Data for (Study ST002822)
(Analysis AN004599)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 1-methyl-4-imidazoleacetate | 4.1261 | 1.6187 | 2.7369 | NA |
| 1-methyl-5-imidazoleacetate | NA | NA | 2.2441 | 2.1867 |
| 1-methylguanidine | 2.6560 | 1.3853 | 2.1823 | NA |
| 1-methylhistamine | 31.7077 | NA | 18.4944 | NA |
| 1-methylnicotinamide | NA | 13.6387 | NA | 18.2857 |
| 1-ribosyl-imidazoleacetate* | NA | NA | NA | NA |
| 2-aminoheptanoate | 4.7332 | NA | 20.5867 | NA |
| 2^-deoxyadenosine | 4.7802 | 3.9457 | 3.8770 | NA |
| 2^-deoxycytidine | 3.2953 | 3.1956 | 0.6560 | NA |
| 2-methylbutyrylcarnitine (C5) | NA | NA | 1.5386 | 5.9854 |
| 2-methylmalonylcarnitine (C4-DC) | 2.5485 | 0.5186 | 2.5393 | NA |
| 2-oxoarginine* | NA | NA | NA | NA |
| 3-amino-2-piperidone | NA | NA | NA | NA |
| 3-aminoisobutyrate | NA | -6.8477 | NA | -7.5479 |
| 3-formylindole | -5.8058 | NA | -21.3403 | NA |
| 3-hydroxyhexanoylcarnitine (1) | NA | NA | -33.7944 | -18.8177 |
| 3-hydroxyhexanoylcarnitine (2) | NA | NA | 7.3129 | 3.7686 |
| 3-hydroxyoctanoylcarnitine (1) | NA | NA | 2.7669 | 1.5965 |
| 3-hydroxyoctanoylcarnitine (2) | NA | NA | 3.3078 | 2.0042 |
| 3-ureidopropionate | -4.4540 | -6.1878 | NA | -1.3136 |
| 4-guanidinobutanoate | NA | NA | NA | -3.4489 |
| 4-hydroxyglutamate | 1.0896 | 1.7658 | 8.0552 | NA |
| 4-imidazoleacetate | 9.3409 | 1.0688 | 10.2609 | NA |
| 5-aminovalerate | NA | NA | NA | NA |
| 5-hydroxylysine | NA | -0.1004 | NA | -0.2385 |
| 5-methylthioadenosine (MTA) | NA | 2.1827 | 0.8142 | 1.6741 |
| acetylcarnitine (C2) | NA | NA | 1.9125 | 1.8474 |
| acetylcholine | 2.8060 | 0.7927 | 2.7171 | NA |
| adenine | NA | NA | -1.1285 | NA |
| adenosine | NA | NA | 5.7503 | 0.9251 |
| adenosine 5^-monophosphate (AMP) | NA | NA | 4.0100 | 1.5392 |
| AICA ribonucleotide | 1.6795 | 0.6805 | NA | 1.4400 |
| alanine | NA | 0.5324 | 5.3765 | 0.7876 |
| alanylleucine | 4.5921 | NA | NA | 7.4329 |
| anserine | 7.8257 | NA | 9.2193 | NA |
| arginine | 1.4948 | 1.7672 | 0.4944 | 0.4582 |
| ascorbate (Vitamin C) | 0.0916 | 1.4231 | NA | 2.0860 |
| asparagine | 0.1372 | 1.4621 | NA | 1.8733 |
| aspartate | 6.7159 | NA | NA | 0.3644 |
| benzoylcarnitine* | -1.5732 | NA | -23.4380 | NA |
| beta-alanine | NA | 2.7207 | 3.5688 | NA |
| beta-hydroxyisovaleroylcarnitine | 4.7503 | 6.9735 | NA | 1.3970 |
| betaine | 0.7012 | 2.2296 | 2.2940 | NA |
| butenoylcarnitine (C4:1) | NA | NA | NA | NA |
| butyrylcarnitine (C4) | NA | 1.6975 | 2.8706 | 0.0307 |
| carnitine | 4.1410 | 2.0521 | 2.8821 | NA |
| carnosine | 7.3196 | NA | 8.4610 | NA |
| C-glycosyltryptophan | 0.5940 | 1.2082 | NA | 1.8386 |
