Data for (Study ST002740)
(Analysis AN004443)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| alpha-Ketoglutaric acid | 1.0192 | 0.7849 | 1.0967 | 0.4782 | 0.4135 | 0.9176 | 2.3218 | 0.3221 | 1.0723 | 0.7461 | 1.6622 | 1.1754 |
| alpha-Ketoglutaric acid +1 | 0.5694 | 0.7383 | 1.0662 | 0.5868 | 0.5338 | 0.8879 | 2.4253 | 0.2824 | 1.0759 | 0.9860 | 1.3951 | 1.4891 |
| alpha-Ketoglutaric acid +2 | 0.4436 | 0.5338 | 1.9116 | 0.8842 | 0.7340 | 0.5880 | 1.2223 | 0.6204 | 1.6959 | 1.3932 | 0.5873 | 1.1020 |
| alpha-Ketoglutaric acid +3 | 0.1116 | 0.2464 | 1.4967 | 1.1544 | 1.0458 | 0.2646 | 0.6554 | 0.6435 | 2.2914 | 1.8769 | 0.2065 | 1.4507 |
| alpha-Ketoglutaric acid +4 | 0.0385 | 0.1202 | 1.3591 | 1.2038 | 0.9956 | 0.1056 | 0.2484 | 0.6724 | 2.5329 | 2.0043 | 0.0491 | 1.0772 |
| alpha-Ketoglutaric acid +5 | 0.0685 | 0.0682 | 0.5451 | 1.0164 | 0.9766 | 0.0668 | 0.0857 | 0.4589 | 2.6381 | 1.7353 | 0.0731 | 1.0819 |
| Citric acid | 1.2198 | 1.2232 | 0.8479 | 0.8543 | 0.7838 | 1.1209 | 1.1517 | 0.5797 | 0.7851 | 0.8970 | 1.6252 | 1.0055 |
| Citric acid +1 | 0.7534 | 1.1150 | 0.7280 | 1.1479 | 1.0506 | 0.9408 | 1.1654 | 0.3875 | 0.8798 | 1.2725 | 1.3308 | 1.4076 |
| Citric acid +2 | 0.6464 | 0.6070 | 1.6406 | 1.2691 | 1.0984 | 0.5485 | 0.7949 | 0.6873 | 1.3350 | 1.4726 | 0.7241 | 1.2925 |
| Citric acid +3 | 0.1755 | 0.3778 | 0.9981 | 1.8093 | 1.6766 | 0.3202 | 0.4382 | 0.5428 | 1.6378 | 2.1659 | 0.3035 | 1.5964 |
| Citric acid +4 | 0.1177 | 0.1490 | 1.6734 | 1.6226 | 1.4518 | 0.1329 | 0.3021 | 0.9214 | 2.0039 | 1.9472 | 0.1386 | 1.4026 |
| Citric acid +5 | 0.0262 | 0.0569 | 1.5462 | 1.6526 | 1.4852 | 0.0599 | 0.1610 | 1.1783 | 2.2672 | 1.8205 | 0.0523 | 1.3667 |
| Citric acid +6 | NA | NA | 0.4269 | 1.1477 | 1.0247 | 0.0255 | 0.0149 | 0.5624 | 1.9988 | 1.3241 | NA | 1.1513 |
| Glutamic acid | 1.2307 | 1.1401 | 0.9011 | 0.7934 | 0.7446 | 1.0479 | 1.5218 | 0.4159 | 0.9464 | 0.8924 | 1.4733 | 0.8982 |
| Glutamic acid +1 | 0.7180 | 1.1295 | 0.7928 | 1.0285 | 0.9851 | 0.9633 | 1.4327 | 0.3687 | 0.9742 | 1.1787 | 1.3119 | 1.1793 |
| Glutamic acid +2 | 0.5174 | 0.7500 | 1.4434 | 1.3479 | 1.2338 | 0.6556 | 0.7530 | 0.7131 | 1.4221 | 1.5750 | 0.5728 | 0.9381 |
| Glutamic acid +3 | 0.1340 | 0.3755 | 1.0525 | 1.7682 | 1.6928 | 0.3090 | 0.3680 | 0.7144 | 1.8554 | 2.1089 | 0.2173 | 1.2397 |
| Glutamic acid +4 | 0.0611 | 0.1881 | 1.0178 | 1.9164 | 1.8183 | 0.1591 | 0.1588 | 0.8090 | 2.1774 | 2.2713 | 0.0752 | 1.0109 |
| Glutamic acid +5 | 0.0087 | 0.0523 | 0.4130 | 1.9443 | 1.9793 | 0.0476 | 0.0492 | 0.5670 | 2.6390 | 2.4200 | 0.0186 | 1.1744 |
