Data for (Study ST002809)

(Analysis AN004566)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6
1-methyl-4-imidazoleacetate 0.6928 1.2509 0.9685 0.9625 1.1175 1.0078
1-methyl-5-imidazoleacetate 0.5348 2.8726 0.7103 0.7540 0.5508 0.5775
1-methyl-5-imidazolelactate 0.5149 2.1736 0.7146 NA NA 0.5969
1-methyladenine 0.6508 1.5580 1.0442 NA NA 0.7471
1-methyladenosine 0.5037 1.5199 1.2779 1.0744 0.8683 0.7558
1-methylhistidine 0.2137 2.2171 1.5250 0.6301 0.9164 0.4978
1-methylnicotinamide NA NA NA 1.0813 0.9187 NA
2-aminoadipate 0.2588 2.5425 0.9105 NA NA 0.2882
2^-deoxyadenosine 1.6619 0.7962 0.9037 NA NA 0.6383
2^-deoxyadenosine 5^-monophosphate 0.9349 1.5794 0.9338 0.8111 1.0890 0.6518
2^-deoxycytidine 1.3100 1.0831 1.0319 1.0366 0.8042 0.7343
2-hydroxyglutarate 0.8223 1.6789 1.0545 0.8231 0.9929 0.6283
2-methylbutyrylcarnitine (C5) 0.3592 1.5727 1.6537 0.3617 1.5406 0.5121
2^-O-methylcytidine 0.5044 1.2121 1.2315 1.1899 0.9266 0.9355
2-oxoarginine* 2.4114 0.3498 0.4102 0.9963 0.6008 1.2315
3-amino-2-piperidone 0.9439 1.0095 1.0405 0.8583 1.1210 1.0269
3-aminoisobutyrate 0.3238 3.4437 0.4975 0.5852 0.6042 0.5457
3-formylindole 0.2566 0.9876 1.4285 0.7100 1.4511 1.1662
3-hydroxyhexanoylcarnitine (1) 0.8732 1.1173 1.1389 0.7731 1.3485 0.7490
3-methoxytyrosine 0.5987 1.9261 0.8765 NA NA 0.5987
3-methylcytidine NA NA NA 0.8605 1.1395 NA
3-methylhistidine 0.5113 2.0265 1.3250 0.8064 0.8128 0.5180
3-phosphoglycerate 1.4335 0.0146 1.3613 0.5093 1.7256 0.9557
3-phosphoserine NA NA NA 0.9348 1.0652 NA
3-ureidopropionate 0.5851 2.1331 0.4171 NA NA 0.8647
4-acetamidobutanoate 0.8836 1.3332 0.9456 0.8983 1.0380 0.9013
4-guanidinobutanoate 0.6753 2.1118 0.4210 1.2785 0.6292 0.8843
4-hydroxyglutamate 0.2065 2.3439 0.9218 NA NA 0.5278
4-imidazoleacetate 0.5206 2.8853 0.6684 0.5508 0.8083 0.5666
5-(2-Hydroxyethyl)-4-methylthiazole 0.1935 3.1302 0.4272 NA NA 0.2490
5,6-dihydrothymine 0.6355 1.9470 0.6473 NA NA 0.7702
5,6-dihydrouridine 0.6548 1.0244 1.2896 1.1621 0.7467 1.1224
5-aminovalerate 0.2611 1.9341 0.7656 1.1488 1.1688 0.7216
5-(galactosylhydroxy)-L-lysine 1.0240 0.8398 1.0663 1.0115 0.8950 1.1634
5^- GMP 0.8155 1.4389 1.1068 0.9741 0.8420 0.8227
5-hydroxylysine 0.9741 1.2699 0.8663 0.9710 0.9602 0.9586
5-methylcytidine 0.4126 1.9113 1.0664 0.9988 0.7916 0.8193
5-methylcytosine 0.4108 1.9915 0.7983 NA NA 0.7995