| choline | 9.9088 | 2.0721 | 7.9711 | NA |
| choline phosphate | 2.5533 | 0.9002 | 2.2368 | NA |
| citrulline | 0.4162 | 1.7719 | 3.2836 | NA |
| creatine | NA | 0.4721 | 4.3924 | 0.1478 |
| creatinine | 0.0032 | 1.7268 | 1.2313 | 0.8039 |
| cystathionine | NA | NA | NA | NA |
| cysteine | 3.8224 | 5.0787 | NA | 0.5796 |
| cysteine-glutathione disulfide | NA | NA | NA | -0.7682 |
| cysteinylglycine | 3.0319 | 2.0002 | NA | 0.1913 |
| cytidine | 0.6680 | 1.5450 | 2.2574 | 0.3538 |
| cytidine 5^-monophosphate (5^-CMP) | 0.7663 | 1.8753 | NA | 1.4998 |
| cytosine | NA | NA | -14.1983 | -22.9893 |
| deoxycarnitine | 2.4231 | 1.5174 | 2.5428 | NA |
| dihydroxyacetone phosphate (DHAP) | NA | NA | NA | NA |
| dimethylarginine (SDMA + ADMA) | 2.8129 | 2.8571 | 2.2278 | NA |
| dimethylglycine | 1.4879 | 0.4392 | 2.0487 | 0.5225 |
| dimethyl sulfone | NA | NA | NA | -0.0971 |
| ergothioneine | NA | 0.7134 | 1.0892 | 1.9583 |
| fructosyllysine | 1.8944 | 1.2145 | NA | 1.1503 |
| gamma-glutamyl-alpha-lysine | 2.4157 | 4.1263 | NA | 1.3545 |
| gamma-glutamyl-epsilon-lysine | 0.6068 | 1.7198 | NA | 1.3537 |
| gamma-glutamylglutamate | -0.8874 | NA | NA | NA |
| gamma-glutamylglutamine | 0.4118 | 0.5528 | 1.7585 | 1.1944 |
| gamma-glutamylleucine | 1.8981 | 2.3216 | NA | 0.4166 |
| gamma-glutamylthreonine | -0.8128 | -0.6084 | NA | -0.6943 |
| gamma-glutamylvaline | -0.0251 | -0.1377 | NA | NA |
| glutamate | 2.7884 | 2.6073 | NA | 0.7397 |
| glutamate, gamma-methyl ester | 0.8177 | 2.2498 | 2.9674 | NA |
| glutamine | NA | 15.4788 | 5.6377 | NA |
| glutathione, oxidized (GSSG) | 0.5694 | 0.9597 | 0.3643 | 1.4789 |
| glutathione, reduced (GSH) | 2.7972 | 2.0258 | 0.6125 | NA |
| glycerophosphorylcholine (GPC) | 0.1333 | NA | 1.9425 | 1.7786 |
| glycerophosphoserine* | 0.0373 | 0.5412 | NA | 2.7505 |
| glycine | 0.2349 | 2.1641 | 2.8720 | NA |
| glycylleucine | NA | NA | NA | 3.0291 |
| glycylvaline | NA | 0.3368 | NA | 3.6739 |
| guanidinoacetate | NA | NA | 8.3931 | NA |
| guanine | NA | NA | NA | NA |
| guanosine | NA | -2.4733 | -1.5285 | -0.5838 |
| histamine | 1.7467 | 1.0494 | 1.3243 | 0.3528 |
| histidine betaine (hercynine)* | 0.2388 | 1.3505 | 0.2968 | 1.5569 |
| histidine methyl ester | 8.3332 | 10.8040 | NA | 1.8643 |
| homostachydrine* | 2.0541 | 2.5927 | NA | 0.0023 |
| hydroxy-N6,N6,N6-trimethyllysine* | 7.0682 | NA | 8.1010 | NA |
| imidazole lactate | NA | NA | 1.0518 | 4.0134 |
| imidazole propionate | NA | NA | NA | -7.0694 |
| inosine 5^-monophosphate (IMP) | 3.7636 | 3.8139 | 0.4083 | NA |
| isobutyrylcarnitine (C4) | NA | NA | 3.5808 | 2.0789 |
| isoleucine | 0.7537 | 1.3757 | 0.1789 | 1.2681 |
