosphocholine 0.8078 0.9398 0.7255 0.7253 1.2900 1.2070 1.0550 1.2496
glycine 0.5052 0.9638 0.5457 0.6298 1.8266 1.3693 1.0251 1.1344
GMP 0.7447 0.9595 0.6022 0.6737 1.3829 1.3742 0.8666 1.3963
GSH 1.0051 1.0062 0.8546 0.7131 1.3411 0.9691 0.9096 1.2013
GSSG 1.1719 0.6593 0.7590 0.4366 2.3979 0.7705 0.9863 0.8185
GTP 0.7859 1.2735 0.6546 0.6421 1.6157 0.9670 0.6277 1.4335
guanosine 1.0569 1.2753 0.6719 0.8998 1.3386 1.0948 0.4956 1.1671
histidine 0.9172 1.0560 0.7122 0.7700 1.5370 1.0943 0.8759 1.0374
hydroxyglutarate 1.4009 1.8901 1.1366 1.5885 0.3918 0.5059 0.2892 0.7969
hypotaurine 0.8046 0.9603 0.6944 0.6244 1.4374 1.1967 0.9709 1.3114
imidazoleacetic acid 0.8638 1.3332 0.9465 1.0116 0.8554 1.0799 0.7869 1.1226
IMP 0.3378 0.4811 0.2683 0.3569 2.2957 1.4239 0.8883 1.9478
kynurenic acid 0.9965 1.0459 1.4248 0.6695 0.6893 0.6018 1.9859 0.5864
kynurenine 0.5063 0.5108 1.5747 0.4024 0.9857 0.7928 2.5489 0.6785
L-2-aminobutyric acid 1.1131 1.1596 0.9306 1.0045 1.1231 0.9725 0.6232 1.0734
lactate 1.1151 0.9513 0.8135 0.9635 1.2042 0.9317 1.0167 1.0040
lauric acid 1.2512 1.1065 0.6447 0.7388 1.3325 0.8524 0.8156 1.2584
leucine / isoleucine 0.8528 0.8663 0.6160 0.6688 1.5893 1.2028 1.0320 1.1720
lysine 0.8609 1.0713 0.6809 0.8042 1.3927 1.1793 0.9708 1.0401
malate 1.7560 2.0470 1.4538 1.5443 0.3330 0.2831 0.2093 0.3735
methionine 0.8724 0.9004 0.4000 0.7469 1.6261 1.4163 0.7171 1.3208
methioninesulfoxide 0.2112 0.3365 2.3992 0.2351 0.5309 0.3668 3.5825 0.3378
myristic acid 1.2357 1.2163 0.7587 0.7412 1.0264 0.6736 0.8400 1.5082
N-acetylglucosamine-phosphate 2.4568 0.7111 0.1885 0.4042 2.5472 0.7355 0.1880 0.7687
N-acetylglutamate 1.1333 1.2554 0.7155 0.9656 1.2600 0.9321 0.5237 1.2144
NAD+ 0.9527 1.2123 0.8699 0.8364 1.1879 0.9862 0.8538 1.1009
NADH 0.8732 1.0086 0.7726 0.8076 1.0047 1.1977 0.8364 1.4993
NADP+ 0.8757 1.2148 0.7544 0.7855 1.2617 1.0396 0.7592 1.3090
nicotinamide 0.9590 1.1100 0.8218 0.8671 1.2767 1.0560 0.9367 0.9727
N-trimethyllysine 0.6267 0.7647 0.5163 0.5654 1.6270 1.4040 1.0889 1.4071
oleic acid 2.8083 0.3579 0.2284 0.2060 3.5450 0.2895 0.2450 0.3199
ornithine 0.8920 0.8906 0.7318 0.8108 1.3040 1.2227 1.1986 0.9495
orotate 1.6852 1.6972 1.4846 1.0196 0.5861 0.6321 0.3468 0.5484
palmitic acid 1.1173 1.2250 0.7389 0.7546 1.0548 0.7714 0.9251 1.4129
phenylalanine 0.8207 0.7917 0.6363 0.7010 1.4962 1.2873 1.1201 1.1468
phosphate 0.9547 1.1770 0.8449 0.9274 1.1411 1.0470 0.9050 1.0029
phosphatidylethanolamine 1.2254 1.6595 0.7059 1.2291 1.0744 0.6537 0.3637 1.0883
phosphocholine 0.9961 1.0741 0.9129 0.9261 1.0955 1.0011 0.9191 1.0751
phosphocreatine 0.9649 1.3378 0.9498 0.8257 1.0298 0.9860 0.7745 1.1316
phosphoenolpyruvate 1.1440 1.4936 0.8841 0.8465 1.1000 0.9544 0.6044 0.9729
phosphoglycerate 1.2423 1.5365 0.8436 0.9374 1.1249 0.7306 0.4871 1.0975
phosphoribosylamine 0.7628 0.7199 0.4961 0.4813 2.5687 0.8123 0.8388 1.3201
phosphorylethanolamine 0.9713 1.4008 0.8812 0.8988 1.1429 0.9096 0.7020 1.0936