5-methylnorleucine 0.7004 1.5443 1.1169 NA NA 0.6384
5-methylthioadenosine (MTA) 0.6301 1.9427 0.9407 0.7566 0.9430 0.7869
6-oxopiperidine-2-carboxylate 0.7640 1.1607 1.2589 NA NA 0.8164
7-methylguanine 0.2703 2.5650 0.7638 0.9887 0.6925 0.7198
acetylcarnitine (C2) 0.3092 2.1596 0.9123 0.8138 0.9774 0.8277
adenine 1.0308 1.1386 1.1081 0.8329 1.2257 0.6639
adenosine 1.4722 0.6230 1.0851 0.5638 1.4683 0.7875
alanine 0.5332 1.9716 0.9340 0.7850 0.9823 0.7939
alanylleucine 0.7849 1.5062 0.9806 0.8989 1.1400 0.6894
AMP 0.8704 1.2642 1.1072 0.8919 1.0302 0.8362
anserine 0.2431 3.2858 0.3099 NA NA 0.1613
arginine 1.2346 0.8507 0.8466 1.5026 0.3886 1.1770
argininosuccinate 1.0369 1.2149 1.0814 1.3292 0.5016 0.8360
asparagine 0.9740 1.2342 0.8665 1.1203 0.8621 0.9429
aspartate 0.7851 1.9756 0.7698 0.7504 0.9387 0.7804
benzoylcarnitine* 0.6271 1.8211 1.0270 0.9157 0.8329 0.7762
beta-alanine 0.4144 1.6399 1.3280 0.8117 1.1329 0.6731
beta-guanidinopropanoate NA NA NA 1.0986 0.9014 NA
beta-hydroxyisovaleroylcarnitine 0.8512 1.2717 1.2348 0.6964 1.2133 0.7327
betaine 0.3573 3.2721 0.5143 0.6194 0.5806 0.6563
betaine aldehyde NA NA NA 0.4737 1.5263 NA
butyrylcarnitine (C4) 0.4676 1.2328 1.7183 0.6291 1.3114 0.6409
cadaverine 0.7788 1.6636 0.7788 NA NA 0.7788
carboxyethyl-GABA 0.6597 1.6791 0.8527 NA NA 0.8085
carnitine 0.7125 1.7589 0.9058 0.7311 1.0315 0.8602
carnosine 0.1857 4.6414 0.4267 0.2879 0.2907 0.1677
C-glycosyltryptophan 0.9244 1.3243 0.6465 1.3239 0.7638 1.0172
choline 0.9035 0.9966 1.4025 0.8366 1.0249 0.8359
citrulline 0.3286 1.8909 1.3670 0.6951 0.9912 0.7271
CMP 0.7137 1.5517 1.3057 0.8624 1.0249 0.5415
creatine 0.2779 3.0728 0.9611 0.6514 0.6142 0.4225
creatinine 0.5299 2.3487 0.7809 0.9253 0.6412 0.7739
cystathionine 0.1838 1.8302 1.6696 0.5517 1.3481 0.4166
cysteine 0.6228 1.9846 0.9612 0.8323 0.7941 0.8050
cysteine-glutathione disulfide 0.1127 2.7755 1.9792 0.4024 0.5844 0.1457
cysteinylglycine 0.0586 4.0632 1.3432 0.1600 0.2883 0.0867
cysteinylglycine disulfide* 0.5587 1.6138 1.2687 NA NA 0.5587
cystine 0.9741 0.9732 1.0352 1.0613 0.9467 1.0095
cytidine 0.5404 1.7273 1.2367 0.9689 0.8504 0.6762
cytosine 0.5584 1.5738 1.2259 0.8080 1.1382 0.6957
dCMP NA NA NA 1.1327 0.8673 NA
deoxycarnitine 0.3787 3.0609 0.7655 0.6277 0.5908 0.5765
diacetylchitobiose 1.4365 0.7652 0.7263 NA NA 1.0720