| kynurenine | 0.6811 | 2.3218 | 0.1683 | 0.9144 |
| leucine | 2.1424 | 3.0622 | NA | 1.0743 |
| leucylalanine | 5.5531 | NA | NA | 14.5679 |
| leucylglutamine* | 3.6465 | 2.7389 | NA | NA |
| leucylglycine | NA | NA | NA | -0.5503 |
| lysine | 2.4864 | 2.5591 | NA | 0.1200 |
| malonylcarnitine | 5.5497 | 3.9588 | 2.2353 | NA |
| methionine | NA | -0.1041 | NA | NA |
| methionine sulfoxide | NA | NA | NA | NA |
| N1-methyladenosine | 2.9149 | 1.6057 | NA | 0.3811 |
| (N(1) + N(8))-acetylspermidine | NA | 2.1989 | NA | 2.3712 |
| N6-carboxymethyllysine | -10.0895 | -1.7258 | -1.0402 | NA |
| N6-methyllysine | 1.6502 | 1.4966 | 1.9664 | NA |
| N6,N6-dimethyllysine | 3.2509 | 2.0434 | 0.8516 | NA |
| N6,N6,N6-trimethyllysine | 1.7010 | 2.9660 | NA | NA |
| N-acetylarginine | NA | NA | NA | -0.2131 |
| N-acetylasparagine | NA | -2.5125 | -20.5668 | NA |
| N-acetyl-aspartyl-glutamate (NAAG) | NA | -1.2011 | NA | -1.7434 |
| N-acetylglucosaminylasparagine | NA | -0.5362 | NA | NA |
| N-acetylglutamine | NA | 2.1785 | 0.2695 | 1.9889 |
| N-acetylhistidine | NA | NA | NA | NA |
| N-acetylmethionine sulfoxide | NA | -0.2526 | NA | NA |
| N-acetylneuraminate | 1.0086 | 0.2851 | 2.0253 | 0.9309 |
| N-acetylputrescine | NA | 7.9111 | NA | 6.0952 |
| N-acetylserine | NA | NA | -218.8579 | -68.6413 |
| nicotinamide | 2.2728 | NA | 3.6547 | NA |
| nicotinamide N-oxide | NA | 5.7488 | 1.2105 | 1.6934 |
| nicotinamide ribonucleotide (NMN) | 2.8430 | 2.7258 | 1.2306 | NA |
| nicotinamide riboside | NA | 4.9624 | 2.5800 | NA |
| N-methylproline | -5.6358 | NA | -8.3978 | NA |
| N-monomethylarginine | 15.9578 | 9.3151 | 20.8684 | NA |
| N,N-dimethylalanine | NA | NA | NA | -3.5754 |
| N,N-dimethyl-pro-pro | 2.6078 | 0.4611 | 2.8122 | NA |
| N,N,N-trimethyl-5-aminovalerate | NA | NA | 6.6453 | 4.1295 |
| N,N,N-trimethyl-alanylproline betaine (TMAP) | 2.9029 | 2.1034 | 5.8085 | NA |
| O-methyltyrosine | 0.9617 | 2.5480 | 0.0194 | 0.4194 |
| ophthalmate | 13.9358 | 5.5695 | NA | NA |
| ornithine | -2.9623 | -0.4685 | NA | NA |
| oxindolylalanine | 3.7335 | 1.7278 | NA | 0.0671 |
| pantetheine | 9.4436 | 3.0900 | 6.2745 | NA |
| phenylacetylglycine | NA | NA | NA | -4.3007 |
| phenylalanine | 2.3363 | 5.7517 | NA | 0.5917 |
| phenylalanylalanine | NA | NA | NA | -0.6109 |
| phenylalanylglycine | NA | NA | NA | -6.9472 |
| pipecolate | NA | 3.7155 | NA | 6.0627 |
| pro-hydroxy-pro | NA | -1.2979 | NA | -4.9998 |
| proline | NA | -0.3610 | NA | NA |
| prolylglycine | 0.3944 | 1.8170 | 0.3394 | 1.0468 |
| propionylcarnitine (C3) | 1.9834 | 0.4857 | 2.8201 | 0.1472 |
| putrescine | NA | 2.3474 | NA | 1.9421 |