phosphoserine 0.4953 0.6205 0.3634 0.3511 2.4318 1.3580 1.1697 1.2103
proline 1.7959 1.7991 1.3871 1.7029 0.3713 0.3004 0.2446 0.3987
propionyl-carnitine 1.4493 1.4652 1.2985 0.8607 0.7713 0.8081 0.6634 0.6837
PRPP 0.5310 1.5135 0.6146 0.5921 1.1914 1.1396 0.5613 1.8565
pyruvate 0.8668 1.1409 0.7612 0.9738 0.7505 1.5285 1.0458 0.9327
quinolinic acid 0.9480 0.6502 0.6533 0.9881 1.4010 1.1926 1.2841 0.8828
riboflavin 1.0268 1.2967 0.3258 0.9919 1.5851 1.3523 0.4834 0.9380
rib/ribul/xylul-ose-phosphate 0.6850 0.6236 0.3514 0.3226 2.7246 1.2386 0.7439 1.3103
S-(1;2-Dicarboxyethyl)glutathione 0.2076 0.3052 0.1741 0.1637 2.0782 1.8251 1.2678 1.9784
S-(2-Succinyl)-L-cysteine 0.4183 0.2467 0.2930 0.1597 2.8016 1.1640 1.6164 1.3002
saccharopine 0.2387 0.3473 0.1987 0.2787 1.6359 1.6601 0.8309 2.8097
S-adenosyl-homocysteine 0.8236 1.2967 0.8958 0.8885 0.9396 1.0568 0.9419 1.1570
S-adenosyl-methionine 0.8991 1.1774 0.7141 0.9824 0.9821 1.2186 0.8265 1.1997
SAICAR 0.1153 0.3075 0.1360 0.1440 2.6280 1.8619 1.1331 1.6742
sarcosine 0.8910 1.0154 0.9056 0.8494 1.0996 1.0545 1.0374 1.1472
sedoheptulose-7-phosphate 0.7295 0.9122 0.5508 0.6190 1.6046 1.1762 0.9678 1.4399
serine 0.5934 0.7050 0.4724 0.5368 1.6865 1.4996 1.1428 1.3634
sorbitol 0.7574 1.0761 0.9205 0.6522 1.1866 1.1182 1.0553 1.2337
stearic acid NA 1.2346 0.9017 0.8313 NA 0.8560 0.8687 1.3076
succinate 0.6904 0.7879 0.5091 0.4776 1.7791 1.4666 1.1084 1.1809
taurine 0.9141 1.0323 0.8462 0.8015 1.2385 1.0797 0.9969 1.0908
threonine 0.8139 0.8801 0.6191 0.6677 1.5716 1.2712 1.0226 1.1537
trifluoromethanesulfonate 0.9545 1.2345 0.8385 0.8096 1.2019 1.0225 0.7918 1.1467
tryptophan 0.8073 0.9639 0.4131 0.6794 1.7297 1.3796 0.7319 1.2951
tyrosine 0.7308 0.8846 0.5391 0.6271 1.6732 1.3074 0.9732 1.2646
UDP 1.0945 1.5560 0.8638 0.8550 1.1667 0.8253 0.5325 1.1062
UDP-glucuronic acid 1.0000 1.4294 0.8114 0.7795 1.2479 0.9003 0.6441 1.1874
UDP-N-acetylglucosamine 1.0510 1.3016 0.8119 0.7415 1.1767 1.0134 0.7298 1.1740
UMP 0.9398 1.2116 0.7595 0.7987 1.1934 1.1299 0.7736 1.1935
uric acid 1.7237 1.1422 0.8837 0.4836 0.9662 1.2159 0.9342 0.6505
urocanic acid 1.1879 0.9150 1.1796 1.3633 1.0989 0.6394 0.7174 0.8985
UTP 1.1023 1.5907 0.9118 0.8696 1.1735 0.7498 0.4951 1.1073
valine 0.8774 0.7964 0.6715 0.7934 1.4466 1.1370 1.1313 1.1465
XMP 0.6955 1.0849 0.2662 0.7121 1.6748 1.3801 0.5232 1.4186
xylonic acid 1.2376 1.5703 0.9408 0.9028 1.0441 0.6612 0.7350 0.9081
xylulose 0.8444 0.9101 0.4069 0.6539 1.6560 1.4647 0.7073 1.3566
Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1Genotype:FH | Tracers used:3,3,3',3'-D4 Cystine
F2Genotype:FH | Tracers used:none
F3Genotype:FH | Tracers used:U-C13 glucose
F4Genotype:FH | Tracers used:U-C13 glutamine
F5Genotype:WT | Tracers used:3,3,3',3'-D4 Cystine
F6Genotype:WT | Tracers used:none
F7Genotype:WT | Tracers used:U-C13 glucose
F8Genotype:WT | Tracers used:U-C13 glutamine
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