dimethylarginine (ADMA + SDMA) 1.0653 1.2650 0.7227 1.1832 0.8004 0.9634
dimethylglycine 0.7072 1.8821 0.8911 0.8585 0.8560 0.8051
ectoine 0.4575 1.1927 0.9102 NA NA 1.4395
ergothioneine NA NA NA 1.1454 0.8546 NA
formiminoglutamate 0.4129 1.7924 1.1837 NA NA 0.6109
fructosyllysine 0.5425 1.7716 0.6678 0.8306 1.3460 0.8414
gamma-glutamyl-2-aminobutyrate 0.5018 1.1450 1.5943 NA NA 0.7590
gamma-glutamylalanine 0.0017 3.2807 0.6774 NA NA 0.0402
gamma-glutamyl-alpha-lysine 0.2798 2.4027 0.7774 NA NA 0.5401
gamma-glutamylcitrulline* 0.5868 1.9716 0.8854 0.1075 1.8619 0.5868
gamma-glutamylcysteine NA NA NA 0.5018 1.4982 NA
gamma-glutamyl-epsilon-lysine 0.4418 1.1351 1.1505 0.3627 1.9958 0.9142
gamma-glutamylglutamate 0.0104 3.6360 1.0038 0.3656 0.8067 0.1776
gamma-glutamylglutamine 0.0339 3.9241 0.7375 0.1062 0.9406 0.2576
gamma-glutamylglycine 0.0225 3.7684 0.7578 0.3720 0.8295 0.2498
gamma-glutamylhistidine 0.1176 3.8925 0.8746 0.3039 0.4675 0.3438
gamma-glutamylisoleucine* 0.3157 2.5704 0.9772 0.3502 1.2026 0.5840
gamma-glutamylleucine 0.2520 2.8252 0.9016 0.3790 1.1118 0.5305
gamma-glutamylmethionine 0.0152 2.4883 1.4715 0.7262 1.1325 0.1663
gamma-glutamylphenylalanine 0.1450 2.8290 0.7017 NA NA 0.3243
gamma-glutamylserine 0.0275 3.1870 0.9213 0.3303 1.2677 0.2662
gamma-glutamylthreonine 0.1517 3.2537 0.9023 0.2923 0.9760 0.4239
gamma-glutamyltyrosine 0.0960 2.8221 0.7780 NA NA 0.3039
gamma-glutamylvaline 0.3407 2.4787 1.0569 0.2639 1.3064 0.5535
glutamate 0.6939 1.9131 0.9089 0.8460 0.8390 0.7991
glutamate, gamma-methyl ester 0.1780 3.8094 1.1035 0.3087 0.3461 0.2543
glutamine 1.0755 1.3684 0.2714 1.1855 0.9976 1.1015
glutamine_degradant* 0.4440 3.2614 0.6851 0.6382 0.4584 0.5129
glutathione, oxidized (GSSG) 0.1293 1.2837 1.2542 0.7413 2.4623 0.1293
glutathione, reduced (GSH) 0.0624 2.9347 2.4881 0.1647 0.2712 0.0788
glycerol 3-phosphate 0.7897 0.9292 1.3445 0.8359 1.1746 0.9262
glycerophosphoethanolamine 0.9111 1.1240 0.9701 0.9410 1.0968 0.9570
glycerophosphorylcholine (GPC) 0.8904 0.9519 1.3685 0.8573 1.0035 0.9284
glycerophosphoserine* 0.9680 0.8773 1.2178 1.3989 0.5750 0.9631
glycine 0.6389 1.8467 0.9126 0.8893 0.8657 0.8467
glycylisoleucine NA NA NA 1.3269 0.6731 NA
glycylleucine 1.1381 0.7743 1.0181 1.0619 0.9361 1.0715
glycylvaline 0.9096 1.0343 1.0121 1.1660 0.7726 1.1055
guanidinoacetate 0.1689 0.4493 3.7606 0.9247 0.5368 0.1597