| Malic Acid | 1.1726 | 0.7628 | 0.9011 | 0.4956 | 0.4721 | 0.8522 | 1.7677 | 0.3980 | 0.8824 | 0.6282 | 2.4701 | 1.4624 |
| Malic Acid +1 | 0.5160 | 0.6323 | 0.7250 | 0.6435 | 0.6139 | 0.6503 | 1.6740 | 0.4370 | 1.1377 | 0.8878 | 1.9144 | 2.3799 |
| Malic Acid +2 | 0.4487 | 0.4874 | 1.2194 | 0.7940 | 0.7185 | 0.5309 | 1.0657 | 0.7711 | 1.6669 | 1.1134 | 0.9850 | 2.0013 |
| Malic Acid +3 | 0.0630 | 0.1825 | 0.9279 | 1.0656 | 1.0062 | 0.2065 | 0.4496 | 0.9297 | 2.3573 | 1.5275 | 0.2656 | 2.4549 |
| Malic Acid +4 | NA | NA | 0.2823 | 0.6772 | 0.7355 | NA | 0.0592 | 0.4706 | 1.9581 | 1.0612 | NA | 1.7979 |
| Palmitic acid | 0.8829 | 0.7629 | 0.7009 | 0.8550 | 0.8490 | 1.0339 | 1.1591 | 1.3474 | 1.0424 | 1.0173 | 1.1728 | 1.1001 |
| Palmitic acid +2 | 0.8773 | 0.7243 | 0.6832 | 0.8579 | 0.8507 | 1.0401 | 1.1523 | 1.3700 | 1.0459 | 0.9903 | 1.1669 | 1.1551 |
| Palmitic acid +4 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Factors:
| F1 | Mouse model:Acss2-/- C57Bl/6 | Cell Type:CD8+ T cells | [13C2-acetate] in mM:100 | Time (hours):1 | ACSS2 inhibitor (Y/N):N |
| F2 | Mouse model:Acss2-/- C57Bl/6 | Cell Type:CD8+ T cells | [13C2-acetate] in mM:100 | Time (hours):2 | ACSS2 inhibitor (Y/N):N |
| F3 | Mouse model:Acss2-/- C57Bl/6 | Cell Type:CD8+ T cells | [13C2-acetate] in mM:500 | Time (hours):1 | ACSS2 inhibitor (Y/N):N |
| F4 | Mouse model:Acss2-/- C57Bl/6 | Cell Type:CD8+ T cells | [13C2-acetate] in mM:500 | Time (hours):2 | ACSS2 inhibitor (Y/N):N |
| F5 | Mouse model:Acss2-/- C57Bl/6 | Cell Type:CD8+ T cells | [13C2-acetate] in mM:500 | Time (hours):2 | ACSS2 inhibitor (Y/N):Y |
| F6 | Mouse model:WT C57Bl/6 | Cell Type:CD8+ T cells | [13C2-acetate] in mM:100 | Time (hours):1 | ACSS2 inhibitor (Y/N):N |
| F7 | Mouse model:WT C57Bl/6 | Cell Type:CD8+ T cells | [13C2-acetate] in mM:100 | Time (hours):2 | ACSS2 inhibitor (Y/N):N |
| F8 | Mouse model:WT C57Bl/6 | Cell Type:CD8+ T cells | [13C2-acetate] in mM:500 | Time (hours):1 | ACSS2 inhibitor (Y/N):N |
| F9 | Mouse model:WT C57Bl/6 | Cell Type:CD8+ T cells | [13C2-acetate] in mM:500 | Time (hours):2 | ACSS2 inhibitor (Y/N):N |
| F10 | Mouse model:WT C57Bl/6 | Cell Type:CD8+ T cells | [13C2-acetate] in mM:500 | Time (hours):2 | ACSS2 inhibitor (Y/N):Y |
| F11 | Mouse model:WT C57Bl/6 | Cell Type:NK cells | [13C2-acetate] in mM:100 | Time (hours):1 | ACSS2 inhibitor (Y/N):N |
| F12 | Mouse model:WT C57Bl/6 | Cell Type:NK cells | [13C2-acetate] in mM:500 | Time (hours):2 | ACSS2 inhibitor (Y/N):N |