| pyridoxamine | 3.3597 | 2.2137 | 0.9103 | NA |
| pyridoxamine phosphate | 5.2535 | NA | 2.4819 | NA |
| (R)-3-hydroxybutyrylcarnitine | NA | NA | NA | NA |
| (S)-3-hydroxybutyrylcarnitine | NA | NA | -5.0658 | -4.4194 |
| S-adenosylmethionine (SAM) | 0.6186 | 1.2384 | NA | 1.6101 |
| serine | NA | 1.7018 | 0.2832 | 1.3416 |
| serotonin | 0.1904 | NA | 2.6796 | 1.2887 |
| spermidine | NA | 5.9149 | NA | 4.7466 |
| spermine | 1.9677 | 1.7818 | NA | 1.3702 |
| stachydrine | NA | 0.5744 | 0.0135 | 2.5194 |
| succinylcarnitine (C4-DC) | 4.2802 | 0.5724 | 3.0896 | NA |
| taurine | NA | 0.6621 | 4.4579 | 0.2809 |
| taurocyamine | NA | NA | NA | -0.2704 |
| thiamin (Vitamin B1) | NA | -0.1360 | NA | NA |
| thioproline | 2.3129 | 2.0071 | NA | 0.7263 |
| threonine | 1.3704 | 1.5750 | NA | 1.4283 |
| tiglylcarnitine (C5:1-DC) | NA | NA | NA | -1.0278 |
| trans-4-hydroxyproline | NA | NA | NA | NA |
| tricine | NA | NA | NA | NA |
| triethanolamine | NA | NA | 3.5915 | 2.9054 |
| trigonelline (N^-methylnicotinate) | NA | NA | NA | 8.6416 |
| trimethylamine N-oxide | 2.0238 | 0.6178 | 0.9075 | 0.9012 |
| trizma acetate | NA | NA | NA | NA |
| tryptophan | 0.9845 | NA | 0.0288 | 2.4951 |
| tyrosine | 1.0426 | 0.1755 | 4.4873 | NA |
| urea | 0.4921 | 1.2227 | NA | 1.8215 |
| valine | 0.4744 | 1.5057 | 0.1665 | 1.4267 |
| X-10445 | NA | NA | NA | NA |
| X-10457 | 2.8587 | 0.6656 | 3.5518 | NA |
| X-11381 | NA | NA | 2.4980 | 1.7362 |
| X-11787 | 0.9831 | 0.5547 | 1.0430 | 1.3032 |
| X-12100 | -3.5197 | NA | NA | NA |
| X-12101 | 2.2404 | 0.0717 | 1.5674 | 0.6762 |
| X-12462 | -2.3827 | NA | NA | NA |
| X-12798 | 2.3297 | 2.2092 | 0.2800 | NA |
| X-14056 | 0.4775 | 1.8668 | 1.4505 | 0.4221 |
| X-15136 | -15.1937 | -29.5381 | -33.8140 | NA |
| X-15161 | NA | NA | NA | -9.3714 |
| X-15461 | 2.8770 | 1.7415 | 1.2548 | NA |
| X-22162 | 2.6372 | 1.5386 | NA | 2.6338 |
| X-23171 | NA | -0.1394 | NA | NA |
| X-23587 | NA | NA | NA | NA |
| X-23593 | NA | 1.4562 | NA | 2.1791 |
| X-23639 | 1.3795 | 1.6244 | NA | 1.4340 |
| X-23665 | NA | 44.1225 | NA | NA |
| X-23739 | NA | 2.0164 | NA | 2.4834 |
| X-24224 | NA | -0.2326 | NA | NA |
| X-24425 | 0.6803 | 0.3154 | 5.8489 | NA |
| X-24697 | NA | -0.5721 | NA | NA |
| X-25109 | NA | NA | NA | NA |
| X-25422 | 0.6145 | 5.3714 | NA | 3.1850 |
| X-25855 | 2.7762 | 1.7078 | 2.0983 | NA |
| X-25936 | NA | NA | NA | -0.2227 |
| xanthine | NA | NA | -1.0346 | NA |
Factors:
| F1 | Treatment:Heart tissue SLU915 with sham surgery |
| F2 | Treatment:Heart tissue SLU915 with TAC surgery |
| F3 | Treatment:Heart tissue vehicle with sham surgery |
| F4 | Treatment:Heart tissue vehicle with TAC surgery |