guanine 0.8063 1.6242 0.9429 0.9594 0.8617 0.8055
hexanoylcarnitine (C6) 0.6264 1.1233 1.5587 NA NA 0.6916
homoarginine 0.3001 2.3300 0.7866 NA NA 0.5834
homocitrulline 0.4584 2.3317 0.7514 NA NA 0.4584
homocysteine NA NA NA 1.2106 0.7894 NA
homostachydrine* 0.5224 2.7541 0.8333 0.7293 0.5586 0.6023
hydroxyasparagine 0.6677 1.6266 0.4783 NA NA 1.2274
hydroxy-N6,N6,N6-trimethyllysine* NA NA NA 0.9954 1.0046 NA
hydroxyproline 0.4306 1.8368 1.0639 0.7165 1.1301 0.8221
hypotaurine 0.5193 2.6027 0.8517 0.6886 0.6963 0.6413
imidazole lactate 0.2118 3.0603 1.0555 0.9996 0.2986 0.3743
imidazole propionate 0.3869 3.2221 0.6130 0.7690 0.4404 0.5687
inosine 5^-monophosphate (IMP) 0.3394 3.3178 0.7476 0.6903 0.5176 0.3872
isobutyrylcarnitine (C4) 0.3233 2.0792 1.4445 0.6187 1.1598 0.3744
isoleucine 0.8785 1.0498 1.0950 1.0019 1.0325 0.9422
isoleucylhydroxyproline* NA NA NA 1.0497 0.9503 NA
isovalerylcarnitine (C5) 0.3522 1.8102 1.5303 0.7507 1.1250 0.4316
kynurenate 0.2273 1.0759 1.7282 0.9351 1.0512 0.9823
kynurenine 0.1933 0.9350 1.4536 0.7577 1.4964 1.1642
lanthionine 0.2645 3.0358 0.3612 NA NA 0.3385
leucine 1.0553 1.0184 0.9867 1.0206 0.9404 0.9785
leucylglutamine* 1.3417 0.7156 0.8256 0.8761 1.2576 0.9835
leucylglycine 1.3499 0.4348 0.8958 0.9571 1.3329 1.0295
lysine 0.9493 1.0043 1.0101 1.0329 1.0058 0.9976
methionine 1.1792 0.8585 0.9604 1.0869 0.8867 1.0283
methionine sulfone 0.2352 2.1055 1.3363 0.7292 0.9942 0.5996
methionine sulfoxide 0.7920 1.3783 1.0405 0.8855 1.0251 0.8786
methylphosphate 2.1481 0.7172 0.6835 0.8440 0.7828 0.8245
N1-methylinosine NA NA NA 1.4978 0.5022 NA
(N(1) + N(8))-acetylspermidine 0.2878 3.2271 0.6969 0.6551 0.7074 0.4257
N2,N2-dimethylguanosine 0.4686 1.7579 0.9753 1.0713 0.7880 0.9389
N4-acetylcytidine 0.6972 1.8761 0.8075 NA NA 0.6191
N6-methyllysine 0.5907 1.8902 0.8113 0.8223 0.9887 0.8969
N6,N6-dimethyllysine 0.4855 1.9136 0.5458 1.0448 0.9278 1.0826
N6,N6,N6-trimethyllysine 0.6827 2.0222 0.5241 0.9346 0.8418 0.9945
N-acetylarginine 0.9520 1.9288 0.4791 0.7508 1.0267 0.8626
N-acetylasparagine 0.6193 1.5030 0.8553 0.9673 1.3959 0.6593
N-acetylaspartate (NAA) 0.8747 1.2688 1.0470 0.9133 0.9856 0.9107
N-acetylcysteine 0.5073 1.1102 1.2523 1.0823 1.0329 1.0150
N-acetylglucosamine/N-acetylgalactosamine 0.9745 0.1783 1.5267 0.8378 1.3645 1.1183
N-acetylglucosaminylasparagine 1.0846 1.0678 0.9294 1.1600 0.8360 0.9222
N-acetylglutamate 0.6965 1.2615 1.1404 0.7341 1.6201 0.5474
N-acetylglutamine 0.7353 1.1463 1.1567 0.6231 1.5806 0.7580
N-acetylglycine 0.6836 1.4346 1.1359 NA NA 0.7459
N-acetylhistidine 0.6454 1.9895 0.7216 NA NA 0.6436
N-acetylisoleucine 0.7264 1.8691 0.7646 NA NA 0.6399
N-acetyl-isoputreanine 0.5997 1.8046 0.5997 0.6429 1.7532 0.5997
N-acetylmethionine sulfoxide 1.2538 0.8188 0.8332 0.6832 1.4732 0.9379
N-acetylproline 1.1325 1.2691 0.9722 NA NA 0.6262
N-acetylputrescine 0.4130 4.4885 0.1704 0.1454 0.5304 0.2523
N-glycolylneuraminate NA NA NA 1.1211 0.8789 NA
nicotinamide 1.0276 1.1753 1.0449 1.0137 1.0262 0.7124
nicotinamide ribonucleotide (NMN) 1.3277 0.6518 1.0959 1.2238 0.8343 0.8666
nicotinamide riboside 0.7557 1.3905 1.1337 1.2023 0.8521 0.6658
N-methyl-GABA NA NA NA 0.8773 1.1227 NA
N-methylpipecolate 0.7985 1.3606 0.9821 NA NA 0.8587
N-methylproline 0.5896 2.6079 0.6461 0.7812 0.6519 0.7234
N-monomethylarginine 1.2906 0.9763 0.7444 1.1578 0.7833 1.0477
N,N-dimethyl-5-aminovalerate 1.2033 0.7950 1.4949 NA NA 0.5068
N,N-dimethyl-pro-pro 1.0440 1.6670 0.5419 NA NA 0.7471
N,N,N-trimethyl-5-aminovalerate 0.6766 1.7771 1.0152 0.7666 0.9879 0.7766
N,N,N-trimethyl-alanylproline betaine (TMAP) 0.9314 2.5098 0.5804 0.7967 0.6017 0.5799
O-methyltyrosine NA NA NA 1.1836 0.8164 NA
ophthalmate 0.0903 2.5656 0.6149 0.7433 1.8955 0.0903
ornithine 0.7542 1.0484 1.1303 0.6750 1.4002 0.9919
oxindolylalanine 0.6783 1.8851 0.5034 1.2820 1.1478 0.5034
pantothenate (Vitamin B5) 0.6843 1.7284 1.0369 0.9533 0.8005 0.7965
phenylacetylglycine 0.4057 0.9584 1.1036 0.9035 1.0718 1.5570
phenylalanine 0.8686 1.2706 1.1049 0.9820 0.9173 0.8565
phenylalanylalanine 1.1023 0.7432 0.6680 1.1774 1.4268 0.8823
phenylalanylglycine 1.4883 0.3583 0.7609 1.0331 1.3011 1.0582
phosphate 0.9901 0.8416 1.2158 0.8768 1.0957 0.9801
phosphocholine 0.6928 1.3938 1.3937 0.9288 1.0345 0.5565
phosphoethanolamine (PE) 0.9038 1.6877 0.8343 1.0094 0.7937 0.7712
pipecolate 2.4202 0.6710 0.5507 1.0490 0.5088 0.8004
proline 0.7573 1.3402 1.2334 1.0018 0.8614 0.8059
prolylglycine 1.1514 1.0792 0.9375 0.8911 1.0307 0.9101
prolylhydroxyproline 0.2373 1.6188 1.7784 1.2286 0.4935 0.6435
propionylcarnitine (C3) 0.3865 1.9631 1.5728 0.5338 1.0254 0.5183
pterin 0.9729 1.1610 1.0373 1.0287 0.8320 0.9683
putrescine 0.3141 4.5752 0.1413 0.1774 0.5156 0.2766
pyridoxal 0.9470 1.1559 0.9788 1.0106 0.9195 0.9882
pyridoxamine 0.9472 0.7776 1.1041 0.9233 1.0089 1.2389
pyridoxamine phosphate NA NA NA 1.0387 0.9613 NA
quinolinate NA NA NA 0.8137 1.1863 NA
(R)-3-hydroxybutyrylcarnitine 0.3643 2.5848 0.6968 NA NA 0.3540
riboflavin (Vitamin B2) 0.7241 2.7646 0.4379 0.7935 0.6139 0.6659
S-1-pyrroline-5-carboxylate 0.7432 1.1789 1.2640 0.8383 1.2407 0.7349
(S)-3-hydroxybutyrylcarnitine 0.5707 1.7643 1.3444 0.6383 1.1730 0.5092
saccharopine 0.2227 1.4775 2.0467 NA NA 0.2531
S-adenosylmethionine (SAM) 0.5519 2.0298 1.0913 0.8240 0.8538 0.6492
sarcosine 0.1666 2.5886 0.7927 NA NA 0.4521
S-carboxymethyl-L-cysteine 0.6010 1.5858 1.0352 NA NA 0.7779
serine 1.0440 1.1837 0.8422 1.0436 0.9043 0.9821
serotonin 0.6030 1.6505 0.8975 NA NA 0.8490
S-methylcysteine sulfoxide 0.3492 2.5449 0.7567 NA NA 0.3492
S-methylmethionine 0.7442 2.4196 0.4103 NA NA 0.4259
spermidine 0.4864 2.7598 0.6836 0.7227 0.6663 0.6812
spermine NA NA NA 1.3248 0.6752 NA
stachydrine NA NA NA 1.0656 0.9344 NA
succinylcarnitine (C4-DC) NA NA NA 0.5908 1.4092 NA
taurine 0.5583 2.1665 0.8846 0.7788 0.8537 0.7582
thiamin monophosphate 0.8858 0.3332 1.3116 0.9266 1.2695 1.2734
thiamin (Vitamin B1) 0.5908 2.4810 0.7632 0.9841 0.5625 0.6184
thioproline 0.6781 1.2950 1.0648 0.9861 1.1383 0.8377
threonine 0.4663 2.1776 1.0432 0.8470 0.7774 0.6884
tiglyl carnitine (C5) 0.5564 2.3733 0.9281 0.6072 0.8929 0.6421
trigonelline (N^-methylnicotinate) 0.8139 1.3678 0.9407 0.9342 1.0295 0.9139
trimethylamine N-oxide NA NA NA 1.0678 0.9322 NA
tryptamine 0.9962 1.3796 0.7020 NA NA 0.9222
tryptophan 1.6051 3.1158 0.0113 0.6785 0.5617 0.0276
tryptophan betaine NA NA NA 1.1813 0.8187 NA
tryptophylglycine 0.5915 0.4855 0.5665 1.2643 2.0245 1.0677
tyrosine 0.8863 1.3889 1.0324 1.0073 0.8619 0.8231
UMP 0.9128 1.4001 1.0640 0.8761 1.0983 0.6487
uracil 0.5827 1.9023 1.0531 1.0371 0.6771 0.7477
urate NA NA NA 0.7105 1.2895 NA
urea 0.8441 0.9049 1.0551 NA NA 1.1959
valine 0.8956 1.3208 0.9644 0.9967 0.9148 0.9076
valylleucine 0.9318 1.0217 0.9740 0.9186 1.3390 0.8149
xanthine 0.4334 2.3330 1.1322 0.5875 0.9530 0.5609
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Factors:

F1Genotype:EXOC5_KD
F2Genotype:EXOC5_KO
F3Genotype:EXOC5_OE
F4Genotype:IFT88_KO
F5Genotype:IFT88_KO_WT
F6Genotype:WT
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